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Alcohol Intake Tied to Fertility Treatment Outcomes

Among those receiving fertility treatments who had higher alcohol intake, women had reduced odds of achieving pregnancy, while men had reduced odds of live birth by partner

TUESDAY, Oct. 25, 2022 (HealthDay News) — Higher alcohol intake is associated with reduced odds of pregnancy or live birth after in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) treatment, according to a systematic review and meta-analysis published online Oct. 20 in Acta Obstetricia et Gynecologica Scandinavica.

Wentao Rao, from Tongji Medical College in Wuhan, China, and colleagues conducted a systematic review to examine the association between caffeine and alcohol consumption and IVF/ICSI outcomes. The review included 12 studies on caffeine consumption and 14 on alcohol consumption; seven and nine were eligible for the meta-analysis, respectively. The studies included 26,922 women and/or their spouses.

The researchers observed no significant association for women’s and men’s caffeine consumption with the pregnancy rate or the live birth rate of IVF/ICSI. There was a negative association for maternal alcohol consumption with pregnancy after IVF/ICSI treatment (odds ratio, 0.83; 95 percent confidence interval, 0.69 to 1.01). A negative association was seen for paternal alcohol consumption with a partner’s live birth after IVF/ICSI treatment (odds ratio, 0.88; 95 percent confidence interval, 0.79 to 0.99). Compared with abstainers, women and men who consumed greater than 84 g alcohol per week had a reduced chance of achieving a pregnancy and live birth with partner, respectively, after IVF/ICSI treatment (odds ratios [95 percent confidence intervals], 0.93 [0.90 to 0.98] and 0.91 [0.88 to 0.94], respectively).

“Couples should be aware that some modifiable lifestyle factors such as drinking habits may affect their fertility treatment outcomes,” a coauthor said in a statement. “But how these factors impact the reproductive system still needs more research to elucidate.”

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