BinaxNOW Rapid Antigen Test Has Lower Sensitivity Than RT-PCR

Sensitivity 64.2 and 35.8 percent for specimens from symptomatic and asymptomatic persons, with near 100 percent specificity

For COVID-19 ICU Patients, Death Linked to COVID-19 ICU Strain

Mortality increased when COVID-19 ICU demand was >75 to 100 percent for patients treated in COVID-19 ICU

Rates of Suicide, Suicide Attempts Up for Individuals With Autism

More than 90 percent of those with ASD with suicide attempt, suicide had another comorbid condition

Tool Can Predict Chemo Toxicity for Seniors With Breast Cancer

Score has been developed and validated that includes eight independent predictors of grade 3 to 5 chemotherapy toxicity

Nearly One in Four Doctors Report Harassment on Social Media

No gender difference seen in personal attacks; women significantly more likely to report online sexual harassment

Rachel Levine Nominated as U.S. Assistant Health Secretary

Levine is secretary of health for Pennsylvania and is currently leading the state's response to the COVID-19 pandemic

Default Opt-Out of Cardiac Rehabilitation Increases Referrals

Redesign of decision pathways from opt-in to opt-out results in increase in referrals for cardiac rehabilitation

Myopia Up in Children Confined to Home During Pandemic

Substantial myopic shift and increased prevalence of myopia seen among children aged 6, 7, 8 years

Improving Access to After-Hours Primary Care Cuts ED Visits

Incentivizing physicians to improve access to after-hours care reduces some less-urgent visits to emergency department

Steps Outlined to Reduce Postop Delirium in Older Adults

Anesthesiologists play key role on multidisciplinary team to optimize perioperative brain health in older adults

Routine Use of Antibiotics After Sinus Surgery Questioned

Small randomized trial shows similar infection rates, more diarrhea with antibiotic versus placebo after endoscopic sinus surgery

1999 to 2018 Saw Decrease in Cancer-Related Suicide

Largest decreases seen among high-risk populations, including men, older patients, patients with prostate and lung cancer

Estrogen Therapy Need Not Stop for Gender-Affirming Surgery

Authors find that perioperative venous thromboembolism rarely occurs, regardless of suspension of hormone therapy prior to surgery

IgG Level in Convalescent Plasma Affects COVID-19 Death Risk

Risk for death reduced with higher versus lower levels of anti-SARS-CoV-2 IgG, but only in patients not receiving mechanical ventilation

COVID-19 Vaccine Likely Safe for Lactating Women

However, Academy of Breastfeeding Medicine calls for lactating women to be included in trials

Many Parents Support Peer Mental Health Programs at Schools

Majority of parents say peers would understand teens' problems better than adults

USPSTF Affirms Evidence-Based Methods for Smoking Cessation

Behavioral and pharmacotherapy interventions, alone or in combination, recommended; evidence insufficient for e-cigarettes

Virtual Care Maintains Quality Cancer Care

Majority of patients, physicians report satisfaction with virtual care

Expert Panel Criticizes WHO, China for Pandemic Response

Panel finds there were 'lost opportunities' to establish basic public health measures early in the pandemic

California First State With Over 3 Million COVID-19 Cases

Biden administration has said it will not be lifting restrictions on international travel

Smokers More Likely to Report Symptoms Suggestive of COVID-19

Current smokers have increased risk for reporting classic symptoms, more than five symptoms, more than 10 symptoms

One-Third of U.S. Adults Likely to Refuse a COVID-19 Vaccine

Blacks, women, and conservatives more hesitant in the United States

Stem Cell Infusions Investigated for Treatment of COVID-19 ARDS

Researchers explore possible anti-inflammatory effects of mesenchymal stem cells in COVID-19 acute respiratory distress syndrome

Higher Dietary Fiber Lowers Premenopausal Depression Risk

Significant association between dietary fiber intake and prevalence of depression seen for premenopausal, but not postmenopausal, women

Stopping RAS Inhibitors May Worsen Outcomes in CKD

Stopping therapy tied to lower risk for dialysis, but higher risk for cardiovascular events and death

Physician’s Briefing Weekly Coronavirus Roundup

Here is what the editors at Physician's Briefing chose as the most important COVID-19 developments for you and your practice for the week of...

Bupropion-Naltrexone Bests Placebo in Methamphetamine Use Disorder

Response was low but higher with naltrexone-bupropion than placebo during 12-week, two-stage trial

Breast, Cervical, CRC Screening Below Healthy People 2020 Targets

Colorectal cancer test receipt near target in 2018, with 66.9 percent of adults aged 50 to 75 years up to date with testing

Cardiorespiratory Fitness Linked to Psoriasis, Psoriatic Arthritis

Significant association found between low cardiorespiratory fitness at mean age of 18.3 years and psoriasis, psoriatic arthritis among men

Life Expectancy Reduced Considerably Due to COVID-19

Life expectancy at birth reduced by 1.13 years to 77.48 years; reductions greater for Blacks, Latinos versus Whites

Repeat Postvasectomy Semen Analyses Down Under New Guidelines

Men in postguideline cohort had lower risk for requiring any repeat postvasectomy semen analysis

Primary Care-Recorded Mental Illness Decreased During COVID-19

Reductions seen in incidence of primary care-recorded depression, anxiety disorders, first antidepressant prescribing in United Kingdom

Memory Preserved in Rare Aphasia Tied to Alzheimer Disease

Decline in language function, but not episodic memory, seen for primary progressive aphasia associated with Alzheimer disease

Previous COVID-19 Infection May Confer Immunity for at Least Five Months

Team from Public Health England analyzed data from months of regular testing of health care workers

Referrals for Acute Heart Failure Dropped During COVID-19

Referrals to acute heart failure team decreased; corresponding increase seen in 30-day case fatality rate

Women Forgoing Reconstruction After Mastectomy Pleased

22 percent experienced 'flat denial,' when the option of no reconstruction after mastectomy was not initially offered

More Diabetes Remission in T2DM Seen With Low-Carb Diets for Six Months

Large clinically important improvements observed in weight loss, triglycerides, and insulin sensitivity, which decreased at 12 months

Drop in ED Visits for Cardiac Conditions Tied to Later Cardiac Deaths

Undertreatment of cardiac conditions during COVID-19 pandemic tied to delayed excess mortality versus previous years

CDC Describes COVID-19 Trends in Nursing Home Residents, Staff

Rates of COVID-19 increased during June and July, followed by decline through mid-September, increase by late November

College Campuses at Risk for Extreme Incidence of COVID-19

Colleges rapidly reduced the number of new infections, but many failed to control the spread beyond the campus

Cochlear Implants Aid Speech Recognition in Most Adults

However, individual benefit shows large degree of variability

Multifocal Microvascular Injury ID’d in Brain in COVID-19

No SARS-CoV-2 detected in postmortem samples, but brain may be susceptible to microvascular damage

Incidence of COVID-19 Increased in Children Since September

Trends for children tracked consistently with those of adults; incidence lower for children aged 0 to 10 years

Greater Levels of Exercise May Protect Brain in Later Life

Greater levels of moderate- to vigorous-intensity physical activity linked to more intact white matter integrity in late life, lower odds of lacunar infarcts

Mental Health Disorders Common Among ICU Staff During COVID-19

45 percent of respondents met threshold for probable clinical significance on measures of depression, PTSD, anxiety, problem drinking

Exercise Key to Lowering Risk for Gestational Diabetes

However, authors say amount of exercise needed may be more than current recommendations

U.S. COVID-19 Vaccine Rollout Nears 1 Million Doses Per Day

News comes as Ohio State University researchers discover new variant of COVID-19 virus

WHO Experts Finally Arrive in Wuhan for COVID-19 Investigation

First known cases of the novel coronavirus appeared in the city more than a year ago

Causal Link Suggested for Smoking, Subarachnoid Hemorrhage

Genetic susceptibility to smoking, assessed using polygenic risk score, is associated with increased risk for SAH

Inhaled Treprostinil Beneficial in Pulmonary Hypertension

Exercise capacity improved, clinical worsening reduced for patients with pulmonary HTN due to interstitial lung disease

Symptom-to-Balloon Time Linked to Infarct Size in STEMI

Patients with long versus short SBT exhibit greater microvascular obstruction; no association seen by door-to-balloon time

Lethal Means Counseling, Cable Locks Promote Safe Firearm Storage

Lethal means counseling outperformed control at six months; cable locks outperformed control at three, six months

Higher Hb Threshold for Transfusion Not Better for Preemies

Use of a higher hemoglobin threshold for transfusion in anemic preterm infants does not lower risk for death, neurodevelopmental impairment

Treatment Plans, Outcomes Better for Women With ACS and Low-Risk HEART Score

Women may receive more appropriate care than men with use of History, Electrocardiogram, Age, Risk factors, and Troponin (HEART) score

Risk for Developing, Dying From Second Cancer Higher for Survivors

Adult-onset cancer survivors have greater risk for subsequent primary cancer; majority of these incidences are cancers associated with obesity or smoking

Practice’s Bariatric Nonsurgical Visits Up With Telehealth During Pandemic

Follow-up visits increased for nonsurgical providers; however, new patient and follow-up surgical visits did decrease

Ad26.COV2-S Vaccine Seems Safe, Immunogenic for SARS-CoV-2

Neutralizing antibodies detected in 90 percent or more of all participants on day 29 after the first vaccine dose

Negative COVID-19 Test to Be Required for People Flying to U.S.

Passengers without proof of a negative test will not be allowed to board flights to America

Women Must Get Abortion Pill in Person: U.S. Supreme Court

Similar in-person rules for other medications have been suspended during the pandemic

Neonatal Abstinence Syndrome, Maternal Opioid-Related Diagnoses Up

Estimated rates of NAS, maternal opioid-related diagnoses increased from 2010 to 2017 in the U.S., with variation between states

COVID-19 Vaccine Recommended for All Americans Over 65

Health officials also recommended COVID-19 vaccines be given to all adults with preexisting conditions

Pregnancy Outcomes Examined for Women With Multiple Sclerosis

Women with pregnancy after versus before MS diagnosis have fewer children, at older age, with increased odds of C-section

Cognitive Performance During Menopause Transition Examined

Longitudinal declines seen in measures of learning, memory, attention/working memory domains in low-income women of color

Consuming Alcohol May Increase Risk for Atrial Fibrillation

Hazard ratio 1.16 for one drink per day; similar associations seen across types of alcohol

DKA Common in Blacks With T1DM and Confirmed COVID-19

Non-Hispanic Blacks with T1DM and COVID-19 have nearly fourfold increased odds of presenting with diabetic ketoacidosis

CVD Risk Lowest at Highest Level of Physical Activity

Risk for cardiovascular disease decreases as accelerometer-measured moderate, vigorous, and total physical activity levels increase

Higher Coffee Intake May Reduce Risk for Prostate Cancer

Pooled relative risk of 0.988 for each increment of one cup of coffee per day revealed in meta-analysis of cohort studies

Few Ob-Gyns Can Prescribe Buprenorphine for Opioid Use

Obstetrician-gynecologists able to prescribe buprenorphine more likely located in the suburbs

Better Hospital Nurse Staffing Tied to Fewer Sepsis Deaths

Staffing more strongly tied to deaths than adherence to mandated sepsis care bundles

Saliva, Nasopharyngeal Samples Equally Sensitive for SARS-CoV-2

Incremental cost of $8,093 per additional detection found with nasopharyngeal swab among individuals without previous SARS-CoV-2

Experimental Drug for Alzheimer Disease Shows Promise

After six to 12 months of treatment with the drug, patients no longer had amyloid protein plaques

Financial Toxicity Linked to QOL After Breast Cancer Surgery

Strongest correlation seen for BREAST-Q psychosocial well-being, with 0.89 change per unit change in financial toxicity score

Overall Cancer Death Rates Decreased From 1991 to 2018

Pace of annual decline in lung cancer mortality increased from 2009-2013 to 2014-2018 for men, women, overall

Disneyland to Be Mass COVID-19 Vaccination Site

California's Orange County plans to open more 'Super Point-of-Dispensing' sites soon

Ischemic Heart, Hypertensive Disease Deaths Up During COVID-19

Second study shows reduction in cardiovascular diagnostic testing across the world during pandemic

WHO and Partners to Stockpile Ebola Vaccine

Emergency reserve of about 500,000 doses of a Merck vaccine will be established

Flat, Flexible No Better Than Stable, Supportive Shoes for Knee OA

Change in pain, but not function, favoring stable, supportive shoes over flat, flexible shoes in knee osteoarthritis

More Infectious COVID-19 Variant Now Seen in Nine States

A South African variant that is also more contagious has not been detected in the United States yet

Link Between T. gondii Infection, Glioma Risk Examined

Significant increase in glioma risk seen for those with higher antibody titers to the sag-1 antigen

Albuminuria Down in Adults With Newly Diagnosed T2DM

Improvements seen in glycemic, blood pressure, lipid control within the population partly explain decrease in albuminuria

Composition of Gut Microbiome Altered in Patients With COVID-19

Several gut commensals with known immunomodulatory potential underrepresented in patients with COVID-19

Three-Quarters of U.S. Adults Likely to Get COVID-19 Vaccine

However, lower education, income, and perceived threat of COVID-19 tied to lower likelihood

Hydroxychloroquine Level Tied to Thrombosis Risk in Lupus

Rate of thrombotic events lower for patients with mean HCQ blood levels >1,068 versus <648 ng/mL

Colorectal Cancer Risk From Obesity Varies by Sex

Authors say more nuanced approach needed to understand link between body weight and risk for colorectal cancer

Autism May Raise Risk for Substance Use Disorder

Risk for SUD lower for subgroups of individuals with ASD receiving one or multiple psychotropic agents

Pediatric Hospitalization for COVID-19 Increasing Across States

Rates at beginning and end of study and extent of change in rates significantly vary across states

Maintaining Exercise During Pandemic Aids Prenatal Mental Health

Findings based on an online survey of more than 1,800 pregnant women

Treatment Success Seen With Antibiotics for Uncomplicated Appendicitis

Seven days of oral antibiotics noninferior to two days of intravenous followed by oral antibiotics

FUS Subthalamotomy Studied in Asymmetric Parkinson Disease

Motor features improved with focused ultrasound subthalamotomy on the side opposite main motor symptoms

One in Four Women With ADHD Attempts Suicide

Women with ADHD and childhood adversities and adults with substance dependence, depression particularly vulnerable

WHO Experts Arrive in China Thursday to Probe COVID-19 Origins

China has stalled on admitting the independent group of WHO experts into the country

Two Billion COVID-19 Vaccine Doses From BioNTech Expected This Year

Company also looking to widen eligibility for the vaccine to include pregnant women, children, and others

Symptoms Persist in Many Discharged COVID-19 Patients

Most common symptoms at six months were fatigue or muscle weakness, sleep difficulties, anxiety or depression

Timing, Intensity of Oral Sex Are Risk Factors for HPV-OPC

Increased odds of human papillomavirus oropharyngeal cancer seen for younger age at first oral sex, oral sex intensity

Trying Multiple Tobacco Products in Teens Tied to Later Daily Smoking

Electronic cigarette use increases the risk for later daily cigarette smoking more than threefold

Food Insecurity Increasing Among Older U.S. Adults

Food insecurity also tied to lower-quality diet in older adults

Early High-Titer Plasma Reduces Progression of COVID-19

Early administration of high-titer convalescent plasma against SARS-CoV-2 reduces progression in mildly ill older adults

Trauma Centers Made New Processes for Optimal Care During COVID-19 Pandemic

Most hospitals designated more beds to the intensive care unit; 50 percent designated an ICU for COVID-19 patients

Drive-Through IOP Screening Clinic Feasible During COVID-19

Intraocular pressure screening clinic allows for continued management, including necessary changes in management

Physician’s Briefing Weekly Coronavirus Roundup

Here is what the editors at Physician's Briefing chose as the most important COVID-19 developments for you and your practice for the week of...

Post-Hip Fracture Mortality Higher in Patients Living Alone

Findings independent of age, education level, number of children, and degree of urbanization

Biden Says He Will Release All Vaccine Doses After Taking Office

The potentially risky move is meant to boost a nationwide COVID-19 vaccination program that has gotten off to a slow start

Laws Promoting Flu Shot for Hospital Workers Can Cut Deaths

2.5 percent drop seen in monthly pneumonia, flu mortality rates with implementation of state laws requiring hospitals to offer flu shot

Affordable Care Act Reduced Income Inequality in United States

Income inequality reduced within and across groups based on race/ethnicity, age, family educational attainment

Virtual Kidney Transplant Evaluation Possible

Telehealth platform enabled maintenance of wait-list evaluation volume in large kidney transplant program during COVID-19 pandemic

Vaccine Rollout Slows as Many Health Care Workers Balk at Shots

In nursing homes and to some degree in hospitals, employees are refusing shots, expressing fears of side effects

Firearm Use Up in Female Nurse Suicides in the U.S.

Female nurses used firearms in suicides less often than other women from 2003 to 2013, but firearm use increased from 2014 to 2017

Moderna COVID-19 Vaccine Protection May Last Years, Company Claims

CDC recommends people who have already had the virus also receive the vaccine as reinfection is possible

Many Dialysis Patients Report Proficiency in Mobile Health

Older patients have lower mobile health proficiency, as do those with Hispanic/Latinx ethnicity, less than college education

Perception of Not Returning to Full Health Common After COVID-19

47 percent experience fatigue, with no correlation between any measures of persistent disease and initial disease severity

Guidance Provided for Management of Pediatric Eating Disorders

Pediatricians should initiate comprehensive evaluations, including medical, psych assessment; refer to multidisciplinary care

Review Confirms Interarm SBP Difference, Mortality Link

All-cause mortality risk increased with interarm systolic blood pressure difference magnitude from ≥5 mm Hg threshold

Predicted Heart Age Higher Among Cancer Survivors

Excess heart age 8.5 years for men and 6.5 years for women; varies by age, race/ethnicity, education, income

Majority of SARS-CoV-2 Transmission Due to Asymptomatic Individuals

In base case of modeling study, 59 percent of transmission attributed to presymptomatic and asymptomatic individuals

Mental Well-Being Worse for Men From Ethnic Minorities During Pandemic

Greater average increase in mental distress during COVID-19 seen for women and for Black, Asian, minority ethnic versus White British men

Vitamins E, C Inversely Linked to Risk for Parkinson Disease

Comparing individuals in highest versus lowest tertile of exposure, inverse link seen for both vitamins C and E; no link for beta-carotene, NEAC

PCPs Spend Average of 18 Minutes With Each Patient

Shorter scheduled appointments tend to run over more often versus longer appointments

Statins May Protect Heart From Chemo for Early Breast Cancer

Risk for heart failure hospital presentations significantly lower in statin-exposed women treated with anthracyclines

NFL Urges Teams to Offer Stadiums as Vaccination Centers

NFL would benefit from Americans being vaccinated because it increases the odds that state officials will reopen stadiums

Red Cross Issues Call for More Blood Plasma to Treat COVID-19 Patients

People who have recovered from COVID-19 may have antibodies in their plasma that could boost immunity in current patients

Allergists Affirm Safety of COVID-19 Vaccines for Most

All patients should be observed for 15 minutes after vaccination; staff should be trained in anaphylaxis management

Sitagliptin Promising Addition for Preventing Acute GVHD

Low incidence of grade II to IV acute GVHD seen in patients undergoing myeloablative allogeneic hematopoietic stem cell transplantation

Mindfulness-Based Cognitive Therapy Aids Depressive Disorder

MBCT tied to significant improvement in Reassure self and significant reduction in Inadequate self

Teen Vaping Doubles Risk for Subsequent Tobacco Use

Adolescent boys who use e-cigarettes twice as likely to initiate cigarettes, smokeless tobacco products

Machine Learning Models Can Predict Gestational Diabetes

Effective discrimination achieved with 73-variable model, seven-variable logistic regression model in early pregnancy

Rehospitalization Down With Remote Monitoring After Arthroplasty

Findings show significant reduction in rehospitalization rate for patients undergoing hip or knee arthroplasty

11.1 Anaphylaxis Cases/Million Doses of Pfizer-BioNTech COVID-19 Vaccine Reported

Median interval from vaccine receipt to symptom onset was 13 minutes

Number of U.S. Adults Willing to Take COVID-19 Vaccine Down

Findings based on a biweekly survey conducted from April through December

Two-Thirds of Lupus Patients Likely to Take COVID-19 Vaccine

However, national survey uncovered racial differences in uptake, safety concerns

Cow’s Milk Intake While Breastfeeding May Cut Child Food Allergies

Findings based on food allergies diagnosed in offspring by age 12 months

Postpartum Trajectory Differs by Race After Hypertensive Disorders of Pregnancy

At six weeks postpartum, 68 percent of Black women and 51 percent of White women meet hypertension criteria

Age at Vasectomy Reversal Not Tied to Achieving Pregnancy

Shorter obstructive interval and female age associated with achieving pregnancy

Pandemic-Related MMR Vaccine Decline Persists

Authors say catch-up strategies are necessary to ensure young children receive preventive care

Mindfulness Training Does Not Reduce Migraine Frequency

However, mindfulness-based stress reduction improves various measures, including disability and quality of life

Pulse Oximeter Readings May Be Inaccurate in Black Patients

Blacks more likely than Whites to have oxygen saturation of less than 88 percent on arterial blood gas while 92 to 96 percent on pulse oximetry

eGFR Variability Linked to All-Cause Mortality Risk

No association seen for estimated glomerular filtration rate variability and cardiovascular disease events

Some Hospitalized Heart Patients Report Frequent Nightmares

Frequent nightmares associated with depression, anxiety, insomnia but not cardiovascular medications, sleep-disordered breathing

AAP Outlines Principles Guiding School COVID-19 Policies

Academy says opening schools generally does not significantly increase community transmission, but mirrors community transmission

Vast Majority of Mild COVID-19 Patients Lose Sense of Smell

Nearly one-quarter of affected patients report lack of recovery at 60 days

Psychological Distress Increased in U.S. During COVID-19

Numbers of people who experienced serious psychological distress over 30 days during pandemic similar to that in entire year prior to pandemic

China Delays Allowing Experts to Study Start of Pandemic

Experts are expected to visit the city of Wuhan, where it is believed COVID-19 first emerged

Drug Makers Raise Prices on 500 Prescription Drugs

AbbVie, Bristol Myers Squibb, GlaxoSmithKline, and Pfizer among companies raising their prices by a median of 4.6 percent

Single-Drug Regimen Now Advised for Uncomplicated Gonorrhea

Single 500-mg intramuscular dose of ceftriaxone recommended for uncomplicated urogenital, anorectal, pharyngeal gonorrhea

~14.3 Percent of U.S. Population Infected With SARS-CoV-2 by Nov. 15

Estimated medians of 46,910,006 SARS-CoV-2 infections, 956,174 hospitalizations, 304,915 deaths reported by mid-November

Top FDA Officials Say Two Full Doses of COVID-19 Vaccines a Must

Agency says it is understandable that people may want to stretch the vaccine supply, but it is not safe to do so

Lifestyle Factors Linked to GERD Risk in Women

Nearly 40 percent of gastroesophageal reflux disease symptoms could be prevented by adherence to five lifestyle factors

Euglycemic DKA ID’d in T2DM Patients With COVID-19

Five cases of euDKA identified in patients with type 2 diabetes using SGLT2 inhibitors who developed SARS-CoV-2 infection

Some Transmission of SARS-CoV-2 Occurs After Seven, 10 Days

81 percent chance that a contact who was negative for SARS-CoV-2 and asymptomatic through seven days would remain so at 14 days

Bone Quality Linked to Complications After Spinal Fusion

Patients who developed complications had lower trabecular vBMD, fewer and thinner trabeculae at radius and tibia

Los Angeles EMS Told to Not Transport Patients Deemed Likely to Die

L.A. County Emergency Medical Services Agency also told EMS workers to give less oxygen to patients

Child Physical Abuse Encounters Declined During COVID-19

Declines occurred during period when total volume of encounters was also lower; severity of encounters unchanged versus previous years

Intradialytic Hypotension Tied to Peripheral Artery Disease

Findings based on large, national study of more than 45,000 hemodialysis patients

Mental Health Consequences of COVID-19 ID’d Across Populations

Health care workers have higher prevalence of insomnia; however, mental health problems seen across countries, gender

U.S. Health Care Spending Increased 4.6 Percent in 2019

Growth rate similar to that experienced in 2018 and consistent with growth rate since 2016

Pandemic Has Disrupted Lung Cancer Screenings

Once operations resumed, decrease seen in new patients screened, proportion of suspicious nodules increased

Fitness Apps, Trackers Boost Physical Activity

Among adults without chronic disease, apps and trackers may boost activity by 1,850 steps per day

NIDA: Teen Vaping Levels Seem to Have Plateaued in 2020

Percentage of teenagers in eighth, 10th, 12th grade vaping nicotine and marijuana remained stable from 2019 to 2020

Polygenic Risk Scores May Improve IBD Risk Prediction

For every population in BioMe biobank, combining risk scores from distinct ancestral populations improved risk prediction for IBD

Jaw Osteonecrosis Tied to Treatment for Bone Metastases

Cancer type, oral health, and frequency of dosing for zoledronic acid linked to risk for osteonecrosis of the jaw

Factors ID’d for Mortality in Nursing Home Residents With COVID-19

Increased age, male sex, impaired cognitive and physical function associated with increased odds of 30-day mortality

Few Adults Report Having Firearm Safety Discussions With Doctors

7.5 percent of respondents report having ever discussed firearm safety; 12 percent among those living with children

Suicide Risk Higher Among Patients With Parkinson Disease

Increased risk not fully explained by higher rates of mental disorders

U.S. COVID-19 Vaccine Rollout Struggling

Scientists are considering ways to speed distribution and uptake of the vaccine

Britain to Try Mix-and-Match COVID-19 Vaccinations

In the United States, the CDC has said that COVID-19 vaccines 'are not interchangeable'

mRNA-1273 Vaccine Highly Effective for Preventing COVID-19

Published data on Moderna vaccine show severe COVID-19 in 30 individuals -- all in the placebo group -- in trial of 30,420 participants

Hypertensive Disorders of Pregnancy Have Lasting Cognitive Impact

Women with gestational hypertension perform significantly worse on 15-word learning test than those with normotensive pregnancy

Odds of Anxiety, Depression, ADHD Up With Congenital Heart Disease

Youth with CHD have increased odds of anxiety and/or depression, ADHD, regardless of CHD severity

CVD Biomarker Levels Up for Dual Use of E-Cigarettes, Cigarettes

Levels of biomarkers of inflammation, oxidative stress similar for dual users and exclusive cigarette users

Autistic Traits ID’d in Carriers of CNVs Linked to Autism

54 percent of carriers of certain copy number variants have elevated levels of autistic traits

No Causal Link Found for COVID-19, Guillain-Barré Syndrome

Incidence of GBS decreased between March and May 2020 compared with same months of 2016 to 2019

In Cirrhosis, Women Have Worse Frailty Scores Than Men

Frailty mediated an estimated 13 percent of the gender gap in wait-list mortality among those awaiting liver transplant

2014 to 2019 Saw Drop in Oncologists Accepting Industry Payments

Annual per-physician payment value decreased for those receiving less than $10,000, increased for those receiving more than $10,000

New Mammogram-Based Measures Improve Breast Cancer Prediction

For screen-detected, younger-diagnosis breast cancers, best-fitting models include new measures based on brightness, texture

First Known U.S. Case of New Variant of COVID-19 Seen in Colorado

Variant is thought to be more contagious -- but not more lethal -- than variants previously circulating this year

Physician’s Briefing Weekly Coronavirus Roundup

Here is what the editors at Physician's Briefing chose as the most important COVID-19 developments for you and your practice for the week of...

Cardiovascular Risk Up With Metabolic Syndrome in Psoriasis

After adjustment for all metabolic syndrome factors, blood pressure, waist circumference linked to noncalcified coronary burden

USDA, HHS Update Dietary Guidelines for Americans

2020 to 2025 guidelines recommend customizing nutrient-dense food and beverage choices to reflect personal preference, cultural traditions

Secondary Bloodstream Infections Tied to Poorer COVID-19 Outcomes

Altered mental status, ICU admission, higher in-hospital mortality more likely in hospitalized patients with severe COVID-19 and sBSI

E-Cigarettes as Consumer Devices May Not Improve Smoking Cessation

In randomized clinical trials, e-cigarette use linked to more quitting for smokers provided e-cigarettes versus conventional therapy

Gaps Found in Opioid Use Disorder Treatment During Pandemic

Percentage of patients receiving at least one urine test lower in March through May of 2020 versus 2019

Ongoing Exposure to Stressors Harms Health

So-called allostatic load increases with age but increases more sharply among Black, Latino populations

Dexamethasone Not Favored for Chronic Subdural Hematoma

Dexamethasone worse than placebo with respect to favorable outcome at six months

More Dangerous Mouthwashes and Hand Sanitizers Recalled

Hand sanitizer recall due to presence of methanol; oral rinse recall due to possible contamination with bacteria

Bariatric Surgery Patients Not Getting Recommended Follow-Up Care

Annual proportions of patients receiving blood tests specific to bariatric surgery, prescription nutritional supplements low

U.K. Is First Country to Approve Oxford-AstraZeneca COVID-19 Vaccine

Vaccine could become the dominant form of inoculation because at $3 to $4 a dose, it is a fraction of the cost of other vaccines

Appetite-Regulating Hormones Lower After Sucrose Versus Glucose

Increases in glucose, insulin, GLP-1, PYY less robust with sucrose versus glucose ingestion; increases in glucose, PYY smaller in obese adults

Donor Kidney Biopsies Do Not Aid Transplant Outcome Prediction

Adding donor histology did not significantly improve prediction of long-term allograft failure in recipients at French, Belgian centers

Glycemic Control in Type 1 Diabetes Improved During Lockdown

Decrease in alcohol consumption, easier diabetes control perception were factors associated with better glycemic control

Altered Mentation, Stroke Up COVID-19 In-Hospital Mortality

Findings revealed by comparison to matched hospitalized COVID-19 patients without neurological involvement

Timing of Antimicrobial Prophylaxis Examined for C-Section

Risk for surgical site infection not increased for surgical antimicrobial prophylaxis after cord clamping versus before incision

Anticoagulants Not Tied to Higher Risk for GI Bleed in COVID-19

3 percent of hospitalized COVID-19 patients experience gastrointestinal bleeding

Oral Azacitidine Benefits Some Older Adults With AML

Overall, relapse-free survival prolonged among older patients in first remission after chemo who receive CC-486 versus placebo

Head and Neck Cancer Surgery Seems Safe During COVID-19

Links seen for severe pulmonary complications in COVID-19-positive patients with advanced tumor stage, critical care admission

Inequities Seen in Accessing Telemedicine During COVID-19

Factors linked to fewer completed telemedicine visits include older age, Asian race, non-English as preferred language, Medicaid insurance

Primary Aldosteronism Testing Rare in Treatment-Resistant HTN

Testing correlated with increased likelihood of initiation of MRA therapy and with better BP control over time

Knee Osteoarthritis Symptoms Improved With Stepped Care

Veterans experience modest improvements with stepped exercise program versus arthritis education control

Incidence of Dislocation After Hip Arthroplasty May Be Higher Than Thought

Age, sex, head size, fixation method, and surgical approach independently associated with dislocation risk

Seizure Frequency Not Up in Pregnancy for Women With Epilepsy

Changes in doses of antiepileptic drugs occurred more often in pregnant women than in nonpregnant controls

Another COVID-19 Vaccine Candidate Begins Final Clinical Trials

Novavax vaccine needs only standard refrigeration, not freezing or ultracold temperature storage

One in Four Older Adults Have Used Emergency Dept in Past Few Years

Cost of emergency care is major concern among most older adults