Circulating Microparticle Proteins Can ID Placenta Accreta Spectrum

Five circulating microparticle proteins differentiated placenta accreta spectrum from controls using plasma samples at median of 26 weeks of gestation

Plastic Surgery Not Seeing Increase in Resident Applications

No increase seen in resident applications despite a very significant increase in integrated plastic surgery residency positions from 2010 to 2018

Air Pollution Independently Linked to Asthma Exacerbations

Independent associations seen and validated in two cohorts of children living in urban areas

iPhone Automated Audiogram Image Recognition Has Low Accuracy

Authors say this has implications for customization of over-the-counter hearing aids

Changes in Lifestyle Habits Linked to Colorectal Cancer Risk

Improving adherence to healthy lifestyle inversely associated with colorectal cancer risk

FDA Approves Second Drug for Alzheimer Disease, Despite Safety Concerns

Approval of Leqembi comes after controversial approval in 2021 of Aduhelm, which met with criticism over concerns about that drug's effectiveness, safety, pricing

MIS-C Seems More Common, Severe Than Previously Thought

Racial disparities seen in outcomes, including more cases in Black children as organ dysfunction increases

VV116 Noninferior to Nirmatrelvir-Ritonavir for COVID-19

Noninferiority established with respect to time to sustained clinical recovery for adults at high risk for progression

Faster Recovery Seen With Unicompartmental Knee Arthroplasty

Recovery faster in terms of 2-minute walk test, Timed Up-and-Go test for unicompartmental versus total knee arthroplasty

Recommendations Developed for Managing Neuromuscular Blockade

Authors recommend against clinical assessment alone when neuromuscular drugs are administered due to insensitivity of assessment

Racial/Ethnic Variation Seen in COVID-19 Vaccination Status in Children

Non-Hispanic Asian children and adolescents have the highest vaccination coverage, followed by Hispanic/Latino children

Mpox Cases Reported in Cisgender Women

2.3 percent of all reported mpox cases were in cisgender women, 44 percent of whom were non-Hispanic Black

Physical Activity May Cut Depressive Symptoms in Children, Teens

Larger benefit seen among those aged 13 years or older or with a mental illness, depression diagnosis

Increasing Staff Vaccination at Nursing Homes Cuts COVID-19 Infections

Increase in vaccination rate linked to fewer COVID-19 cases and deaths among residents, cases among staff

Social Work Staffing May Increase Access, Use of Palliative Care

Intervention to increase social work staffing on primary care teams serving rural veterans tied to increased use of palliative care following hospitalization

Procrastination in Adolescents Tied to Poorer Self-Reported Health Outcomes

Worse outcomes seen for mental health, pain, unhealthy lifestyle behaviors, and psychosocial health factors

Modified Atkins Diet Plus Drug Therapy Beneficial in Drug-Resistant Epilepsy

Modified Atkins diet added to standard drug treatment more effective for reducing seizure frequency than standard drug therapy alone

In Diabetes, Women Have Higher Risk for Venous Thromboembolism

Significantly higher association between diabetes and VTE seen among women versus men, especially those aged 50 to 59 years

Patient-Centered Texting Platform Beneficial for Interstitial Cystitis

Text message-based platform enhances self-efficacy for managing symptoms of IC/bladder pain syndrome

Nomogram Predicts Upper Urinary Tract Damage in Pediatric Neurogenic Bladder

Nomogram showed good discrimination, with areas under the curve of 0.806 and 0.831 in training, validation cohorts

BMI Up in 3-, 4-Year-Olds in Sweden During COVID-19 Pandemic

Risk for obesity higher for children in areas of low socioeconomic status

AI Promising for Detecting Adenomas in Patients With Lynch Syndrome

Significant increase seen in detection of flat adenomas with Paris classification 0 to IIb in patients with Lynch syndrome

Underserved Patients Report Positive Experience With Telehealth

High satisfaction reported for addressing medical and social concerns in primary care

Nighttime Hot Spring Bathing May Decrease Prevalence of HTN in Older Adults

Inverse relationship seen between habitual nighttime hot spring bathing and history of hypertension

Risk for Psychiatric Disorders Up for Spouses of Patients With Cancer

Most prominent increase seen for spouses of patients diagnosed with cancer with poor prognosis, at advanced stage

Wearable Technology Device Can Optimize In Vivo Exposure for PTSD

Significant effects seen for treatment condition and time for participants who used Bio Ware during one or more IVEs

Risk for SARS-CoV-2 Breakthrough Infection Increased for Cancer Patients

Risk for severe outcomes of COVID-19 higher for patients with hematologic versus solid cancer

Ob-Gyn Preventive Care Often Skips General Services

Lipid testing provided in only 2.8 percent of ob-gyn preventive visits

One in Four Patients Experience Breast Reconstruction Burnout

Incompletion of reconstruction tied to tissue expander complications, high body mass index, radiation therapy

Antiepileptic Drugs Tied to Incident Parkinson Disease

Magnitude of the association increased with the number of antiepileptic drugs prescribed

2017 to 2021 Saw Increase in Pediatric Edible Cannabis Exposure

When comparing pre-COVID-19 years with COVID-19 years, significant increase seen in both ICU and non-ICU admissions

Biomarkers Elevated in Patients With Immune Checkpoint Inhibitor-Induced Myocarditis

Elevations in creatine phosphokinase had sensitivity and specificity of 99 and 23 percent, respectively, for identifying myocarditis

Diabetes Exposure in Utero Linked to Neurodevelopmental Disorders

Increased risk for developmental delay, intellectual disability, and epilepsy/intellectual spasms observed for those exposed to T1DM

DAAs Less Likely for Hep C Patients With Alcohol Use Disorder

Those with current alcohol use disorder or abstinent with alcohol use disorder history had lower likelihood of receiving direct-acting antivirals

AI Models Have Higher Accuracy for Estimating Gestational Age

Image model, video model, ensemble model were all superior to standard fetal biometry-based gestational age estimates

One in Three Veterans Live in Areas With Psychiatrist Shortages

Psychiatric capacity structurally inequitable along both income gradient and rurality

FDA Says Retail Pharmacies Can Now Offer Abortion Pills

Patients will still need a doctor's prescription to access the drugs, and pharmacies must follow certain rules to dispense the medication

Current Depression Linked to Systemic Inflammation in Psoriasis

Correlation of PHQ-2 scores with neutrophil count greater and significant only for women

~10 Percent of Psoriasis Patients Have High Risk for Liver Fibrosis

Increased odds ratios seen for advanced liver fibrosis with age older than 50 years, BMI >30, diabetes, hypertension, dyslipidemia, metabolic syndrome

Smoking in Middle Age Linked to Subjective Cognitive Decline

Graded association observed between smoking and subjective cognitive decline, with greatest prevalence seen for current smokers

Number of Youth With Diabetes Set to Keep Increasing

Assuming trends from 2002 to 2017 continue, increases of 65 and 673 percent expected in types 1 and 2 diabetes, respectively, to 2060

Whole-Tumor Cell Culture Can Predict Drug Response in Breast Cancer

WTC model allows for personalized drug testing within 10 days, even for small-sized tumors

Significant Link Seen for Persistent Postconcussion Symptoms, Depression

No significant moderators identified for the association, possibly due to small number of studies included

Biologic Age Up for Those With Serum Sodium >142 mmol/L

Those with middle-age serum sodium >142 mmol/L also have increased risk for developing chronic diseases, premature mortality

Adverse Events Increased for Induced Abortion With Mifepristone-Misoprostol

Serious adverse events are rare, occur more often with mifepristone-misoprostol versus procedural induced abortion in first trimester

ACP Updates Living Guideline on Pharmacologic Treatment of Osteoporosis

Bisphosphonates strongly recommended for initial treatment of primary osteoporosis for postmenopausal women

Occurrence of Cardiovascular Events, Death Compared Between Thiazides

Occurrence of major cardiovascular events, non-cancer-related deaths no lower with chlorthalidone versus hydrochlorothiazide

Risk for COVID-19-Linked Endocarditis Up in Patients With Opioid, Cocaine Use Disorders

180-day hospitalization risk significantly increased following endocarditis for those with opioid use disorder, cocaine use disorder

Progression-Free Survival Increased With Zanubrutinib in Leukemia

Longer progression-free survival seen with zanubrutinib versus ibrutinib for patients with relapsed or refractory chronic or small lymphocytic leukemia

Methylprednisolone No Benefit in Cardiopulmonary Bypass for Infants

No significant difference seen in likelihood of worse outcome in adjusted analysis for methylprednisolone versus placebo

Flu Vaccine 36 Percent Effective Against A(H3N2) in 2021/2022

All sequenced A(H3N2) viruses belonged to genetic group 3C.2a1b subclade 2a.2, which was antigenically different from 2021-2022 vaccine component

PCP-Specialist Cotraining Improves Patient Experiences

Adjusted composite patient rating of specialist care higher in association with cotraining of PCPs and specialists

No Increase in Adverse Events Seen With COVID-19 Vaccination After MIS-C

Minor adverse events seen in 48.6 percent of patients, most often arm soreness and/or fatigue

Social Media Checking Behaviors in Teens Linked to Brain Changes

Teens with habitual social media checking behaviors showed lower neural sensitivity to social anticipation in amygdala, other areas

Drug Approved to Help Young Patients Battle a Rare Cancer

Trial funded by the NCI has prompted the FDA to approve Tecentriq for children and adults with alveolar soft part sarcoma

Noninvasive Interventions Can Reduce Spine Pain Versus Usual Care

Small reductions in pain-related disability at three months for multidisciplinary biopsychosocial intervention, individualized postural therapy

Women With Employer Insurance More Likely to Report Unaffordability of Care

Highest reported unaffordability seen for dental care, followed by prescription drugs, medical care, mental health care

Factors ID’d for Hearing Loss in Newborns With Congenital Cytomegalovirus

Risk for congenital hearing loss increased for those with petechiae at birth, periventricular cysts on MRI, seroconversion in first trimester

COVID-19 Booster mRNA Dose Increases Antibody Duration

Immunoglobulin G spike receptor binding domain antibody levels similar after primary series, booster dose

Acupuncture May Aid Irritable Bowel Syndrome With Diarrhea

However, improvements not significantly better than those seen with sham acupuncture

Alcohol-Related Problems Common Eight Years After Metabolic, Bariatric Surgery in Teens

Nearly half have alcohol use disorder, symptoms of alcohol-related harm, or alcohol-related problems at eight years after surgery

Gastroesophageal Reflux Disease Causally Linked to Lung Cancer

Based on inverse variance weighted method, GERD found to substantially increase lung cancer risk

Recommendations Developed for Treating Hypercalcemia of Malignancy

Authors strongly recommend treatment with denosumab or an intravenous bisphosphonate for adults with HCM

Independence Valued Over Survival for Neuroendocrine Tumor Patients

Adults with neuroendocrine tumors value independence as most important, with most valuing their future versus current quality of life

Guidelines Updated for Reducing Hypoglycemia Risk in Diabetes

Strong recommendations include use of glucagon preparations that do not need reconstitution, real-time CGM for those receiving multiple daily injections

AAP Guidelines Help Detect Invasive Bacterial Infections in Febrile Infants

Clinical practice guidelines can help detect IBI in infants aged 8 to 60 days with high sensitivity but low specificity

Natural Environments May Cut Hospitalization for Patients With Neurodegenerative Diseases

Normalized difference vegetation index negatively associated with hospitalization for Alzheimer disease and related dementia, Parkinson disease

Measles Outbreak in Ohio Infects 82 Children, Most of Them Unvaccinated

All with data available were at least partially unvaccinated, having had no doses or just one dose of the two-shot MMR vaccine

Nurse-Driven Protocol Ups Pneumococcal Vaccination Rates

Findings for pneumococcal vaccine among immunosuppressed rheumatology patients

Over 28,000 ZLINE Gas Ranges Recalled Due to Carbon Monoxide Danger

There have been 44 reports of carbon monoxide emission from customers, including three reports of people needing medical attention

FDA Approves Sunlenca for Treatment-Resistant HIV

Sunlenca is the first capsid inhibitor approved for HIV

U.S. to Require Negative COVID-19 Test For Chinese Visitor Entry

The new rule, set to go into effect on Jan. 5, was created in response to a surge in COVID-19 cases in China

Ransomware Attacks on Health Care Organizations on the Rise

Nearly twofold increase in annual number of attacks seen from 2016 to 2021, exposing information of nearly 42 million patients

Many Thyroid Cancer Survivors Cite Inadequate Pretreatment Understanding

Self-reported failure to have understanding of treatment linked to failure to meet treatment expectations

Costs, Effectiveness of Laparoscopic, Open Gastrectomy Similar

Minimal difference observed in total costs and effectiveness after one year of follow-up

Gastroesophageal Reflux Disease Raises Risk for Periodontitis

Patients with GERD have increased risk in analyses stratified by age, sex, and presence or absence of comorbidities

Molnupiravir Does Not Reduce COVID-19-Related Hospitalization, Death

No reduction in COVID-19-associated hospitalizations or deaths seen among high-risk, vaccinated adults

Opioids Frequently Prescribed to Patients With Cirrhosis

Opiate prescriptions predicted by primary care physician specialty and patient age, gender, race

Black Patients Less Likely to Undergo Minimally Invasive Mitral Valve Surgery

Furthermore, Black patients more likely to experience major complications, death than White patients

Parental Astigmatism Increases Risk for Child Astigmatism

Astigmatism ≥1.0 D in both parents associated with greater odds of refractive and corneal astigmatism in the child

Mediterranean Diet Tied to Fewer Adverse Pregnancy Outcomes

Findings similar across race/ethnicity and prepregnancy body mass index, but stronger in women aged 35 years or older

5α-Reductase Inhibitors Linked to Depression, but Not Dementia

Magnitude of association for finasteride and dutasteride with dementia decreased over time and became nonsignificant

Fewer Symptoms for Mpox Infection Seen After Vaccination

Mpox cases that occurred in vaccinated individuals associated with lower percentage of hospitalization

Diagnostic Accuracy High in Emergency Departments

Only about 5.7 percent of patients receive incorrect diagnosis, with about 2.0 percent suffering adverse events as a result

Congressional Report Slams FDA, Drugmaker Over Approval of Alzheimer Drug Aduhelm

Controversy over Aduhelm stretches back to its June 2021 approval by the U.S. Food and Drug Administration

Few NICUs Regularly Screen for Social Determinants of Health

No hospital-level factors (e.g., region, size) were associated with conducting screening

Social Frailty Linked to Worse Outcomes for Elderly Heart Failure Patients

Social frailty linked to composite of all-cause death, cardiovascular events among elderly hospitalized heart failure patients

Most Older Adults Concerned About Emergency Department Costs

Predictors of emergency department avoidance include lower income, being uninsured, poor or fair mental/physical health, and younger age

Alcohol Abstinence Aids Alcohol-Related Cirrhosis Across Portal Hypertension Stages

Findings seen even among patients who have already progressed to high-risk portal hypertension

COVID-19 Vaccination Bests Natural Immunity for Cutting Death, Hospitalizations

However, natural immunity tied to lower incidence of new infection

Dietary Nitrate Intake Linked to Lower Risk for AMD Progression

Higher dietary nitrate intake linked to reduced risk for progression to late age-related macular degeneration

Autologous Hematopoietic Stem Cell Transplant Slows Disability Progression in MS

Slowing of disability progression and higher likelihood of disability improvement observed compared with standard disease-modifying therapies

Outcomes Worse for Black Patients With Head, Neck Cancer in Clinical Trials

Outcomes worse for Black versus White patients enrolled in clinical trials that minimize access to care, socioeconomic status confounders

Recommendations Updated for Radiation Therapy in Endometrial Cancer

Radiation therapy recommended to reduce risk for vaginal and/or pelvic recurrence; data limited for sequencing radiation therapy and chemo

Expectant Management Noninferior to Ibuprofen for Extreme Preemies With Patent Ductus Arteriosus

Primary outcome event occurred in more infants in the early-ibuprofen group than the expectant-management group

Network Meta-Analysis Compares DOACs to LMWH for Cancer-Linked Thrombosis

Apixaban dominated enoxaparin and edoxaban; rivaroxaban was slightly more effective than apixaban

Artificial Intelligence Rarely Passes Radiologists’ Mock Exams

AI had overall accuracy of 79.5 percent and passed two of 10 mock Royal College of Radiologists exams when excluding noninterpretable images

FDA Updates Guidance on ‘Morning After’ Pill, Making Clear It Does Not Cause Abortions

New revised leaflets now clearly state that Plan B and its kin work 'before release of an egg from the ovary'

Per-Patient Costs of Metastatic Prostate Cancer Estimated at $31,427

Increase in annual attributable costs observed over time, from $28,311 in 2007-2013 to $37,055 in 2014-2017

Prices for Total Joint Arthroplasty Not Linked to Hospital Quality

No association seen between mean negotiated price and TJA complication rate, readmission rate, hospital performance score

Pediatric Mental Health Emergency Visits With Prolonged LOS Up During 2021

Pediatric mental health visits with length of stay >12 and >24 hours accounted for 20.9 and 7.3 percent of all visits

Screening Catches Only One in Seven Cancers

Vast majority of cancers diagnosed due to symptoms or other medical care

Target Recalls More Than 200,000 Weighted Blankets After Two Children Suffocated

Four children have become trapped in the blankets, including a 4-year-old girl and a 6-year-old girl who both died

Factors Linked to Pediatric Mental Health Emergency Revisits Identified

Psychiatric comorbidities, chemical restraint use, public insurance tied to emergency revisits; substance use disorders associated with lower likelihood of revisits

Computer Vision Approach Identifies Posterior Thoracolumbar Hardware

Model performed five-way classification with 79 percent accuracy in 14 seconds on 100 test images

Atopic Dermatitis Raises Subsequent Fracture Risk in Children

Findings show dose-response relationship, with higher risk tied to more severe atopic dermatitis

Acupressure Aids Self-Reported Sleep Disturbances in Cancer Patients

Systematic review finds acupressure better than acupuncture or electroacupuncture

On-Site Genetic Testing for Prostate Cancer Increases Patient Compliance

Implementation of on-site guideline-based genetic testing for prostate cancer patients increased compliance from 33.3 to 98.7 percent

Peritonitis Tied to Cardiovascular Mortality in Peritoneal Dialysis Population

Higher risk seen with increasing peritonitis episodes; risk for cardiovascular mortality lower for those commencing peritoneal dialysis in 2012-2019 versus 2003-2011

Risk for Persistent Postural Perceptual Dizziness Increases With Vestibular Conditions

Vestibular migraine plays key role in precipitating PPPD as a single comorbidity or component of multiple vestibular comorbidities

Bidirectional Association for Ménière Disease, Osteoporosis

Adults with prior history of osteoporosis have increased risk of Ménière disease and those with prior Ménière disease have increased risk of osteoporosis

Rural Hospital Closures Put Strain on Nearby Hospitals

In two years following a rural hospital closure, nearby hospitals see increase in emergency department visits and hospital admissions

Treatment-Resistant Depression Common and Costly

Treatment-resistant depression episodes tied to more psychiatric comorbid conditions, health care utilization, self-harm, and all-cause mortality

Glycemic Control Stagnant in U.S. From 1988 to 2020

Mexican American adults receiving insulin less likely than non-Hispanic Whites to achieve glycemic control

Tough New Labeling Law for Sesame Prompts Companies to Add It to Their Products

New requirements are so strict that it costs less to add sesame to food products than to try to keep it out

Children’s Firearm Injuries Up During the Pandemic

Significant increases seen among children who are Black, very young, and with public insurance

Life Expectancy Down to 76.4 Years in 2021

Age-specific deaths rates increased for all age groups 1 year and over; no significant change seen in infant mortality rates

Weekly Dupilumab Beneficial in Eosinophilic Esophagitis

More patients receiving dupilumab have histologic remission, improvement in Dysphagia Symptom Questionnaire scores

Differences ID’d Between Men, Women With Cluster Headache

Alcohol as trigger occurred more often in men; lack of sleep as trigger more common in women

Patient-Centered Communication Tool Feasible for Seniors With Acute Myeloid Leukemia

Patients, caregivers scored higher on AML knowledge and perceived greater efficacy in communicating with oncologists

Low Serum Vitamin D Tied to Age-Related Loss of Muscle Strength

Findings for both 25-hydroxyvitamin D deficiency and insufficiency

Blacks More Likely to Undergo Emergency Surgery for Colorectal Cancer

Emergency surgery associated with incomplete oncologic evaluation, and increased incidence of postoperative complications, including mortality

Child Homicides Up Across Several Subpopulations

Children ≤10 years often victims perpetrated by parents/caregivers, while children ≥11 years more often perpetrated by friends/acquaintances

Black Race, Male Sex Tied to Use of Pharmacological Restraint in Pediatric Emergency Visits

No significant association observed between average annual emergency department volume and restraint use

Reduced eGFR Linked to Increased Mortality in A-Fib

Moderately-to-severely decreased eGFR had significant effect on all-cause mortality specifically in those with low socioeconomic status

Genetic + Registry Data AI Model May Predict Mental Disorder Diagnosis

Deep learning, multidiagnostic model shows high accuracy before clinical examination

Mindfulness Training, Exercise No Aid for Cognitive Function

No benefit seen for episodic memory or executive function at six or 18 months for older adults

Satisfaction With Physician Relationship Tied to Bariatric Surgery Completion

However, no association seen between racial/ethnic group and patient satisfaction

Single-Tube Multiparametric Flow Cytometry Predicts Treatment Response in Leukemia

Multiparametric flow cytometry has excellent prediction for survival among patients with B-cell acute lymphoblastic leukemia

Endolymphatic Hydrops Volume Down in Ménière Disease With Positive Pressure Therapy

Volume of endolymphatic hydrops decreased with reduction of vertigo attacks during eight months of PPT plus medication; however, volume increased with medication alone

U.S. to Release Flu Meds From National Stockpile to Ease Shortages

Decision comes as the nation suffers from an unusually early and hard flu season, with about 9,300 deaths so far

Bivalent COVID-19 mRNA Booster Effective

Bivalent booster is effective against COVID-19 hospitalization in immunocompetent adults, seniors

Nonphysician Practitioners More Likely to Use Contrast Media for CT

1.55 percent difference in utilization rate for CT contrast media between localities with 10 percent different in NPP evaluation and management share

Smartphone App May Be Beneficial for Some With Bipolar Disorder

Does not reduce risk of relapse overall, but can reduce relapse risk and manic symptom severity for low-risk individuals

2001 to 2021 Saw Decline in Physician Work Hours

However, trend offset by increase in advanced practice professionals weekly work hours

High Coffee Intake Linked to CVD Mortality in Severe Hypertension

No association seen for people with optimal and normal BP, high-normal BP, grade 1 hypertension

Trends in Genitourinary Cancers Examined in the United States

Among non-Hispanic Whites, highest incidence rates seen in Northeast for bladder cancer, Appalachia for kidney cancer

2012 to 2021 Saw Drop in Bicycle-Related Injuries

Increase in rate of injuries seen among elderly adults; head was most commonly affected body part

Review: Probiotics May Relieve Halitosis in Short Term

No significant difference observed in terms of tongue coating scores, plaque index for those receiving probiotics

Aerobic Exercise Tied to Better Sleep, Mental Health in Perimenopausal Women

Higher frequency of practice tied to greater impact on self-reported symptoms

Renal Impairment Linked to Worse Prognosis in IgD Multiple Myeloma

Median survival significantly shorter for patients with renal impairment versus those with no renal impairment

First-Line Regimens With Endocrine Therapy Show Benefits in Breast Cancer

Findings seen among subgroup of patients with human epidermal growth factor receptor 2-positive metastatic breast cancer

Psychological Distress May Be Causal Risk Factor for Dementia

Risk varies by type of distress, but significant relationships seen for exhaustion and stress

Commercial Rates for Breast Reconstruction Vary Significantly

Higher rates seen in less competitive markets and facilities that are large, for-profit, and non-safety net

Late-Onset Meningitis ID’d in 1 Percent of Extreme Preemies

Performance of lumbar puncture has decreased in late-onset sepsis evaluations; 16 percent of late-onset meningitis cases occurred without late-onset sepsis

Combustible Tobacco Use Tied to Adverse Oral Health Outcomes

Electronic nicotine delivery system use tied to gum bleeding

No Change Seen in Limited Access to Mammography From 2006 to 2022

Variation seen in accessibility to mammography by states; in 10 states, more than 26 percent of women aged 45 to 84 years had limited access in 2022

In Face of Tripledemic, CVS and Walgreens Limit Purchases of Pediatric Pain Meds

Medication limits are meant to 'ensure equitable access,' according to a CVS statement

Nursing Care Shortages Likely to Have Predated Pandemic

No evidence that large numbers of nurses left health care or hospital practice during first 18 months of pandemic

FDA Tobacco Unit Overloaded and Lacking Direction, Panel Says

Experts recommend agency leaders set clear objectives and expectations to prevent more 'detrimental’ effects on the agency's work and staff morale

Clinical Report Addresses Screening, Management of Congenital Hypothyroidism

When clinical symptoms and signs of hypothyroidism are present, TSH, free thyroxine should be measured, regardless of screening results

Risk for T2DM Reduced With Higher Daily Step Count

Hazard of incident diabetes reduced by 44 percent in adjusted models comparing average daily step count of 10,700 to 6,000

PET Changes Similar for Alzheimer Disease, Down Syndrome

No difference seen in global PET amyloid burden between asymptomatic with Down syndrome, asymptomatic mutation carriers

Coinfection With Flu, SARS-CoV-2 Described in Children

SARS-CoV-2 coinfection occurred in 6 percent of pediatric influenza-associated hospitalizations

Environmental Risk Factors Linked to Increased Risk for Schizotypy

Cumulative environmental risk score most strongly associated with true schizotypy, followed by affective, introverted schizotypy

HPV Vaccine Refusal Explored Among Cancer Survivors

Most of the cancer survivors who refused participation in a trial of the vaccine did so for vaccine-related concerns

Metformin Use Linked to Lower Risk for Joint Replacement in T2DM

Reduced risk seen for total knee replacement and total hip replacement with metformin use

ASH: Glofitamab Aids Relapsed, Refractory Diffuse Large B-Cell Lymphoma

39 percent of patients had a complete response, with median time to complete response of 42 days

Bacteria From Oral Cavity ID’d in Brain Abscess Without Clear Cause

Brain abscesses where no primary source of infection identified have higher counts of Streptococcus anginosus

Adding Yoga to Aerobic Training Lowers Blood Pressure

BP reduction greater with 15 minutes a day of yoga, five times a week for three months plus 30 minutes of aerobic training, compared with stretching control

Direct-to-Consumer Testosterone Not Offered in Accordance With Guidelines

Most direct-to-consumer platforms offer testosterone therapy despite consumer reporting normal testosterone levels, free testosterone

Overdose Deaths Up in Teens From July to December 2019 to 2021

About 90 and 83.9 percent of overdose deaths involved opioids and illicitly manufactured fentanyls

Left Atrial Reservoir Strain Plus CHA₂DS₂-VASc Ups Stroke Prediction

Addition of left atrial reservoir strain also yields predicted net benefit in people without prior a-fib or stroke

Decision Aid Improves Decision Quality for Seniors With CKD

DART improves decisional quality at three and six months; results decrease thereafter

One in Seven Dual Users Continue Using Both Tobacco Products

However, early electronic cigarette quitters plus stable cigarette use was the most common trajectory in 41.6 percent of participants

FDA Approves Gene Therapy for Tough-to-Treat Bladder Cancer

About 57,000 men and 18,000 women are diagnosed with bladder cancer annually

New Surveillance Case Definition Developed for MIS-C

Four changes included in new case definition, including no required duration of subjective or measured fever

CKD Linked to Greater Neuromuscular Fatigability

Only peak force fatigability, but not peak rate of force development, contributed to fatigue variance

Fecal Microbiota Transplant Does Not Improve Results of Bariatric Surgery

FMT from lean donor does not reduce body weight, improve results of bariatric surgery at six months or one year

Global Inequalities Remain in Cervical Cancer Incidence

Different patterns of age-specific incidence observed between countries with and without well-developed population-based screening and treatment

Fingerprint Images Have Potential for Predicting Schizophrenia

Right thumb network achieved highest level of accuracy from networks based on single fingers at 68 percent

Mobile Devices for Calming May Harm Young Children’s Emotion Regulation

Authors say mobile devices for calming should be avoided in preschool-aged boys, children with higher surgency

Atopic Dermatitis May Be Risk Factor for New-Onset Migraine

Among those with atopic dermatitis, smoking and male sex were significantly associated with higher risk for new-onset migraine

Rheumatoid Arthritis Linked to Peripheral Artery Disease

Authors say systematic inflammation likely contributes to increased incidence of PAD in this population

Drinking Alcohol Not Tied to Migraine Attack Within 24 Hours

Among participants with episodic migraine, the interaction of migraine presence on day 2 with alcohol intake on day 2 not significant

Most Older Adults With COPD Are Doing Well Mentally

Being married, having a confidant associated with better mental health with COPD

HPV Vaccination Rates Increased After ACIP Update for Adults Aged 27 to 45

Immediate increase seen in vaccine administration rate in women; increased slope seen over time postupdate

Not All Pediatric Cases of Type 2 Diabetes Have Obesity

Prevalence of obesity with type 2 diabetes highest in White children and lowest in Asian children

Sublingual Buprenorphine/Naloxone Tied to More Adverse Dental Outcomes

More adverse dental outcomes seen with sublingual buprenorphine/naloxone compared with use of transdermal buprenorphine or oral naltrexone

Lifestyle May Counter Genetic Risk for Thyroid Cancer

Highest risk for thyroid cancer seen among participants with both high genetic risk and unfavorable lifestyle

Artificially Sweetened Drinks May Up Risk for Urinary Incontinence

Higher risk seen among women drinking one or more beverages per day

Men Face Five to Seven Times Higher Rates of Firearm Deaths Than Women

Black men disproportionately impacted by firearm homicide, while White men most impacted by firearm suicide

Prior SARS-CoV-2 Infection Not Linked to Worse Outcomes After Surgery

No association seen with death, major adverse cardiovascular events, rehospitalization following elective major noncardiac surgery

CDC Extends BMI-for-Age Growth Charts to Monitor Severe Obesity in Children, Adolescents

Extended method uses additional data from 1999 to 2016 NHANES, rather than extrapolation; improves characterization of extremely high BMI in children

Restless Leg Syndrome More Common in Psoriasis Patients

Presence of RLS associated with significantly more severe psoriasis and more severe systemic inflammation

Value-Based Outcome Set Developed for Psoriasis

Twelve instruments were selected to measure outcomes in the value-based outcome set, which were reported by patients and providers

Rocatinlimab Effective for Moderate-to-Severe Atopic Dermatitis

Lasting improvement seen for patients receiving anti-OX40 antibody rocatinlimab compared with placebo

Chemosensory Dysfunction Predicts Serologic Response After COVID-19

Altered smell and taste are significant predictors of positive anti-spike IgG response in multivariable models

Psychosocial Stress Tied to Higher Risk for Acute Stroke

Locus of control appears to modify the effect size of work stress on stroke risk

Football Players Face Accelerated Aging

Findings show fewer years free of disease at all ages compared with the general population

Self-Service Vending Machine Provides Harm Reduction Services

Vending machine dispenses naloxone, sharps containers, safer injection/smoking kits, pregnancy tests, HIV tests

HPV Vaccine Coverage in Children Remains Lower Than Prepandemic

However, recovery seen in monthly volume of vaccine doses administered

Recommendations Developed for Lower-Extremity Varicose Veins

Recommendations include duplex ultrasound scanning as diagnostic test of choice; venous intervention over long-term compression stockings

Countering Antivax Misinformation Ups Parents’ Perceptions of HPV Vaccines

These social media messages build positive attitudes, which are tied to intention to vaccinate

Childhood Chronic Conditions Up With Maternal Schizophrenia

Children exposed to maternal schizophrenia have increased risk for mental health and non-mental health conditions

U.S. Deaths Drop in 2022, But Still Higher Than Prepandemic Levels

COVID-19 will remain the third-largest killer for 2022, behind heart disease and cancer, even with the reduced numbers

White House ‘Winter Preparedness Plan’ Revives Free At-Home COVID-19 Test Program

Every household in the country is eligible to receive four free COVID-19 nasal swab testing kits

Biden Administration Calls for Crackdown on Misleading Medicare Ads

New rule would ban ads that have confusing words, imagery, or logos, or that do not specifically mention a health insurance plan by name