Machine-Learning Models Allow Early Detection of Sepsis in NICU

Models using EHR data from infants in NICU can detect sepsis hours before clinical signs are apparent

CDC: 2000 to 2017 Saw Increase in Mortality Due to Dementia

Age-adjusted death rate was 66.7 deaths per 100,000 U.S. population in 2017

Diet Quality in Midlife Not Linked to Later Risk for Dementia

No significant difference in incidence rates for dementia according to measures of diet quality

2000 to 2015 Saw Increase in Liver Cancer Mortality

Increase generally steeper in less educated women; confined to men with ≤15 years education

First Two-Drug Regimen Approved for HIV-1 Treatment

Dovato indicated for use in patients with no history of antiretroviral treatment

Back Sleeping in Late Pregnancy Linked to Lower Birth Weight

Authors say this is a modifiable risk and campaigns should target third-trimester side sleeping

Factors Predict Low BMD in Pediatric Blood Cancer Survivors

Low bone mineral density detected during guideline-recommended dual-energy X-ray absorptiometry

September 2019 Briefing – Neurology

Here are what the editors at HealthDay consider to be the most important developments in Neurology for September 2019. This roundup includes the latest...

Children’s Robitussin Honey Cough and Chest Congestion DM Recalled

Dosing cups missing some graduation markings

Results of Pediatric Genomic Epilepsy Tests Often Reclassified

Over 30 percent of pediatric patients with genetic dx, undiagnosed conditions had results reclassified

Seniors Still Report Barriers to Hearing Care Services

Difficulties accessing hearing care services seen particularly in older Americans with lower incomes

USPSTF Affirms Guidance for Hep B Screening at First Prenatal Visit

Evidence convincing that universal prenatal screening reduces perinatal transmission of HBV

More Comorbidities, Lower Mortality for Holocaust Survivors

Mean age at death significantly higher for survivors versus controls

Adoption of Advanced Health IT Capabilities Inconsistent

Degree of EHR standardization strongest predictor of health information technology adoption

Initiative Can Cut Gender Gap in Medical School Faculty Salaries

Overall mean salary gap by gender decreased from −2.6 to −1.9 percent after a decade

Mindfulness, Stress Linked to Menopausal Symptoms

Link between mindfulness and symptoms more robust in women experiencing higher stress

Death at 10 Years Similar With Bilateral-, Single-Artery CABG

No difference seen in rate of death from any cause at 10 years in intention-to-treat analysis

Paclitaxel Exposure in Vascular Device Not Linked to Mortality

No deaths thought to be related to use of paclitaxel drug-coated balloons for vascular procedures in PAD

Initiative Tied to Decreased Racial Inequity in Breastfeeding

Compliance with Ten Steps program linked to increased breastfeeding in African-Americans

ASCO: Guidelines Released for Early Detection, Treatment of CRC

Stratified guidelines emphasize optimal detection methods and treatments of colorectal cancer

FDA Approves New Generic Valsartan to Ease Shortage

Certain lots of valsartan recalled due to contamination with trace amounts of nitrosamine

SSI Risk Up After C-Section for Medicaid Beneficiaries

Odds of surgical site infection increased for women covered by Medicaid versus private insurance

Functional Impairment in Middle Age Linked to Adverse Outcomes

Impairment in activities of daily living linked to increased risk for hospitalization, nursing home admission

Ibrance Approval Expanded to Include Men With Breast Cancer

Kinase inhibitor approved in combination with endocrine therapy for male patients with breast cancer

Hysterectomy Technique Tied to Poorer Uterine Cancer Outcomes

Uncontained uterine power morcellation tied to higher mortality in women with undetected uterine cancer

Risk Calculator Can Help Predict Postmenopausal Morbidity

The online tool assesses risks for heart disease, stroke, falls, cancer for postmenopausal women

September 2019 Briefing – Radiology

Here are what the editors at HealthDay consider to be the most important developments in Radiology for September 2019. This roundup includes the latest...

Arthritis Patients Needing to Shelter in Place Require More Support

Survey finds many experiencing increased symptoms, less physical activity, emotional issues

Pembrolizumab Promising for Metastatic Head, Neck SCC

Prolongs survival among patients with recurrent, metastatic head and neck squamous cell carcinoma

Limiting Social Media May Improve Psychological Well-Being

Limiting exposure to 30 minutes per day cut loneliness and depression in undergraduates

Measles Outbreak in New York State Largest in Recent History

There has been an increase in measles cases across the United States and worldwide

Childhood Hodgkin Lymphoma Survivors at Risk for Later Cancers

Survivors have 14-fold increased risk for developing a solid subsequent malignant neoplasm

High Symptom Burden in Elderly Linked to Adverse Outcomes

Higher symptom count seen with increasing age and for women versus men

Incorrect Prescribing Alerts Common for Psychotropic Meds

One-third with electronic Rx system that provides alerts believe system provides incorrect warnings

Universal Vaccination for MenB at College Entry Not Cost-Effective

Incremental cost per quality-adjusted life-year gained $13.8 million under societal perspective

Wait Times Have Improved in VA Health Care System

Wait times similar to private sector in 2014 but shorter overall and in some specialties in 2017

Blood Conservation Safe, Effective During Heart Surgery

Intraoperative autologous donation strategy leads to improved outcomes

Assessment Tools Aid Risk Planning at Nursing Homes

Residents with heart failure have higher rates of hospitalization, death, health instability

Daily Cannabis Use May Up Risk for Developing Psychotic Disorder

Daily cannabis use, especially high-potency types, linked to increased odds of psychotic disorder

‘Brain Vital Signs’ Detect Concussion-Related Changes

Six brainwave metrics can detect even subclinical changes in nonconcussed hockey players

Stillbirth Risk Up With High Serum Bile Acids in Pregnancy

Higher risk of stillbirth with serum bile acids ≥100 µmol/L in intrahepatic cholestasis of pregnancy

Peripheral Nerve Block May Cut Opioid Use After Amputation

Peripheral nerve block helps improve pain control after major lower extremity amputation

Draft Recommendation Promotes Screening Women for Anxiety

Teen, adult women, including pregnant women, should be assessed for anxiety as part of routine care

Neoadjuvant Chemotherapy Key to Survival in Pancreatic Cancer

Three factors independently linked to prolonged survival in BR/LA pancreatic ductal adenocarcinoma

Survey: Many U.S. Adults Not Planning to Get Flu Vaccine

Vaccine knowledge and anticipated rates of vaccination even lower for pneumococcal disease

Only Half of Ear, Nose, Throat Infections Receive Recommended Antibiotics

First-line antibiotics prescribed at 50 percent of outpatient visits for pharyngitis, sinusitis, otitis media

Decrease in Stroke Incidence Continued Through 2017 in ARIC

Decrease in stroke rates for 1987 to 2011 extended to 2017; decrease seen across decades, sex, race

ASH: Ibrutinib Tops Bendamustine + Rituximab for CLL

Improved progression-free survival with ibrutinib for older adults with untreated CLL

Use of Diabetes Monitoring Tests in Primary Care Suboptimal

Less than 60 percent of patients with diabetes given HbA1c, lipid profile tests in preceding 12 months

Long Work Hours Tied to Poor Glycemic Control in T2DM

Findings seen in young male, but not female, Japanese workers with type 2 diabetes mellitus

Myelodysplastic Syndrome/AML Risk Increased After Chemo

Since 2000, risks for therapy-related myelodysplastic syndrome, AML up after chemo for solid cancers

Accidental IV Dislodgement Reported to Be Very Common

Top 3 causes were confused patient, removal of catheter by patient, tape or securement loose

Fecal Occult Blood Test May Improve CRC Outcomes in Some

For men with left-sided tumors, those undergoing screening had lower N, M categories, higher survival

Risk for Breast Cancer Increased With False-Positive Screening Result

Increased risk for screen-detected and interval breast cancer persists for 12 years after false-positive result

Management of MS in Pregnancy Reviewed in U.K. Guideline

Pros and cons of continuing treatment throughout pregnancy should be discussed individually

9/11 Responders May Have Higher Head, Neck Cancer Risk

Authors call for ongoing monitoring, treatment of those initially exposed

Assay Aids Anticoagulant Dosing of Obese Patients for Bariatric Sx

Thrombin generation assay may allow more accurate determination of anticoagulation adequacy

2011 to 2015 Saw Increase in Psychiatric ED Visits for Youth

Largest increases in emergency department visits seen for teens, African-Americans, Hispanic patients

Complex Dosing, Polypharmacy Common With Interstitial Lung Disease

Patients receiving systemic corticosteroids are at high risk for drug-disease interactions

Children With Poorly Controlled Asthma Suffer Academically

Latino and black children have poorer academic outcomes than non-Latino whites

FDA: Patients Should Not Abruptly Stop Taking a Prescribed Opioid

Agency warns that rapid discontinuation can result in uncontrolled pain or withdrawal symptoms

Alcohol, Drug Misuse Tied to Long-Term Health Problems

Despite recovery, chronic physical disease continues to impact quality of life, life expectancy

Data Suggest Viral Etiology for Pediatric Acute Flaccid Myelitis

Seventy-nine percent of confirmed cases of AFM had antecedent respiratory or febrile illness

PTSD Symptoms Tied to Higher Risk for Ovarian Cancer

Correlation moderately attenuated after adjustment for health and ovarian cancer risk factors

Incidence of HPV-Positive Head and Neck Cancer Up in the U.S.

From 2013 to 2014, incidence of HPV-positive oropharyngeal cancers was 4.62 per 100,000 persons

Smoking Cessation Messages Focusing on Child Most Important

Parent smokers highly rank messages with outcomes focused on respiratory, general health, cancer

Hypnotherapy Beats Education for Relief of IBS Symptoms

Group, individual hypnotherapy both effective; group hypnotherapy noninferior to individual tx

Outcomes Poorer for Medicaid Beneficiaries With STEMI

Rates of revascularization lower, in-hospital mortality higher for Medicaid versus privately insured

Medical Marketing Has Increased in Past 20 Years

Considerable increase seen from 1997 through 2016, especially in direct-to-consumer advertising

Risk for MCI Up With Progressive Cerebral Small Vessel Disease

Patients with hypertension with progressive cSVD have increased risk for mild cognitive impairment

A-Fib Risk Up for Antidepressant Users, but Higher Before Tx

Antidepressant treatment linked to threefold increased risk during first month; link decreased over year

Updated Guidelines Developed for Diagnosing, Treating Influenza

Rapid molecular assays should be used to improve diagnosis; antivirals should begin as soon as possible

Radiographic Knee Osteoarthritis Tied to Increased Risk for Death

Risk higher for cardiovascular disease, diabetes, renal mortality; lower risk for cancer mortality

Expanded Recall Announced for Ibuprofen Oral Suspension Drops

Higher levels of ibuprofen concentration found in some units may cause harm to infants

Evidence Lacking for Benefit of Surgery for Vertebral Fractures

No significant benefit with percutaneous vertebroplasty over placebo for acutely painful VF

Jury Finds Roundup a Major Contributor to Man’s Cancer

Landmark verdict could impact hundreds of other similar lawsuits

Induction for Late-Term Pregnancies at 41 Weeks Tied to Small Benefits

Study could not show noninferiority of expectant management; outcomes good with both strategies

Bronchiolitis Hospitalization in Infancy Predicts More Admissions

Higher risk seen for future admissions by age 5; link strongest for asthma, wheezing admissions

CDC: Superbug Fungus Has Sickened 600 Americans

Candida auris can survive on surfaces after routine cleaning and is often drug-resistant

Continued Smoking Among Cancer Patients Ups Costs by $3.4B

Estimates based on additional treatment following higher failure risk for first-line cancer treatment

Racial Disparities Persist in Revascularization for CHD

Rates of revascularization lower for black women with acute coronary syndrome, coronary heart disease

Older Adults Have Mixed Feelings About Telehealth Visits

Only 4 percent of older adults have had a video-based telehealth visit in the past year

Early Adult Income Volatility Tied to Later Brain Health

Association found between income volatility, cognitive function, brain integrity

September 2019 Briefing – Family Practice

Here are what the editors at HealthDay consider to be the most important developments in Family Practice for September 2019. This roundup includes the...

AACR: Ovarian Cancer Patients at Higher Risk for Mental Illness

Increased risks for anxiety, depression, adjustment disorder especially high during first two years after diagnosis

Structured Family-Centered Peds Rounds Improve Patient Safety

Forty percent decrease seen in harmful errors; decrease also in nonpreventable adverse events

Case Description Can Reliably Define Acute Flaccid Myelitis

Differences between patients with AFM, other diagnoses include asymmetry of weakness

Nine Cases of Wound Botulism ID’d in Injection Drug Users

All patients used injection drugs; seven reported using black tar heroin and six practiced skin popping

Home Monitoring of Lung Function Feasible in Teens With Duchenne

Peak flow meter handheld device useful for adolescents with Duchenne muscular dystrophy

Achieving Healthy Diet From Sustainable Food Feasible

Global adoption of healthy reference diet would reduce morbidity, environmental degradation

FDA Announces Safety Monitoring Measures for the Essure Device

Measures include having women in the postmarket surveillance study followed for five years, not three

Oculomotor Response to Head Impacts Studied in Youth Football

Near point of convergence measured in players during a single high school football season

More High-Value Care Associated With Receipt of Primary Care

Increasing investment in primary care may improve value in the U.S. health care system

Public Health Interventions Could Cut Global Burden of Hepatitis C

Package of prevention, screening, treatments could avert 15.1 million new infections versus 2015

Improved Genetic Risk Score Aids Type 1 Diabetes Classification

Revised risk score also improves newborn screening versus HLA genotyping alone

ACC: Catheter Ablation Does Not Cut Mortality, Stroke in A-Fib

But it is associated with more favorable quality-of-life end points at 12 months versus medical therapy

New AI Model May Predict Cancerous Lung Nodules

Model relies on CT features, demographics, clinical data, and improves on current methods

Out-of-Hospital Cardiac Arrest Third Leading Cause of DALYs

Disability-adjusted life year rates 1,347 per 100,000 individuals, behind ischemic heart disease, back pain

Haptoglobin Expression Tied to Outcomes in Preterm Newborns

Worse outcomes in preemies lacking haptoglobin who were exposed to inflammation in utero

Guidance Statements Issued for Breast Cancer Screening

Clinicians should discuss mammography with patients aged 40 to 49, discontinue screening for those ≥75

State Texting-While-Driving Bans Cut Crash-Related ED Visits

Findings show laws curbing distracted driving are effective

With Comorbidities, Less Than Six Hours of Sleep Ups Risk for Early Death

Risk for dying from heart attack, stroke twofold higher among those with high BP, diabetes and short sleep

Obesity Associated With Higher Risk for Chronic Diarrhea

Relationship appears independent of dietary, lifestyle, psychological, medical comorbidities

September 2019 Briefing – Pharmacy

Here are what the editors at HealthDay consider to be the most important developments in Pharmacy for September 2019. This roundup includes the latest...

Cost-Related Insulin Underuse May Affect One in Four Patients

Patients reporting cost-related underuse more likely to have poor glycemic control

Adverse Birth Outcomes Up for Women With H1N1 Flu in ICU

Pregnant women admitted to ICU with flu more likely to deliver preterm infants, low birth-weight infants

Antibiotics Prescribed for Children More Often at Nonpediatric EDs

Frequency of guideline-concordant prescribing for respiratory conditions lower at nonpediatric EDs

Applying Population Health Data IDs Patients at Risk for CVD

Patients at risk for cardiovascular disease identified even with missing electronic health record data

Replacing Sitting Time With Activity Lowers Mortality Risk

No risk reduction seen when replacing prolonged sedentary bouts with shorter sedentary bouts

Home Oxygen Users Experience Problems Related to Equipment

Health care providers report lack of readily accessible resources for prescription of oxygen systems

Pregnancy Complications Up for Women Born at Low Birth Weight

Risk greatest for women born with birth weight <2,500 g who develop overweight/obesity

E-Cigarettes More Effective for Smoking Cessation

One-year abstinence higher with e-cigarettes than other nicotine replacement products

Benefits, Barriers to Exercise Examined for Patients With ESKD

Patients undergoing dialysis would like to be able to exercise to improve energy, strength

Virtual Video Visits Liked by Patients, Providers

Virtual video visits highly ranked by patients for quality, convenience

Adenocarcinoma, High-Grade Dysplasia Up With Barrett Esophagus

But Barrett esophagus length has decreased, as has prevalence of low-grade dysplasia on endoscopy

E-Cigarettes May Threaten Goal of Achieving Tobacco Endgame

Concern increasing that use of newer tobacco products may catalyze transition to tobacco products, drugs

Anxiety, Depression More Likely for Adults With Atopic Dermatitis

Individuals with AD more likely to have been diagnosed with anxiety or depression in past year

FDA Warns of Consumer Devices That Claim to Diagnose Concussion

Tools include smartphone apps marketed to coaches or parents for use during sporting events

Patient Behaviors Identified That Impact Weight Regain After RYGB

Independent links for sedentary time, eating fast food, eating when feeling full, eating continuously

Guideline for Community-Acquired Pneumonia Updated

Recommendations relate to diagnosis, management; recommend against routine use of Gram stain, culture

Universal Screening for Autism Feasible in Pediatric Network

Sensitivity of 38.8 percent found for M-CHAT/F; specificity lower in children of color, lower-income households

Marine Omega-3 Supplements May Lower CVD Risk

Updated meta-analysis shows lower risks for MI, CHD death, total CHD, CVD death, total CVD

Transmissibility of SARS-CoV-2 High Within Households

No significant difference in infectivity seen for incubation period versus symptomatic period

Higher Cardiovascular Risk Seen With Psoriatic Arthritis

Risk seems to be increased especially in patients with a high inflammatory burden, late-onset psoriasis

Minority Med Students Report More Barriers to Dermatology

Students with lower incomes, ethnic minorities cite lack of diversity, socioeconomic barriers

Women With CVD Have Worse Self-Reported Outcomes

Women with atherosclerosis also report lower aspirin, statin use and higher ED use versus men

Prenatal Valproate Exposure Linked to Increased ADHD Risk

Maternal use of other antiepileptic drugs not tied to increased ADHD risk

Evidence on ED Diversion Strategies Inconclusive

But prehospital diversion does not seem to decrease proportion of patients transferred to ED

Study IDs Risk Factors for Violent Sleep Disorder

Authors say factors that reduce risk of disorder are important, given its link to other neuro disorders

Frailty Could Increase Susceptibility for Dementia

Authors say frailty should be considered in clinical care, management of Alzheimer dementia

ASA: Increased Odds of Stroke, MI With E-Cigarette Use

E-cigarettes linked to increased odds of stroke, myocardial infarction, angina or coronary heart disease

Screen Time Linked to Poorer Child Developmental Performance

More screen time tied to poorer performance on developmental screening tests at 36, 60 months

Patients With Diabetes at Increased Risk for Sleep Apnea

In addition to known predictors of apnea, diabetes-related foot disease, insulin treatment up risk

MitraClip Device Approved for Patients With Secondary Mitral Regurgitation

Data show 47 percent reduction in risk for rehospitalization for HF symptoms with device implantation

Prediagnosis Psychiatric Care Linked to Worse Cancer Mortality

Higher cancer-specific, all-cause mortality seen with increasing intensity of prediagnosis psychiatric care

Cytomegalovirus Linked to Faster Progression of Cystic Fibrosis

Faster progression to end-stage lung disease observed among patients with CMV IgG positivity

Suicide-Related ED Visits Increased in Children From 2007 to 2015

Proportion of emergency department visits increased for suicide attempts/suicide ideation

Topical Corticosteroids Associated With Higher Risk for Type 2 Diabetes

Dose-response relationship observed in large European cohort

Treatment of Male Breast Cancer Has Evolved From 2004 to 2014

Significant increases seen in total mastectomy, radiotherapy after breast conservation, endocrine tx

Few Critical Care Nurses Feel Competent in Providing Palliative Care

Moral distress levels vary with perceived use of care; higher levels of distress seen with less frequent use

No Benefit Found for High-Dose Vitamin C Infusions in Sepsis, ARDS

No differences seen versus placebo in organ dysfunction scores, biomarkers of inflammation or vascular injury

Even Moderate Caffeine Intake in Pregnancy Tied to Smaller Babies

Consuming more than 50 mg of caffeine per day (the amount in about half a cup of coffee) linked to lower birth weight

Exposure to Metals, Pesticides Tied to CVD in Hispanics/Latinos

Prevalence ratio for any cardiovascular disease was 2.18 for those working with pesticides

Teva Recalls Two Blood Pressure Medications

Tablets tainted with N-nitrosodiethylamine, a suspected human carcinogen

Nursing Intervention Promotes Better Sleep for Inpatients

Nighttime room entries reduced in unit where nurses received coaching, integrated SIESTA

About 11 Percent of U.S. Adults Have Food Allergy

But nearly 20 percent think they are food-allergic; shellfish, milk, peanut are most common allergies

Antibiotics Often Inappropriately Prescribed for Bronchiolitis in ED

In almost 70 percent of bronchiolitis cases, antibiotics prescribed with no concomitant infection

FDA Warns Companies on Unsafe, Unapproved Stem Cell Treatments

Patients contracting deadly infections at clinics offering the unapproved treatments

Health Care Screening Practices Impact Skin Cancer Diagnosis

Likelihood of being diagnosed with skin cancer increased for those undergoing health care screening

Methotrexate Well Tolerated, Effective for Psoriasis in Chinese

Greater therapeutic response, fewer adverse events seen in those without psoriatic arthritis

Finasteride Not Tied to Increase in Prostate Cancer Mortality

Finasteride tied to lower risk for death from prostate cancer, but lower risk not statistically significant

Direct-Acting Antivirals Not Tied to Liver Cancer Recurrence

Among patients with previous complete response to HCC tx, DAA not linked to overall or early recurrence

Practices for Reducing COPD Hospital Readmissions Explored

Communication emphasized as well as consideration of readmission as proxy for other health factors

Infertility in Women Linked to Modestly Elevated Cancer Risk

Overall risk higher for developing cancer; increased risks seen for uterine, ovarian, lung, thyroid cancers

Acupressure Reduces Lasting Symptoms in Breast Cancer Survivors

Tied to improvements in pain, anxiety, depression among breast cancer survivors with fatigue

Cardiac-Specific Comorbidity Index Beats Generic Indexes

Cardiac-specific index outperforms other indexes for predicting in-hospital mortality, length of stay

Older Patients With Crohn Disease May Benefit From Early Combo Tx

Early step-up combo therapy includes tumor necrosis factor-α antagonist plus an antimetabolite

Adherence to Prenatal Screening Recommendations Varies by Lab

Laboratories vary in the extent to which they meet ACMG position statement recommendations

Triplet Tx Ups Survival in BRAF V600E-Mutated Colorectal Cancer

Overall survival longer for encorafenib, cetuximab, and binimetinib combo versus standard therapy

Breast Cancer Mortality Rate Continues to Decline in the U.S.

Pace of decline slowed from 1.9 percent during 1998 to 2011 to 1.3 percent during 2011 to 2017

September 2019 Briefing – Pathology

Here are what the editors at HealthDay consider to be the most important developments in Pathology for September 2019. This roundup includes the latest...

Prevalence of Ever-Diagnosed ASD 2.79 Percent in U.S. Children

~70 percent of children with current ASD are treated; 20.3 percent receive behavioral tx and meds

Prices Still Explain High U.S. Health Care Spending

Health care prices explain difference in spending between United States and other countries

Single-Family Rooms May Benefit Very Preterm Infants

Reduced sepsis, increased breastfeeding rates observed; no difference in neurodevelopment vs. open bay units

Early Classification Predicts One-Year Trauma Outcomes

Six-week assessment of risk, protective factors explains one-year functional, health outcomes

Intermittent Fasts Plus Energy Restriction Best for Weight Loss

IF with 70 percent energy intake has better outcomes versus continuous diet restriction in obese women

Massage Offers Short-Term Relief of Knee Pain in Arthritis Patients

Findings among patients with knee osteoarthritis; long-term benefit unclear

Toll on Health From Depression, Anxiety Akin to Smoking, Obesity

For older adults, effect of anxiety, depression on physical health similar to that of obesity, smoking

Meta-Analysis: Small Weight Increase Seen for Breakfast Eaters

Total daily energy intake higher for participants who eat breakfast, but results inconsistent

Large Insulin Price Hike to Be Investigated by U.S. Congress

Currently, there is no effective generic alternative to brand-name insulin

Lean Body Mass in Childhood Linked to Lung Function at 15

In both sexes, higher lean body mass in childhood, adolescence linked to higher lung function at 15

Outcomes for AMI Improved During 1995 to 2014

Declines seen in AMI hospitalization, 30-day mortality, 30-day all-cause readmissions, one-year recurrent AMI

Elderly Men Undertreated for Osteoporosis

Also, black men and women are much less likely to be treated than their white counterparts

Long-Acting Regimen Noninferior to Daily ART for HIV-1

Monthly long-acting cabotegravir and rilpivirine noninferior in two randomized controlled trials

Recurrence Score May Cut Costs for High-Risk Breast Cancer Care

Testing with 21-gene assay linked to lower relative, absolute costs among high-risk patients

CDC: Prevalence of COPD High Among Some Nonsmokers

High prevalence observed in certain industries and occupations, including information industry

Teens Using Oral Contraceptives Report More Depressive Symptoms

No association seen between oral contraceptives, depressive symptoms when ages 16 to 25 years were combined

2014 to 2018 Saw Drop in Flavored Tobacco Products in Youth

Current use of flavored e-cigarettes among high school students increased during same period

September 2019 Briefing – Cosmetic Surgery

Here are what the editors at HealthDay consider to be the most important developments in Cosmetic Surgery for September 2019. This roundup includes the...

Taste, Smell Dysfunction With COVID-19 Can Be Severe

Reduced taste and/or smell without severe nasal obstruction may be early sign of COVID-19 infection

Rotating Night Shift Work, Lifestyle Factors Linked to T2DM

Significant additive interaction identified for night shift work, unhealthy lifestyle for female nurses

Private Equity Acquisition of Physician Practices Discussed

Critics warn private equity firms might focus on increased profitability at expense of patient care

Muscle Atrophy Occurs Rapidly in Critically Ill, Ventilated Children

47 percent of cohort experienced ≥11 percent decrease in diaphragm thickness after six days

Health Benefits of Nonsugar Sweeteners Uncertain

However, large systematic review could not rule out harms from nonsugar sweeteners

Endurance Exercise Tied to Anti-Aging at Cellular Level

Effect seen with aerobic endurance and high-intensity training but not resistance training

Exome Sequencing Provides Genetic Diagnosis for Some With CKD

Genetic diagnosis for 9.3 percent of 3,315 patients with chronic kidney disease from two cohorts

Trained Alert Dogs Can Detect Impending T1DM-Related Events

In study, individual dogs' performance varied for detecting hypoglycemic episodes, hyperglycemia

Patient Attitude Tied to Physical Therapy Outcomes

In patients with shoulder pain, self-efficacy, patient expectation linked to pain and disability outcomes

Financial Stress, Coronary Heart Disease Linked in African-Americans

Association no longer significant after adjustment for depression, smoking, diabetes

Healthy Food Rx Could Be Cost-Effective for Medicare, Medicaid

Coverage for healthy food could improve health, reduce costs, and pay for itself after five years

Influences on New NIH Policy for Age Limits in Research Explored

'Inclusion Across the Lifespan' policy eliminates non-risk-justified age limits on research participants

Adding Bempedoic Acid to Statin Therapy Reduces LDL Cholesterol

Genetic variants mimicking effect of ATP citrate lyase inhibitors, statins lower LDL-C in same way

DLQI With ‘Not Relevant’ Answers May Underrate Psoriasis Severity

Objective, subjective disease severity worse for those responding 'not relevant' versus 'not at all'

More Secondary Prevention Meds May Reduce Deaths After AMI

Mortality lower with more meds for older nursing home residents after acute myocardial infarction

October May Be Best Time for Older Adults to Receive Flu Shot

Waning protection with early vaccine must be balanced with fewer vaccinated with compressed schedule, early peak

Many Perceive People With Mental Illness as Dangerous

By 2018, more than 60 percent perceived those with schizophrenia as dangerous; many support coercive treatment

Urinary Catheters Not Needed for Joint Replacement Surgery

There is no increased risk for adverse genitourinary complications without the catheter

Glycemic Control Worse Than Thought in Adults With T1DM

Rates of both acute and chronic complications significantly increase with increasing HbA1c

Asthma Exacerbations, ED Admissions Decreased During Lockdown

Nonpharmaceutical interventions to reduce COVID-19 associated with reduction in admissions for COPD, asthma

Global Lifetime Risk for Stroke About 25 Percent in 2016

Estimated risk from age 25 years onward is 24.9 percent, with geographic variation in risk