Physician’s Briefing Weekly Coronavirus Roundup

Here is what the editors at Physician's Briefing chose as the most important COVID-19 developments for you and your practice for the week of...

Poll: Most Older Adults Want to Age in Place

Authors urge investing in home improvements to ensure future independence

Three Main Barriers Hamper Weight Loss Surgery for Obese Teens

Barriers include lack of information, social stigma, and access issues related to costs

Inflammatory Skin Diseases Classified at Molecular Level

Molecular signatures for inflammatory skin diseases can help with classification of clinically indeterminate skin rashes

New Law Allows FDA to Police E-Cigarettes Made With Synthetic Nicotine

Vaping companies must now follow the same federal sales restrictions and age requirements as tobacco product companies

Incidence of Herpes Zoster Up for ≥50s With COVID-19 Diagnosis

Increased herpes zoster risk found for those with versus without COVID-19, with more pronounced risk following COVID-19 hospitalization

Posttraumatic Epilepsy More Likely to Be Drug Resistant

Lowest quality of life reported for those with posttraumatic epilepsy, drug-resistant epilepsy

Fourth Dose of BNT162b2 Offers Protection Against Severe COVID-19

Protection against COVID-19 did not wane in six weeks after receipt of fourth dose; protection against infection waned

COVID-19 Linked to Increased Risk for DVT, PE, Bleeding

Rate ratios were highest for critical COVID-19, and during first versus second and third pandemic waves in Sweden

Intra-Articular Injection of Triamcinolone Beneficial in Hip Osteoarthritis

Pain improved with ultrasound-guided intra-articular hip injection of corticosteroid and local anesthetic added to best current treatment

ACC: Lasting Reduction in BP Seen With Radiofrequency Renal Denervation

Significant reductions in systolic and diastolic BP observed at up to 36 months following intervention versus sham control procedure

Benefits of Smoking Cessation Quantified in Patients With ASCVD

About five event-free years gained through either quitting smoking or the use of three medications combined in persistent smokers

Insomnia Linked to Recurrent MACE in Coronary Heart Disease

Association remained significant after adjustment for major coronary risk factors, comorbidity, anxiety and depression symptoms

Recommendations Updated for Management of Heart Failure

Sodium-glucose cotransporter-2 inhibitors recommended for HF with reduced, mildly reduced ejection fraction

Hundreds of Overseas Flights Canceled After Mask Rules Dropped

Recent increase in canceled flights is the result of 'higher than usual staff sickness levels' due to recent surge in COVID-19

Report Says Nursing Home Industry Needs an Overhaul

Staffing was a major focal point of the study, which advocates say is too low in sheer numbers, while staff is also untrained and underpaid

Despite Improvements, Disparities in Faculty Diversity Persist

Compared with U.S. demographic characteristics, female representation increased among clinical faculty, but URM representation decreased

Middle Ear Effusion Up for Children With Tracheostomy on Ventilator

Mechanical ventilation increases risk for development of middle ear effusion in tracheostomy-dependent children

ACC: Low-Sodium Intervention Has Little Benefit in Heart Failure

Low-sodium diet did not reduce composite primary outcome of cardiovascular admission to hospital or ED or all-cause death

Sitting Tai Chi Program Benefits Subacute Stroke Survivors

Tailored sitting tai chi program in the subacute phase can improve recovery outcomes in stroke survivors

Tebipenem Pivoxil Hydrobromide Noninferior to Ertapenem for UTI

Findings observed in patients with complicated urinary tract infection or acute pyelonephritis

Fear of Cancer Recurrence Prevalent in Patients, Survivors

FCR decreased with age, but was observed across cancer types and continents, and for all time periods since cancer diagnosis

ACC: Bleeding Risk Lower With Tranexamic Acid in Noncardiac Surgery

But, though difference is small, tranexamic acid not noninferior to placebo for primary safety outcome of composite cardiovascular outcome

Substance Use Treatment Cuts Depression With Co-Occurrence

One-third of teens show early depression response with substance use treatment alone

Eligibility Criteria Add to Race Gap in Pancreatic Cancer Clinical Trials

Black patients disproportionately excluded from participation in pancreatic cancer clinical trials

Psychological Interventions + Physical Therapy Ease Chronic Low Back Pain

Pain education, behavioral therapy delivered with physical therapy can help with physical function and pain intensity

Frequent Insomnia Symptoms Can Cause Higher HbA1c

Association seen across multivariable regression, one- and two-sample Mendelian randomization analyses

Serum Sodium in Upper Part of Normal Range Linked to Heart Failure

Serum sodium above 143 mmol/L linked to increased odds of left ventricular hypertrophy, heart failure

FDA Advisers Weigh COVID-19 Booster Shots for Fall

Vaccine experts still guessing at what the ever-changing pandemic will bring

FDA Panel Meets to Craft Future Vaccine Strategy

No official vote is planned, and no specific vaccine products will be discussed

EPA Proposes to Ban Last Form of Asbestos Used in the United States

Asbestos is banned in more than 50 countries and its use in the United States has been declining for years

Biden Makes National Push for ‘Long COVID’ Research

Efforts will include speeding up registrations of 40,000 people both with and without long COVID for a study on the condition

Primary Care-Based Screening Ups Thin Melanoma Detection

Incidence of melanoma thicker than 4 mm did not differ significantly for screened and unscreened patients

Racial Disparities Seen in Adverse Renal Outcomes for Pediatric Lupus

Proportion of admissions with adverse renal outcomes decreased from 2006 to 2019, but racial disparities persisted

Teens With Severe Substance Use Disorder May Not Grow Out of It

Many teens with severe substance use symptoms had symptoms for alcohol, cannabis, prescription, and other drug use disorders in adulthood

Simplified Approaches to Hypertension Screening Seem Reliable

Surveys conducted across 60 countries reveal screening strategies using the second blood pressure reading had the smallest misdiagnosis rate

Fine Particulate Matter Levels Up With Social Cannabis Smoking

PM₂.₅ level increases with smoking in the home, decays gradually after smoking stops, and remains elevated indoors 12 hours later

AAD: Skin Videomicroscopy Biomarker May Help Predict Cancer Relapse

Assessment of leukocytes adherent to and rolling along vessel wall may help predict outcomes after HCT for hematologic cancer

Plastic Surgery Consultations for Complex Cases Add Financial Value to Hospitals

Study shows substantial increase in net revenues for complex surgeries with plastic surgeon consultants

Cardiac Complications Up After SARS-CoV-2 Infection Versus Vaccines

Incidence of cardiac outcomes after mRNA COVID-19 vaccination highest in males aged 12 to 17 years, but risk 1.8 to 5.6 times higher after infection

Selfies Give Distorted Facial View

Selfies introduce measurable distortions in the size and perception of facial features

Inadequate Sleep Tied to Abdominal Fat Accumulation

Fat accumulation seen for subcutaneous and visceral abdominal fat depots

Most COVID-19 Patients Benefit at Long-Term Acute Care Hospitals

Patients treated for COVID-19 discharged with greater improvements in ambulation distance, assistance needs versus reference patients

Vaccination Offers Extra Protection After SARS-CoV-2 Infection

Two studies show additional protection against reinfection and COVID-19-linked hospitalization with vaccination

Burst Wave Lithotripsy Promising for Breaking Up Kidney Stones

Median of 90 percent comminution of total stone volume observed in the first 19 humans undergoing burst wave lithotripsy

ACC: Childhood Risk Factors Linked to Cardiovascular Events in Midlife

Change in combined-risk z score from childhood to adulthood also linked to cardiovascular events in midlife

Migraines May Affect Outcomes in Takotsubo Cardiomyopathy

Odds of mortality and acute complications lower for Takotsubo cardiomyopathy patients with versus without migraine headaches

Study Explores Characteristics of Vestibular Migraine

Severe headache associated with age 43 years or younger, while severe vertigo associated with age 41 years or older

ACC: Treatment Beneficial for Mild Chronic HTN in Pregnancy

Reduction seen in risk for primary outcome event, with no increased risk for small-for-gestational age birth weight

AAOS: Patients Mostly Satisfied After Flatfoot Reconstruction

Postoperatively, physical activities less difficult for 50 percent, equally difficult for 33 percent, and more difficult for 17 percent

U.S. Nursing Home Deaths Reach Lowest Levels Since Pandemic Began

Nursing home residents continue to be more vulnerable both because of their age and underlying medical conditions

A-Fib Detected in Nearly Three in 10 Cryptogenic Stroke Patients

Most patients diagnosed with AF were asymptomatic; arrhythmia detected with 12 months of continuous cardiac monitoring

Risk for Atrial Fibrillation Recurrence Increases With Body Weight

Body mass index linked to both short- and long-term risk for return of the heart rhythm disorder following ablation

CDC Director Walensky Announces Sweeping Review of Agency

Revamp would focus on improving the nation's public health workforce, data modernization, laboratory capacity, rapid response to outbreaks

COVID-19 Vaccination Early in Pregnancy Not Linked to Fetal Anomalies

Vaccination within teratogenic window not linked to presence of congenital anomalies identified on ultrasonography

FDA Warns of U.S. Norovirus Cases Linked to Canadian Oysters

Oysters were distributed in 13 states, but others may also have received them through further distribution within the United States

Sexual, Emotional Abuse in Childhood May Up Multiple Sclerosis Risk

Exposure to two or all three abuse categories associated with further increased risk for multiple sclerosis

Medicare Now Covers COVID-19 Tests Bought at Drug Stores

Now the 59 million Americans covered by Medicare Part B can get up to eight free, at-home tests each month

Clinical, Economic Impact of Nonfatal Firearm Injuries Explored

Increases in substance use disorders, psychiatric disorders, pain diagnoses, health care use and spending seen in survivors

Commercial-to-Medicare Hospital Price Ratios Stable 2012 to 2019

Trends in ratios varied considerably across hospital referral regions

WHO: 99 Percent of Planet’s Population Breathes Dirty Air

Air quality is the worst in WHO Eastern Mediterranean and Southeast Asia regions

Napping More Frequent in Women With Chronic Migraine

Nap duration linked to greater headache severity, lower sleep efficiency in chronic migraine

Body Mass Index, Obesity Up During the Pandemic for U.S. Adults

Higher rates of alcohol consumption and lower smoking rates may have contributed to higher obesity

2014 to 2019 Saw Decrease in Postoperative Opioid Use for Children

Rapid opioid deadoption identified beginning in late 2017; was first seen in teens followed by school- and preschool-aged children

BP Genetic Risk Score Linked to Risk for CV Events in Type 2 Diabetes

Each standard deviation increase in BP polygenic risk score linked to 12 percent increased hazard of adverse CV events

Early Ivermectin Does Not Reduce Hospital Admission in COVID-19

Also no decrease seen in prolonged ED visits for patients with COVID-19 symptoms for up to seven days, at least one risk factor for progression

BNT162b2 Prevents Critical COVID-19 in Children and Adolescents

During omicron-predominant period, effectiveness of two doses against hospitalization 68 percent for children, 40 percent for adolescents

AAOS: Outcomes Good for New ACL Repair Technique in Teens

For teens at high risk for failed ACLR, lateral extra-articular tenodesis with modified Lemaire technique used in conjunction with ACLR

AAOS: Early Outcomes Similar for Cementless, Cemented Fixation TKR

Groups did not differ in hospital length of stay, complications, 90-day readmission, revision surgery at two years

New Instrument Developed for Assessing Patient Knowledge of CKD

KART 2.0 can differentiate patients who have spent less than one versus one or more hours speaking to health professionals, reading about transplantation

Fetal Exposure to Cannabis Linked to Adiposity in Childhood

Exposure linked to higher fat mass, fat-free mass, adiposity, and fasting glucose; no link seen with BMI, BMI z-score

Yoga May Cut Migraine Frequency

However, no significant benefit seen for migraine pain intensity

Risk for Death by Homicide Up for Cohabitants of Gun Owners

Of homicides occurring at home, sevenfold increased risk for being fatally shot by spouse, partner seen for cohabitants of gun owners

Risk for Acute MI Not Increased With Two-Dose HepB-CpG Vaccine

Noninferiority study shows no increased risk for acute MI with two-dose HepB-CpG vaccine versus three-dose HepB-alum vaccine

Diabetic Eye Complications More Common in Blacks, Hispanics

Additionally, minorities less likely to receive all recommended diabetes care

HTN, T2DM Contribute to Brain Changes in Puerto Rican Seniors

High prevalence of HTN, T2D seen among Puerto Rican cohort; those with both have deteriorating patterns in major white matter tracts

House Passes Bill To Limit Insulin Costs to $35 a Month

Bill now has to pass the Senate with at least 10 Republican votes

160,000 lb of Skippy Peanut Butter Recalled Due to Metal Fragments

Recall was voluntary, and no consumer complaints have been associated with it

Health, Economic Impact of COVID-19 Set to Lessen in Coming Years

Health care use projected to normalize after decline in 2020; remaining federal supplemental spending expected to decrease through 2024

Alzheimer Disease, Related Dementia Diagnoses Up in Medicare Decedents

Percentage of older U.S. decedents with a diagnosis of Alzheimer disease and related dementias increased significantly from 2004 to 2017

Higher Incidence of SARS-CoV-2 Infection in Under 5s During Omicron

Higher incidence rate of infection compared with delta variant, but significantly lower risk of severe clinical outcomes

Mental Health Among High School Students Explored During COVID-19

Students who felt close to someone at school had lower prevalence of poor mental health, had considered or attempted suicide

Living-Donor Liver Transplant Promising for CRC With Liver Mets

Recurrence-free survival of 62 percent, overall survival of 100 percent at 1.5 years after LDLT in select patients

At-Home Visual Acuity Tests Valid Versus In-Office Testing

Printed, mobile phone app, and website at-home self-administered visual acuity tests valid within one line of in-office Snellen visual acuity

Early Use of COVID-19 Convalescent Plasma Cuts Hospitalization Risk

Administration of convalescent plasma within nine days after symptom onset can reduce risk of COVID-19-linked hospitalization

Eight-Gene Model Can Help Predict Progression to Severe Dengue

Model predicted severe dengue progression with 86.4 percent sensitivity and 79.7 percent specificity

Buprenorphine Prescribing for Medicaid Beneficiaries Down in 2020

Despite increases in units per prescription, the amount of buprenorphine dispensed to Medicaid beneficiaries decreased early in the pandemic

VNS May Cut Hospital Costs for Children With Refractory Epilepsy

Antiseizure medication plus vagus nerve stimulation linked to lower hospital costs over time compared with antiseizure medication alone

Physician’s Briefing Weekly Coronavirus Roundup

Here is what the editors at Physician's Briefing chose as the most important COVID-19 developments for you and your practice for the week of...

Universal HepB Vaccination Recommended for Adults Age 19 to 59

Those aged 60 years or older with risk factors should receive vaccine; those without risk factors should be offered vaccine

FDA Advisory Panel Narrowly Votes Against New ALS Drug

Panelists said they hoped results of a larger study, now underway, would provide more evidence on the drug

Biden to Lift Pandemic Rule Restricting Immigrants at Land Border

Once lifted, migrants entering the country to seek asylum will not be quickly turned back because of public health concerns

CDC Lifts Warning on Cruise Ship Travel

Agency still advises passengers to get up-to-date vaccinations before boarding a cruise ship

New White House Website Speeds Access to Free COVID-19 Care

COVID.gov will bring into one place several types of critical COVID-19 information

New-Onset Cardiovascular Complications Common After Stroke

Odds of five-year all-cause mortality up for stroke patients with ACS, atrial fibrillation/flutter, heart failure, severe ventricular arrhythmias

Seizures of Drugs Containing Illicit Fentanyl Increasing in U.S.

From 2018 to 2021, increases seen in number of fentanyl-containing powder seizures, number of pill seizures

Stage Shift Seen With CT Screening for Lung Cancer in the U.S.

Stage shift toward Stage I NSCLC observed following introduction of low-dose CT screening for lung cancer

Memory Concerns Stable, but Incidence of Cognitive Decline Increased

Women, those older than 80 years, and those living in more deprived areas more likely to have memory concern, cognitive decline recorded in primary care

Amygdala Grows Faster Between 6 and 24 Months in Babies With Autism

Amygdala growth rate between 6 and 12 months linked to greater social deficits at 24 months when the infants were diagnosed

In Utero Antipsychotic Exposure May Not Up Neurodevelopmental Disorder Risk

Commonly prescribed antipsychotic medications taken late in pregnancy seem not to meaningfully increase NDD risk in offspring

SARS-CoV-2 Vaccination Seems Safe After MIS-C

No major adverse events seen among 15 children with MIS-C who were subsequently vaccinated against SARS-CoV-2

GLP-1 RA Use May Up Risk for Gallbladder, Biliary Diseases

GLP-1 RA treatment linked to increased risk, especially in trials for weight loss, and with higher doses and longer duration of use

Mini-Slings Noninferior to Mid-Urethral Slings for Stress UI in Women

Rate of patient-reported success similar for women in mini-sling, mid-urethral sling groups at 15 months, 36 months

ED-Initiated Buprenorphine for OUD Often Not Sustained

Many patients filling buprenorphine prescriptions written by emergency physicians do not subsequently fill prescriptions for the treatment

Rotating Shift Work Tied to Delay in Onset of Natural Menopause

Delay in onset of menopause linked to rotating shift work in current and longest job period

Booster Strategies After Janssen Shot Increased Protection Against Omicron

Vaccination with one Janssen dose plus mRNA booster provides higher protection than two Janssen doses

Use of Medications for Opioid Use Disorder Low

Past-year use lowest for adolescents and adults aged 50 years and older

Racial, Ethnic Disparities ID’d in Pediatric Acute Asthma Care

Spanish-preferring Latine children had higher odds of clinic visits for asthma exacerbation than non-Hispanic Whites

Cancer Survivors Face Transportation Barriers to Accessing Care

Survivors who are younger, poor, uninsured or publicly insured, unmarried, or who have functional limitations have greatest barriers

COVID-19 Vaccination Not Linked to Peripartum Adverse Outcomes

Large population-based cohort of more than 22,000 women shows no increased risks with vaccination during pregnancy

21 States Sue to Overturn CDC Public Transport Mask Mandate

Lawsuit claims mask mandate exceeds the authority of the U.S. Centers for Disease Control and Prevention

Probability of False-Positives Lower With Digital Breast Tomosynthesis

Cumulative probabilities of false-positive results substantially lower for biennial versus annual screening, regardless of modality

Global Burden of Melanoma Considerable, Set to Rise by 2040

If 2020 rates continue, burden estimated to increase by about 50 percent for incidence, 68 percent for deaths by 2040

Avocado Intake Linked to Lower Risk for CVD, Coronary Heart Disease

Replacing animal products such as butter, cheese, eggs, processed meat with avocado linked to lower risk for CVD events

Light Alcohol Intake May Not Protect Against Cardiovascular Disease

Heavy consumption tied to exponential increases of cardiovascular disease risk

Preconception Paternal Metformin Linked to Major Birth Defects

Genital birth defects, all in boys, more common among metformin-exposed offspring

CDC Supports Second COVID-19 Booster for Americans 50 Years and Older

Echoing the FDA, the CDC also supported a second booster for 'certain immune-compromised individuals'

Risk, Burden of Diabetes Up After Acute SARS-CoV-2 Infection

Risks and burdens of postacute outcomes increased in graded manner based on COVID-19 severity

Early Aspirin Cuts In-Hospital Mortality With Moderate COVID-19

Largest benefits seen for patients older than 60 years with no increased risk for hemorrhagic complications

USPSTF: Evidence Lacking for OSA Screening in Asymptomatic Adults

The evidence is insufficient to assess the balance of benefits and harms of screening for obstructive sleep apnea in the general adult population

FDA Approves Second COVID-19 Booster for Americans 50+

Agency also authorized a second booster for Americans 12 and older who are immune-compromised

FDA Reviewers Give Thumbs Down to New ALS Drug

Agency said results were 'not persuasive,' citing missing data, mistakes in enlisting patients, other issues

Out-of-State Residents Can Now Seek Medical Aid in Dying in Oregon

Lawsuit that challenged the residency requirement as unconstitutional was settled Monday

1999 to 2018 Saw Increase in Prevalence of Prediabetes in Teens

Disparities in prevalence of prediabetes remained stable and were pronounced in subgroup analyses of sex and BMI category

2019 to 2020 Saw Risk-Linked Deaths From Heart Disease, Stroke Up

Highest risk-associated increases were seen in non-Hispanic Black people followed by Hispanics, non-Hispanic Asian or Pacific Islanders

Motivational Interviewing Not Better in Weight Loss Programs

Evidence lacking that MI makes meaningful difference to weight loss, well-being when added to behavioral weight management program

Live Attenuated Flu Vaccine Does Not Increase Frequency of Asthma Exacerbations

Frequency of asthma exacerbations not increased with live attenuated versus inactivated flu vaccine in children aged 5 to 17 years with asthma

Risks for Anaphylaxis Compared Among IV Iron Products

Rates of anaphylaxis low for IV iron products, but risk for anaphylaxis increased with iron dextran and ferumoxytol compared with iron sucrose

No Adverse Outcomes Seen With SARS-CoV-2 Vaccination in Pregnancy

No significantly increased risk reported for preterm birth, stillbirth, SGA, low Apgar score, or neonatal care admission

For Men Aged 60 to 64, CVD Deaths Up With Warmer Summer Nights

Risk for CVD deaths increased with warmer summer nights for men aged 60 to 64 years in England and Wales; King County, Washington, USA

Memory Deficits Seen in Individuals With ‘Long COVID’

Deficits increased with severity of ongoing self-reported symptoms; severity of initial illness did not influence later cognitive performance

Prenatal Occupational Disinfectant Use Tied to Child Allergies

Risks for asthma, eczema increased in offspring of pregnant women with work-related disinfectant use

Immune Response to SARS-CoV-2 Infection Persists in Children

Ninety-six percent of those with evidence of nucleocapsid antibodies at baseline still had antibodies more than six months later

Risk for Ischemic Stroke Up With Antidopaminergic Antiemetic Use

Increase in risk greatest for metopimazine and metoclopramide; risk for ischemic stroke may be higher in first days of use

COVID-19 Tied to Higher Risk for Pregnancy Complications

Infection tied to worse outcomes for severe maternal morbidity, preterm birth, and venous thromboembolism

Stakes Are High Ahead of FDA Panel Vote on ALS Drug

AMX0035 is a combination of two established drug ingredients -- sodium phenylbutyrate and taurursodiol

Biden Administration to Offer Second COVID-19 Boosters to Those 50+

While a second booster for older adults will be offered, federal health officials will not go so far as to recommend it

Many Local Health Departments Report Harassment During Pandemic

Public health officials reported experiencing structural and political undermining of their professional duties

2004 to 2017 Saw Increase in Appendiceal Cancer

Increase appears to be driven by a rise in carcinoids

Less Than Half of Primary Care Providers Ask About Teens’ Mental Health

Parents also report that it is difficult to get mental health care for teens

Amino Acid Supplementation Beneficial After Fracture Fixation

Reduction in postoperative complications for adults receiving conditionally essential amino acid supplementation

Intimate Partner Violence Referrals Increased After COVID-19 Emergence

Face-to-face consults decreased, but total number of consults, mainly for emotional abuse, increased

Management of Antithrombotics in GI Bleed, Endoscopy Addressed

Guideline addresses management of anticoagulants, antiplatelets during acute gastrointestinal bleeding and in the elective endoscopy setting

Use of Injectable Local Anesthetics Up for Hip Fracture

Increasing use of injected local anesthetics may represent move away from opioid analgesia for hip fracture patients

AMA Poll: Most Physicians Continuing to Use Telehealth

Most users (93 percent) are conducting live, interactive video visits with patients, while 69 percent are conducting audio-only visits

ACC: Use of Salt Substitute to Prevent Stroke Is Cost-Saving

Salt substitute intervention shown to be cost-saving among individuals with prior stroke or uncontrolled high blood pressure living in rural China

Awake Prone Positioning Does Not Improve Outcomes in COVID-19

Findings seen among non-critically ill patients with moderate hypoxemia, admitted to hospital with COVID-19

Videogaming Rehabilitation Studied in Stroke Patients

Use of self-managed, at-home video game rehabilitation compared to other methods for upper-extremity therapy

AAD: Baricitinib Tops Placebo for Hair Regrowth in Alopecia Areata

In two phase 3 trials, baricitinib superior to placebo in terms of percentage of patients with a SALT score of 20 or less at week 36

ACC: Pericardial Effusion Prevalent in Hospitalized COVID-19 Patients

Prevalence of pericardial effusion in hospitalized COVID-19 patients is about 14 percent, but it rarely is attributable to pericarditis

Pregnant Obese, Overweight Women Have Higher Risk of Perinatal Death

Earlier gestational age at delivery may be implicated in many of these obesity-related perinatal deaths

Physician’s Briefing Weekly Coronavirus Roundup

Here is what the editors at Physician's Briefing chose as the most important COVID-19 developments for you and your practice for the week of...

Neurodevelopmental Disorders for Most Children Born <24 Weeks

75 percent born before 24 weeks of gestation had neurodevelopmental disorders; 88 percent had somatic diagnoses

Overtreatment of T2DM Common Among VA Nursing Home Residents

Minority of those overtreated or potentially overtreated have their medication regimens appropriately deintensified

Model Predicts CRC Risk in Ulcerative Colitis Patients With LGD

Four clinicopathological variables significantly associated with advanced neoplasia risk among those with low-grade dysplasia

One in Three Children With Disabilities Experience Violence

Children with disabilities twice as likely to experience any form of violence (physical, emotional, sexual, neglect) than children without disabilities

Survival Up With Bortezomib in T-Cell Lymphoblastic Lymphoma

No differences in EFS or OS seen with/without bortezomib overall or in patients with T-cell acute lymphoblastic leukemia

FDA Authorizes More E-Cigarette Products

Agency said it has acted on approximately 99 percent of the nearly 6.7 million e-cigarette products submitted for authorization

AI Model May Help Predict Ovarian Cancer Treatment Outcomes

Artificial intelligence model trained to recognize distinct morphologic patterns in high-grade serous ovarian cancer at the time of laparoscopy

Higher Internet Use Tied to Poorer Mental Health in Teens

Teens with higher usage self-report higher level of stress, and feelings of sadness and suicidal ideation

Vicious Cycle Seen Between Daytime Napping, Alzheimer Dementia

Excessive daytime napping over a year predicts worse cognitive performance the following year and vice versa

CDC: Vaccinated More Likely to Die During Omicron Wave If They Got J&J Shot

However, breakthrough infections among J&J vaccine recipients were similar or lower compared to the other vaccines

Medical Marijuana May Not Aid Pain, Anxiety, Depression Symptoms

But many obtaining immediate access to a medical marijuana card developed cannabis use disorder

Psychotropic Meds Tied to Risk for Post-COVID Dementia in Seniors

One-year incidence rate of post-COVID dementia was 12.7 percent in adults ≥65 years hospitalized with COVID-19

Outcomes Better With Open Hysterectomy for Early Cervical Cancer

Poorer disease-free survival seen with minimally invasive versus open radical hysterectomy for early cervical cancer at 4.5 years of follow-up

Artificial Sweeteners Linked to Increased Cancer Risk

Risks seen for aspartame and acesulfame-K; higher risks also seen for breast cancer and obesity-related cancers

Airlines Ask Biden to Drop Mask Mandates, COVID-19 Testing

Federal requirement that people wear masks on public transportation was recently extended until April 18

Improved CRC Outcomes With Recent Colonoscopy in IBD

Those with colonoscopy within one and one to three years less likely to be diagnosed at later stage

Incidence of TB Increased 9.4 Percent in U.S. During 2021

Incidence increased among U.S.-born and non-U.S.-born persons; increase may be due to delayed diagnosis during 2020

Nearly One in Three People With Depression Report Owning a Gun

Authors say there is opportunity to cut suicide risk through focused interventions

Mentalizing Imagery Therapy Aids Family Caregivers

Findings show lower depression, anxiety and better well-being versus support group attendance

Midlife Antibiotic Use Tied to Minor Cognitive Decline Later

Small decreases in cognitive scores seen at seven years for women reporting at least two months of antibiotic use during midlife

Hydrocortisone Does Not Up Survival Without BPD in Preemies

Survival without moderate or severe bronchopulmonary dysplasia in extremely preterm infants similar with hydrocortisone versus placebo

Fourth mRNA COVID-19 Vaccine Immunogenic, Safe

Vaccine efficacy 30 percent for BNT162b2 and 11 percent for mRNA-1273 against any SARS-CoV-2 infection

Risk for Myocarditis Low After Third Dose of BNT162b2 Vaccine

Incidence of myocarditis among young men estimated to be 6.43 and 11.25 per 100,000 vaccines in the week, two weeks after third dose

Timing, Type of Food Intake Linked to Mortality Risks in Diabetes

Among people with diabetes, higher intake of processed meat in the evening linked to increased risk for CVD mortality

Violent Assault Risk Up for People With Tourette Syndrome, Chronic Tic

Compared with the general population, individuals with these conditions also more likely to have criminal convictions

Addition of Icosapent Ethyl Cuts CV Risk in Patients With Prior PCI

Risk for cardiovascular events reduced when icosapent ethyl is added to statins in patients with elevated triglycerides and history of prior PCI

Presenting Symptoms Do Not Predict NSTEMI Outcomes

Presenting symptoms, such as chest pain, dyspnea/fatigue, syncope were not independent predictors of death from any cause at one year

Handheld Device Used to Screen for A-Fib in Primary Care Setting

Single-lead ECG device did not increase new diagnoses of atrial fibrillation for those aged 65 years or older compared with usual care

Older Adults Using Statins Have Reduced Risk of Parkinsonism

Lower risk of parkinsonism partly mediated by reduced odds of brain atherosclerosis

Risk of A-Fib Up With Occupational Exposure for Firefighters

Prevalence of atrial fibrillation increased for firefighters with increasing numbers of fires fought per year

Trastuzumab Deruxtecan Ups PFS in HER2+ Metastatic Breast Cancer

Trastuzumab deruxtecan better than trastuzumab emtansine for patients previously treated with trastuzumab and a taxane

QOL Advantages in Young Adulthood for Those Conceived Through ART

Being ART conceived associated with higher scores on social relationships and environmental WHOQoL-BREF domains

Pandemic Tied to Drop in New Cancer Diagnoses

While weekly detection increased from March 2020 low, incidence rates have not fully recovered

Ivermectin Effect in COVID-19 Varies With Strongyloidiasis Prevalence

Risk for mortality decreased only in ivermectin trials that took place in regions with high prevalence of strongyloidiasis

Ozone Exposure Tied to Adolescent Depressive Symptoms

Findings seen even in neighborhoods that meet national air quality standards

Living Review Compares Treatments for Atopic Dermatitis

Abrocitinib, 200 mg daily, and upadacitinib, 30 mg daily, slightly better than dupilumab, while upadacitinib, 15 mg daily is similar to dupilumab

Free COVID-19 Tests, Treatments for Uninsured Americans Cut for Lack of Funding

Program reimburses hospitals, clinics, doctors, and other service providers for COVID-19 care for uninsured people

Emergency Mental Health Visits Up After COVID-19 Surges

Findings show increases specifically for young adults and individual racial and ethnic minoritized subpopulations

Moderna Will Ask FDA to Approve COVID-19 Vaccine for Young Children

Request is based on interim results from clinical trial that showed the youngest children had an immune response similar to young adults

Decision Support System Cuts Pneumonia Deaths in Community Hospitals

Other benefits include improved antibiotic prescribing, faster time to first antibiotic

Hypertriglyceridemia Linked to Vascular Risk After Stroke

Risk of major adverse cardiovascular events increased for patients with hypertriglyceridemia even after adjustment for statin use

Patency of Iliac Vein Stents Examined in Subsequent Pregnancy

Small retrospective review shows good patency of iliac vein stents during and after pregnancy, no need for reintervention due to compression

Survival Inferior in Black Patients With Acute Myeloid Leukemia

Most disparities in acute myeloid leukemia mortality death accounted for by census tract measures

Review Explores Telehealth for Substance Use Disorders

And guideline developed to guide and inform treatment of active service members and veterans with substance use disorders

Low SARS-CoV-2 Positivity for Babies Born to Moms With COVID-19

SARS-CoV-2 positivity up in offspring in association with severe maternal COVID-19, maternal death, admission to ICU

Meds, Exercise Recommended for Stroke Prevention After sICAS

Clinicians should not recommend percutaneous transluminal angioplasty and stenting for stroke prevention