Home News Cancer News Earlier Screening Urged for Relatives of Prostate Cancer Patients

Earlier Screening Urged for Relatives of Prostate Cancer Patients

Men with family history of prostate cancer reach the screening risk threshold up to 12 years earlier than men in the general population

FRIDAY, June 4, 2021 (HealthDay News) — The optimal age for starting prostate cancer (PCa) screening in relatives of patients with PCa is younger than that in the general population, and varies by the number of first-degree relatives with PCa as well as their age at diagnosis, according to a study published June 1 in PLOS Medicine.

Xing Xu, from the German Cancer Research Center in Heidelberg, and colleagues used a nationwide cohort of all men aged 0 to 96 years at baseline (born after 1931) residing in Sweden and their fathers. From 1958 to 2015, a total of 6,343,727 men were identified, and their risk for prostate cancer was assessed.

The researchers report that 88,999 men were diagnosed with stage III/IV PCa or died of PCa. For men aged 50 years in the general population, the overall 10-year cumulative risk for stage III/IV or fatal PCa was 0.2 percent. For men with two or more first-degree relatives diagnosed with PCa and the youngest relative diagnosed before age 60 years, this screening level was reached at age 41 years. With two or more first-degree relatives diagnosed after age 59 years, men reached this screening level at age 43 years, which was similar to that of men with one first-degree relative diagnosed before age 60 years. This screening level was reached at age 45 years when one first-degree relative was diagnosed between ages 60 and 69 years and at 47 years when one first-degree relative was diagnosed after 69 years.

“Our clinically relevant findings could be used for evidence-based personalized PCa screening guidance and supplement current PCa screening guidelines for relatives of patients with PCa,” the authors write.

Abstract/Full Text

Copyright © 2021 HealthDay. All rights reserved.