Federal Court Backs COVID-19 Vaccine Mandate at Indiana University

Ruling judge said students' right in refusing unwarranted medical treatment must be weighed against the state's greater interest

Canada to Welcome Fully Vaccinated Americans in August

Canada's 14-day quarantine requirement will be waived for people who are residing in the United States and are fully vaccinated

Impact of June 2021 Northwestern U.S. Heatwave on ED Visits Explored

Mean daily number of heat-related illness ED visits in HHS Region 10 was more than sevenfold higher for June 2021 than June 2019

Cycling Linked to Reduced All-Cause, CVD Mortality in Diabetes

Multivariable-adjusted hazard ratios for all-cause mortality reduced for one to 59, 60 to 149, 150 to 299, and ≥300 minutes/week

Global Prevalence of Young-Onset Dementia Examined

Worldwide, an estimated 3.9 million people aged 30 to 64 years are living with young-onset dementia

Score Assesses Health-Related QOL in Patients With Kidney Failure

Study supports validity of preference-based health utility score for patients undergoing hemodialysis, recent recipients of kidney transplants

Prescription Drug Dispensing to Children Down During Pandemic

Percentage changes were −51.3 and −17.4 percent for drug classes typically treating acute infections, chronic diseases

AAP Advises All School Children, Staff Should Continue to Wear Masks

Guidance runs counter to recommendations released by the U.S. Centers for Disease Control and Prevention earlier this month

Multitarget Fecal Immunochemical Test Ups Diagnostic Accuracy

Cross-validated sensitivity improved with multitarget FIT compared with standard FIT test for advanced neoplasia and advanced adenoma

Rates of Adverse Events Lower With Apixaban for A-Fib in Older Adults

Apixaban the only direct oral anticoagulant linked to lower adverse event rates than warfarin for patients with atrial fibrillation across frailty levels

More Than One-Quarter of Eligible Teens Have Received COVID-19 Shot

Obtaining more information about teen vaccine safety and efficacy, school vaccine requirement would increase vaccination intentions

Chinese Man Dies of Rare Virus From Monkeys

The Monkey B virus, also called the herpes B virus, is prevalent among macaque monkeys, but extremely rare among humans

SARS-CoV-2 Vaccines Effectively Prevent Infection in VA Population

Vaccine effectiveness was 96.2 percent for Pfizer-BioNTech BNT162b2 and 98.2 percent for Moderna mRNA-1273

Intensive BP Control After ICH May Be Risky for Some Patients

Intensive BP lowering after intracerebral hemorrhage linked to poorer outcomes in patients with decreased renal function

ASH Suggests Not Using Outpatient Thromboprophylaxis for COVID-19

For discharged patients without suspected or confirmed VTE or other indication for anticoagulation, panel suggests not using anticoagulants

Neck Symptoms Occur Relatively Frequently in MIS-C

28.5 percent of the identified MIS-C cases had neck-related symptoms; 38 of 39 had neck pain

U.S. Surgeon General Backs Local Mask Mandates When Needed

Such local orders are consistent with federal guidelines that permit local authorities to require prevention measures

An Estimated 279,000 Deaths Averted by U.S. COVID-19 Vaccine Program

By the end of June, there would have been up to 1.25 million additional hospitalizations without a vaccination program

Court Blocks Lifting of COVID-19 Restrictions on Cruise Ships

Florida lawsuit claims that the CDC rules for cruise ships are overly burdensome and affect state jobs and revenues

Testosterone Therapy for Hypogonadism May Cut Risk for CV Events

Risk for myocardial infarction or stroke lower with testosterone therapy among men with hypogonadism and other cardiovascular risk factors

Canada Surpasses U.S. COVID-19 Vaccination Rates

As of Saturday, more than 49 percent of eligible people in Canada were fully vaccinated, 70 percent had received at least one dose

Monkeypox Case Confirmed in U.S. Resident, Threat of Spread Is Low

Officials working to contact airline passengers and others who may have come into contact with the patient during two flights

Greater Daily Coffee Intake May Lower Risk for Arrhythmia

No evidence of effect modification seen in interaction analyses using polygenic score with seven polymorphisms, CYP1A2 rs762551 alone

COVID-19 mRNA Vaccine Reduces Infections in Cirrhosis Patients

64.8 percent reduction in COVID-19 infections seen 28 days after receipt of first dose of mRNA vaccine

AAP Issues Guideline for Managing Young Infants With Fever

Recommendations address evaluation, management of fever in infants aged 8 to 21, 22 to 28, 29 to 60 days; role of parents emphasized

Arthritis Rate ID’d After Posterior Shoulder Stabilization

Incidence of glenohumeral arthritis 1.7 per 100 person-years for posterior shoulder instability requiring surgical fixation

Even Low Levels of Lead in Drinking Water May Harm ESKD Patients

Hemoglobin levels lower, erythropoietin stimulating agent use higher, even for water lead levels below EPA threshold for regulatory action

Non-Antimicrobial Drugs Tied to Drug-Resistant Bacterial Infection

Proton pump inhibitors, beta-blockers, antimetabolites linked to infection with antibiotic-resistant bacteria

Globally, 8 Percent of Men Who Have Sex With Men Have Syphilis

Researchers say this is 15 times higher than estimates for men in the general population

Physician’s Briefing Weekly Coronavirus Roundup

Here is what the editors at Physician's Briefing chose as the most important COVID-19 developments for you and your practice for the week of...

FDA to Prioritize Full Approval for Pfizer COVID-19 Vaccine

Full approval could help boost vaccination efforts in the United States

$345 Million Settlement Proposed in EpiPen Lawsuits

Pfizer spokesperson denied any wrongdoing and said settlement was sought to avoid 'the distraction of continued litigation'

High-Dose Buprenorphine Induction in ED Seems Safe for Treating OUD

High-dose buprenorphine protocol well tolerated in patients with untreated opioid use disorder; no reports of respiratory depression or sedation

Canada May Open Borders to Fully Vaccinated Americans by Mid-August

However, mask mandate returns to Los Angeles as COVID-19 cases rise

Adding Ipilimumab to Nivolumab No Better in Pretreated Squamous NSCLC

No difference in overall survival seen with nivolumab plus ipilimumab, nivolumab alone for advanced, chemotherapy-pretreated disease

CDC Advisers to Discuss Third COVID-19 Vaccine Dose for Immunocompromised

Booster shots have become a hot topic since Pfizer-BioNTech said last week it would seek EUA for a third shot of its two-dose vaccine

No Benefit Seen From Adjuvant Celecoxib in ERBB2-Negative Breast Cancer

Disease-free survival did not improve with two years of celecoxib versus placebo in ERBB2-negative breast cancer

U.S. Surgeon General Issues Call to Counter ‘Urgent Threat’ of Vaccine Misinformation

Warning comes as the pace of COVID-19 vaccinations has slowed throughout the United States

Restrictive Eating Disorders Up Among Teens During Pandemic

For first 12 months of pandemic, number of admissions at children's hospital more than double for same period in previous three years

Outpatient Antibiotic Prescribing Down in VA System

Annual percent decrease for all outpatient antibiotic use averaged 3.9 percent; largest decrease seen in ciprofloxacin use at 12.6 percent

Staff Size, COVID-19 Outcomes Linked at Skilled Nursing Facilities

Conventional measures of staff quality, including direct care staff-to-resident ratio did not predict COVID-19 cases, deaths

Neutralizing Monoclonal Antibody Combo Treats Mild, Moderate COVID-19

For those at high risk, COVID-19-related hospitalization or death from any cause reduced with bamlanivimab/etesevimab versus placebo

Almost Half of Patients Admitted With COVID-19 Have Complications

Likelihood of having complications higher for men than women and for those aged older than 60 years

Meniscal Implant May Ease Post-Partial Meniscectomy Pain

Greater improvements in KOOS Overall and KOOS Pain seen in patients receiving synthetic medial meniscus implant versus nonsurgical care

Ruxolitinib Best for Glucocorticoid-Refractory, -Dependent GVHD

Overall response, failure-free survival, symptom response significantly greater with ruxolitinib versus control therapy

COVID-19 Outcomes May Be Worse for People With Learning Disability

Risks for COVID-19-related hospital admission, death higher for people with learning disability registered with a general practice in England

AHA Addresses Diagnosis, Management of Pediatric Myocarditis

Acute myocarditis commonly has an infectious cause, most often viral; myocarditis in children presents as several distinct clinical profiles

48.3 Percent of U.S. ≥16s Have Had at Least One Dose of COVID-19 Vaccine

As of May 15, 2021, coverage was lower for non-Hispanic Blacks and Hispanics versus Whites; higher for those at risk for severe COVID-19

Many States Move to Ban Vaccine Mandates, Passports in Public Schools

At least seven states have already passed such laws

Five Neutrogena and Aveeno Spray Sunscreens Recalled Due to Benzene

Johnson & Johnson said it was still investigating how traces of benzene were discovered in the sunscreens

Two Major Health Systems Will Not Administer Controversial Aduhelm

Individual doctors can prescribe Aduhelm, but patients would have to go elsewhere to receive the drug via infusion

Chinese Man Hospitalized With H5N6 Bird Flu

55-year-old, hospitalized in Bazhong, came down with a fever and tested positive for the virus on July 6

1999 to 2019 Saw Drop in Rate of Unintentional Drowning Deaths

Rate of unintentional drowning deaths decreased from 1.6 to 1.0 per 100,000 among children aged 0 to 17 years

Factors ID’d for Six-Year Outcomes of ACL Revision Surgery

Use of interference screw versus cross-pin for femoral fixation linked to better outcomes at six years

Atropine Plus Patching Ups Visual Acuity in Amblyopic Eye

Visual acuity of the affected eye improved more with atropine plus patching than patching alone in children with severe amblyopia

Review: Benefit Outweighs Harm of Statins for Primary Prevention of CVD

Risk for adverse events attributable to statins low when used for primary prevention of cardiovascular disease

Model Estimates Routine Child Vaccine Doses Missed During 2020

About 8.5 and 8.9 million more children than expected missed routine vaccination for DTP3 and MCV1, respectively, due to COVID-19 pandemic

Ultra-Processed Food May Up Risk for Inflammatory Bowel Disease

Higher risk for developing IBD associated with higher intake of ultra-processed foods, such as soft drinks, salty snacks, processed meat

Impact of Pandemic Projected for U.S. Breast Cancer Mortality

Cumulative increase of 0.52 percent expected in breast cancer deaths by 2030 due to disruptions during the first six months of the pandemic

Review Compiles Myocarditis Cases Associated With COVID-19

COVID-19-related myocarditis profiled from 42 cases reported in articles published from December 2019 through January 5, 2021

Late-Life Cognitive Activity May Delay Dementia

Taking up reading, puzzles, and games even in one's 80s may provide cognitive protection

Some Hospitalized COVID-19 Patients Have Ongoing GI Symptoms

Malnutrition is the most persistent GI symptom up to six months following hospitalization

New COVID-19 Cases Doubled in U.S. in Past Three Weeks

As cases climb, health authorities in places such as Los Angeles County and St. Louis are begging even the fully vaccinated to don their masks in public

Rahul Gupta to Be Nominated as Next U.S. Drug Czar

Gupta was the former health commissioner of West Virginia and is chief medical and health officer for the March of Dimes

Plant-Based, Soy-Rich Diet Studied in Postmenopausal Women

Low-fat, vegan diet that includes whole soybeans may reduce frequency, severity of hot flashes and improve QOL in postmenopausal women

U.S. Drug Overdose Deaths Up ~30 Percent in 2020

Increases seen in overdose deaths from opioids, as well as cocaine and psychostimulants

Study Looks at Cancer Cases Attributable to Alcohol Use

In 2020, an estimated 4.1 percent of all new cancer cases globally attributed to alcohol consumption

Iron Deficiency May Increase Mortality, CV Risks in Nondialysis CKD

Iron deficiency, indicated by low transferrin saturation, tied to higher mortality, CV event risks in nondialysis CKD patients with or without anemia

Methamphetamine-Linked Heart Failure Up in California

Increase of 585 percent seen in methamphetamine-associated cardiomyopathy/heart failure hospitalizations from 2008 to 2018

Unmet Social Needs, Distress Linked in Gynecologic Oncology Patients

Social isolation and lack of safety at home associated with distress; unmet needs also linked to treatment interruption

EHR Use Varies Across Primary Care Specialties

Pediatric clinicians spend less total and after-hours time versus general medicine and family medicine clinicians

Multiple Sclerosis Disease Burden Higher in Black Patients

Both self-reported disability and objective assessments worse for Black patients, independent of socioeconomic status

Rx Treatment for Opioid Use Disorder Up Among Medicaid Enrollees

There are still considerable gaps in medication care, with Black enrollees having lower use than Whites

Risk Factors ID’d for Severe COVID-19 With Sickle Cell Disease

Hydroxyurea use does not impact development of serious COVID-19 or need for hospitalization in children or adults

Teen, Parent Response Explored for Cardiomyopathy Genetic Tests

Families with positive predictive test results had better functioning scores than those with negative predictive test results

WHO: Get COVID-19 Vaccines to Poor Nations Instead of Making Booster Shots

Advocacy group ONE Campaign says only 1 percent of people in poor countries have received even one COVID-19 vaccine dose

Medicare Mulls Coverage for Controversial Drug for Alzheimer Disease

CMS says a final decision on coverage is not likely until next spring

Pfizer Presses U.S. Scientists, Officials on Third Booster Shot

U.S. officials say that more data are needed before regulators can determine whether booster shots are necessary

Lawsuits Claim Pesticide Caused Harm to Children’s Brains

Chlorpyrifos is approved for use on more than 80 crops but was banned for household use in 2001

Questionnaire Responses About Dermatology History Inconsistent

History of psoriasis consistently reported, whereas history of atopic dermatitis is not

AAN Presents Ethical Considerations Relating to Dementia Care

Timely anticipatory planning in early dementia is crucial to preserve autonomy over future decisions and to reduce caregiver strain

High-Efficacy Therapy May Reduce Relapses in Active SPMS

But no difference in disability progression seen for high-efficacy versus low-efficacy therapy for secondary progressive multiple sclerosis

Athletes Have Higher Risk for Developing Atrial Fibrillation

Risk greater in athletes younger than 55 years and among those participating in mixed sport versus endurance sport

Disparities in Breast Cancer Survival Persist for Black Women

Although nearly all metrics improved for racial-ethnic minorities, recent breast cancer-related mortality in Florida still higher in Black women

Risk for Atherosclerotic CVD Increased With South Asian Ancestry

Higher risk persisted after adjustment for broad range of clinical, anthropometric, and lifestyle risk factors

ACIP: Benefits of mRNA COVID-19 Vaccines Outweigh Risks for ≥12s

After reviewing evidence, including data on risks for myocarditis, vaccination benefits outweigh risks for all populations

Omega-3 Fatty Acids Tied to Better Cardiovascular Outcomes

Cardiovascular risk reduction more prominent with EPA monotherapy versus EPA + DHA therapy

Longer Reproductive Window Could Up Risk for Alzheimer Disease

Authors suggest longer exposure to endogenous estrogen may be associated with increased levels of Alzheimer disease biomarkers

Androgenetic Alopecia May Reduce Health-Related Quality of Life

Authors say patients with androgenetic alopecia may need psychological, psychosocial support

mRNA From COVID-19 Vaccines Not Detectable in Breast Milk

Authors say lactating women receiving a COVID-19 vaccine do not need to stop breastfeeding

Nearly Four in 10 With Mild COVID-19 Report Symptoms Seven Months Later

Fatigue remains the most common symptom among otherwise healthy people

Guidance Updated for Managing C. difficile Infection in Adults

Fidaxomicin suggested instead of vancomycin for initial Clostridioides difficile infection episode, recurrent CDI episodes

Teens, Parents View Provider Sexual Health Discussions as Important

However, less than one-third of teens reported discussions about sexual and reproductive health topics other than puberty at most recent visit

MRI-Enhanced Screening Strategy Noninferior for Prostate Cancer​

MRI with targeted and standard biopsy in those with positive MRI results noninferior to standard biopsy in men with elevated PSA levels

CDC: Vaccinated Teachers, Students Can Skip Masks This Fall

Relaxed recommendation comes as a national vaccination campaign in which children as young as 12 years can get COVID-19 shots unfolds

Pfizer to Seek Approval for COVID-19 Booster Shot

However, just hours after the announcement, the FDA and CDC issued joint statement saying Americans do not need booster shots yet

No Spectators to Be Allowed at Tokyo Olympic Games

Decision came after a new state of emergency was declared in the city due to a sudden surge in COVID-19 cases

COVID-19 Cases Surge in Los Angeles County as Delta Variant Spreads

Across California, the rate of COVID-19 tests that are positive has tripled since the state fully reopened last month

Health Equity Not Adequately Addressed in COVID-19 Vaccine Distribution

Minority group representatives present in only a minority of state vaccine plans

ASCO Updates Recommendations for Managing Hereditary Breast Cancer

Rapid recommendation provides updated guidance on the use of adjuvant olaparib

Face Masks May Expose Children to Higher Carbon Dioxide Levels

Authors say levels, especially in younger children, are higher than recommended limits

Surges in Hospital Caseload Tied to Higher COVID-19 Mortality

Patients receiving care in hospitals during surges have up to twice the COVID-19 mortality risk versus those seen in nonsurging hospital-months

Endometriosis Can Have Major Impact on Women’s Work Life

Finnish study shows endometriosis associated with significantly more disability days among women aged 46 to 48 years

Orthopedic Surgery May Not Be More Effective Than Nonsurgical Alternatives

For six of the 10 most common elective orthopedic procedures, evidence showed no benefit over nonoperative care

Digital Self-Monitoring Effective for Weight Loss, Healthy Lifestyle

Finding significantly associated with tailored advice among adults with obesity, overweight

Preablation Weight Loss Linked to Freedom From A-Fib

Change in weight over preceding year linked to success of catheter ablation for AF at 15 months for obese, nonobese patients

Reading Problems in Childhood Tied to Poorer Memory Scores in Adulthood

Reading problems also linked to poorer Addenbrooke's Cognition Examination scores at age 69 years, which were partially mediated by education

Physician’s Briefing Weekly Coronavirus Roundup

Here is what the editors at Physician's Briefing chose as the most important COVID-19 developments for you and your practice for the week of...

Hepatitis B Virus Monitoring Needed After Liver Transplantation

While the risk is small, there have been 20 cases of unexpected donor-derived hepatitis B virus infection

New Rx Instructions Tighten Use of Controversial Alzheimer Disease Drug

Major changes to prescribing instructions are rare, especially so soon after approval; change could curb the drug's use

Benefit, Safety of Muscle Relaxants for Low Back Pain Uncertain

Findings based on large literature review and meta-analysis

COVID-19 Death Toll Passes 4 Million Globally

Rapid spread of the Delta variant has prompted the U.S. government to send a COVID-19 surge team to provide support in Southwest Missouri

Tooth Loss May Up Risk for Cognitive Decline, Dementia

Dose-response relationship demonstrated between the number of missing teeth and risk for cognitive decline

Pharmacy Exec Behind Meningitis Outbreak Gets Longer Prison Sentence

President and co-owner of the New England Compounding Center received a 14.5-year sentence from a federal judge Wednesday

One in Five Privately Insured Births May Result in a Surprise Medical Bill

Surprise bills more frequent and larger with cesarean delivery and neonatal intensive care

California to Pay Reparations to Victims of Forced Sterilization

California will be the third state to compensate victims of the so-called eugenics movement that peaked in the 1930s

Cytisine Not Noninferior to Varenicline for Smoking Cessation

Significantly fewer adverse reactions reported by those in the cytisine group versus the varenicline group

Carbogen and Nicotinamide With Radiation Feasible for Bladder Cancer

Trial involving seven patients with locally advanced bladder cancer shows concurrent CON with radiation therapy feasible in Australia

Mesh Removal Has Limited Impact for Women With Pain

Mesh removal often does not improve symptoms among women with pain after urogynecological mesh insertion

Link Found for Weight-, Shape-Related Bullying, Eating Disorder Behaviors

Frequency of bullying positively linked to purging, muscularity-oriented behavior, but not dietary restriction, binge eating

Use of Self-Applied TENS Device at Home Can Relieve Migraine Pain

Pain scores significantly reduced with use of TENS device; greater improvement seen in functionality

Factors ID’d for Radiologist Performance in Screening Mammography

Geographic location of radiology practice, breast subspecialization, performing diagnostic mammography tied to radiologist performance

Racial, Ethnic Disparities Explored in Subjective Cognitive Decline

More Black and Hispanic adults than White adults report subjective cognitive decline at age 45 to 54 years

U.S. Cancer Mortality Rates Down From 2014 to 2018

Decrease seen for 11 of the 19 most common cancers among men and for 14 of the 20 most common cancers among women

Glycemic Control Has Not Been Impacted by Pandemic

Despite drop in diabetes-related outpatient visits and testing, no negative association found with glycemic control

AI Can Estimate Age Reduction Effect of Face-Lift Surgery

Algorithms can reliably estimate reductions in apparent age after face-lift surgery; reduction correlates with patient satisfaction

Behavioral, Biological Links Studied in Eating Disorders

Functional brain imaging used to assess brain reward response and ventral striatal-hypothalamic circuitry in young women with eating disorders

Cognitive, Functional Decline Detected Prior to Stroke

Patients with stroke have steeper declines in the 10 years before stroke compared with stroke-free controls

Impact of Age Examined for Ticagrelor Monotherapy After PCI

Ticagrelor monotherapy reduces bleeding without increasing ischemic events among patients undergoing PCI

Mortality Rates for Those Entering HIV Care Reduced Over Time

Difference in five-year mortality decreased between those entering HIV care and matched population during 1999 to 2017

Treatment at Infusion Center Beneficial in Sickle Cell Disease

Outcomes significantly better for treatment of vaso-occlusive crises at infusion center versus emergency department

Mental, Physical, Sexual Abuse Up for Transgender Adolescents

Transgender males and nonbinary adolescents assigned female at birth have higher odds of psychological abuse

Oral Contraceptives Lower Ovarian Cancer Risk in BRCA Carriers

Findings seen in BRCA1 and BRCA2 mutation carriers; reduction greater with longer duration of use in BRCA1 carriers

Catheter Ablation Improves A-Fib Outcomes in Racial/Ethnic Minorities

In contrast, much higher event rate seen for racial and ethnic minorities randomly assigned to drug therapy in CABANA trial

Past-Year Dental Visits More Frequent in Urban Versus Rural Areas

Women more likely than men, and those with higher income more likely to have dental visit within past 12 months

Telephone Consults Convenient, Effective for Gynecological Care

77 percent of patients would repeat a telephone consult; most beneficial for menopause, fertility, endometriosis follow-up

Patient Engagement May Not Drive Return to In-Person Visits

Findings seen among patients receiving letter during reopening following cancellation of in-person care during COVID-19

Delta Variant Now Behind More Than 50 Percent of U.S. COVID-19 Cases

Alpha variant, which first surfaced in Britain and dominated infections in America for months, now only accounts for 28.7 percent of cases

Blood Shortages Causing Surgery Delays Across the United States

Some U.S. blood centers have only a one-day supply

Many Youth With Blood Cancers Receive Intensive End-of-Life Care

Influencing factors include hospital size, insurance type, geographic region

Glucose-Lowering Therapy Delayed for Newly Diagnosed T2DM Patients

Factors in therapeutic inertia examined in adults newly diagnosed with T2DM receiving primary care in the U.K.

Ticagrelor, Prasugrel Compared in ACS Treated With PCI

Prespecified subgroup analysis of data from a randomized clinical trial suggest that a prasugrel-based strategy is preferable

Prevalence of Psoriasis 3 Percent in U.S. Population Age 20+

Prevalence similar for women and men, highest among Whites, not significantly different from 2003

Two-Dose Novavax Vaccine Protects Against SARS-CoV-2 Infection

Vaccine efficacy in adults was 89.7 percent overall, 86.3 percent against B.1.1.7 (alpha) variant, and 96.4 percent against non-B.1.1.7 variants

Recommended Therapy for Low Back Pain May Cut Lost Workdays

Adherence to guideline-recommended interventions linked to fewer lost workdays in workers with acute low back pain injuries

Tool Estimates Mortality Risk for ​Seniors Using Home Care​

Model uses data reported by older adults receiving home care and their caregivers, family members to estimate six-month mortality risk

Familial Hereditary Risk Seen for Hematologic Cancers

Findings based on large study of twins, which showed risk is higher if twin has a hematologic cancer

Teens’ Perceived Availability of Pot, Alcohol, Vaping Devices Down During Pandemic

Findings based on survey taken before, during COVID-19 pandemic, but actual use did not decline as dramatically

Just 20 States Reached Biden’s July 4 Vaccination Goal

Parts of the South, Southwest, and Midwest starting to see surges, particularly Florida, with about 17 percent of all new cases reported there

Radioligand Therapy Slows Advanced PSMA+ Prostate Cancer

177Lu-PSMA-617 added to standard care prolonged imaging-based progression-free survival and overall survival

Britain to Fully Reopen Soon, Despite Rising COVID-19 Cases

Confirmed COVID-19 cases in Britain have increased, but number of deaths has stayed stable

Use of Bronchodilators Down for Bronchiolitis Treatment in Infants

High hospital-level bronchodilator use not associated with better outcomes; adjustment follows AAP recommendations to limit routine use for bronchiolitis

CDC: Listeria Outbreak Linked to Precooked Chicken

Three people have been hospitalized; one death has been reported in Texas

Male Circumcision for HIV Prevention Up in African Region

By 2019, prevalence was 90.2 percent among males aged 15 to 24 years, but remained below 80 percent for older men

Racial Differences Seen in Inherited Risk of Early-Onset Cancer

Higher familial risks for early-onset cancer seen in Latinos, Blacks for solid tumors and in Asian/Pacific Islanders for hematologic cancers

Changes in Movement May Indicate Preclinical Alzheimer Disease

Changes in daytime fractal motor activity regulation may occur in women before cognitive symptoms of Alzheimer disease

Physician’s Briefing Weekly Coronavirus Roundup

Here is what the editors at Physician's Briefing chose as the most important COVID-19 developments for you and your practice for the week of...

Hearing Impairment Tied to Poorer Physical Function

Findings for physical performance, balance, and gait in community-dwelling older adults

Mental Health Needs Described After Hurricane Irma

In 20 months after hurricane, 17 percent of households reported need for a mental health care provider; 37.9 percent did not receive these services

Exercising With a Mask Safe, Does Not Impact Exercise Capacity

However, masks may impact how well individuals perceive tolerance to vigorous-to-peak intensity exercise

J&J Vaccine Guards Against Delta Variant, Company Says

Although there was a slight drop in potency against the Delta variant, vaccine was more effective against the Delta variant than the Beta variant

Biden Administration Pushes Forward With Law on Surprise Medical Bills

Proposed provisions would more clearly outline charges to be expected during medical emergencies, offer protections to consumers

HIV Incidence Remains Low With PrEP in Real-World Setting

Study of mainly gay or bisexual men shows low incidence of HIV, even when PrEP was mostly purchased rather than provided free

Wealth Mobility in Midlife Tied to Risk for CV Events, Death

Upward wealth mobility linked to lower levels of cardiovascular events or related deaths, while downward mobility linked to higher risks

Response to COVID-19 Vaccine Variable in Multiple Myeloma Patients

Considerable variation seen in magnitude of antibody response, from 5 to 7,882 AU/mL, following two doses of mRNA COVID-19 vaccine

Outcomes Worse for Immediate Sequential Bilateral Cataract Surgery

Slightly better outcomes in visual acuity seen for short-term versus long-term delayed sequential bilateral cataract surgery

MIS-C Diagnosed More Often in Black, Hispanic Children

No differences seen in phylogenetic analysis of viral genome sequences when comparing MIS-C, primary COVID-19 patients

Multiple Physical Morbidities Tied to Later Mental Health Disorders

People with two or more physical health conditions are at higher risk for developing depression, anxiety

Very Elderly Can Benefit From Brain Tumor Surgery

While there is short-term excess mortality, cumulative survival is similar to the general population

Gestational Diabetes May Increase Risk for Fetal Hypoxia

Hypoxia-related ZigZag pattern, late decelerations of FHR on intrapartal CTG and increased risk of fetal asphyxia seen in GDM pregnancies

House Committees to Investigate New Alzheimer Disease Drug Approval

FDA approved Aduhelm earlier this month, despite advisory committee's conclusion that there was not enough evidence to support its effectiveness

COVID-19 Falls From America’s No. 1 Killer to No. 7 by June

COVID-19 deaths have fallen sharply as vaccination rates have surged in recent months

Diet Rich in Omega 3 Fatty Acids Cuts Migraines in Adults

Diets with increased EPA, DHA with or without decrease in linoleic acid reduced headaches but did not significantly improve QOL

Masks Still Not Needed for Vaccinated Americans, CDC Director Says

However, there are instances where local authorities might set mask mandates to protect unvaccinated against the Delta variant

Physician Knowledge Linked to Less Opioid Prescribing in 2015 to 2017

During 2015 to 2017, opioids prescribed less often for back pain at visits with physicians in highest versus lowest knowledge quartile

Women’s Cancer Screenings Plummeted During Pandemic

Decline especially noticeable among women of racial and ethnic minority groups with low incomes

Oral Transglutaminase 2 Inhibitor Beneficial in Celiac Disease

ZED1227 attenuates gluten-induced duodenal mucosal damage among patients undergoing daily gluten challenge

Drug May Curb ‘Sluggish’ Thinking in Some Adults With ADHD

Lisdexamfetamine found to reduce symptoms of sluggish cognitive tempo in small group of adults with ADHD

Higher Grit Scores Tied to Wellness in Surgery Residents

Those with higher grit scores were significantly less likely to report burnout, thoughts of attrition, suicidal thoughts

Inflammation at IP Thumb Joint Common in Psoriatic Arthritis

Risk of MRI global inflammation around thumb IP joint higher than in patients with undifferentiated inflammatory arthritis

mRNA Vaccines Effectively Prevent SARS-CoV-2 in Adults in Real-World Setting

For those with SARS-CoV-2 infection, vaccinated participants had lower mean viral load, risk of febrile symptoms, illness duration

Risk of Migraine May Be Higher With Rosacea

Men with rosacea have twice the risk for self-reported migraine versus those without rosacea

Prediction Model for Brain Age May Help Detect Cognitive Decline

Greater differences between predicted age based on brain MRI and actual age seen in those with amnestic MCI versus healthy controls

Pediatric Obstructive Sleep Apnea Linked to Elevated BP in Teens

Dose-response correlation seen, with about twofold increased risk of elevated BP with apnea-hypopnea index of 5 or more

Ovarian Stimulation Drugs Not Tied to Higher Breast Cancer Risk

Use of clomiphene citrate or gonadotropins, alone or in combination, not associated with increased risk for breast cancer

Drop Seen in Physician Work Hours During COVID-19 Pandemic

Full-time status significantly declined among female physicians with preschool-aged children

16.8 Million Undiagnosed COVID-19 Cases in First Six Months in U.S.

Overall weighted undiagnosed seropositivity estimate was 4.6 percent, with estimates ranging from 1.1 to 14.2 percent by subgroup

Most Americans Who Wanted COVID-19 Vaccine Have Already Gotten One

Only 3 percent of those who have not been vaccinated said they plan to do so as soon as they can

Zuranolone Bests Placebo in Postpartum Depression

At day 15, significantly greater reduction seen in depressive symptoms as measured by change in HAMD-17 score from baseline

Low Exercise May Amplify Link Between Poor Sleep, Mortality Risk

Highest risks for all-cause, total CVD, total cancer, lung cancer mortality seen in no moderate-to-vigorous physical activity/poor sleep group

Lower BMI Cutoff Tied to Endometrial Cancer in Chinese Women

Lower obesity threshold of BMI ≥25 kg/m2 tied to increased risk of endometrial cancer in Asian women presenting with postmenopausal bleeding

Strategies ID’d Than Can Interrupt Spread of Infectious Disease

Key elements of effective system include border controls, restricted entry, quarantine for inbound travelers

Many Saw Improvements in Migraine During Quarantine

Authors say findings suggest reduction in daily challenges may have benefited migraine sufferers

Dietary Patterns May Affect Risk for Sudden Cardiac Death

Greater adherence to Southern dietary pattern linked to higher risk for sudden cardiac death, but the association was not statistically significant

Annual Hospital Costs of $109 Million for Pediatric Firearm Injuries

Substantial cost differences seen based on hospital region, patient race, and income quartile

Providing Infant Carrier May Up Breastfeeding at Six Months

Parents receiving ergonomic infant carrier, instructions on proper use more likely to breastfeed at six months postpartum

Medication Type for T2DM May Affect Severe COVID-19 Outcomes

Premorbid GLP1-RA use, SGLT2i use associated with lower 60-day mortality compared to premorbid DPP4i use

Guideline Updated for Blood Management During Heart Surgery

Measures of blood conservation should be undertaken, including retrograde autologous priming of cardiopulmonary bypass circuit

ADA: Peds Hospitalization Rates for New-Onset T2DM Up During Pandemic

Hospitalization rate for new onset diabetes up from 0.27 percent in 2019 to 0.62 percent in 2020; mean admission HbA1c, glucose also higher