Home News General Health News Tenapanor Reduces Elevated Serum Phosphate in CKD

Tenapanor Reduces Elevated Serum Phosphate in CKD

Adverse events limited to softened stool, modest increase in bowel movement freqeuncy

FRIDAY, March 8, 2019 (HealthDay News) — For hyperphosphatemic patients with chronic kidney disease receiving maintenance hemodialysis, tenapanor significantly reduces elevated serum phosphate, according to a study published online March 7 in the Journal of the American Society of Nephrology.

Geoffrey A. Block, M.D., from Denver Nephrology, and colleagues conducted a phase 3 randomized trial involving hyperphosphatemic patients undergoing maintenance hemodialysis who received twice-daily oral tenapanor (3, 10, or 30 mg) for eight weeks. Patients were then randomly assigned to receive their previously assigned dose or placebo for a withdrawal period of four weeks.

Two hundred nineteen patients were randomly assigned; 152 completed both phases. The researchers found that all three treatment groups experienced significant decreases in mean serum phosphate during the initial eight-week treatment period (reductions of 1.00, 1.02, and 1.19 mg/dL, respectively). During the withdrawal period, tenapanor also showed a significant benefit over placebo, with a mean increase in the serum phosphate level of 0.85 versus 0.02 mg/dL in the placebo group versus the pooled tenapanor group. Adverse events were mainly limited to softened stool and a modest increase in the frequency of bowel movements.

“I am extremely excited about the therapeutic potential of tenapanor in patients with advanced chronic kidney disease,” a coauthor said in a statement. “Tenapanor is not a phosphate binder, but rather, a novel agent that inhibits the intestinal absorption of phosphorus.”

All study authors disclosed financial ties to Ardelyx, which manufactures tenapanor and funded the study.

Abstract/Full Text (subscription or payment may be required)

Copyright © 2019 HealthDay. All rights reserved.