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Age-Related Disease Risks Up for Younger B-NHL Survivors

Relative risks for acute renal failure, pneumonia, and nutritional deficiencies increased for survivors younger than 65 years versus 65 years of age or older

THURSDAY, Nov. 4, 2021 (HealthDay News) — Younger B-cell non-Hodgkin lymphoma (B-NHL) survivors have increased relative risks for specific age-related diseases (acute renal failure, pneumonia, and nutritional deficiencies) compared with older survivors relative to their peers in the general population, according to a study published online Nov. 1 in Cancer Epidemiology, Biomarkers & Prevention.

Krista Ocier, Ph.D., M.P.H., from the University of Utah School of Medicine in Salt Lake City, and colleagues estimated the incidence of age-related disease beside cardiovascular disease among younger versus older B-NHL survivors compared with general population cohorts. Survivors of B-NHL, diagnosed between 1997 and 2015, were matched with up to five cancer-free individuals on sex, birth year, and state of birth; data were included for 2,129 B-NHL survivors and 8,969 matched individuals.

The researchers found that at five or more years after cancer diagnosis, younger B-NHL survivors (<65 years) had higher relative risks for acute renal failure, pneumonia, and nutritional deficiencies (hazard ratios, 2.24, 2.42, and 2.08, respectively) compared with older survivors (≥65 years) relative to matched individuals.

“Earlier onset of age-related diseases is likely to occur among younger NHL survivors; therefore, periodic screening for a range of health outcomes and standardized care targeting these outcomes may be beneficial,” Ocier said in a statement. “Our results also support the possible need for nutritional intervention during and after cancer treatment because nutritional deficiencies may impact the overall quality of life of B-NHL survivors, especially the younger ones, as they age.”

One author disclosed financial ties to Backdrop Health, which specialized in analytics using electronic health record data. A second author disclosed receipt of personal fees from McKesson Corporation.

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