FDA OKs Marketing of New Device to Reduce Snoring, Mild OSA

The removable eXciteOSA device, to be used when a patient is awake, delivers neuromuscular stimulation to the tongue

COVID-19 Tied to Higher Mortality After Cardiac Arrest

Findings revealed for patients suffering cardiac arrest, either in or out of hospital, who were infected with COVID-19

Artificial Light at Night Tied to Thyroid Cancer Risk

Positive association mainly driven by incidence of papillary thyroid cancer

Laser Therapy May Aid Sexual Function in Breast Cancer Survivors

Patient-reported improvements seen at four weeks and 12 months among survivors with genitourinary syndrome of menopause

Canadian Primary Care Shifted to Virtual Early in Pandemic

Total visits declined least among those with higher health care needs

COVID-19 Mortality Tied to Social Determinants of Health

Counties with higher proportion of Black residents, poverty, lower education have higher COVID-19 death rates

Chronic Pain Patients Taking Opioids Have Hard Time Finding Care

Patients with history suggestive of aberrant opioid use have even harder time getting an appointment

Genes That Best Predict Breast Cancer Risk Identified

And estimates determined for breast cancer risk in association with pathogenic variants in known predisposition genes

Female Breast Cancer Most Commonly Diagnosed Cancer in 2020

Female breast cancer surpassed lung cancer, although lung cancer remained leading cause of cancer deaths in 2020

Physician’s Briefing Weekly Coronavirus Roundup

Here is what the editors at Physician's Briefing chose as the most important COVID-19 developments for you and your practice for the week of...

Nurse Burnout Remains an Issue in the United States

One-third of nurses leaving their jobs cite burnout as the reason

J&J Submits EUA Request for COVID-19 Vaccine

FDA committee will hold public meeting to discuss the EUA request on Feb. 26

Model Predicts Persistent Opioid Use After Total Knee Replacement

Reduced model with 10 predictors identifies persistent high-dose opioid use with high discrimination

Racial Disparities Seen in Mental Health Conditions During COVID-19

Hispanic adults reported having higher prevalence of psychosocial stress related to not having enough food or stable housing

Global Prevalence of Any Tobacco Use Substantial for Teens

In most countries, the prevalence of cigarette smoking decreased over time, but use of other tobacco products did not

Bimekizumab Superior to Ustekinumab for Plaque Psoriasis

More patients met targets for improvement in Psoriasis Area and Severity Index, Investigator's Global Assessment response at week 16

Cannabis Dispensaries Negatively Linked to Opioid-Related Death

Particularly strong negative association seen for dispensary count with deaths caused by synthetic opioids other than methadone

Smartwatch Sensors Could Monitor Parkinson Disease Symptoms

Motor Fluctuations Monitor for Parkinson's Disease system measurements linked to clinical evaluations of tremor severity

United States Sees Continued Drop in New COVID-19 Cases

Current decline in infections most pronounced in the Midwest

Small Study Tests Colchicine for Moderate-to-Severe COVID-19

Authors call for larger clinical trials to further evaluate the efficacy and safety of colchicine as an adjunctive therapy for COVID-19

Residential Segregation May Worsen NSCLC Outcomes for Black Patients

Blacks more likely to present at advanced stage, less likely to receive surgery, have higher mortality at higher residential segregation levels

Black Children More Likely to Have Fish, Shellfish Allergies

Shellfish allergy independently associated with having asthma, even after adjusting for race

Mammography-Based AI Model May Predict Breast Cancer Risk

Discriminatory capacity for accurately identifying high-risk patients improved compared with prior methods

AAO-HNS Issues Guidance for Bell’s Palsy Treatment During COVID-19

Corticosteroid therapy and/or antiherpes viral therapy recommended for patients developing Bell's palsy after vaccination

High Efficacy Reported for Sputnik V COVID-19 Vaccine

Interim analysis of data from phase 3 trial shows 91.6 percent efficacy at 21 days after the first dose of the vaccine

Elective C-Sections, Induced Delivery Up for Moms With MS

Women with MS have no increase in pregnancy-related complications, emergency C-section, stillbirth, preterm birth

Blood Lead Level Testing Among Children Decreased During COVID-19

Estimated 9,603 children with elevated BLL were missed due to decreased testing in January to May 2020

High Refined Grain Intake Ups Risk for Mortality, Major CVD Events

Highest category of total intake linked to increased risk for total mortality, major cardiovascular disease events, their composite

Patient-Ordered Testing May Up CRC Screening Adherence

Patients self-ordering FIT tests for colorectal cancer screening through an electronic reminder more likely to complete a kit

Green Tea Consumption Improves Prognosis for Stroke, MI Survivors

No association seen for those without history of stroke or MI, while coffee consumption is beneficial without history of stroke, MI

Music May Cut Postoperative Heart Surgery Anxiety, Pain

Findings based on systematic literature review and meta-analysis

Companies Developing Vaccines Against New Coronavirus Variants

GlaxoSmithKline and CureVac to create vaccines that use messenger RNA to combat the virus

McKinsey to Pay $573 Million Over Role in Opioid Crisis

Most of the money would be distributed to states in less than a year and be used to combat the opioid overdose epidemic

COVID-19 Outcomes Worse for Persons Living With Diagnosed HIV

COVID-19 diagnosis rates are similar for those with, without HIV, but hospitalization and death rates are up with HIV

Racial Disparities Seen in Excess Mortality Early in Pandemic

Adjusted excess all-cause mortality was 6.8 per 10,000 for Blacks and 1.5 per 10,000 for Whites, with considerable variation across states

Predictors ID’d for Progression of Mono to Chronic Fatigue

More physical symptoms, immune irregularities seen at baseline in college students who develop postmononucleosis chronic fatigue syndrome

Deprivation Tied to Foot Disease With New Type 2 Diabetes

Risks include foot ulcer, lower-limb amputation, peripheral neuropathy, peripheral vascular disease, and gangrene

Oncology Clinical Trials Decline During Pandemic

Decline in trial launches could have long-term negative impact, authors say

First Federal COVID-19 Vaccination Sites to Open in California

One center will be housed in the Oakland Coliseum, another on the campus of California State University, Los Angeles

About Four in 10 U.S. Adults Skipped Medical Care During Pandemic

Some cited fear of COVID-19 and financial reasons

USPSTF Advises Against Screening for Asymptomatic Carotid Artery Stenosis

USPSTF reaffirms 2014 stance of D recommendation because harms of screening for asymptomatic CAS outweigh the benefits

Many Cancer Survivors Have Conditions Linked to Risk for Severe COVID-19 Illness

56.4 percent of cancer survivors report having one or more conditions, with increased prevalence in Black survivors

Biden Administration to Start Shipping COVID-19 Vaccines Directly to U.S. Pharmacies

In addition, starting this week, states are receiving 5 percent more vaccine doses

Colonoscopy Delay After Abnormal FOBT, FIT Ups CRC Risk

Risk for CRC, mortality increased with delayed receipt of colonoscopy compared with colonoscopy within one to three months

COVID-19 Vaccine Uptake Moderately High for Residents at SNFs

Median of 77.8 percent of residents and 37.5 percent of staff members per facility received one or more doses of COVID-19 vaccine

Women Less Likely to Undergo Guideline-Concordant CABG

Women have lower odds of receiving LIMA graft to the LAD artery, undergoing complete vascularization, receiving multi-arterial grafting

Severe, Active Atopic Eczema Tied to Increased Mortality Risk

In those with severe atopic eczema, strongest associations seen for infectious, respiratory, and genitourinary causes of death

Full Functionality After Hip Fracture Takes Two to Three Years

Older adults with large social networks experience better recovery

Opioid-Minimizing Pain Management Feasible for Trauma Patients

MAST MMPR regimen includes oral acetaminophen, naproxen, gabapentin, lidocaine patches, and as-needed opioids

AstraZeneca Vaccine Guards Against Severe COVID-19 Illness

Researchers also found that a single dose of the vaccine was 76 percent effective at preventing COVID-19

Moms2B Program Seeks to Improve Pregnancy, Infant Outcomes

Community-based program targets urban neighborhoods with high rates of infant mortality

WHO Team Probing COVID-19 Origins Visits Wuhan Research Center

WHO team has visited hospitals, research institutes, and a traditional wet market linked to many of the first cases

Sustained Blindness Risk Higher With Severe Diabetic Retinopathy at Diagnosis

Too many U.S. patients still presenting with advanced diabetic retinopathy, researchers note

Mutation That Helps Coronavirus Evade Vaccines Showing Up in British Variant

Worrisome mutation known as E484K appears to have arisen in 11 of more than 200,000 B.1.1.7 coronavirus variant samples in the United Kingdom

Perioperative Chemo Feasible for Resectable Pancreatic Cancer

Phase 2 randomized trial revealed similar overall survival for two active regimens compared with adjuvant therapy

>60 Percent Receiving COVID-19 Vaccine in U.S. Are Non-Hispanic Whites

Of those having received their first dose by Jan. 14, 2021, 63.0 percent were women, 55.0 percent were aged 50 years and older

Study Refutes ‘Fat but Healthy’ Theory

Active lifestyle does not negate the deleterious effects of overweight and obesity

Psychological Distress High Among Students During COVID-19

10.5 percent of students self-reported psychological distress; increased odds seem for those in high school, those who exercise less

Skin Infections in Early Childhood Linked to Pediatric Psoriasis

Independent associations with pediatric psoriasis also seen for atopic dermatitis, family history of psoriasis

Half of Alzheimer Disease Dementia Cases Are Mild

Among Framingham Heart Study participants, one in five cases were severe

Lack of Staff, PPE Hinder Nursing Homes’ Fight Against COVID-19

Although worker turnover in the nursing home industry has always been high, the pandemic has worsened the problem

Moderna Wants to Increase Number of Doses in COVID-19 Vaccine Vials

However, there are potential downsides to putting more vaccine in each vial

Mortality Risk Higher for Young Black Heart Recipients

Mortality risk elevated in the first year after transplant for 18- to 30-year-olds; risk also up for those aged 31 to 40 years, 41 to 60 years

Long-Term Exposure to UVB Radiation May Cut Breast Cancer Risk

Longer duration of exposure, highest cumulative exposure inversely linked to risk after age 50 years

Many Physicians Have Negative Attitudes About Disability

Only 56.5 percent strongly agree that they welcome patients with disability into their practices

Preseason Poses Biggest Risk for College Football Head Injuries

Most concussions and head impacts occur during football practices, rather than games

Dexmedetomidine No Better Than Propofol for Adults With Sepsis

For light sedation of mechanically ventilated patients with sepsis, number of days alive without delirium or coma similar between groups

Regular Aspirin Use Before Diagnosis May Cut CRC Mortality

Long-term aspirin use before diagnosis also linked to lower odds of diagnosis with distant metastases

High Tibial Osteotomy May Delay, Prevent Need for TKR

For patients undergoing high tibial osteotomy, cumulative incidence of total knee replacement 5 and 21 percent at five and 10 years, respectively

EPA, DHA Intake From Fish May Reduce Childhood Asthma Risk

Higher intake at age 7 years linked to lower odds of incident asthma at 11 or 14 years among FADS minor G allele carriers

Maternal IgG Antibodies to SARS-CoV-2 Transferred Across Placenta

Positive correlation found for cord blood IgG concentrations with maternal IgG concentrations

Coronary Artery Calcification Risk Up With Gestational Diabetes

Risk increased about twofold for women with gestational diabetes with normoglycemia, prediabetes, incident diabetes

Outcomes Similar for Younger, Older Teens Undergoing Bariatric Surgery

Remission of type 2 diabetes high for both groups of teens; weight loss and quality of life similar for older and younger teens

NIH Launches Database to Study COVID-19-Related Neurological Complications

Clinicians are invited to submit data through an online portal

Rifaximin Prevents Overt Hepatic Encephalopathy After TIPS

For patients with cirrhosis, rifaximin reduces odds of overt HE after transjugular intrahepatic portosystemic shunt

T2DM Associated With Premature Heart Disease in Women

Most other factors tied to premature coronary heart disease attenuated with increasing age of onset

Telemedicine Use Increased Considerably During COVID-19

Telemedicine use was lower in communities with higher rates of poverty; use varied across specialties, conditions

Global Demand for Cancer Surgery Expected to Climb

Greatest relative increase projected to occur in 34 low-income countries, which have largest gaps in workforce requirements

WHO Team Probing COVID-19 Origins Visits Wuhan Food Markets

Team's visit has quickly become embroiled in politics, as China has sought to cast blame elsewhere for the emergence of COVID-19

Premature Ovarian Insufficiency Tied to More Menopausal Symptoms

Most common symptoms related to psychological and sexual domains

CDC Makes Masks Mandatory on Planes and Public Transportation

While it reserves the right to use criminal penalties to enforce the order, the CDC said it 'does not intend' to primarily rely on them

Schizophrenia Tied to Increased Risk for Later Parkinson Disease

Authors say risk may be due to alterations in the brain's dopamine system

U.S. Awards Contract for COVID-19 Home Test Kit

With the product from Australian company Ellume, users can swab themselves at home and check their status in about 20 minutes

COVID-19 Admissions, Fatalities Up for Pregnant Women

COVID-19 hospitalization rates 3.5-fold higher, case fatality rates 13.6-fold higher in pregnant patients versus similarly aged adults

Schizophrenia Linked to Mortality in Adults With COVID-19

In terms of strength of association with mortality, diagnosis of schizophrenia ranked only behind age

Afternoon Napping Tied to Better Cognition in Elderly

Cognitive benefits in orientation, language, and memory observed in napping versus non-napping older adults living in China

Marijuana Use Tied to Self-Harm, All-Cause Death in Youth With Mood Disorders

Analysis included youth 10 through 24 years of age with mood disorder; 10.3 percent had documented cannabis use disorder

Meta-Analysis Quantifies Lifestyle Factors Accounting for RA Incidence

Smoking, excess body mass index, and low alcohol consumption account for 32.69 percent of rheumatoid arthritis incidence

Social Factors in Health Tied to Odds of Kidney Transplant

Probability of any kidney transplant lower in association with Black race, older age, lower income, more comorbidities, greater religiosity

Nurse Navigators Boost Advance Care Planning

Findings based on randomized trial integrated into outpatient primary care practices

Proportion of Cancer Cases, Deaths Due to Alcohol Intake Quantified

Across all 50 states and District of Columbia, alcohol accounted for 75,199 cancer cases, 18,947 cancer deaths annually

Fracture at Certain Ages May Prompt Child Abuse Evaluation

Expert panel recommends evaluation for children younger than 3 years with rib fracture, younger than 18 months with humeral, femoral fractures

Physician’s Briefing Weekly Coronavirus Roundup

Here is what the editors at Physician's Briefing chose as the most important COVID-19 developments for you and your practice for the week of...

New COVID-19 Variants May Weaken Efficacy of Vaccines

But experts stress that even a weakened vaccine can still largely protect people from a severe case of COVID-19

SARS-CoV-2 Seroconversion Tied to Out-of-Hospital Sudden Deaths

Moderate positive correlation seen between OHSD and percentage of positive antibody tests to SARS-CoV-2 in NYC neighborhoods

EU Regulator Approves Oxford-AstraZeneca COVID-19 Vaccine

Vaccine is added to those made by Pfizer and Moderna, which have already been approved in the EU

Nearly Half of U.S. Adults Want the COVID-19 Vaccine as Soon as Possible

Messages about effectiveness of the vaccine and the experience of friends and family are most influential factors

J&J COVID-19 Vaccine 66 Percent Effective in Interim Analysis

Efficacy varies by region, with 57 percent efficacy in South Africa and 72 percent efficacy in the United States

Patients With RA Have Increased Anxiety During Pandemic

Anxiety during pandemic correlated with Health Assessment Questionnaire, biologic drug use, and previous anxiety point

Levonorgestrel IUD Noninferior for Emergency Contraception

Pregnancy rates at one month were 0.3 percent in levonorgestrel IUD group and 0 percent in copper IUD group

Perivascular Space Pathology Linked to Dementia in Seniors

Severe PVS pathology in both basal ganglia and centrum semiovale independently predicted dementia across eight years

Early Anticoagulation May Not Up Survival in Severe COVID-19

Venous thromboembolism seen in 6.3 percent and major bleeding seen in 2.8 percent of critically ill COVID-19 patients

Transient Return of Cardiac Activity ID’d After Pulselessness

Based on waveform analysis, cardiac activity occurred in 14 percent of patients after planned withdrawal of life-sustaining measures

Targeted Inpatient Screening Mammogram Can Up Screening Rates

17 of 21 appropriate candidates successfully completed inpatient mammograms; all except one were negative

Plant-Based Diet Adherence Tied to Lower Type 2 Diabetes Risk

Large study revealed inverse association, too, with lower adherence tied to higher risk

Fresh Embryos May Yield More Live Births From Donor Eggs

Findings seen for fresh compared to cryopreserved-thawed embryo transfers during IVF cycles using freshly retrieved donor eggs

Mortality Rate Up for Koreans With Rheumatoid Arthritis

Individuals who die more likely to be male, smokers, diagnosed with RA at older age compared with survivors

Some Inflammatory Diseases Linked to Stroke-Associated Pneumonia

Risk for SAP reduced among patients with psoriasis, other chronic inflammatory diseases among acute ischemic stroke discharges

Cervical Cancer Screening Rates Dropped During Stay-at-Home Order

Cervical cytology screening rates per 100 person-months decreased 78 percent among women aged 21 to 29 years

U.S. Drug Prices 256 Percent Higher Than in 32 OECD Countries

U.S. prices higher than those in comparison countries for brand-name originator drugs, but lower for unbranded generics

Crohn Disease, Comorbidities Up Risk for Severe Pneumococcal Disease

Receipt of PCV13 alone or in combination with PPSV23 predicts fivefold reduced risk for SPD compared with no vaccination

MIND and Mediterranean Diets Tied to Delayed Parkinson Onset

Strongest association seen in women, with delay in onset of up to 17 years

Biden Signs Orders to Expand Health Care Access

Reopened Affordable Care Act health insurance enrollment period will run from Feb. 15 to May 15

Guidance Issued for COVID-19 Vaccination of Cancer Patients

Patients with cancer should be prioritized for vaccination; caregivers and household/close contacts should undergo vaccination when possible

Cardiovascular Disease Still Leading Cause of Death Worldwide

18.6 million deaths attributed to CVD in 2019, representing a 17.1 percent increase from 2010

COVID-19 Antibody Treatments Exceed Expectations in Early Trials

Eli Lilly and Regeneron asking regulators to expand authorization of their drugs based on the new findings

Adverse Drug Reactions Linked to Hydroxychloroquine Up in 2020

ADRs associated with hydroxychloroquine, chloroquine more than doubled in 2020 versus 2018 and 2019

Exercise-Based Cardiac Rehab Beneficial for Stroke Survivors

Exercise-based cardiac rehab improves exercise endurance with improvement on six-minute walk test and maximum metabolic equivalents

Air Pollution May Up Risk for Age-Related Macular Degeneration

Exposure to different pollutants including PM2.5, NO2, NOx linked to differences in retinal layer thickness

Metformin Use for T2DM May Reduce COVID-19 Mortality

Odds of contracting COVID-19, COVID-19-related mortality higher for individuals with diabetes

Many Adults Do Not See Link Between Racism, Poorer Health

Findings revealed in national survey of U.S. adults with family incomes of less than $125,000

Aspirin Use Tied to Longer Bladder, Breast Cancer Survival

However, aspirin use in older adults not tied to incidence of various cancer types

Childhood Insulin Levels Linked to Later Psychosis Risk

Additionally, major increase in body mass index during puberty tied to increased risk for depression as young adult

Retired Doctors, Nurses Will Be Approved to Give COVID-19 Vaccine, White House Says

During press briefing, White House COVID-19 Response Team also addressed new mutant variants of coronavirus that have been surfacing

Blood Biomarker May Detect Acute Heart Transplant Rejection

Blood test measuring percent donor-derived cell-free DNA could eliminate much of the need for endomyocardial biopsy

Respiratory, Physical, Psych Sequelae ID’d After COVID-19 Discharge

Reduced exercise tolerance was most common symptom identified up to four months after hospital discharge

U.S. Government to Increase Vaccine Deliveries to States

The United States ranks fifth in the world in the number of doses administered relative to the country's population

Certain Factors Increase Pandemic’s Psychological Impact on College Students

Nearly half of college students at high risk for psychological impact

FDA: All Alcohol-Based Hand Sanitizers From Mexico on ‘Import Alert’

Large number of hand sanitizers from Mexico have tested positive for methanol contamination

Brazilian Coronavirus Variant Found in Minnesota

No immediate indication seen that the variant is spreading in the state

Pediatric Ocular Exposure to Alcohol-Based Hand Sanitizers on the Rise

Compared with 2019, seven times more pediatric cases of ABHS eye exposures reported in April to August 2020

COVID-19 Also Hazardous for Middle-Aged Adults

Age-specific infection fatality rate very low for children and younger adults, but increases progressively among adults

Women More Likely to Suffer Nighttime Sudden Cardiac Death

Other independent risk factors include central nervous system-affecting drugs and COPD or asthma

CDC: Most Teens Do Not Meet Recommended Fruit, Veggie Intake

Nationally, 7.1 and 2.0 percent of students met U.S. Department of Agriculture recommendations for fruit, vegetable intake in 2017

Adherence to Low-Dose Aspirin Improves Pregnancy Outcomes

Women with previous pregnancy loss taking LDA had more human chorionic gonadotropin-detected pregnancies and live births

Smoking History Tied to Worse COVID-19 Outcomes

Risk for hospitalization, death higher for both current and former smokers

COVID-19 Outcomes No Worse for Patients on Immunosuppressive Meds

Findings for ventilator use, length of stay, in-hospital mortality similar for those with, without chronic use of immunosuppressant agents

No Evidence Found to Support Discontinuing ACEIs, ARBs in COVID-19

Mean number of days alive and out of hospital not significantly different for those discontinuing, continuing meds

Burden of Sexually Transmitted Infections High in United States

Estimated 67.6 million prevalent and 26.2 million incident STIs identified in U.S. in 2018; mostly chlamydia, trichomoniasis, genital herpes, HPV

Sociodemographic Differences Seen in Receipt of Breast Density Notifications

Those in notification states more likely to receive density information, but likelihood lower for older Black and Asian women of lower income

Large Number of SARS-CoV-2-Infected Are Asymptomatic

About one-third identified as asymptomatic in nationwide, representative serosurveys conducted in England and Spain

Hospitalizations for Diabetic Foot Ulcer Up in Australia

Risk factors include peripheral sensory neuropathy, peripheral arterial disease, nephropathy, and poor glycemic control

Anxiety, Depression Remain High Following Initial Lockdown

Depression more likely among men; anxiety more likely for women

Considerable Proportion of Cancer Deaths Attributable to Smoking

Smoking-related population-attributable fractions for cancer varied from 8.8 percent to 35.7 percent

Lower Oxygen Target Does Not Cut Deaths in Respiratory Failure

Findings show no difference in mortality for lower-, higher-oxygenation target in adults with acute hypoxemic respiratory failure

U.S. to Get Fewer Vials of Pfizer COVID-19 Vaccine

Pharmacists found they could get an extra dose out of Pfizer vials that were supposed to contain only five doses

Metabolic Surgery Effective for Long-Term T2DM Control

37.5 percent of all patients treated with RYGB or BPD maintained diabetes remission throughout a 10-year follow-up

Moderna COVID-19 Vaccine Effective Against British, South African Variants

Company says it is working on a new form of the vaccine to use as a booster shot against the South African variant

Vitamin D Deficiency Associated With Increased COVID-19 Risk

Significant association persists after adjustment for race, periodontal disease status, diabetes, and obesity

Fauci Awarded Medal by Academy of Sciences

Medal is the academy's most prestigious award, presented annually to honor extraordinary use of science for the public good

Moderate Alcohol Consumption Does Not Up Stroke Risk in A-Fib

Risk for stroke or systemic embolism not increased with low-to-moderate drinking; no increased risk found for bleeding

2.5 Anaphylaxis Cases Reported Per Million COVID-19 Moderna Vaccine Shots

Nine of the 10 cases occurred in individuals with documented history of allergies, allergic reactions

Children Less Susceptible to SARS-CoV-2 but More Infectious

Asymptomatic individuals less likely to infect others; symptomatic cases more likely to infect others before symptom onset

Revised WIC Food Package May Aid Child Development

Children of mothers receiving revised WIC food package during pregnancy have better developmental outcomes

Fried Food Intake May Increase Cardiovascular Disease Risk

Highest versus lowest fried food intake linked to increases in major cardiovascular events, coronary heart disease, heart failure

Groups Jointly Issue Guidelines for Von Willebrand Disease

ASH, ISTH, NHF, and WFH developed clinical guidelines for the diagnosis, management of von Willebrand disease

Full-Dose Heparin May Aid Moderately Ill COVID-19 Patients

Interim results show improvement in primary end point of need for ventilation, other organ-supportive interventions

Induced Abortion Rates Not Up for Childhood Cancer Survivors

Likelihood of first pregnancy was reduced for childhood cancer survivors compared with population controls

Cardiovascular Comorbidity Common in Male Breast Cancer Patients

Of 24 patients, three developed tachyarrhythmias while undergoing treatment; two had decrease in ejection fraction during treatment

Bamlanivimab + Etesevimab Reduces SARS-CoV-2 Viral Load

No significant reduction seen in viral load at day 11 with bamlanivimab monotherapy in mild-to-moderate COVID-19

Renal Insufficiency May Worsen Multiple Myeloma Outcomes

Risk for disease progression or death increased for those with renal insufficiency in relapsed/refractory, newly diagnosed MM

Methamphetamine OD Deaths Up for All Races, Ethnicities

Highest rates within each sex seen for non-Hispanic American Indian or Alaska Native individuals, followed by non-Hispanic Whites

Cases of Idiopathic Intracranial HTN on the Rise in Wales

Prevalence of IIH is associated with increasing body mass index in the population and increased deprivation

Cancer Screening, Diagnoses Down During Early Pandemic

Higher positivity rate during the early pandemic might reflect prioritizing of higher-risk patients

Opioid Use May Contribute to Risk for Pancreatic Cancer

At the state level, opioid death rate at four years prior predicted the initial incidence of pancreatic cancer

Accidental Awareness High With General Anesthesia in Obstetric Surgeries

Incidence one in 256 for all obstetric surgery and one in 212 for cesarean section surgery; seven of 12 patients reported distressing experiences

Physician’s Briefing Weekly Coronavirus Roundup

Here is what the editors at Physician's Briefing chose as the most important COVID-19 developments for you and your practice for the week of...

Total Pediatric ED Visits Decreased in 2020 Versus 2018, 2019

Total trauma number decreased by 34 percent, but proportion of trauma increased significantly

Nearly Two-Thirds of Canadian Cardiac Physicians Burned Out

Burnout driven by perception of inadequate staffing levels, being treated unfairly at work

Oily Fish Consumption Tied to Lower Type 2 Diabetes Risk

Use of fish oil supplements over time also tied to lower diabetes risk

Disparities in Lung Cancer Screening Eligibility Still Exist

Findings seen despite the U.S. Preventive Services Task Force revised eligibility criteria

Cannabis Use May Be Tied to More Difficulty Conceiving

Findings based on women with a history of pregnancy loss attempting pregnancy

FDA Approves First Monthly Injectable Regimen for HIV

Trials show virologic suppression in comparable numbers of patients receiving monthly injection with Cabenuva, daily current antiretroviral regimen

Adults Delaying Even Emergency Care During COVID-19

More than half report being hesitant going to doctor or hospital when COVID-19 cases are high

Antibody Drug May Protect Nursing Home Residents, Staff From COVID-19

Preliminary results of the study conducted by drug maker Eli Lilly have not been peer-reviewed or published

Tocilizumab Does Not Improve Outcomes in Severe COVID-19

Tocilizumab plus standard care no better for improving clinical outcomes at 15 days and may increase mortality

Hahn Resigns as Head of FDA, Dr. Janet Woodcock New Interim Chief

A permanent FDA commissioner has not yet been nominated, but Woodcock is under consideration

Stem Cell Transplant May Slow Disability in Multiple Sclerosis

Long-term outcomes assessed in 210 patients with MS who underwent autologous hematopoietic stem cell transplantation

Impact of Antidepressants Examined in Back Pain, Osteoarthritis

SNRIs have small, not clinically important effect on back pain; may have clinically important effect on osteoarthritis pain

Mortality Decreased for COVID-19 ICU Patients Over Time

Mortality decreased from 43.5 to 19.2 percent between first and last 15-day periods; no change seen in other patient factors

President Biden Unveils Details of National Pandemic Response Plan

On Wednesday, Biden signed three executive orders relating to the coronavirus pandemic shortly after taking office

Denosumab Studied for Prosthesis-Related Osteolysis

Fewer osteoclasts seen at osteolysis membrane-bone interface with denosumab versus placebo in patients undergoing revision hip arthroplasty

AI Algorithms May Fail to Detect Diabetic Retinopathy

Evaluation of performance on real-world retinal imaging data showed sensitivities varied widely

Mediterranean Diet Tied to Lower Risk for Prostate Cancer Progression

Risk lower for men with newly diagnosed prostate cancer on active surveillance protocol

Supplemental Oxygen Often Unnecessary During Childbirth

Systematic literature review shows no significant improvement in umbilical artery pH or other neonatal outcomes

Aspirin Use Cuts CRC Risk in Those Initiating Use Before Age 70

Inverse association seen for aspirin users starting use before age 70, but not for those initiating use at or after age 70 years

2.3 Percent of Kindergarteners Not Up to Date With MMR in 2019-2020

2.5 percent of kindergartners had an exemption, but additional 2.3 percent were not up to date and had no exemption

Non-Hispanic Blacks Underrepresented on Transplant Wait List

However, racial disparities in liver transplantation are greatly diminished

Study Estimates Prevalence of Lupus in the U.S.

Prevalence nine times higher for women versus men; rates highest in American Indian/Alaska Natives, Black women

Patient Age Linked to Choice of Telepsychiatry Visit Type

Patients aged 44 years and older more likely to opt for telephone visits; telephone visit users less likely to anticipate future televisits

Mortality, Preeclampsia Up for Women With COVID-19 Giving Birth

Women hospitalized to give birth who had COVID-19 also had higher rates of myocardial infarction, venous thromboembolism, preterm birth

Men More Likely to Test Positive for SARS-CoV-2, Die From COVID-19

During their hospital course, more men than women experience pulmonary and extrapulmonary complications

Green-Mediterranean Diet Boosts Intrahepatic Fat Loss

Diet amplified in Mankia, green tea, walnuts achieves greater intrahepatic fat loss than other nutritional strategies

Either Trivalent Flu Vaccine Safe for Use in Seniors

Trivalent adjuvanted, trivalent high-dose inactivated influenza vaccines comparable for moderate-to-severe injection-site pain in adults 65 years and older

Smoking Marijuana Ups Toxic Chemical Levels in Blood, Urine

However, levels of smoke-related chemicals lower compared with those seen with tobacco smoking

New York City May Run Out of COVID-19 Vaccines

Mayor asked the federal government to send more vaccine doses as soon as possible

Retinal Changes Linked to Cognitive Function in T1DM Patients

Structural and vascular changes detected on noninvasive retinal imaging tied to performance on tests of cognitive function

Continuing Blood Pressure Meds Safe for Those With COVID-19

No difference in outcomes seen among hospitalized COVID-19 patients continuing, discontinuing renin-angiotensin system inhibitors

In Utero Exposures May Up Thyroid Cancer Risk in Offspring

Maternal benign thyroid conditions strongly associated with increased thyroid cancer risk in offspring

Pollen May Trigger Urologic Chronic Pelvic Pain Flares

Pollen count increases associated with UCPPS flares in individuals who also have allergies or respiratory tract disorders