Stem Cell Transplant Reviewed for Peripheral T-Cell Lymphoma

Three- and five-year overall survival similar with allogeneic or autologous HSCT, but transplant-related mortality higher with allogeneic HSCT

COVID-19 Cases, Deaths Down in Seniors After Vaccine Introduction

Lower rate ratios for COVID-19 cases, ED visits, hospital admission, and deaths comparing oldest age group with younger adults

Review IDs Reasons for Disparities in Headache Treatment

Factors that contribute to disparities include racism, socioeconomic status and insurance status, geographic disparities

Neurological, Neuropsychiatric Symptoms Common in COVID-19

Symptoms with the highest prevalence included anosmia, weakness, fatigue, dysgeusia, myalgia, and depression

Recent Decline Seen in Diabetes Control Among U.S. Adults

After a long period of progress, glycemic and blood pressure control declined while lipid control plateaued in adults with diabetes

Houston Methodist Suspends Nearly 200 Workers Who Refuse COVID-19 Vaccines

Nearly 25,000 workers met Monday's deadline to be fully immunized, but 178 failed to do so and were suspended

American Academy of Neurology Says Police Must End Use of Neck Restraints

At a minimum, law enforcement and policymakers should classify neck restraints as a form of deadly force

Arsenic Levels Trigger Recall of Beech-Nut Infant Cereal

No illnesses related to the recalled products have been reported, according to the company

Child Drownings in U.S. Pools, Spas Are on the Rise

Child drownings remain the leading cause of unintentional death among U.S. children ages 1 to 4

U.S. to Send 500 Million COVID-19 Vaccine Doses to Countries Desperate for Shots

First 200 million doses will be sent out this year, with 300 million more shared in the first half of next year

Heart Transplant Outcomes Comparable in Advanced Age

Five-year mortality did not differ for adults aged ≥70 years and <70 years after adjustment for relevant confounders

FETO Beneficial for Severe Left Congenital Diaphragmatic Hernia

Studies examine benefits of fetoscopic endoluminal tracheal occlusion for severe, moderate left diaphragmatic hernia

Breast Cancer Risk Up With Inflammatory Potential of Diet

Women in highest quintile of inflammatory score of the diet had significantly increased risk, especially premenopausal women

ASCO: Sotorasib Targets KRAS p.G12C-Mutated NSCLC

Objective response seen in 37.1 percent of patients with previously treated KRAS p.G12C-mutated non-small cell lung cancer

Second-Opinion Strategy Analyzed for Cutaneous Melanocytic Lesions

Decision-analytic model shows selective second-opinion strategy could increase diagnostic accuracy, decrease population-level costs

Diets Compared for Mild-to-Moderate Crohn Disease in Adults

Rate of symptomatic remission at week 6 similar for Mediterranean diet, specific carbohydrate diet in randomized trial

Cardiac Monitor Implant Detects A-Fib in More Stroke Patients

Rate of incident AF over 12 months higher with implant versus usual care with external cardiac monitoring in patients with ischemic stroke

United Nations: Urgent Global Action Needed to End AIDS

Assembly's 193 member nations commit to efforts such as reducing annual new HIV infections, annual AIDS-related deaths

Expiration Date Looming for Millions of J&J COVID-19 Vaccine Doses

Research into extending the shelf life of the one-dose vaccine is ongoing

State Department Eases Travel Advisories for Dozens of Countries

Japan, France, Italy, Spain, Greece, Switzerland, Canada, and Mexico no longer in the 'Do Not Travel' category

Vaccinations More Urgent as Variant That Crippled India Shows Up in the U.S.

However, vaccines do appear to work well against this variant of the coronavirus

Barriers to Physician Skin Exam ID’d for Young Melanoma Survivors

Barriers to health care access linked to increased odds of suboptimal physician skin examination adherence

Osteoarthritis May Be Linked to Increased Risk for Subsequent Parkinson Disease

Highest increased risk for developing Parkinson disease seen among those with knee or hip osteoarthritis

Nintendo Wii Therapy Benefits Children With Cerebral Palsy

Systematic review and meta-analysis show improvement in functional balance and dynamic balance among children with cerebral palsy

Alcohol Intake Inversely Linked to Fecundability

During luteal phase, moderate and heavy drinking are associated with reduction in fecundability versus no alcohol intake

Gap Between Mortality in Rural and Urban Areas Has Increased

Difference increased in age-adjusted mortality rates between large metropolitan areas, rural areas from 1999 to 2019

Real-World Study Shows Power of Pfizer, Moderna Vaccines to Prevent COVID-19

Symptomatic and asymptomatic infection reduced by 81 percent after partial vaccination and by 91 percent after full vaccination

Mortality Increased for Racial/Ethnic Minorities With TBI

Hazard ratio for in-hospital mortality 2.21 for minority patients after adjustment for injury type, probability of survival, operative status

COVID-19 Vaccine Patent Rules Reconsidered by World Trade Organization

Idea backed by more than 60 countries, including the United States

India to Provide Free COVID-19 Shots for All Adults

So far, just over 222 million vaccines have been given in India; less than 5 percent of its population has been fully vaccinated

ASCO: Pembrolizumab Ups DFS in High-Risk Resected Clear-Cell RCC

Estimated DFS rate 77.3 and 68.1 percent at 24 months with pembrolizumab versus placebo; benefit consistent across subgroups

Decline in Births Linked to COVID-19 Pandemic Societal Shutdown

However, prospective modeling using electronic medical records suggests a birth volume surge will occur in summer 2021

Diet to Induce Weight Loss Can Reduce BP in Type 2 Diabetes

69 of 78 participants on treatment for hypertension stopped all or some antihypertensive and diuretic meds

AGA Issues Recommendations for Moderate-to-Severe Crohn Disease

Anti-TNFα recommended over no treatment for induction and maintenance of remission for adult outpatients

Severe Glycemic Events in T1D May Raise Risk for Dementia

Dementia risk increased more than sixfold for older adults with T1D who experienced severe episodes of hypoglycemia and hyperglycemia

Cataract Surgeries Down in Those Diagnosed With Alzheimer Disease

Authors say patients with Alzheimer disease would still be expected to benefit from cataract surgery

Earlier Screening Urged for Relatives of Prostate Cancer Patients

Men with family history of prostate cancer reach the screening risk threshold up to 12 years earlier than men in the general population

Switching to Plant Protein for Dinner May Reduce CVD Risk

Consuming low-quality carbohydrates and animal protein at dinner versus breakfast linked to increased CVD risk

ASCO: Adding Olaparib Slows High-Risk Early Breast Cancer

Higher rates of invasive disease-free survival seen in adjuvant setting for HER2-negative early-stage disease with germline BRCA1 or BRCA2 mutations

New HIV Infections in the U.S. Continued to Drop in 2019

Most infections attributable to male-to-male sexual contact; increase seen in proportion of infections among Blacks, Hispanics

SARS-CoV-2 RNAemia Infrequent in Blood Donors

Estimated prevalence of SARS-CoV-2 RNA reactive donations 1.16/100,000; no infectivity seen in inoculated permissive cell cultures

FDA Warns Against Use of Implantable Heart Device

The agency says the Medtronic HVAD system should no longer be used because it increases risk for neurological problems, death

Adults With Schizophrenia Have Higher Risk for Suicide

Younger adults with schizophrenia, those with history of suicide attempts or self-injury at especially high risk

After Editor-in-Chief’s Resignation, JAMA Journals Outline Steps to Address Racism

AMA will take steps to promote diversity, equity, inclusion within the medical society and its journals

Prenatal Acetaminophen Exposure May Up Risk for ADHD, Autism

However, no link seen between postnatal exposure and later symptoms in childhood

Salmonella Outbreak Linked to Raw Frozen Breaded Chicken Products: CDC

Eight people have been hospitalized; no deaths have been reported

e-ECE: Autoantibodies in Pregnancy Tied to Adult-Onset T1DM

Detection of ICA, GADA, IA2A autoantibodies in women with gestational diabetes linked to decreased T1DM-free survival time, time to diagnosis

New Drug For Vaginal Yeast Infections Approved by FDA

Brexafemme offers an alternative to Diflucan but at greater cost

e-ECE: Testosterone Therapy Mitigates NAFLD in Obese Men With FH, T2D

Testosterone undecanoate therapy reduces NAFLD grade in obese men with functional hypogonadism and type 2 diabetes

Functionally Impaired Older Adults May Use/Misuse Cannabis, Rx Drugs

Higher risk seen for medical cannabis use and prescription opioid and tranquilizer/sedative use and misuse

Testing for STIs in the U.S. Dropped During Early Pandemic

Low point in testing for chlamydia and gonorrhea seen in early April 2020, raising the possibility of many missed cases

Financial Penalties for Dialysis Centers Do Not Increase Performance

Performance-based financial penalties not associated with improvement in total performance scores, specific measures

Mastocytosis and Hymenoptera Venom Allergy Profiled in the U.S.

Mastocytosis occurs more often among U.S. patients with hymenoptera venom anaphylaxis versus general population

CGM Tied to Better Glycemic Control in Insulin-Treated Diabetes

Improvement in HbA1c, reduction in ER visits and hospitalizations for hypoglycemia seen in insulin-treated patients with diabetes

Benefits of Deep Brain Stimulation Persist in Parkinson Disease

Reductions in time spent with dyskinesia, time spent in the off state, and in dopaminergic drugs sustained for more than 15 years

Transplant Referral Less Likely For Dialysis Patients at For-Profit Facilities

Rates of starting evaluations within six months of referral and wait-listing within six months similar at for-profit, nonprofit centers

Recommended Vaccines Associated With Few Serious Adverse Events

No increased risk for autism found following MMR in children; no evidence of intussusception or diabetes seen with rotavirus vaccine

Immediate Kangaroo Mother Care Aids Low-Birth-Weight Infants

Reduced 28-day mortality seen for infants with birth weight of 1.0 to 1.799 kg who received immediate versus delayed kangaroo mother care

ASCO: COVID-19 Infections, Deaths Not Up With  Breast Cancer Chemo

Risk for death following SARS-CoV-2 infection increased with advanced-stage disease, higher comorbidity, but not receipt of chemotherapy

Drug-Induced Immunosuppression Examined in U.S. Adults

Drug-induced immunosuppression, particularly from oral corticosteroids, may limit response to COVID-19 vaccine

WHO Approves Second Chinese COVID-19 Vaccine

Emergency use authorization based on data showing two doses of Sinovac are about 50 percent effective

J&J’s Appeal in $2 Billion Verdict Rejected by U.S. Supreme Court

Supreme Court will not hear J&J's appeal over ruling in favor of women who said they developed ovarian cancer from using talc products

Depressive Symptoms Linked to Rapid Kidney Function Decline

Baseline depressive symptoms positively linked with decline in kidney function for Chinese adults with normal kidney function

Asthma Flares Down Among Black, Hispanic Patients During Pandemic

Greatest decrease seen for those previously working outside of the home and in those without 'allergic-type' inflammation

ATS Guideline Addresses Testing for Viral Pathogens in CAP

Nucleic acid-based testing for noninfluenza pathogens suggested for hospitalized patients who have severe CAP or are immunocompromised

NIH Starts Trial Assessing ‘Mix & Match’ COVID-19 Vaccine Approach

Individuals who received J&J, Moderna, or Pfizer-BioNTech vaccine will receive single booster dose of Moderna vaccine 12 to 20 weeks later

Delaying Surgery Linked to Worse Outcomes for NSCLC

Risk for recurrence increased with surgical delay beyond 12 weeks; overall survival improved with surgery within 12 weeks

First Human Case of H10N3 Bird Flu Reported in China

The China National Health Commission says risk for large-scale spread in humans is low

BNT162b2 Vaccine Safe, Effective for Teens Aged 12 to 15 Years

Vaccine efficacy was 100 percent; no cases of COVID-19 with onset of seven or more days after dose 2 seen among BNT162b2 recipients

Most Severe Effects of PIMS-TS Resolved at Six Months

Findings generally favorable for patients with pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2

ASCO: Oncologists Underestimate Patient Use of Complementary Medicine

Furthermore, oncologists and patients differ in their opinions of modalities offering benefits, boost to quality of life

Cardiac-Related Calls to EMS Down, OHCA Up During COVID-19

Decrease in calls to emergency medical services and increase in out-of-hospital cardiac arrest persisted after initial wave

ASCO: Incidence of Cervical Cancer Has Decreased in the United States

Other HPV-related cancers have increased in recent years; incidence of anal and rectal cancer expected to surpass cervical cancer

Tai Chi Helps Reduce Central Obesity in Adults ≥50 Years

Reductions in waist circumference seen in tai chi and conventional exercise groups compared with control group

JAMA Journals Editor-in-Chief Steps Down After Deputy’s Racism Comments

AMA investigating how podcast and tweet, which contained controversial statements, were developed, reviewed, and published

Microvascular Angina Linked to Major Adverse CV Events

In multivariable analyses, hypertension, previous history of coronary artery disease were predictors of MACE

CDC Updates COVID-19 Guidelines for Summer Camps

Masks no longer required for campers, staff who are fully vaccinated

Arthroplasty, Arthrodesis Outcomes for Ankle Arthritis Examined

Better functional improvement seen with total ankle arthroplasty at 48 months after surgery for end-stage ankle arthritis

WHO Says New Coronavirus Variants to Be Named Using Greek Alphabet

With new public labeling system, governments may be more willing to disclose newly detected variants

Food Allergy Training, Action Plans Suggested for Schools, Day Care

Site-wide food prohibitions or allergen-restricted zones are not suggested, except in special circumstances

Some Prisons Highly Successful in Vaccinating Inmates

Success in prisons could convince some in the general public to get vaccinated

Osteoporosis, Low Bone Density May Contribute to Hearing Loss

Magnitude of elevated risk similar among women who did and did not use bisphosphonates

AHA Issues Statement on Central Retinal Artery Occlusion

Acute CRAO is a medical emergency and patients should be immediately triaged to an emergency department

Excess Pericardial Fat May Increase Risk for Heart Failure

High pericardial fat volume linked to twofold increase in risk for women, 53 percent increase in risk for men

Diabetes Care Lacking in Low-, Middle-Income Countries

Of adults with diabetes in a pooled sample from 55 LMICs, 4.6 percent self-report meeting need for all treatments recommended

Healthy Behaviors Independently Linked to Lower Dementia Risk

For those with familial dementia, risk for dementia is reduced with three or more healthy behaviors

Physician’s Briefing Weekly Coronavirus Roundup

Here is what the editors at Physician's Briefing chose as the most important COVID-19 developments for you and your practice for the week of...

Number of Smokers Continuing to Rise Worldwide

And, most smokers start smoking before age 25 years, with 82.6 percent initiating between ages 14 and 25 years

Many Americans Confused About Sunscreens: Poll

AAD poll highlights common misconceptions about sunscreen application

OCD Linked to Increased Risk for Ischemic Stroke

Risk elevated during follow-up, especially for middle-aged and elderly adults, compared with non-OCD controls

FDA Approves Tracer That Improves Detection of Advanced Prostate Cancer

Tracer is injected into the bloodstream and lights up metastatic prostate cancer cells during PET scan

Functional Decline Common in Adults Hospitalized for COVID-19

More than 40 percent of survivors were not assessed by physical medicine and rehab professionals during hospitalization

Breastfeeding Initiation Varies by Race/Ethnicity Across U.S.

Overall prevalence of breastfeeding initiation was 84.1 percent, with a range from 90.3 to 73.6 percent for infants of Asian, Black mothers

Poll Finds Herd Immunity in U.S. Possible by Summer

In latest KFF survey, 62 percent of respondents said they had received at least one dose of a COVID-19 vaccine

Review Shows COVID-19 Symptoms Often Linger

Median of 72.5 percent of patients experienced one or more persistent symptoms based on data from 16 studies

ED Presentations for Appendicitis, Miscarriage Down in Pandemic

During pandemic, initial reduction seen in ED visits for cholecystitis, ectopic pregnancy; reductions sustained for appendicitis, miscarriage

Several Nongenetic Factors Tied to Early-Onset Colorectal Cancer

Greater red meat intake, lower educational attainment, and heavier alcohol use up risk for early-onset colorectal cancer

ASCO: Nivolumab, Relatlimab Combo Slows Advanced Melanoma

Median progression-free survival of 10.1 versus 4.6 months seen among those receiving combo versus nivolumab alone, respectively

ACG Issues Guidelines for C. Diff Management in Adults

Authors recommend against probiotics for prevention of CDI; in those with CDI recurrence, FMT recommended to prevent further recurrence

Tdap Vaccination Tied to Lower Dementia Risk in Older Adults

Findings seen in two cohorts of older adults with different sociodemographic characteristics

AI Algorithm Aids Early Detection of Low Ejection Fraction

Diagnosis of low EF was increased with the intervention in the overall cohort, among patients with positive AI results

One Dose of BNT162b2 Inadequate for Hemodialysis Patients

Single mRNA vaccine dose often fails to elicit a humoral response; 57 percent of dialysis patients have undetectable anti-RBD IgG at four weeks

COVID-19 Vaccines May Give Protection for Years: Studies

Findings suggest that most people who have recovered from SARS-CoV-2 infection and were later vaccinated will not require booster shots

Providers Less Likely to Prescribe Statins in the Afternoon

Even for at-risk patients, primary care providers are less likely to prescribe during afternoon appointments

Guidelines Issued for Endoscopy of Surgically Altered Bowel

Multidisciplinary approach usually needed to address complexities in diagnosis and management of surgically altered bowel in IBD

Outcomes Poorer With Six Versus 12 Weeks of Antibiotics for PJI

Six weeks of therapy did not meet the criteria for noninferiority among patients with microbiologically confirmed prosthetic joint infections

Black Patients More Likely to Die From Triple-Negative Breast Cancer

Higher mortality risk partially explained by disparities in Black patients' receipt of surgery and chemotherapy

Nitrogen Dioxide Exposure May Up Risk for Parkinson Disease

However, no other significant associations seen between particulate matter and other air pollutants and Parkinson incidence

Portable PCR Platform Allows Rapid Diagnosis of Gonorrhea

Rapid test detects NG within 15 minutes and simultaneously determines whether strains are resistant to ciprofloxacin

FDA Approves Third COVID-19 Antibody Treatment for Emergency Use

Study found that patients who received sotrovimab showed an 85 percent reduction in their risk for hospitalization or death versus placebo

Sleep Disorders Tied to Higher Health Care Utilization, Costs

Sleep disorders affect an estimated 13.6 million U.S. adults, with approximately $94.9 billion in incremental costs per year

U.S. Intelligence Told to ‘Redouble’ Efforts to Determine Source of COVID-19

Move prompted by a new report questioning whether the new coronavirus originated in a lab in Wuhan, China

Internet-Delivered CBT Treats Social Anxiety Disorder in Youth

Internet-delivered cognitive behavioral therapy was more efficacious than an active comparator in reducing the severity of SAD symptoms

Restrictions Eased on Use of Embryos in Research

However, the ISSCR did not specify how much longer embryos could be grown beyond the 14-day limit specified in 2016 guidelines

Improved Cognition Seen With Healthier Cardiovascular Phenotype

Better cognitive performance linked to larger LV/RV volumes, higher LV/RV stroke volumes, greater LV mass

Possible Cause Found for Rare Blood Clots Tied to Some COVID-19 Vaccines

Scientists say substandard proteins, some of which appear to split apart inside the body, can provoke the rare clots

Dialysis Patients Maintain Humoral Response to SARS-CoV-2 Infection

SARS-CoV-2 receptor-binding domain IgG persisted over six months followed by slow, continual decline

Dupilumab Cuts Exacerbations in Children With Asthma

FEV1pp improved and FENO was reduced with dupilumab among children with type 2 inflammatory asthma phenotype

Childhood BMI Tied to Later Eating Disorder Risk

Low BMI associated with higher risks for anorexia, higher BMI associated with increased risks for bulimia

CDC Offers Details on SARS-CoV-2 Vaccine Breakthrough Infections

27 percent of vaccine breakthrough infections were asymptomatic; 10 and 2 percent resulted in hospitalization, death

U.S. Officials Say 50 Percent of American Adults Are Now Fully Vaccinated

At least 25 states, plus Washington, D.C., have now fully vaccinated at least half of their adult residents

Brooks-LaSure Confirmed as CMS Head

Brooks-LaSure will be the first Black person to lead CMS

Insurance Coverage Disruptions Have Adverse Consequences for Care

Disruptions linked to lower receipt of preventive services, forgoing needed care, medication nonadherence

Prior Head Injury With Loss of Consciousness Linked to Disability

Almost half have disability, with highest prevalence seen in the domains of mobility and work productivity

Methotrexate May Impair Immune Response to mRNA COVID-19 Vaccine

Poorer humoral, cellular immune responses seen in patients receiving methotrexate for immune-mediated inflammatory disease

SARS-CoV-2 Reinfection Risk Low Among Health Care Workers

Risk for reinfection was significantly reduced by 85 percent with the presence of antibodies

Severe Carpal Tunnel Syndrome Up After Bilateral Oophorectomy

Estrogen therapy after oophorectomy did not appear to have a protective effect

Undervaccination for COVID-19 Found for Individuals With Schizophrenia

Differences between those with schizophrenia, controls became more profound as age increased

Risk for Autoimmunity Up With Concomitant Vitiligo, Psoriasis

Occurrence of psoriasis was reported before vitiligo in 62.2 percent of patients, especially those with colocalization of lesions

Cortisol Secretion, Mortality Link Explored in Adrenal Incidentalomas

About twofold and threefold increase in mortality seen with cortisolDST of 83 to 137 nmol/L and cortisolDST of 138 nmol/L or higher

Oral, IV Tranexamic Acid Compared for Joint Replacement Surgery

Interim results of a randomized study indicate that oral and IV TXA are equally effective in reducing perioperative blood loss

‘Race Correction’ May Lead to Underdiagnosis of Lung Disease

Removing race correction in PFT results leads to higher prevalence, severity of lung disease diagnoses in Black patients

Study Supports Delaying Pregnancy for One Year After Bariatric Surgery

Pregnancy within 12 months linked to lower gestational age at delivery, lower gestational weight gain, lower neonatal birth weight

Needle Size Not Tied to Postdural Puncture Headache in Orthopedic Patients

Among 3,980 patients receiving spinal injections with 22-gauge Quincke cutting needle or 25-gauge pencil-point needle, none developed PDPH

RA Linked to Restrictive, Obstructive Spirometry Patterns

Compared with controls, rheumatoid arthritis was associated with lower percent predicted FEV1, percent predicted FVC, and FEV1/FVC

Duloxetine Cuts Opioid Use After Total Knee Arthroplasty

Duloxetine, given on the day of surgery and once daily for 14 days, reduces opioid use by about 30 percent

ACG Issues Guideline for Management of Upper GI Bleeding

For patients hospitalized with upper GI bleeding, suggested threshold for red blood cell transfusion at hemoglobin level of 7 g/dL

Moderna COVID-19 Vaccine Highly Effective in Children 12 and Older

Side effects among adolescents who received the Moderna vaccine were similar to those reported in adults

U.S. Issues Tough Travel Warnings for Japan Ahead of Olympics

Travel advisories issued by both the U.S. Centers for Disease Control and Prevention and the U.S. State Department

Rybrevant Approved for NSCLC With EGFR Exon 20 Insertion Mutations

Efficacy data revealed 40 percent response rate, median response duration of 11.1 months

USPSTF Recommends Counseling for Healthy Pregnancy Weight Gain

Behavioral counseling interventions aimed at promoting healthy gestational weight gain have moderate net benefit

Wearable Devices Can Predict Clinical Lab Measurements

Vital sign data collected from wearables offer more consistent and precise depiction of resting heart rate than clinic measures

Gamification Increases Physical Activity in T2DM Patients

But no differences between intervention and control groups seen for weight loss or glycemic control in adults with uncontrolled diabetes

Cannabis Exposures Higher in States With Legalized Marijuana

Exposures reported to poison control most commonly involve unprocessed plant materials

ACC: Tailored Rehab Beneficial for Heart Failure in Seniors

Greater physical improvement seen with early, transitional, tailored, progressive rehab intervention including physical function domains

Cause of First Stroke Guides Prevention of Second Stroke

Recommendations include diagnostic workup to define stroke etiology to reduce risk for recurrent stroke

COVID-19 Symptom Exacerbation Leading Cause of Reencounters

Neurologic illness prior to COVID-19 a predictor for acute-care hospital reencounters within 30 days and four months

CDC Investigating Heart Problems in Teens, Young Adults After COVID-19 Vaccination

Health care providers should watch for unusual heart symptoms among young people who have just received the vaccine

Epigenetic Age Acceleration Up in Head and Neck Cancer

Correlation found for increased EAA with elevated fatigue, which was mediated by inflammatory markers CRP, IL-6

Latin America’s COVID-19 Death Toll Climbs Above 1 Million

Region with only 8 percent of the world's population has accounted for about 29 percent of COVID-19 deaths worldwide

ACC: Ultrasound Renal Denervation Cuts BP in Med-Resistant HTN

Reduction in daytime ambulatory systolic blood pressure at two months greater with ultrasound renal denervation versus sham procedure

Pfizer, AstraZeneca COVID-19 Vaccines Effective Against Indian Variant: Study

Study shows that after two doses, the Pfizer vaccine is 88 percent effective in protecting against symptomatic disease from the variant

DDW: Irritable Bowel Syndrome Severity Symptoms Improved in Lockdown

Proportion of severe IBS patients and mean IBS Severity Scale decreased during lockdown versus prepandemic, may be secondary to reduction in external stress burdens

Thousands of ‘Black Fungus’ Cases Reported in COVID-19 Patients in India

Nearly 9,000 cases of the fungal infection mucormycosis have been reported so far

ACC: Fish Oil Does Not Improve Outcomes for Those at High CV Risk

Patients with the highest levels of EPA had similar rates of major adverse cardiovascular events as patients taking placebo

U.S. COVID-19 Infections, Deaths Drop to Levels Not Seen Since Last Summer

United States reporting about 25,700 new COVID-19 cases daily, a 39 percent decrease from two weeks ago

Bariatric Surgery Linked to Reduced Risk for Cataracts

Lowest risk for cataracts seen for patients aged 40 to 49 years; null result observed in patients aged 60 to 79 years

Ethnicity-Specific BMI Cutoffs for Obesity Needed to Assess T2DM Risk

BMI cutoffs equivalent to 30.0 kg/m2 in Whites were 23.9, 28.1, 26.9, and 26.6 kg/m2 for South Asian, Black, Chinese, Arab populations

Access to Pulmonary Rehab Limited for Many COPD Patients

Overall, 61.5 percent of Medicare beneficiaries have pulmonary rehabilitation center within a 10-mile radius

COVID-19 Had Major Impact on ICU Nurses’ Mental Health

Moderate-to-severe depression and anxiety reported for 44.6 and 31 percent, respectively; 47 percent were at risk for PTSD

Minority of Those With AUD Referred to, Receive Treatment

However, health care use and screening are common for alcohol use disorder

Progress Mixed in Cancer Prevention, Early Detection Measures

Cigarette smoking reached historic low in 2019, but obesity levels high and cancer screening, HPV vaccination levels suboptimal

Majority of Pediatric Spinal Fractures Occur in Teens

Almost two-thirds of pediatric spinal fractures in the U.S. occur in patients aged 15 to 17 years, most often due to motor vehicle accidents

Outcomes Worse When Calling for Help With Atypical MI Symptoms

Patients presenting with atypical symptoms when calling for help have lower chance of emergency dispatch, increased mortality

Neighborhood, Socioeconomic Factors Affect Heart Attack Survival

Findings seen during 11 years of follow-up among those having a heart attack at age 50 years or younger

More Body Surface Area Clearance With Psoriasis Tied to Better Quality of Life

Findings consistent at both six and 12 months of treatment with systemic therapy

AI Can Detect Scaphoid Fractures on Conventional Radiographs

No significant difference in AUC seen for detecting scaphoid fractures with convolutional neural network versus 11 radiologists

Backyard Poultry Tied to Salmonella Outbreak in Dozens of States: CDC

34 people had been hospitalized, but no deaths had been reported

CDC: Self-Administered Subcutaneous DMPA Should Be Made Available

WHO recommendation adopted based on evidence that self-administered DMPA-SC is safe, effective with higher continuation rates

Meds Used for Hospitalized COVID-19 Patients Shifted Over 2020

Dexamethasone and remdesivir use grew substantially, while azithromycin and hydroxychloroquine both declined from early peaks

Upadacitinib Treats Moderate-to-Severe Atopic Dermatitis

Two replicate double-blind, randomized, placebo-controlled trials show short-term efficacy for upadacitinib in adolescents and adults

Approved Vaccines ‘Respond’ to All COVID-19 Variants So Far: WHO

However, unknown variants of the virus could still emerge and be resistant to existing vaccines

Screening Endoscopy May Lower CRC-Related Mortality in Healthy Elderly

Risk for CRC-related mortality reduced with screening endoscopy for those older than 75 years who do not have significant comorbidities

Secondhand Smoke Exposure Linked to Odds of ADHD Symptoms

Odds of ADHD symptoms increased for children with exposure in prenatal period, early postnatal period, current period

Screening Does Not Reduce Ovarian, Tubal Cancer Deaths

Increase in stage I disease, decrease in stage IV disease incidence seen with multimodal screening versus no screening

Physician’s Briefing Weekly Coronavirus Roundup

Here is what the editors at Physician's Briefing chose as the most important COVID-19 developments for you and your practice for the week of...

Modest Dietary Changes ID’d in Women After GDM Diagnosis

Pregnant women diagnosed with gestational diabetes mellitus decreased intake of juice, added sugar; maintained prediagnosis exercise routine

SARS-CoV-2 Seropositivity Not Associated With Low Vitamin D

SARS-CoV-2 seropositivity not linked to having vitamin D level less than 20 ng/mL or less than 30 ng/mL before or during pandemic

Presentation of Multisystem Inflammatory Syndrome Varies in Adults

60 percent of patients with MIS-A had acute COVID-19 symptoms, 20 percent were admitted for COVID-19 before being admitted for MIS-A

About 1 Million Excess Deaths Reported in 29 High-Income Countries in 2020

All 29 high-income countries had excess deaths except New Zealand, Norway, Denmark; absolute number of deaths highest in U.S., Italy, U.K.

HR Status, Age Impact Risk for Subsequent Cancers in Breast Cancer Survivors

Those surviving breast cancer for more than one year have higher risk for subsequent primary cancers

Key Factors ID’d for Bipolar Medication Nonadherence

Patients report side effects, beliefs, and knowledge about bipolar disorder are top reasons for not taking medications

Intensive BP Lowering Cuts Major Adverse CV Events, Mortality

But adverse effects, including hypotension, acute kidney injury, syncope, more frequent with intensive treatment in those at increased CV risk

MS Linked to Lower Survival After Breast Cancer Diagnosis

Risk for all-cause mortality increased, but no association seen between multiple sclerosis and cancer-specific survival

Risk for Post-COVID-19 Clinical Sequelae Examined in Adults

Risk increased for new sequelae attributed to SARS-CoV-2 infection, including chronic respiratory failure, myocarditis, anxiety, fatigue

AI Algorithm Helps Evaluate Pulmonary Nodules Detected on Screening CT

Deep learning algorithm could aid malignancy risk estimation of pulmonary nodules detected on low-dose screening CT

Endovascular Therapy Studied for Stroke Due to Basilar-Artery Occlusion

With respect to a favorable functional outcome, no significant difference seen between endovascular therapy and medical therapy

Almost One in Four Patients With Heart Failure Develop Depression

Heart failure patients have significantly higher likelihood of developing depression within five years

FDA Eases Storage Rules for Pfizer COVID-19 Vaccine

New guidance means the vaccine can be used in more locations that do not have ultra-cold storage facilities

COVID-19 Pandemic Tied to Increase in Overdose Deaths

Weekly median overdose deaths increased by 50 percent after stay-at-home order

COVID-19 Booster Shots Likely Needed Within a Year: Fauci

Fauci also said that variant-specific booster shots may not be needed

Fully Vaccinated Travelers Can Soon Visit EU Countries

New measures for tourists and other travelers could take effect as early as next week

College Athletes’ Concussion Knowledge Varies by Race

Awareness low despite NCAA concussion education requirements for athletes

Less Than 1 Percent of COVID-19 Patients Experience Recurrence

90 percent of repeat positive tests ≥60 days from initial diagnosis are not consistent with true recurrence

CRC Risk Up in First-Degree Relatives of Patients With Polyps

Link between family history of polyps and CRC risk strengthened with increasing number of relatives and lower age at polyp diagnosis

Guidelines Developed for Diagnosing, Treating Botulism

Signs and symptoms of some neurologic conditions overlap with botulism; thorough, serial neurologic exams should be conducted

Venous Thromboembolic Event Rates Up With ChAdOx1-S Vaccine

However, absolute risks are small, with 11 excess venous thromboembolic events per 100,000 vaccinations

Fish Oil Supplements Tied to Risk for Atrial Fibrillation

Patients at high risk for cardiovascular disease or who had established cardiovascular disease had higher risk for a-fib with fish oil supplements