Risk for Acute Kidney Injury High With Protocol for Post-TKA Infection

AKI seen in 14 percent of patients treated with antibiotic-loaded bone cement spacer after resection of periprosthetic joint infection

Interval Cancers Down With Digital Breast Tomosynthesis

Interval cancer rate 1.6 per 1,000 women screened with DBT compared with 2.8 per 1,000 women screened with digital mammography

Chest CT Indicates Mortality Risk in COPD

Individuals with higher SAT index had lower risks for mortality, while higher IMAT index linked to higher mortality risk

‘Possible Link’ Found Between AstraZeneca COVID-19 Vaccine, Rare Blood Clots

EU agency experts reviewed several dozen cases and determined that such clots are 'very rare' side effects of the vaccine

Systemic Inflammatory Disease Tied to Mortality After MI in Young Adults

During follow-up, patients had increased risk for all-cause mortality

COVID-19 Funeral Assistance Program Announced by White House

Number of people who will be eligible is not known and neither is the program's cost

1999 to 2018 Saw Decline in Mean BP Among U.S. Children, Teens

However, authors warn that stagnation and possible increase in more recent years may indicate reversal of trend

Branded Rx Requests Up Medicare Costs by $1.6 Billion

Physician, patient requests account for almost one-third of branded dispensing

Mass COVID-19 Vaccinations May Help Protect Unvaccinated People

Researchers found that vaccination rates among adults reduced rates of infection among children younger than 16 years

Shelter-in-Place Orders Tied to Weight Gain

Findings regardless of geography or comorbidities and translate to 1.5 pounds per month

Few COVID-19 Infections Seen in Vaccinated Health Care Workers

Incidence of COVID-19 infection extremely low among fully vaccinated health care workers

New Coordinator Appointed for U.S. Global Response to COVID-19 Pandemic

Gayle Smith's duties will include harnessing U.S. knowledge and resources to increase COVID-19 vaccine production and distribution worldwide

Acupuncture Effective for Chronic Muscular Pain in Cancer Survivors

However, more adverse events seen with auricular acupuncture versus electroacupuncture

First U.S. Trachea Transplant Patient Breathing Freely

So far, patient has not had any complications or signs of rejection

Patient Navigation Services Cut Readmission in Adults With SUD

Readmissions and emergency department use reduced among hospitalized adults with comorbid substance use disorder

Walgreens Was Not Following COVID-19 Dose Timing Guidelines

CDC has asked Walgreens to use the recommended three-week period between doses

Persistent Midlife Loneliness May Up Later Dementia, AD Risk

However, transient loneliness compared with no loneliness during middle age appears to lower dementia risk

High Physical Activity, Low Air Pollution Exposure Cut T2DM Risk

However, habitual exercise reduces risk for type 2 diabetes regardless of level of exposure to particulate matter air pollution

Prevalence of Psychiatric Disorders High After Juvenile Detention

At 15 years after detention, 52.3 and 30.9 percent of men and women had one or more psychiatric disorders

No Increase Seen in Outpatient VTE for SARS-CoV-2-Positive Patients

Patients with positive SARS-CoV-2 test had higher 30-day incidence of hospital-associated, but not outpatient, VTE

Remote Cardiology Visits Tied to Less Prescribing, Diagnostic Testing

Findings seen for both video and telephone cardiovascular care visits compared with pre-COVID-19 in-person visits

Previously Infected May Only Need Single Dose of COVID-19 Vaccine

Spike-specific IgG antibody levels and ACE2 antibody binding inhibition responses similar to those in infection-naive after two doses

Increased CVD Risk With ß-Blockers for HTN in Veterans With HIV

Twenty-five percent experienced CVD event during follow-up; risk up for ß-blocker use but not with calcium channel blockers, diuretics

About 40,000 Children Have Lost a Parent to COVID-19

Three-fourths of children losing a parent to COVID-19 are teens; Black children disproportionately affected

Risk of Quitting Up for Medical Center Employees, Faculty During Pandemic

Lack of child care tied to consideration of leaving the workforce, lessening hours

Increase in Overall Costs With Use of Urgent Care Centers

Reduction in lower-acuity emergency department visits was offset by increase in urgent care center costs

Consuming Processed Meat Regularly May Up CVD, Mortality Risk

Higher intake of unprocessed red meat, poultry not tied to increased risks for mortality, major cardiovascular disease

Navajo Nation Curbs COVID-19 Cases

Tribe currently averaging about 11 new cases a day, compared with a peak of 250 in late November

Tislelizumab Plus Chemo Slows Advanced Squamous NSCLC

Progression-free survival significantly longer with tislelizumab plus chemotherapy versus chemotherapy alone

Utah Law Requires Fathers to Contribute to Pregnancy Costs

Father's financial obligation would include a pregnant woman's health insurance premiums and any pregnancy-related medical costs

2005 to 2015 Saw Increase in LOS for Pediatric ED Mental Health Visits

Increase in prolonged length of stay for pediatric mental health ED visits; no change in LOS for non-mental health visits

‘Vaccine Passports’ to Be Part of Britain’s Reopening Plan

Other proposals in the plan expected to be unveiled Monday include frequent mass testing with at-home test kits

Pregnant Women Show Robust Immune Response to COVID-19 Vaccine

And passage of antibodies through the placenta and breastmilk appears to confer immunity to newborns

Routine HPV Vaccination for Older Adults May Not Be Cost-Effective

Two microsimulation models used to examine cost-effectiveness of HPV vaccination for U.S. women and men aged 30 to 45 years

Substance Use Disorder Costs Topped $13 Billion for Hospitals in 2017

Costs of treatment and prevention could potentially be offset by cutting direct medical costs, authors say

Medicare Spending on Physician Services Down $9.4B During First Half of 2020

Declines seen regardless of service type, setting, or specialty, and state or region

Physician’s Briefing Weekly Coronavirus Roundup

Here is what the editors at Physician's Briefing chose as the most important COVID-19 developments for you and your practice for the week of...

CDC: Fully Vaccinated Americans Can Now Travel Safely

However, social distancing, mask-wearing, and hand-washing precautions should still be taken

Faster-Spreading COVID-19 Variant Expanding in United States

New study finds B.1.1.7 variant is 40 to 50 percent more transmissible than versions of the virus that were previously dominant

More Cases of Blood Clots Linked to AstraZeneca COVID-19 Vaccine

Britain's medical regulatory agency has received 30 reports of clotting events after people were vaccinated

Moderna Gets OK to Increase Doses in COVID-19 Vaccine Vials

Company expects to begin shipping the 15-dose vials within weeks

Biden Administration Kicks Off Campaign to Boost COVID-19 Vaccinations

The 'We Can Do This' campaign creates a 'community corps' of public health, athletic, faith, and other groups to spread the word about vaccines

Increase Seen in Co-Involvement of Opioids in Drug Overdose Deaths

From 2009 to 2019, increase in OD deaths involving cocaine and opioids faster than for those involving cocaine with no opioids

Screening May Improve Early Detection for Melanoma-Prone

Reduced thickness of melanoma lesions seen for patients receiving routine skin cancer screening, education about self-exam

More Advanced Cancer at Presentation Possible Effect of Pandemic

May be the result of treatment postponements and deferrals that were common at the beginning of the pandemic

Mortality, Readmission Low With COVID-19 Discharge on Home Oxygen

All-cause mortality rate 1.3 percent; 30-day readmission rate 8.5 percent among 621 patients discharged on home oxygen

Diabetes Mortality Rates Higher Among Blacks Than Whites

Rate ratios significantly higher in 11 cities; Black-White rate ratio about three times higher in Washington, D.C., than national rate ratio

Belly Fat Gain During Menopause May Elevate CVD Risk

Increases in visceral adipose tissue associated with subclinical atherosclerosis in the internal carotid artery

Benign Bone Tumors Commonly Detected on X-Rays in Children

Historical collection shows nonossifying fibromas detected in asymptomatic children had resolved in 37 percent at time of last radiograph

Benzodiazepines Up Risk for Nonfatal Drug-Related Poisoning in OUD

Risk partially mitigated by buprenorphine treatment

Cardiovascular Risk Factors Tied to Poor Pregnancy Outcomes

First-trimester cardiovascular risk factors also tied to hypertension years after delivery

Mobile Robotic System Perceived as Acceptable for Health Tasks

Survey suggests robotic system perceived as useful; patients report satisfaction with triage interview using mobile robotic system

EEG Abnormalities Common in Hospitalized COVID-19 Patients

Nonconvulsive seizures detected in 9.6 percent of patients with COVID-19 needing clinically indicated electroencephalogram monitoring

COVID-19 Was Third Leading Cause of Death in US in 2020

COVID-19 reported as underlying or contributing cause of death for 11.3 percent of deaths in 2020

Clinical Preventive Service Use Varies Across the United States

Insurance status is dominant factor linked to service use; use of nine of 10 services lower for uninsured

Pfizer/BioNTech COVID-19 Vaccine Highly Effective Six Months After Second Dose

Companies also announced that the vaccine is safe and effective in children as young as 12

Production Error at US Plant Ruins 15 Million Doses of J&J COVID-19 Vaccine

Situation will not impact doses of the Johnson & Johnson vaccine currently being delivered and used across the United States

FDA: Complications Up for Two Brands of Surgical Mesh Used in Breast Reconstruction

FlexHD and AlloMax brands lead to significantly higher rates of implant removal, reoperations, and infection within two years

Alcohol Consumption Linked to Lower Risk for Cataract Surgery

Findings seen in two large cohorts from United Kingdom; strongest protective association seen with wine consumption

Lower Thresholds Could ID Hypertension in More Pregnant Women

Reclassification of hypertension status could also identify more women at risk for preeclampsia, adverse fetal/neonatal events

Readmission, Mortality Up After Discharge for Acute COVID-19

Patients with COVID-19 also had significantly elevated rates of respiratory disease, diabetes, CVD compared with controls

Adjuvant Nivolumab Beneficial in Esophageal, GE Junction Cancer

Disease-free survival significantly longer in patients with resected esophageal, gastroesophageal junction cancer

Frequency of Acute Ischemic Stroke Low in COVID-19 Patients

Occurrence of acute ischemic stroke in COVID-19 is associated with increased risk for requiring long-term care

Weekly Semaglutide Bests Placebo for Greater Weight Loss

Semaglutide superior when used as an adjunct to intensive behavioral therapy and initial low-calorie diet among obese, overweight adults without diabetes

Global Maternal, Fetal Outcomes Worsened During COVID-19 Pandemic

Increase seen in stillbirth and maternal deaths, surgically managed ectopic pregnancies, and maternal depression

New OTC Rapid COVID-19 Test Approved by FDA

Test provides results in about 15 minutes and 'will be simple, even for people who have never tested themselves'

Tobacco Use Up During Early COVID-19 Lockdown

Inability to obtain lower-risk products drove some to turn to more readily available cigarettes

Community Exposures Tied to SARS-CoV-2 Seropositivity in HCWs

Workplace factors not linked to seropositivity for health care personnel

Upadacitinib Beats Placebo for Psoriatic Arthritis

Percentage of patients with ACR20 response significantly higher with upadicitinib versus placebo at week 12

Sotatercept Reduces Pulmonary Vascular Resistance in PAH

Decrease in pulmonary vascular resistance at 24 weeks greater with sotatercept versus placebo for pulmonary arterial hypertension

Pfizer Says Its COVID-19 Vaccine Is Very Effective in Kids as Young as 12

Vaccine triggered immune responses that were even more robust than those seen in young adults

Exercise May Slow Cognitive Decline in Some With Early Parkinson Disease

Higher physical activity related to slower APOE ε4-related cognitive decline in early Parkinson disease

Half of Parents Report Pandemic Negatively Impacting Teen Mental Health

Parents also report methods to improve mental health largely work

Osteoporosis Prevalence at Femur Neck, Lumbar Spine 12.3 Percent

Findings seen among adults 50 years and older in 2017 to 2018; prevalence of osteoporosis increased since 2007-2008 in women, not men

Prevalence of Cognitive Impairment Up in Normal-Tension Glaucoma

Linear trend identified between lower absolute cognitive scores in the NTG versus HTG cohort, but association not significant

Odds of MetS Lower With Adherence to Exercise, Diet Guidelines

Odds of metabolic syndrome reduced with adherence to guidelines; odds lowest for adherence to both guidelines

Aflibercept Cuts Vision-Threatening Complications of Diabetic Retinopathy

But no improvement in visual acuity seen with aflibercept versus sham for eyes with nonproliferative diabetic retinopathy

Tuberculosis Cases Largely Declined Across United States in 2020

20 percent relative reduction in TB cases reported to the CDC National Tuberculosis Surveillance System compared with 2019

Anxiety, Depression Common With Inflammatory Bowel Disease

Up to one-third of patients affected by anxiety symptoms and one-fourth affected by depression symptoms

Incidental Findings on Brain MRI Common in Children

21.1 percent had incidental findings; in 3.7 and 0.2 percent, nonurgent and urgent referral, respectively, were recommended

Physician Payment Source May Affect Evaluation for Black Lung Disease

Odds of classifying chest radiographs as negative for findings of pneumoconiosis increased when physician was hired by employer

Effectiveness of Anticoagulants Compared for Valvular A-Fib

Risks for ischemic stroke or systemic embolism, major bleeding events lower with DOACs overall as a class versus warfarin

Frequency Low for Dual Allergy to Cefazolin, Natural Penicillins

Evidence suggests that most patients with penicillin allergy history could safely receive cefazolin for surgical prophylaxis

Pandemic Lockdowns Tied to More Eating Disorder Symptoms

Exercise addiction fell following lockdown, but post-COVID-19 lockdown, exercise rates increased

US Study Confirms mRNA Vaccine Effectiveness Against SARS-CoV-2

Estimated mRNA vaccine effectiveness 90 percent for full immunization, 80 percent for partial immunization

COVID-19 Precautions Cut Transmission of Other Common Viruses

Flu and other common infections down 80 percent compared with similar time periods in previous years

Recurrent CHD Risk Up With Long Working Hours After First MI

Risk for recurrent coronary heart disease up for those working ≥55 hours/week; linear risk increase seen after 40 hours/week

​Biden, Top Health Officials Warn of Risk for Another COVID-19 Surge

As of Sunday, the seven-day average of new virus cases was about 63,000

First Cell-Based Gene Therapy Approved for Multiple Myeloma

Abecma indicated for patients with relapsed or refractory multiple myeloma who have received at least four previous types of therapy

Anxiety, Depressive Disorders Increased August 2020 to February 2021

In addition, increase seen in percentage of adults reporting they needed but did not receive mental health counseling or therapy

Births Registered in United States Decreased in 2019

Decrease in birth rates seen among women aged 15 to 19 years, 20 to 34 years; birth rates declined in married, unmarried women

Obesity Tied to Increased Mortality Overall in Patients With Cancer

Risk for death lower for patients with lung cancer, renal cell carcinoma, melanoma with versus without obesity

In-Hospital Cardiac Procedures Up for Those With Gout, RA

Annual volume of cardiac procedures for patients with gout exceeded those for patients with RA from 1998 to 2014

Inflammatory Bowel Disease May Up Risk for Psychiatric Disorders

Increased risk for suicide attempts associated with all types of inflammatory bowel disease

Text Messaging Tracks Use of Postop Opioid Prescriptions

About 60 percent of prescribed opioid tablets unused based on patients' self-reported use following common orthopedic, urologic procedures

Perinatal Obsessive-Compulsive Disorder May Be Underestimated

The point prevalence of maternal OCD peaked at 9 percent at eight weeks postpartum

Outcomes for Complex GI Cancer Surgery Better at Top-Ranked Hospitals

In-hospital mortality and mortality index lower at top-ranked compared with nonranked hospitals

Socioeconomic Factors Add to Risk for COVID-19 Positivity

Population density, income, and household size partly explain increased odds for COVID-19 positivity in Blacks, Hispanics

Poll: Big Jump Seen in Older Adults Wanting COVID-19 Vaccine

In a national survey of adults ages 50 to 80 years, 71 percent have either received or plan to receive the vaccine

Experts Address Osteoporosis Therapy and COVID-19 Vaccination

Oral bisphosphonates should be continued without delay; one-week interval recommended between IV bisphosphonate and vaccine

Psoriasis Linked to Higher Risk for Thyroid Disease

Psoriasis also associated with higher odds of thyroid dysfunction

WHO: Coronavirus Likely Transmitted From Bats to Humans Through Another Mammal

Draft report provides little new insight into how the virus started to spread worldwide, leaves many questions unanswered

CVD Risk Factors Tied to Disease Activity, Disability in RA

More than one CVD risk factor, compared with one or none, associated with greater disease activity, disability in rheumatoid arthritis

IRS: COVID-19 PPE Tax-Deductible

The government agency says that eligible deductions include PPE bought since Jan. 1, 2020

Biden Administration Working on ‘Vaccine Passport’ Initiative

However, U.S. officials face numerous challenges, including data privacy and health care equity

FDA Approves First Nonsurgical Heart Valve for Congenital Heart Disease

The Harmony TPV System provides less invasive option to treat pulmonary regurgitation in patients with native or surgically repaired right ventricular outflow tract

Periodontitis Linked to Higher Systolic BP in Healthy Adults

Diagnosis of periodontitis linked to higher mean systolic blood pressure and increased odds of systolic BP ≥140 mm Hg

Burden of Noninfluenza Respiratory Virus Infection Considerable

Admission to ICU, hospital length of stay, 30-day mortality, ordinal outcomes similar for those with NIRV, influenza

Nearly 20 Percent of High School Students Report Access to a Handgun

Students with mental health issues, including suicide attempt, or who had been in a fight report more access

Actinic Keratosis Diagnosis Ups Cumulative Risk for Skin Cancer

Older age is strong risk factor for cutaneous squamous cell carcinoma, independent of actinic keratosis diagnosis

Women No More Likely to Use Contraception After Diabetes Diagnosis

Prescriptions for short-acting hormonal methods, such as pills and injections, declined in the year after diabetes diagnosis

Short-Term Exposure to Nitrogen Dioxide May Up Mortality Risk

Link to increased risk for daily total, cardiovascular, respiratory mortality seen in 398 cities from 22 low- to high-income countries/regions

FDA Clamping Down on Abuse of an OTC Decongestant

Misuse of propylhexedrine in over-the-counter inhalers can bring dangers

Nondrug Interventions Can Help Alleviate Depression in Dementia Patients

Nondrug interventions more efficacious than drug interventions for those without a major depression disorder

Miscarriage Linked to Higher Risk for Premature Mortality

Association stronger for spontaneous abortions occurring early in reproductive life, recurrent spontaneous abortions

Review: Aerobic Exercise Improves Hemodialysis-Related Symptoms

Symptoms of restless legs syndrome, muscle cramping, fatigue improved; and reduction seen in Beck Depression Inventory score

Physician’s Briefing Weekly Coronavirus Roundup

Here is what the editors at Physician's Briefing chose as the most important COVID-19 developments for you and your practice for the week of...

Treatment Patterns for Postpartum Hemorrhage Examined

Hysterectomy used more often for clinically significant PPH despite shorter hospital stays, lower costs with uterine artery embolization

2015 to 2018 Saw Decrease in HPV Infections Among Young Women

Significant decreases seen among sexually experienced women both reporting and not reporting vaccination

Genicular Artery Embolization Promising for Knee Osteoarthritis

Technical success achieved in all 40 patients; reduction in symptom and pain scores seen at 12 months

Experimental Pfizer Arthritis Drug Too Risky: FDA Panel

In clinical trials, a small percentage of participants had joint damage get worse faster with use of tanezumab

Toxic Metabolic Encephalopathy Worsens COVID-19 Outcomes

TME was associated with increased risk for in-hospital death, with the highest risk for TME due to hypoxemia

Bill Would Limit Toxic Heavy Metals in Baby Food

If the bill becomes law, baby food manufacturers would have to verify that their foods meet new, low limits for four heavy metals

FDA Approves New Indication for Myrbetriq in Children With NDO

Extended-release tablets and extended-release oral suspension forms approved to treat neurogenic detrusor overactivity in children 3 years and older

China Briefs Foreign Diplomats on COVID-19 Origins Research

United States and others have expressed concerns about Chinese influence and the independence of the WHO findings

Neurologic Symptoms Persistent for Many COVID-19 ‘Long-Haulers’

Main neurologic manifestations included brain fog for 81 percent and headache for 68 percent; 85 percent experience fatigue

US Blacks Underrepresented in Cardiovascular Drug Trials

Black residents accounted for 2.9 percent of participants in clinical trials for cardiovascular drugs approved by the FDA from 2006 to 2020

Suicide Risk Prediction Models Could Be Cost-Effective

Suicide risk prediction models would need specificity of ≥95 percent and sensitivity of ≥17 percent to target active contact and follow-up

Hypertensive Disorders of Pregnancy Tied to Child Neurodevelopment

Results of cohort study suggest link between HDP and small increase in risk for autism spectrum disorders in offspring

Legal Recreational Cannabis Tied to More Claims of Self-Harm in Younger Men

Findings seen among insured men younger than 40 years; no associations seen for women or other age groups

Race May Affect Link Between Vitamin D Level, COVID-19 Risk

Vitamin D levels less than 40 ng/mL linked to increased risk for COVID-19 positivity in Black, but not White, individuals

Median Health Care Delay 24 Days for TB Patients in United States

Longer delays linked to older age and non-HIV immunosuppression; shorter delays linked with chest imaging, care by TB specialist provider

Remdesivir Linked to Faster Clinical Improvement of COVID-19

Findings seen in mainly non-White race/ethnicity patients hospitalized with confirmed SARS-CoV-2 infection

AstraZeneca Reports Slightly Lower Estimate of COVID-19 Vaccine Effectiveness

After saying that the vaccine was 79 percent effective on Monday, the company said Wednesday that the vaccine was 76 percent effective

Current Smoking Linked to Increase in CHD Risk in African-Americans

Compared with never smokers, current smokers have increased odds of having coronary artery calcification score >0

White House Announces $10 Billion More to Increase COVID-19 Vaccination Rates

About $6 billion will go to community health centers to expand COVID-19 vaccinations, testing for high-risk populations

Sexist, Racial Microaggressions Prevalent Among Surgeons

Female and minority surgeons and anesthesiologists frequently report microaggressions, which are linked to burnout

State AGs Urge Facebook, Twitter to Tackle Vaccine Misinformation

Attorneys general say 'anti-vaxxer' accounts on Facebook, YouTube, Instagram, and Twitter reach more than 59 million followers

ENDO: Continuing Semaglutide Aids Weight Loss in Overweight, Obese

Maintaining treatment resulted in continued weight loss during additional 48 weeks compared with switching to placebo

New US Assistant Secretary of Health Is First Openly Transgender Federal Official

Rachel Levine is expected to be in charge of Health and Human Services offices and programs nationwide

Drug Combo Superior to Placebo for Posttraumatic Headache

Pain relief greater with IV metoclopramide + diphenhydramine administered in the ED, but more adverse events reported

High Anesthesiologist Volume Tied to Better Outcomes for Complex GI Surgical Cases

High volume defined by annual number of complex gastrointestinal cancer-related surgery procedures of interest supported by that anesthesiologist in two years before the index surgery

PTSD Linked to Ischemic Heart Disease in Female Veterans

Effect sizes largest for those younger than 40 years at baseline, then decrease monotonically with increasing age

Lifestyle Changes May Up CVD Risk in Some T2DM Patients

Intensive lifestyle intervention may be detrimental for overweight, obese patients with type 2 diabetes who have poor glycemic control

Racial Disparities Found in Heart Care in the UK During Pandemic

Black, Asian, and minority ethnic patients less likely to receive guideline-based care, more likely to die

Radiologists Now Perform Majority of Lumbar Punctures in Seniors

Findings based on patterns for lumbar puncture procedure claims from 2004 to 2017 in a sample of Medicare beneficiaries

Mental Health Symptoms Improve With Smoking Cessation

Anxiety symptoms, depression symptoms, mixed anxiety and depression symptoms improved with cessation versus continuing to smoke

Abrocitinib Bests Placebo for Treatment of Atopic Dermatitis

Significantly greater reductions seen in signs and symptoms of moderate-to-severe atopic dermatitis at week 12 compared with placebo

Decline in Exercise Linked to Higher Depression During Pandemic

Among college students, disruption to physical activity a leading risk factor for depression during the COVID-19 pandemic

Vaccine Regimen Fails to Prevent HIV-1 Infection in South Africa

Canarypox-protein HIV vaccine regimen did not prevent HIV-1 infection in phase 2b-3 trial in South Africa

Risk for Attempted Suicide Up With Recent Diagnosis of MCI, Dementia

After adjustment for demographics and medical and psychiatric comorbidities, risk for suicide attempt consistently higher with recent diagnosis

Vivek Murthy Confirmed as New US Surgeon General

Murthy plans to focus on COVID-19, mental health, and substance use disorders

States Receive $12.7 Billion for Alternatives to Long-Term Care Homes

Money will only be available over four calendar quarters this year and next

ENDO: In Utero 17-OHPC Exposure Ups Later Cancer Risk

Risk for any cancer increased in adult offspring with in utero exposure, particularly colorectal, prostate cancer

Antibody Response to SARS-CoV-2 mRNA Vaccine Poor in Transplant Recipients

Anti-S1 or anti-receptor-binding domain antibody detectable in 17 percent of solid organ transplant recipients after first dose

Maintenance Therapy Without Steroids Feasible in Elderly Myeloma Patients

Progression-free, three-year overall survival similar for lenalidomide maintenance regimen without dexamethasone

Poor Sleep, Burnout Increase COVID-19 Risk in Health Care Workers

Longer sleep duration linked to reduced odds of COVID-19; sleep problems, burnout linked to increased odds

Magnet Exposures in Children Up by 444 Percent After Ban Lifted

From 2008-2011 to 2012-2017, there was a 33 percent decrease in cases after removal of high-powered magnet sets from the market

Fine Particles From Wildfire Smoke Impact Children’s Respiratory Health

Effect of PM2.5 attributable to wildfire estimated to be 30.0 percent increase in visits to emergency, urgent care facilities

High-Risk Clinic for Melanoma Surveillance Is Scalable

Even expansion to a primary care skin cancer clinic tied to consistent and sustainable benefits

Type 2 Diabetes Tied to Higher Risk for Parkinson Disease

Additionally, among patients with Parkinson disease, type 2 diabetes tied to more rapid Parkinson progression

Hormone Therapy May Reduce Nocturia After Menopause

Prevalence of nocturia reduced among postmenopausal women who selected systemic hormone therapy compared with no treatment

Central Line-Associated Bloodstream Infections Increased in 2020

More infections came as hospitals experienced high numbers of COVID-19 admissions

USPSTF: Evidence Lacking for Screening Seniors for Hearing Loss

Current evidence insufficient for assessing balance of benefits and harms of screening for asymptomatic older adults

Willingness to Get COVID-19 Vaccine Up in Health Care Workers

Numbers of health care personnel intending to get and receiving vaccine increased as rollout unfolded

US Health Officials Raise Flags About AstraZeneca COVID-19 Vaccine Trial Data

NIH monitoring board says the company may have relied on 'outdated information' that 'may have provided an incomplete view of the efficacy data'

Fully Vaccinated People Can Visit Unvaccinated Family and Friends: CDC

Fully vaccinated means two weeks since receiving the second dose of a two-dose vaccine or the single-dose J&J vaccine

ACA’s Reach Surges With 200,000 New Signups, More States Involved

Response shows that people who lost insurance during COVID-19 pandemic are in desperate need of coverage, experts say

ENDO: Once-Weekly Basal Insulin Fc Promising for T2DM

In phase 2 trial, fewer hypoglycemic events (≤70 mg/dL) seen in both BIF dosing groups compared with insulin degludec

SARS-CoV-2 Viral-Specific Antibody Response Profiles Vary With Age

Younger children exhibit higher median IgG levels, total antibody levels, surrogate neutralizing antibody activity

Infliximab May Impede Serologic Response to SARS-CoV-2

Concomitant immunomodulator use further blunted antibody responses to SARS-CoV-2 among infliximab-treated IBD patients

ENDO: T1DM Patients With DKA Readmitted Fairly Often

Predictors of readmission include female sex, discharge against medical advice, hypertension, chronic kidney disease, anemia

AstraZeneca Says Its COVID-19 Vaccine Is 79 Percent Effective in US Trial

US government has preordered 300 million doses of the AstraZeneca vaccine

Seroprevalence of Anti-SARS-CoV-2 Antibodies Reported for Wuhan

Seroprevalence for antibodies against SARS-CoV-2 in Wuhan population sample estimated to be 6.92 percent in April 2020

ENDO: Three Months After COVID-19, Thyroid Function Normalizes

Thyroid ultrasound revealed 32 percent of patients had focal hypoechoic areas of thyroiditis

Incidence of Gallbladder and Biliary Tract Cancer Up From 1990 to 2017

Incidence increased 76 percent, mortality increased 65 percent, and disability-adjusted life years increased 52 percent

2008 to 2017 Saw Drop in Serious Vision Impairment in U.S. Seniors

If rates had remained at 2008 level, there would have been an additional 848,000 cases of serious vision impairment in 2017

Effect of Living With Children on COVID-19 Risk Explored in U.K.

For adults living with versus without children, risk for infection no higher during wave 1, but higher during wave 2, of the pandemic

CV Risk in Early Adulthood Tied to Later Cognitive Decline

Cardiovascular risk factors in early adulthood associated with greatest change in late-life cognitive decline

Many Older Adults Unaware of Potential Side Effects for New Rx

Physicians should spend more time discussing possible side effects of a newly prescribed medication during the office visit, authors say

Increasing Primary Care Doctor Density Would Up Life Expectancy

Increasing density of primary care providers above 1:3,500 threshold would increase mean life expectancy by 22.4 days

Biden Administration Has Met 100 Million Vaccinations Goal Early

An average of about 2.2 million doses each day are going into the arms of Americans

Total Knee Replacement Cost-Effective for Those With BMI ≥40

Incremental cost-effectiveness ratios less than $75,000 per QALY for those with BMI ≥ 40kg/m2, diabetes, cardiovascular disease

Many At-Risk Children Are Not Receiving Clinical Services

More than half with high levels of adverse childhood experiences, high distress symptoms report no clinical contact

Ultra-Processed Foods Linked to Increased Risk for CVD Incidence

Each additional daily serving linked to increased risk for hard CVD, hard CHD, overall CVD, and CVD mortality

COVID-19 May Increase Risk for Adverse Pregnancy Outcomes

Risks for adverse pregnancy outcomes higher for severe infection versus mild infection

COVID-19 Vaccination Cover Varies With Social Vulnerability

Coverage higher in low versus high social vulnerability counties for overall measure of social vulnerability index

ENDO: Common Meds Interfere With TFTs in Older Adults on Thyroid Hormone

Almost one-third of older adults on thyroid replacement therapy take at least one medication that interferes with thyroid function tests

ENDO: Rates of Drug Treatment for Osteoporosis Low in the US

Patterns of drug prescribing for the treatment of osteoporosis often do not follow clinical practice guidelines

Digital App Cuts Meds Discrepancies in Outpatients With CKD

Patients in eKidneyCare group had fewer total medication discrepancies and a reduction in severity of discrepancies

Burnout Symptoms Common for Neonatal Health Care Workers

66 percent of HCWs reported burnout symptoms; 73 percent felt burnout had increased among their coworkers during pandemic

ASA: Women at Greater Risk for Poststroke Depression

Additionally, patients with acute ischemic stroke at higher risk for developing depression than patients with acute myocardial infarction

Prenatal, Postnatal Exposure to PM2.5 Linked to Pediatric Allergic Rhinitis

Association seen between incident allergic rhinitis and increase in PM2.5 during period from 30 gestational weeks to 52 weeks after birth

Head Injury Linked to Long-Term Risk for Dementia

Head injury linked to dementia risk in dose-dependent manner, with stronger associations for women, Whites

Physician’s Briefing Weekly Coronavirus Roundup

Here is what the editors at Physician's Briefing chose as the most important COVID-19 developments for you and your practice for the week of...

Greater Disability Tied to Worse COVID-19 Severity in MS Patients

Risk for hospitalization, ICU admission/ventilator support, death increased in multiple sclerosis patients with ambulatory disability, older age

CDC Says 3 Feet of Social Distancing Now OK in Most Classrooms

Middle school, high school students should remain at least 6 feet apart in communities where COVID-19 transmission is high

U.S. to ‘Loan’ COVID-19 Vaccines to Mexico, Canada

Ensuring Canada and Mexico can contain the pandemic will aid in the effort to reopen borders