More than one-quarter are classified as rapid decliners, which was more common with type 2 diabetes
WEDNESDAY, June 23, 2021 (HealthDay News) — More than four in 10 patients with diabetes have diabetic kidney disease (DKD), according to a study published online June 14 in BMJ Open Diabetes Research & Care.
TomÃ¡s P. Griffin, M.B., B.Ch., Ph.D., from Galway University Hospitals in Ireland, and colleagues assessed the prevalence of DKD and rapid renal function decline, as well as associated risk factors, among 4,606 adults attending a diabetes center in Northern Europe.
The researchers found that 42 percent of all diabetes patients had DKD, as did 23.4 percent with type 1 diabetes and 47.9 percent with type 2 diabetes. Rapid decline was more frequent with type 2 diabetes than with type 1 diabetes (32.8 versus 14 percent). Factors independently associated with rapid estimated glomerular filtration rate decline included older age, greater number of antihypertensive medications, higher log-normalized urine albumin to creatinine ratio (LNuACR), serum alkaline phosphatase, thyroid stimulating hormone, variability in systolic blood pressure and variability in LNuACR, lower glycated hemoglobin, high-density lipoprotein cholesterol and diastolic blood pressure, and lack of angiotensin-converting enzyme inhibitor/angiotensin receptor blocker prescription.
“The relatively high prevalence of diabetic kidney disease and ‘rapid decliners’ in a well-managed cohort of adults with diabetes highlights the need for urgent public health intervention and for optimization of diabetic kidney disease prevention/treatment strategies,” the authors write.
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