Odds ratios for acute grade 2 or higher genitourinary and gastrointestinal toxicities reduced for MRg-A-SBRT versus CT-SBRT
By Elana Gotkine HealthDay Reporter
MONDAY, July 24, 2023 (HealthDay News) — For patients with prostate cancer, magnetic resonanceâguided daily adaptive stereotactic body radiotherapy (MRg-A-SBRT) is associated with reduced toxicity compared with computed tomographyâguided nonadaptive prostate SBRT (CT-SBRT), according to a systematic review and metaâanalysis published online July 24 in Cancer.
Jonathan E. Leeman, M.D., from the DanaâFarber Cancer Institute/Brigham and Women’s Hospital in Boston, and colleagues conducted a meta-analysis to compare acute toxicity rates associated with MRgâAâSBRT and CTâSBRT for prostate cancer. A total of 29 prospective studies, with 2,547 patients, met the inclusion criteria.
The researchers found that the pooled estimates for acute grade 2 or higher (G2+) genitourinary and gastrointestinal toxicity were 16 and 4 percent, respectively, for MRg-A-SBRT, compared with 28 and 9 percent, respectively, for CT-SBRT. The odds ratios for acute G2+ genitourinary and gastrointestinal toxicities comparing MRg-A-SBRT and CT-SBRT were 0.56 and 0.40, respectively, on meta-regression.
“Because there are multiple technical differences between these approaches, further prospective investigation is needed to pinpoint the specific underlying causes, and in particular the role of daily adaptive planning,” the authors write. “Whether late toxicity and cancer control rates differ with the use of MRgâAâSBRT compared to CTâSBRT will require longer followâup to determine.”
Several authors disclosed ties to the biopharmaceutical industry.
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