Circulating Microparticle Proteins Can ID Placenta Accreta Spectrum
Five circulating microparticle proteins differentiated placenta accreta spectrum from controls using plasma samples at median of 26 weeks of gestation
Plastic Surgery Not Seeing Increase in Resident Applications
No increase seen in resident applications despite a very significant increase in integrated plastic surgery residency positions from 2010 to 2018
Air Pollution Independently Linked to Asthma Exacerbations
Independent associations seen and validated in two cohorts of children living in urban areas
iPhone Automated Audiogram Image Recognition Has Low Accuracy
Authors say this has implications for customization of over-the-counter hearing aids
Changes in Lifestyle Habits Linked to Colorectal Cancer Risk
Improving adherence to healthy lifestyle inversely associated with colorectal cancer risk
FDA Approves Second Drug for Alzheimer Disease, Despite Safety Concerns
Approval of Leqembi comes after controversial approval in 2021 of Aduhelm, which met with criticism over concerns about that drug's effectiveness, safety, pricing
MIS-C Seems More Common, Severe Than Previously Thought
Racial disparities seen in outcomes, including more cases in Black children as organ dysfunction increases
VV116 Noninferior to Nirmatrelvir-Ritonavir for COVID-19
Noninferiority established with respect to time to sustained clinical recovery for adults at high risk for progression
Faster Recovery Seen With Unicompartmental Knee Arthroplasty
Recovery faster in terms of 2-minute walk test, Timed Up-and-Go test for unicompartmental versus total knee arthroplasty
Recommendations Developed for Managing Neuromuscular Blockade
Authors recommend against clinical assessment alone when neuromuscular drugs are administered due to insensitivity of assessment
Racial/Ethnic Variation Seen in COVID-19 Vaccination Status in Children
Non-Hispanic Asian children and adolescents have the highest vaccination coverage, followed by Hispanic/Latino children
Mpox Cases Reported in Cisgender Women
2.3 percent of all reported mpox cases were in cisgender women, 44 percent of whom were non-Hispanic Black
Physical Activity May Cut Depressive Symptoms in Children, Teens
Larger benefit seen among those aged 13 years or older or with a mental illness, depression diagnosis
Increasing Staff Vaccination at Nursing Homes Cuts COVID-19 Infections
Increase in vaccination rate linked to fewer COVID-19 cases and deaths among residents, cases among staff
Social Work Staffing May Increase Access, Use of Palliative Care
Intervention to increase social work staffing on primary care teams serving rural veterans tied to increased use of palliative care following hospitalization
Procrastination in Adolescents Tied to Poorer Self-Reported Health Outcomes
Worse outcomes seen for mental health, pain, unhealthy lifestyle behaviors, and psychosocial health factors
Modified Atkins Diet Plus Drug Therapy Beneficial in Drug-Resistant Epilepsy
Modified Atkins diet added to standard drug treatment more effective for reducing seizure frequency than standard drug therapy alone
In Diabetes, Women Have Higher Risk for Venous Thromboembolism
Significantly higher association between diabetes and VTE seen among women versus men, especially those aged 50 to 59 years
Patient-Centered Texting Platform Beneficial for Interstitial Cystitis
Text message-based platform enhances self-efficacy for managing symptoms of IC/bladder pain syndrome
Nomogram Predicts Upper Urinary Tract Damage in Pediatric Neurogenic Bladder
Nomogram showed good discrimination, with areas under the curve of 0.806 and 0.831 in training, validation cohorts
BMI Up in 3-, 4-Year-Olds in Sweden During COVID-19 Pandemic
Risk for obesity higher for children in areas of low socioeconomic status
AI Promising for Detecting Adenomas in Patients With Lynch Syndrome
Significant increase seen in detection of flat adenomas with Paris classification 0 to IIb in patients with Lynch syndrome
Underserved Patients Report Positive Experience With Telehealth
High satisfaction reported for addressing medical and social concerns in primary care
Nighttime Hot Spring Bathing May Decrease Prevalence of HTN in Older Adults
Inverse relationship seen between habitual nighttime hot spring bathing and history of hypertension
Risk for Psychiatric Disorders Up for Spouses of Patients With Cancer
Most prominent increase seen for spouses of patients diagnosed with cancer with poor prognosis, at advanced stage
Wearable Technology Device Can Optimize In Vivo Exposure for PTSD
Significant effects seen for treatment condition and time for participants who used Bio Ware during one or more IVEs
Risk for SARS-CoV-2 Breakthrough Infection Increased for Cancer Patients
Risk for severe outcomes of COVID-19 higher for patients with hematologic versus solid cancer
Ob-Gyn Preventive Care Often Skips General Services
Lipid testing provided in only 2.8 percent of ob-gyn preventive visits
One in Four Patients Experience Breast Reconstruction Burnout
Incompletion of reconstruction tied to tissue expander complications, high body mass index, radiation therapy
Antiepileptic Drugs Tied to Incident Parkinson Disease
Magnitude of the association increased with the number of antiepileptic drugs prescribed
2017 to 2021 Saw Increase in Pediatric Edible Cannabis Exposure
When comparing pre-COVID-19 years with COVID-19 years, significant increase seen in both ICU and non-ICU admissions
Biomarkers Elevated in Patients With Immune Checkpoint Inhibitor-Induced Myocarditis
Elevations in creatine phosphokinase had sensitivity and specificity of 99 and 23 percent, respectively, for identifying myocarditis
Diabetes Exposure in Utero Linked to Neurodevelopmental Disorders
Increased risk for developmental delay, intellectual disability, and epilepsy/intellectual spasms observed for those exposed to T1DM
DAAs Less Likely for Hep C Patients With Alcohol Use Disorder
Those with current alcohol use disorder or abstinent with alcohol use disorder history had lower likelihood of receiving direct-acting antivirals
AI Models Have Higher Accuracy for Estimating Gestational Age
Image model, video model, ensemble model were all superior to standard fetal biometry-based gestational age estimates
One in Three Veterans Live in Areas With Psychiatrist Shortages
Psychiatric capacity structurally inequitable along both income gradient and rurality
FDA Says Retail Pharmacies Can Now Offer Abortion Pills
Patients will still need a doctor's prescription to access the drugs, and pharmacies must follow certain rules to dispense the medication
Current Depression Linked to Systemic Inflammation in Psoriasis
Correlation of PHQ-2 scores with neutrophil count greater and significant only for women
~10 Percent of Psoriasis Patients Have High Risk for Liver Fibrosis
Increased odds ratios seen for advanced liver fibrosis with age older than 50 years, BMI >30, diabetes, hypertension, dyslipidemia, metabolic syndrome
Smoking in Middle Age Linked to Subjective Cognitive Decline
Graded association observed between smoking and subjective cognitive decline, with greatest prevalence seen for current smokers
Number of Youth With Diabetes Set to Keep Increasing
Assuming trends from 2002 to 2017 continue, increases of 65 and 673 percent expected in types 1 and 2 diabetes, respectively, to 2060
Whole-Tumor Cell Culture Can Predict Drug Response in Breast Cancer
WTC model allows for personalized drug testing within 10 days, even for small-sized tumors
Significant Link Seen for Persistent Postconcussion Symptoms, Depression
No significant moderators identified for the association, possibly due to small number of studies included
Biologic Age Up for Those With Serum Sodium >142 mmol/L
Those with middle-age serum sodium >142 mmol/L also have increased risk for developing chronic diseases, premature mortality
Adverse Events Increased for Induced Abortion With Mifepristone-Misoprostol
Serious adverse events are rare, occur more often with mifepristone-misoprostol versus procedural induced abortion in first trimester
ACP Updates Living Guideline on Pharmacologic Treatment of Osteoporosis
Bisphosphonates strongly recommended for initial treatment of primary osteoporosis for postmenopausal women
Occurrence of Cardiovascular Events, Death Compared Between Thiazides
Occurrence of major cardiovascular events, non-cancer-related deaths no lower with chlorthalidone versus hydrochlorothiazide
Risk for COVID-19-Linked Endocarditis Up in Patients With Opioid, Cocaine Use Disorders
180-day hospitalization risk significantly increased following endocarditis for those with opioid use disorder, cocaine use disorder
Progression-Free Survival Increased With Zanubrutinib in Leukemia
Longer progression-free survival seen with zanubrutinib versus ibrutinib for patients with relapsed or refractory chronic or small lymphocytic leukemia
Methylprednisolone No Benefit in Cardiopulmonary Bypass for Infants
No significant difference seen in likelihood of worse outcome in adjusted analysis for methylprednisolone versus placebo
Flu Vaccine 36 Percent Effective Against A(H3N2) in 2021/2022
All sequenced A(H3N2) viruses belonged to genetic group 3C.2a1b subclade 2a.2, which was antigenically different from 2021-2022 vaccine component
PCP-Specialist Cotraining Improves Patient Experiences
Adjusted composite patient rating of specialist care higher in association with cotraining of PCPs and specialists
No Increase in Adverse Events Seen With COVID-19 Vaccination After MIS-C
Minor adverse events seen in 48.6 percent of patients, most often arm soreness and/or fatigue
Social Media Checking Behaviors in Teens Linked to Brain Changes
Teens with habitual social media checking behaviors showed lower neural sensitivity to social anticipation in amygdala, other areas
Drug Approved to Help Young Patients Battle a Rare Cancer
Trial funded by the NCI has prompted the FDA to approve Tecentriq for children and adults with alveolar soft part sarcoma
Noninvasive Interventions Can Reduce Spine Pain Versus Usual Care
Small reductions in pain-related disability at three months for multidisciplinary biopsychosocial intervention, individualized postural therapy
Women With Employer Insurance More Likely to Report Unaffordability of Care
Highest reported unaffordability seen for dental care, followed by prescription drugs, medical care, mental health care
Factors ID’d for Hearing Loss in Newborns With Congenital Cytomegalovirus
Risk for congenital hearing loss increased for those with petechiae at birth, periventricular cysts on MRI, seroconversion in first trimester
COVID-19 Booster mRNA Dose Increases Antibody Duration
Immunoglobulin G spike receptor binding domain antibody levels similar after primary series, booster dose
Acupuncture May Aid Irritable Bowel Syndrome With Diarrhea
However, improvements not significantly better than those seen with sham acupuncture
Alcohol-Related Problems Common Eight Years After Metabolic, Bariatric Surgery in Teens
Nearly half have alcohol use disorder, symptoms of alcohol-related harm, or alcohol-related problems at eight years after surgery
Gastroesophageal Reflux Disease Causally Linked to Lung Cancer
Based on inverse variance weighted method, GERD found to substantially increase lung cancer risk
Recommendations Developed for Treating Hypercalcemia of Malignancy
Authors strongly recommend treatment with denosumab or an intravenous bisphosphonate for adults with HCM
Independence Valued Over Survival for Neuroendocrine Tumor Patients
Adults with neuroendocrine tumors value independence as most important, with most valuing their future versus current quality of life
Guidelines Updated for Reducing Hypoglycemia Risk in Diabetes
Strong recommendations include use of glucagon preparations that do not need reconstitution, real-time CGM for those receiving multiple daily injections
AAP Guidelines Help Detect Invasive Bacterial Infections in Febrile Infants
Clinical practice guidelines can help detect IBI in infants aged 8 to 60 days with high sensitivity but low specificity
Natural Environments May Cut Hospitalization for Patients With Neurodegenerative Diseases
Normalized difference vegetation index negatively associated with hospitalization for Alzheimer disease and related dementia, Parkinson disease
Measles Outbreak in Ohio Infects 82 Children, Most of Them Unvaccinated
All with data available were at least partially unvaccinated, having had no doses or just one dose of the two-shot MMR vaccine
Nurse-Driven Protocol Ups Pneumococcal Vaccination Rates
Findings for pneumococcal vaccine among immunosuppressed rheumatology patients
Over 28,000 ZLINE Gas Ranges Recalled Due to Carbon Monoxide Danger
There have been 44 reports of carbon monoxide emission from customers, including three reports of people needing medical attention
FDA Approves Sunlenca for Treatment-Resistant HIV
Sunlenca is the first capsid inhibitor approved for HIV
U.S. to Require Negative COVID-19 Test For Chinese Visitor Entry
The new rule, set to go into effect on Jan. 5, was created in response to a surge in COVID-19 cases in China
Ransomware Attacks on Health Care Organizations on the Rise
Nearly twofold increase in annual number of attacks seen from 2016 to 2021, exposing information of nearly 42 million patients
Many Thyroid Cancer Survivors Cite Inadequate Pretreatment Understanding
Self-reported failure to have understanding of treatment linked to failure to meet treatment expectations
Costs, Effectiveness of Laparoscopic, Open Gastrectomy Similar
Minimal difference observed in total costs and effectiveness after one year of follow-up
Gastroesophageal Reflux Disease Raises Risk for Periodontitis
Patients with GERD have increased risk in analyses stratified by age, sex, and presence or absence of comorbidities
Molnupiravir Does Not Reduce COVID-19-Related Hospitalization, Death
No reduction in COVID-19-associated hospitalizations or deaths seen among high-risk, vaccinated adults
Opioids Frequently Prescribed to Patients With Cirrhosis
Opiate prescriptions predicted by primary care physician specialty and patient age, gender, race
Black Patients Less Likely to Undergo Minimally Invasive Mitral Valve Surgery
Furthermore, Black patients more likely to experience major complications, death than White patients
Parental Astigmatism Increases Risk for Child Astigmatism
Astigmatism ≥1.0 D in both parents associated with greater odds of refractive and corneal astigmatism in the child
Mediterranean Diet Tied to Fewer Adverse Pregnancy Outcomes
Findings similar across race/ethnicity and prepregnancy body mass index, but stronger in women aged 35 years or older
5α-Reductase Inhibitors Linked to Depression, but Not Dementia
Magnitude of association for finasteride and dutasteride with dementia decreased over time and became nonsignificant
Fewer Symptoms for Mpox Infection Seen After Vaccination
Mpox cases that occurred in vaccinated individuals associated with lower percentage of hospitalization
Diagnostic Accuracy High in Emergency Departments
Only about 5.7 percent of patients receive incorrect diagnosis, with about 2.0 percent suffering adverse events as a result
Congressional Report Slams FDA, Drugmaker Over Approval of Alzheimer Drug Aduhelm
Controversy over Aduhelm stretches back to its June 2021 approval by the U.S. Food and Drug Administration
Few NICUs Regularly Screen for Social Determinants of Health
No hospital-level factors (e.g., region, size) were associated with conducting screening
Social Frailty Linked to Worse Outcomes for Elderly Heart Failure Patients
Social frailty linked to composite of all-cause death, cardiovascular events among elderly hospitalized heart failure patients
Most Older Adults Concerned About Emergency Department Costs
Predictors of emergency department avoidance include lower income, being uninsured, poor or fair mental/physical health, and younger age
Alcohol Abstinence Aids Alcohol-Related Cirrhosis Across Portal Hypertension Stages
Findings seen even among patients who have already progressed to high-risk portal hypertension
COVID-19 Vaccination Bests Natural Immunity for Cutting Death, Hospitalizations
However, natural immunity tied to lower incidence of new infection
Dietary Nitrate Intake Linked to Lower Risk for AMD Progression
Higher dietary nitrate intake linked to reduced risk for progression to late age-related macular degeneration
Autologous Hematopoietic Stem Cell Transplant Slows Disability Progression in MS
Slowing of disability progression and higher likelihood of disability improvement observed compared with standard disease-modifying therapies
Outcomes Worse for Black Patients With Head, Neck Cancer in Clinical Trials
Outcomes worse for Black versus White patients enrolled in clinical trials that minimize access to care, socioeconomic status confounders
Recommendations Updated for Radiation Therapy in Endometrial Cancer
Radiation therapy recommended to reduce risk for vaginal and/or pelvic recurrence; data limited for sequencing radiation therapy and chemo
Expectant Management Noninferior to Ibuprofen for Extreme Preemies With Patent Ductus Arteriosus
Primary outcome event occurred in more infants in the early-ibuprofen group than the expectant-management group
Network Meta-Analysis Compares DOACs to LMWH for Cancer-Linked Thrombosis
Apixaban dominated enoxaparin and edoxaban; rivaroxaban was slightly more effective than apixaban
Artificial Intelligence Rarely Passes Radiologists’ Mock Exams
AI had overall accuracy of 79.5 percent and passed two of 10 mock Royal College of Radiologists exams when excluding noninterpretable images
FDA Updates Guidance on ‘Morning After’ Pill, Making Clear It Does Not Cause Abortions
New revised leaflets now clearly state that Plan B and its kin work 'before release of an egg from the ovary'
Per-Patient Costs of Metastatic Prostate Cancer Estimated at $31,427
Increase in annual attributable costs observed over time, from $28,311 in 2007-2013 to $37,055 in 2014-2017
Prices for Total Joint Arthroplasty Not Linked to Hospital Quality
No association seen between mean negotiated price and TJA complication rate, readmission rate, hospital performance score
Pediatric Mental Health Emergency Visits With Prolonged LOS Up During 2021
Pediatric mental health visits with length of stay >12 and >24 hours accounted for 20.9 and 7.3 percent of all visits
Screening Catches Only One in Seven Cancers
Vast majority of cancers diagnosed due to symptoms or other medical care
Target Recalls More Than 200,000 Weighted Blankets After Two Children Suffocated
Four children have become trapped in the blankets, including a 4-year-old girl and a 6-year-old girl who both died
Factors Linked to Pediatric Mental Health Emergency Revisits Identified
Psychiatric comorbidities, chemical restraint use, public insurance tied to emergency revisits; substance use disorders associated with lower likelihood of revisits
Computer Vision Approach Identifies Posterior Thoracolumbar Hardware
Model performed five-way classification with 79 percent accuracy in 14 seconds on 100 test images
Atopic Dermatitis Raises Subsequent Fracture Risk in Children
Findings show dose-response relationship, with higher risk tied to more severe atopic dermatitis
Acupressure Aids Self-Reported Sleep Disturbances in Cancer Patients
Systematic review finds acupressure better than acupuncture or electroacupuncture
On-Site Genetic Testing for Prostate Cancer Increases Patient Compliance
Implementation of on-site guideline-based genetic testing for prostate cancer patients increased compliance from 33.3 to 98.7 percent
Peritonitis Tied to Cardiovascular Mortality in Peritoneal Dialysis Population
Higher risk seen with increasing peritonitis episodes; risk for cardiovascular mortality lower for those commencing peritoneal dialysis in 2012-2019 versus 2003-2011
Risk for Persistent Postural Perceptual Dizziness Increases With Vestibular Conditions
Vestibular migraine plays key role in precipitating PPPD as a single comorbidity or component of multiple vestibular comorbidities
Bidirectional Association for Ménière Disease, Osteoporosis
Adults with prior history of osteoporosis have increased risk of Ménière disease and those with prior Ménière disease have increased risk of osteoporosis
Rural Hospital Closures Put Strain on Nearby Hospitals
In two years following a rural hospital closure, nearby hospitals see increase in emergency department visits and hospital admissions
Treatment-Resistant Depression Common and Costly
Treatment-resistant depression episodes tied to more psychiatric comorbid conditions, health care utilization, self-harm, and all-cause mortality
Glycemic Control Stagnant in U.S. From 1988 to 2020
Mexican American adults receiving insulin less likely than non-Hispanic Whites to achieve glycemic control
Tough New Labeling Law for Sesame Prompts Companies to Add It to Their Products
New requirements are so strict that it costs less to add sesame to food products than to try to keep it out
Children’s Firearm Injuries Up During the Pandemic
Significant increases seen among children who are Black, very young, and with public insurance
Life Expectancy Down to 76.4 Years in 2021
Age-specific deaths rates increased for all age groups 1 year and over; no significant change seen in infant mortality rates
Weekly Dupilumab Beneficial in Eosinophilic Esophagitis
More patients receiving dupilumab have histologic remission, improvement in Dysphagia Symptom Questionnaire scores
Differences ID’d Between Men, Women With Cluster Headache
Alcohol as trigger occurred more often in men; lack of sleep as trigger more common in women
Patient-Centered Communication Tool Feasible for Seniors With Acute Myeloid Leukemia
Patients, caregivers scored higher on AML knowledge and perceived greater efficacy in communicating with oncologists
Low Serum Vitamin D Tied to Age-Related Loss of Muscle Strength
Findings for both 25-hydroxyvitamin D deficiency and insufficiency
Blacks More Likely to Undergo Emergency Surgery for Colorectal Cancer
Emergency surgery associated with incomplete oncologic evaluation, and increased incidence of postoperative complications, including mortality
Child Homicides Up Across Several Subpopulations
Children ≤10 years often victims perpetrated by parents/caregivers, while children ≥11 years more often perpetrated by friends/acquaintances
Black Race, Male Sex Tied to Use of Pharmacological Restraint in Pediatric Emergency Visits
No significant association observed between average annual emergency department volume and restraint use
Reduced eGFR Linked to Increased Mortality in A-Fib
Moderately-to-severely decreased eGFR had significant effect on all-cause mortality specifically in those with low socioeconomic status
Genetic + Registry Data AI Model May Predict Mental Disorder Diagnosis
Deep learning, multidiagnostic model shows high accuracy before clinical examination
Mindfulness Training, Exercise No Aid for Cognitive Function
No benefit seen for episodic memory or executive function at six or 18 months for older adults
Satisfaction With Physician Relationship Tied to Bariatric Surgery Completion
However, no association seen between racial/ethnic group and patient satisfaction
Single-Tube Multiparametric Flow Cytometry Predicts Treatment Response in Leukemia
Multiparametric flow cytometry has excellent prediction for survival among patients with B-cell acute lymphoblastic leukemia
Endolymphatic Hydrops Volume Down in Ménière Disease With Positive Pressure Therapy
Volume of endolymphatic hydrops decreased with reduction of vertigo attacks during eight months of PPT plus medication; however, volume increased with medication alone
U.S. to Release Flu Meds From National Stockpile to Ease Shortages
Decision comes as the nation suffers from an unusually early and hard flu season, with about 9,300 deaths so far
Bivalent COVID-19 mRNA Booster Effective
Bivalent booster is effective against COVID-19 hospitalization in immunocompetent adults, seniors
Nonphysician Practitioners More Likely to Use Contrast Media for CT
1.55 percent difference in utilization rate for CT contrast media between localities with 10 percent different in NPP evaluation and management share
Smartphone App May Be Beneficial for Some With Bipolar Disorder
Does not reduce risk of relapse overall, but can reduce relapse risk and manic symptom severity for low-risk individuals
2001 to 2021 Saw Decline in Physician Work Hours
However, trend offset by increase in advanced practice professionals weekly work hours
High Coffee Intake Linked to CVD Mortality in Severe Hypertension
No association seen for people with optimal and normal BP, high-normal BP, grade 1 hypertension
Trends in Genitourinary Cancers Examined in the United States
Among non-Hispanic Whites, highest incidence rates seen in Northeast for bladder cancer, Appalachia for kidney cancer
2012 to 2021 Saw Drop in Bicycle-Related Injuries
Increase in rate of injuries seen among elderly adults; head was most commonly affected body part
Review: Probiotics May Relieve Halitosis in Short Term
No significant difference observed in terms of tongue coating scores, plaque index for those receiving probiotics
Aerobic Exercise Tied to Better Sleep, Mental Health in Perimenopausal Women
Higher frequency of practice tied to greater impact on self-reported symptoms
Renal Impairment Linked to Worse Prognosis in IgD Multiple Myeloma
Median survival significantly shorter for patients with renal impairment versus those with no renal impairment
First-Line Regimens With Endocrine Therapy Show Benefits in Breast Cancer
Findings seen among subgroup of patients with human epidermal growth factor receptor 2-positive metastatic breast cancer
Psychological Distress May Be Causal Risk Factor for Dementia
Risk varies by type of distress, but significant relationships seen for exhaustion and stress
Commercial Rates for Breast Reconstruction Vary Significantly
Higher rates seen in less competitive markets and facilities that are large, for-profit, and non-safety net
Late-Onset Meningitis ID’d in 1 Percent of Extreme Preemies
Performance of lumbar puncture has decreased in late-onset sepsis evaluations; 16 percent of late-onset meningitis cases occurred without late-onset sepsis
Combustible Tobacco Use Tied to Adverse Oral Health Outcomes
Electronic nicotine delivery system use tied to gum bleeding
No Change Seen in Limited Access to Mammography From 2006 to 2022
Variation seen in accessibility to mammography by states; in 10 states, more than 26 percent of women aged 45 to 84 years had limited access in 2022
In Face of Tripledemic, CVS and Walgreens Limit Purchases of Pediatric Pain Meds
Medication limits are meant to 'ensure equitable access,' according to a CVS statement
Nursing Care Shortages Likely to Have Predated Pandemic
No evidence that large numbers of nurses left health care or hospital practice during first 18 months of pandemic
FDA Tobacco Unit Overloaded and Lacking Direction, Panel Says
Experts recommend agency leaders set clear objectives and expectations to prevent more 'detrimental’ effects on the agency's work and staff morale
Clinical Report Addresses Screening, Management of Congenital Hypothyroidism
When clinical symptoms and signs of hypothyroidism are present, TSH, free thyroxine should be measured, regardless of screening results
Risk for T2DM Reduced With Higher Daily Step Count
Hazard of incident diabetes reduced by 44 percent in adjusted models comparing average daily step count of 10,700 to 6,000
PET Changes Similar for Alzheimer Disease, Down Syndrome
No difference seen in global PET amyloid burden between asymptomatic with Down syndrome, asymptomatic mutation carriers
Coinfection With Flu, SARS-CoV-2 Described in Children
SARS-CoV-2 coinfection occurred in 6 percent of pediatric influenza-associated hospitalizations
Environmental Risk Factors Linked to Increased Risk for Schizotypy
Cumulative environmental risk score most strongly associated with true schizotypy, followed by affective, introverted schizotypy
HPV Vaccine Refusal Explored Among Cancer Survivors
Most of the cancer survivors who refused participation in a trial of the vaccine did so for vaccine-related concerns
Metformin Use Linked to Lower Risk for Joint Replacement in T2DM
Reduced risk seen for total knee replacement and total hip replacement with metformin use
ASH: Glofitamab Aids Relapsed, Refractory Diffuse Large B-Cell Lymphoma
39 percent of patients had a complete response, with median time to complete response of 42 days
Bacteria From Oral Cavity ID’d in Brain Abscess Without Clear Cause
Brain abscesses where no primary source of infection identified have higher counts of Streptococcus anginosus
Adding Yoga to Aerobic Training Lowers Blood Pressure
BP reduction greater with 15 minutes a day of yoga, five times a week for three months plus 30 minutes of aerobic training, compared with stretching control
Direct-to-Consumer Testosterone Not Offered in Accordance With Guidelines
Most direct-to-consumer platforms offer testosterone therapy despite consumer reporting normal testosterone levels, free testosterone
Overdose Deaths Up in Teens From July to December 2019 to 2021
About 90 and 83.9 percent of overdose deaths involved opioids and illicitly manufactured fentanyls
Left Atrial Reservoir Strain Plus CHA₂DS₂-VASc Ups Stroke Prediction
Addition of left atrial reservoir strain also yields predicted net benefit in people without prior a-fib or stroke
Decision Aid Improves Decision Quality for Seniors With CKD
DART improves decisional quality at three and six months; results decrease thereafter
One in Seven Dual Users Continue Using Both Tobacco Products
However, early electronic cigarette quitters plus stable cigarette use was the most common trajectory in 41.6 percent of participants
FDA Approves Gene Therapy for Tough-to-Treat Bladder Cancer
About 57,000 men and 18,000 women are diagnosed with bladder cancer annually
New Surveillance Case Definition Developed for MIS-C
Four changes included in new case definition, including no required duration of subjective or measured fever
CKD Linked to Greater Neuromuscular Fatigability
Only peak force fatigability, but not peak rate of force development, contributed to fatigue variance
Fecal Microbiota Transplant Does Not Improve Results of Bariatric Surgery
FMT from lean donor does not reduce body weight, improve results of bariatric surgery at six months or one year
Global Inequalities Remain in Cervical Cancer Incidence
Different patterns of age-specific incidence observed between countries with and without well-developed population-based screening and treatment
Fingerprint Images Have Potential for Predicting Schizophrenia
Right thumb network achieved highest level of accuracy from networks based on single fingers at 68 percent
Mobile Devices for Calming May Harm Young Children’s Emotion Regulation
Authors say mobile devices for calming should be avoided in preschool-aged boys, children with higher surgency
Atopic Dermatitis May Be Risk Factor for New-Onset Migraine
Among those with atopic dermatitis, smoking and male sex were significantly associated with higher risk for new-onset migraine
Rheumatoid Arthritis Linked to Peripheral Artery Disease
Authors say systematic inflammation likely contributes to increased incidence of PAD in this population
Drinking Alcohol Not Tied to Migraine Attack Within 24 Hours
Among participants with episodic migraine, the interaction of migraine presence on day 2 with alcohol intake on day 2 not significant
Most Older Adults With COPD Are Doing Well Mentally
Being married, having a confidant associated with better mental health with COPD
HPV Vaccination Rates Increased After ACIP Update for Adults Aged 27 to 45
Immediate increase seen in vaccine administration rate in women; increased slope seen over time postupdate
Not All Pediatric Cases of Type 2 Diabetes Have Obesity
Prevalence of obesity with type 2 diabetes highest in White children and lowest in Asian children
Sublingual Buprenorphine/Naloxone Tied to More Adverse Dental Outcomes
More adverse dental outcomes seen with sublingual buprenorphine/naloxone compared with use of transdermal buprenorphine or oral naltrexone
Lifestyle May Counter Genetic Risk for Thyroid Cancer
Highest risk for thyroid cancer seen among participants with both high genetic risk and unfavorable lifestyle
Artificially Sweetened Drinks May Up Risk for Urinary Incontinence
Higher risk seen among women drinking one or more beverages per day
Men Face Five to Seven Times Higher Rates of Firearm Deaths Than Women
Black men disproportionately impacted by firearm homicide, while White men most impacted by firearm suicide
Prior SARS-CoV-2 Infection Not Linked to Worse Outcomes After Surgery
No association seen with death, major adverse cardiovascular events, rehospitalization following elective major noncardiac surgery
CDC Extends BMI-for-Age Growth Charts to Monitor Severe Obesity in Children, Adolescents
Extended method uses additional data from 1999 to 2016 NHANES, rather than extrapolation; improves characterization of extremely high BMI in children
Restless Leg Syndrome More Common in Psoriasis Patients
Presence of RLS associated with significantly more severe psoriasis and more severe systemic inflammation
Value-Based Outcome Set Developed for Psoriasis
Twelve instruments were selected to measure outcomes in the value-based outcome set, which were reported by patients and providers
Rocatinlimab Effective for Moderate-to-Severe Atopic Dermatitis
Lasting improvement seen for patients receiving anti-OX40 antibody rocatinlimab compared with placebo
Chemosensory Dysfunction Predicts Serologic Response After COVID-19
Altered smell and taste are significant predictors of positive anti-spike IgG response in multivariable models
Psychosocial Stress Tied to Higher Risk for Acute Stroke
Locus of control appears to modify the effect size of work stress on stroke risk
Football Players Face Accelerated Aging
Findings show fewer years free of disease at all ages compared with the general population
Self-Service Vending Machine Provides Harm Reduction Services
Vending machine dispenses naloxone, sharps containers, safer injection/smoking kits, pregnancy tests, HIV tests
HPV Vaccine Coverage in Children Remains Lower Than Prepandemic
However, recovery seen in monthly volume of vaccine doses administered
Recommendations Developed for Lower-Extremity Varicose Veins
Recommendations include duplex ultrasound scanning as diagnostic test of choice; venous intervention over long-term compression stockings
Countering Antivax Misinformation Ups Parents’ Perceptions of HPV Vaccines
These social media messages build positive attitudes, which are tied to intention to vaccinate
Childhood Chronic Conditions Up With Maternal Schizophrenia
Children exposed to maternal schizophrenia have increased risk for mental health and non-mental health conditions
U.S. Deaths Drop in 2022, But Still Higher Than Prepandemic Levels
COVID-19 will remain the third-largest killer for 2022, behind heart disease and cancer, even with the reduced numbers
White House ‘Winter Preparedness Plan’ Revives Free At-Home COVID-19 Test Program
Every household in the country is eligible to receive four free COVID-19 nasal swab testing kits
Biden Administration Calls for Crackdown on Misleading Medicare Ads
New rule would ban ads that have confusing words, imagery, or logos, or that do not specifically mention a health insurance plan by name