Sleep-Disordered Breathing Tied to Insulin Resistance in Pregnancy

In pregnant women with BMI ≥27 kg/m², respiratory event index and oxygen desaturation index linked to HOMA-IR

Vitamin D Supplementation Could Reduce Migraine Headache Attacks

Vitamin D supplementation had no obvious effect on attack duration or headache severity

Severe COVID-19 Outcomes Rare After Primary Vaccination

Risk higher for people who were aged 65 years or older, immunosuppressed, or had at least one of six underlying conditions

Interventions to Promote Physical Activity May Benefit Asthma Patients

Programs to increase physical activity may improve quality of life, but no effect seen on asthma control or asthma medication usage

Responsive Neurostimulation Tolerated in Pediatric Epilepsy

Further study needed to determine long-term efficacy and safety and optimize patient selection

Psychological Distress More Likely in Young Adult Cancer Survivors

AYA cancer survivors with versus without psychological distress have additional medical expenses, office visits, use of meds

Trauma Rates High After Operative Vaginal Delivery in Canada

Rates of maternal trauma higher after forceps than vacuum delivery; rates vary by region

Global Prevalence of Dementia Forecasted for 2050

Number of people with dementia worldwide estimated to increase from 57.4 million in 2019 to 152.8 million in 2050

Effect of Types of Screen Use on Child Mental Health Examined

Different types of screen use during the pandemic associated with distinct mental health symptoms in children according to age group

Incarceration Tied to Lower Life Expectancy in Blacks

Disparities in incarceration may partially explain the lower life expectancy of Blacks, authors say

Parenting Program to Prevent Obesity in Firstborn May Help a Sibling

The effects of a responsive parenting intervention for preventing overweight in firstborn may extend to the next child

COVID-19 Vaccines Significantly Cut MIS-C Risk in Teens

Of 107 children hospitalized with multisystem inflammatory syndrome in children, none were fully vaccinated

10 Percent of U.S. Adults Meet Vegetable Intake Recommendations

12.3 percent meet fruit intake recommendations, ranging from 8.4 to 16.1 percent in West Virginia and Connecticut

Three Bat Exposure-Linked Human Rabies Deaths Reported in Fall 2021

All three patients had recognized direct contact with bat about three to seven weeks before onset of symptoms

Physician’s Briefing Weekly Coronavirus Roundup

Here is what the editors at Physician's Briefing chose as the most important COVID-19 developments for you and your practice for the week of...

White House Finalizes Plan to Send Americans Free COVID-19 Rapid Tests

Administration plans to launch a website where people can request the rapid tests

Prevalence of Suicidal Thoughts, Planning, Attempts Described

Estimated 10.6 million adults reported having had suicidal thoughts in previous year during 2015 to 2019

FDA Shortens Time to Booster After Moderna Vaccine to Five Months

Similar time window for boosters is already in place for people who received the Pfizer/BioNTech vaccine

Adverse Birth Outcomes Tied to ART Unlikely Due to Treatment

Difference in frequency of adverse outcomes small and statistically insignificant for siblings conceived naturally, through ART

Moderna CEO Says Fourth COVID-19 Dose May Be Needed Next Fall

Governments, including the United Kingdom and South Korea, are already ordering the doses in preparation, Bancel said

Link Between Maternal Thyroid Hormone, Offspring Behavior Studied

Link between maternal thyroid hormone trajectories and preschoolers' behavioral development seen for boys but not girls

Supreme Court Hears Arguments on Biden’s Vaccine Mandate for Big Business

Court also hearing arguments on separate vaccine mandate for most heath care workers

Vaccination Seems Less Protective Against Transmission of Delta Variant

Reduction in transmission of SARS-CoV-2 associated with COVID-19 vaccination smaller for delta variant versus alpha variant

Hospitals Are Rationing COVID-19 Pills, Infusions as Cases Rise

Doctors, health systems are in the difficult position of rationing supplies to meet the needs of those in the most dire situations

Midlife CV Conditions, Risk Factors Linked to Cognitive Decline

Most cardiovascular conditions more strongly linked to cognition among women

Heterogeneity Identified in Global Kidney Nutrition Care

Dietitians and nephrologists only communicated sometimes on kidney nutrition care in 60 percent or more of countries

Duloxetine Does Not Alleviate Pain in Chronic Osteoarthritis

No differences seen in WOMAC pain at three or 12 months with duloxetine added to usual care, or in subgroup with symptoms of centralized pain

Cochlear Implants Can Benefit Deaf Children With Autism

Improvement seen in language skills and social engagement

Delayed Cerebral Ischemia Increased for Cannabis Users With aSAH

Independent association seen for cannabis use with DCI in patients with aneurysmal subarachnoid hemorrhage

Members of Biden Transition Team Call for New COVID-19 Plan

Six former advisers published opinion articles Thursday in JAMA detailing what needs to be done now to put a plan in place

CDC Backs FDA Approval of Boosters for Those Aged 12 to 17 Years

In arriving at its decision, the CDC advisory panel pointed to rising COVID-19 hospitalizations among the young

Some At-Home Tests May Miss Omicron in Early Stages of Infection

Study focused on 30 people infected with COVID-19 at five workplaces that experienced likely outbreaks of the omicron variant last month

COVID-19 Vaccination in Pregnancy Not Linked to Preterm Birth, SGA

Risk not increased when results stratified by vaccination in second or third trimester, mRNA COVID-19 vaccine dose

United Kingdom Eases COVID-19 Testing Rules for International Visitors

Change will be welcome news to people who refrained from traveling for fear they would get stranded in a foreign country

Combustion-Related Nitrogen Dioxide Contributes to Pediatric Asthma

An estimated 1.85 million new pediatric asthma cases attributable to nitrogen dioxide globally in 2019

Most of World’s Urban Population Live in Areas With High PM₂.₅

About 86 percent of urban dwellers live in areas that exceed WHO guidelines for annual PM2.5, contributing to >1.8 million deaths

Relatlimab-Nivolumab Ups PFS in Untreated Advanced Melanoma

Combination provides greater benefit than nivolumab alone for progression-free survival in untreated metastatic or unresectable melanoma

Eltrombopag Augments Immunosuppression in Severe Aplastic Anemia

Improvement seen in the rate, rapidity, strength of hematologic response in previously untreated patients with severe aplastic anemia

Cell-Free RNA Profiles in Maternal Blood May Predict Preeclampsia

cfRNA signatures from maternal blood draw may identify women at risk for developing preeclampsia prior to clinical presentation

Inequities Seen in GLP-1 RA Use for Type 2 Diabetes in the U.S.

Asian, Black, Hispanic, and low-income patients less likely to receive treatment with a glucagon-like peptide-1 receptor agonist for T2DM

Pandemic Cut Orthopedic Residency Application Cycle Expenses

Difference attributed to the use of virtual interviews and lack of away rotations

In Utero Hormone Levels May Affect Migraine Risk in Adulthood

Sex differences in migraine prevalence may not be entirely accounted for by genetic factors

Kroger, Walmart Hike Prices on At-Home COVID-19 Tests

Both stores were selling the kits at cost or at a discount but now have raised the prices

Biden Urges Calm During Omicron Surge

Biden also announced that his administration is doubling its order of new Pfizer antiviral pill

Atopic Dermatitis Exacerbations Seen in Premenstrual Period

Worsening reported in eczema area and severity index score, numerical rating scale worst itch, and dermatology life quality index

Hypertension-Related Maternal Mortality Up for Chronic HTN

Maternal mortality rate related to chronic hypertension increased by 9.2 percent annually in the United States from 1979 to 2018

Fewer Teens Meeting Physical Activity Recommendations During Pandemic

Significant disparities by race and socioeconomic status observed

Hearing Loss, Dual Sensory Loss Tied to Higher Mortality

More severe hearing loss or dual sensory loss tied to excess all-cause and cardiovascular mortality

Early Exercise Not Tied to Breast Augmentation Complications

Findings show similar scar quality and higher patient satisfaction and self-reported outcomes with exercise

Antibiotic Choices for Skin, Soft Tissue Infections Vary by Race

Compared with White inpatients, Black inpatients less likely to receive cefazolin, more likely to receive clindamycin for SSTIs

Serious Adverse Effects From COVID-19 Vaccines Reported Rarely

Full vaccination dose, younger age, female sex, and previously having had COVID-19 linked to greater odds of adverse effects

Stage Shift Tied to Decreased Population Mortality in NSCLC

Diagnostic shift from later-stage to earlier-stage disease may have implications for evaluation of treatments and mortality outcomes

Excess Cortisol From Benign Adrenal Tumors Ups Hypertension Risk

Blood pressure, glucose levels should be checked regularly in individuals with mild autonomous cortisol secretion from benign adrenal tumors

Multistage Screening in Early Intervention Setting IDs Autism

Screening associated with significant increase in ASD diagnoses in children, including in Spanish-speaking families

Physicians Lack Knowledge About Responsibilities Under ADA

71.2 percent of the physicians answered incorrectly about who determined reasonable accommodations for patients with disability

Employment of Nurses Decreased Early in COVID-19 Pandemic

Employment rebounded during the course of 2020, apart from nursing homes, where it remained lower in June 2021 than February 2020

CDC Backs Boosters for High-Risk Children Ages 5 to 11 Years

Agency also endorses shorter time between shots

U.S. Hospitals Seeing Record Numbers of Young COVID-19 Patients

At least nine states have reported record numbers of COVID-19-related pediatric hospitalizations

Tailored Strategies Can Up Depression Referrals in Breast Cancer

Tailored strategies for implementation of routine depression screening result in greater proportion of referrals to behavioral care

No Link Found Between Youth Tackle Football, Neurocognitive Issues

However, premorbid attention-deficit/hyperactivity disorder, mental health conditions tied to worse cognitive or behavioral scores

Incident Psychotropic Use Down in Children in Second Quarter of 2020

Greatest decline in incident stimulant and anxiolytic/sedative-hypnotic medications was in quarter 2 of 2020

Birth During COVID-19 Pandemic Impacts Infant Neurodevelopment

However, in utero exposure to maternal SARS-CoV-2 infection is not associated with significant differences in ASQ-3 domains at 6 months

E-Cigarettes Tied to Quitting Among Smokers Not Trying to Quit

Findings seen for both discontinuation overall and discontinuing daily smoking

Low Inflammatory Diet in Early Pregnancy May Cut Risk for GDM

Greater adherence to healthier diet among pregnant women with overweight or obesity linked to lower risk for gestational diabetes mellitus

Major Financial Hardship Prevalent in Metastatic Colorectal Cancer

At 12 months, cumulative incidence of major financial hardship was 71.3 percent, despite insurance cover

Maternal Hormonal Contraception, CNS Tumors Not Linked in Children

No significant association seen for recent or previous maternal hormonal contraception use with CNS tumors in children younger than 20 years

Timing of COVID-19 Vaccination in Pregnancy Examined

Maternal anti-spike IgG levels detectable at delivery regardless of timing of vaccination; levels highest with early third-trimester vaccination

Metabolic Syndrome Ups Odds of ARDS, Death in COVID-19

For each additional metabolic syndrome criterion, risk for ARDS increases in an additive manner

Machine Learning IDs Predictors of Treatment Response in RA

Machine learning integrating clinical and genomic data can predict methotrexate treatment response in early rheumatoid arthritis

Frail Patients With Nonvalvular A-Fib Less Likely to Receive Anticoagulants

Frail patients with nonvalvular atrial fibrillation also less likely to receive a direct oral anticoagulant versus warfarin

AAOS Updates Guideline for Managing Hip Fracture in Seniors

Interdisciplinary care programs recommended to decrease complications and improve outcomes

Hip Fracture Surgery Generally Lower During COVID-19 Pandemic

Apart from fall 2020, hip fracture surgery volumes among older individuals were lower than among historic controls until vaccination

Israel Will Give Fourth COVID-19 Shot to People Older Than 60, Health Workers

About 60 percent of Israel's 9.4 million people are fully vaccinated with either a recent second dose or booster dose

Scientists Spot Clues to Why Omicron Infections Are Milder

More than a dozen research groups have been observing the omicron variant in lab settings using animals this past month

Negative COVID-19 Test May Be Required After Isolation Among Asymptomatic

CDC is considering adding extra safeguard after getting some 'pushback' on its Dec. 27 guidance that shortened isolation times

Packaged Salads Tied to E. Coli Outbreak in Six States

The 13 people known to be infected include four who were hospitalized; no deaths reported so far

FDA Approves Pfizer Booster Shots for Children Ages 12 to 15

Agency also reduced the period people must wait between their second dose and booster shot from six to five months

COVID-19 Omicron Wave in South Africa Characterized

Fewer hospitalizations, reduced severity of illness, lower mortality seen in fourth wave compared with previous waves of COVID-19

Many U.S. Adults Report Pandemic-Related Sleep Disturbances

Top reported sleep disturbances include more trouble falling or staying asleep, poor sleep quality, disturbing dreams

BNT162b2 Still Effective, but Less So, Against Omicron

Vaccine effectiveness 70 percent compared with 93 percent against hospitalization for COVID-19 during delta predominance

Risk Factors for Heart Disease Tied to Patterns on Cardiac MRI

Vascular risk factors associated with radiomics phenotypes on cardiovascular magnetic resonance imaging

AI Model May Aid Screening for Acute Pulmonary Embolism

Deep learning of ECG waveforms and clinical variables used to create fusion algorithm that may predict likelihood of pulmonary embolism

Physician’s Briefing Weekly Coronavirus Roundup

Here is what the editors at Physician's Briefing chose as the most important COVID-19 developments for you and your practice for the week of...

Global Burden of Cancer Increasing

From 2010 to 2019, largest percentage increase in numbers of cases and deaths occurred in low and middle-low SDI quintiles

Adverse Events Rare After BNT162b2 Vaccine in 5- to 11-Year-Olds

Data show 4,249 reports of adverse events after about 8.7 million doses of vaccine were administered; 97.6 percent not serious

Impact of Inadequate Gestational Weight Gain Explored

For overweight, obese women, lower bound of optimal gestational weight gain ranges are higher than existing recommendations

BNT162b2 Vaccine Effectiveness 92 Percent for Teens Ages 12 to 17

Estimated vaccine effectiveness of full Pfizer-BioNTech vaccination 92 percent for preventing SARS-CoV-2 infection

Seniors Report Medical Care Missed During the Pandemic

Rates of forgone medical care because of COVID-19 decreased over time; about 70 percent of forgone care due to physician-driven factors

Severe Illness, Viral Coinfection Common in Children With COVID-19 Hospitalization

Only one of 272 vaccine-eligible pediatric patients hospitalized with COVID-19 was fully vaccinated

Optimal Acetabular Positioning Redefined in Total Hip Arthroplasty

Optimal acetabular positioning differs from historic values, with reduced risk for dislocation with increased anteversion

ATS Issues Guidance for Managing Postprematurity Respiratory Disease

Recommendations address the outpatient management of postprematurity respiratory disease in infants, children, and adolescents

Dolutegravir-Based ART Superior for Children, Teens With HIV

Rate of serious adverse events similar for participants receiving dolutegravir, standard care as first-, second-line treatment for HIV-1 infection

FDA May Allow Pfizer Boosters for 12- to 15-Year-Olds by Monday

Agency also expected to reduce the amount of time adolescents and adults must wait between their second dose of vaccine and booster

Survival Advantage Observed for Second Kidney Transplant

After loss of the first allograft, survival time longer with timely second kidney transplant versus remaining wait-listed and on dialysis

AAN Updates Guideline for Treatment of Painful Diabetic Neuropathy

When patients do not experience meaningful improvement with initial therapeutic class, medication from different class should be offered

Most COVID-19-Related EUAs Not Supported by High-Quality Evidence

Most EUAs were for diagnostic products; most supported by comparisons with previously authorized assays, analytical in vitro studies

Rivaroxaban Improves Clinical Outcomes After COVID-19 Hospitalization

Risk for thrombotic events reduced after 35 days of rivaroxaban compared with no extended thromboprophylaxis

Health Care Workers Had Acceptable Preparedness During First COVID-19 Wave

However, female health care workers had lower preparedness and awareness scores than male counterparts

Primary Care Clinicians Tailor Colorectal Cancer Screening to Patients

One in four primary care clinicians select a stool-based test as their preferred screening option

FDA Says Rapid At-Home COVID-19 Tests Not as Sensitive to Omicron

Agency says that antigen tests 'do detect the omicron variant, but may have reduced sensitivity'

CDC Lowers Estimate of Omicron Prevalence in the United States

Predictions likely to become more accurate as researchers learn more about omicron

Omicron Might Help Shield Against Delta, New Research Suggests

As omicron appears to produce less severe illness than delta, its overall effect might end up having a positive side

Weight Loss Via Surgery Linked to Improved COVID-19 Outcomes

Adults who underwent weight loss surgery between 2004 and 2017 had a reduced risk for severe outcomes

No Effect on Ovarian Reserve Seen After mRNA COVID-19 Vaccination

Mean levels of anti-Müllerian hormone unchanged from baseline to three months after vaccination among reproductive-aged women

Guidance Offered for Managing Pain in Patients With Cancer and OUD

For patients with opioid use disorder taking buprenorphine-naloxone, it is deemed appropriate to continue three times-daily dosing

Dopamine Agonists, DRIs Similar for QoL in Parkinson Disease

No measurable difference in patient-rated quality of life seen for dopamine agonists versus dopamine reuptake inhibitors as adjuvant therapy

Vaccinated Kidney Transplant Recipients Vulnerable to SARS-CoV-2 Variants

After two-dose vaccination, only 64 and 67 percent of kidney transplant recipients showed neutralization against B.1.351 (β) and B.1.617.2 (δ)

High-Altitude Exercise May Up Hypoglycemia Risk With Type 1 Diabetes

Greater decline in blood glucose seen during and after exercise performed under acute hypoxia versus normoxia conditions

Visceral Fat Tied to Arterial Stiffness in Obese Youth

Visceral fat predictive of carotid-femoral pulse wave velocity beyond body mass index and waist circumference

WMS Issues Guidelines on Tickborne Illness in the U.S.

Strong recommendations include the use of tick repellents for the skin (DEET, picaridin) and clothing (permethrin)

Genetic Diagnosis May Aid Management of Pediatric Epilepsy

Establishing a genetic diagnosis for patients with unexplained infantile or childhood-onset epilepsy can help individualize treatment

Delay to Diagnosis of Nonmotor Seizures Longer in Youth

Delays tied to more seizures prior to diagnosis, conversion to motor-type seizures, potentially preventable injuries

Breast Cancer Survival Up With Access to Integrative Therapies

Survival up at institutions in low-mid, mid-high cohorts based on efforts to educate, support, and fund complementary and lifestyle approaches

Homeless Individuals Particularly Vulnerable to Heat Waves

Increased odds of emergency department visits seen among homeless during heat waves

Characteristics of Hospitalized Pregnant Women With Flu ID’d

Likelihood of severe outcomes increased for pregnant women with influenza A H1N1 versus influenza A H3N2

Unclear Labeling Tied to Sesame Food Allergy

Less than half of packaged food products tied to clinical reactions did not declare sesame on the label

Depressive Symptoms Increased Among Seniors During COVID-19

Increase seen in prevalence of clinically significant depressive symptoms accompanied by increased loneliness, worse QoL

Sex Hormone-Binding Globulin May Be Biomarker for CVD Risk in Men

Findings appear to be independent of total testosterone concentrations

Intimate Partner Violence Injury Patterns Differ Between Men, Women

Men more likely to sustain injuries due to cutting, lacerations

POCUS Measure of JVP Predicts Elevated CVP in Heart Failure

Point-of-care ultrasonography assessment of jugular venous pressure height can predict elevated right atrial pressure

As Omicron Spreads, Child Hospitalizations Climb 30 Percent in Past Week

By Dec. 28, country had an average of 260 pediatric COVID-19 hospitalizations each day

High-Fiber Diet May Benefit Melanoma Patients on Immunotherapy

Higher intake of dietary fiber linked to longer progression-free survival in melanoma patients on immune checkpoint blockade

Total Alcohol Intake Not Linked to Ventricular Arrhythmia Risk

Total alcohol intake has U-shaped association with sudden cardiac death; beer, cider, spirits linked to increased risk

CDC Reduces Recommended Isolation Time for People With COVID-19

Agency also released updated emergency guidance for health care facilities, decreasing isolation time after infection with COVID-19

2008 to 2017 Saw Decline in Serious Hearing Loss in U.S. Seniors

Substantial sex differences identified, with 10 percent decrease in hearing loss in women, but 2 percent increase in men

Lower Socioeconomic Status Linked to Incidence of Orofacial Clefts

Receiving assistance under the Special Supplemental Nutrition Program for Women, Infants, and Children associated with cleft palate only

Breakthrough COVID-19 Infection Risk Higher With Immune Dysfunction

Risk for breakthrough infection higher for those with immunocompromising conditions, such as HIV, rheumatoid arthritis, solid organ transplant

U.S. Adults Support Net-Risk Pediatric Research

Most support pediatric research posing minimal risk and research posing greater risk if it has high social value

Cancer Patients With Breakthrough COVID-19 Remain at Risk for Severe Outcomes

No significant difference observed in 30-day mortality for fully vaccinated versus unvaccinated cancer patients with COVID-19

Spesolimab Clears Lesions in Generalized Pustular Psoriasis

In phase 2 trial, spesolimab cleared more lesions than placebo, but it was associated with infections, systemic drug reactions

NVX-CoV2373 Vaccine Protects Against COVID-19

Study conducted in the U.S. and Mexico shows vaccine 90 percent effective overall, 100 percent effective against moderate-to-severe disease

Factors for Nativity-Related Disparities in Preeclampsia May Vary by Race

After adjustment for sociodemographic and cardiovascular risk factors, nativity-related disparities persisted in non-Hispanic Black women

Formaldehyde Exposure at Work Tied to Cognitive Impairment

Longer duration of exposure, higher cumulative exposure over entire working life may increase risk for cognitive impairment

Heart Surgery Patients May Not Need Opioids at Home

Incidence of postdischarge opioid prescriptions low for opioid-naive patients undergoing CABG and/or valve surgery through sternotomy

Decline Seen in Total Opioid MME Per Capita in Last Decade

Greatest decline in MME volume per capita seen among persons aged 46 to 55 years and in metropolitan counties

Intermittent Fasting Shows Weight Loss, Cardiometabolic Benefits

High-quality evidence shows association between alternate-day fasting and moderate reduction in BMI for healthy adults and those with overweight, obesity

COVID-19-Related Alcohol Consumption Will Increase Liver Disease

One-year increase in alcohol consumption to result in 8,000 additional liver disease-related deaths

Omicron Cases Pass U.S. Peak Seen With Delta

However, numbers of hospitalizations have not yet reached those higher levels

More Flights Canceled as Omicron Continues to Hit Flight Crews

Several airlines acknowledge that COVID-19 contributed significantly to recent cancellations

U.S. to Lift Travel Restrictions for Southern African Countries

Omicron variant was identified first in Southern Africa

New Model Predicts Pediatric Pneumonia With Reduced X-Ray Need

Three variables in the model included age, fever duration, and decreased breath sounds

Few Providers Discuss Transportation With Autistic Patients

Only 8 percent of providers say they have adequate knowledge to assess driving readiness among autistic patients

Fiber, FODMOP, Micronutrient Intake Lower in Patients With Active IBD

Individuals with inflammatory bowel disease have lower food-related quality of life

AI Allows Automated Scoring of Psoriasis Area, Severity

Convolutional neural networks have the potential to automatically perform image-based Psoriasis Area and Severity Index scoring

Three Days of Remdesivir Cuts Risk for Severe COVID-19 in Outpatients

Three-day course of treatment results in reduced risk for hospitalization or death compared with placebo

Botox Injections Linked to Lower Incidence of Anxiety Symptoms

Protective effect of BoNT found for different indications, including in cosmetic use/facial muscles, migraine/facial and head muscles

Premature AMI Mortality Declined From 1999 to 2019

Decline slowed since 2011; was higher among large and medium/small metros versus rural counties

Marine ω−3 FAs May Up Risk for Depression in Older Adults

Small increase in risk for depression or clinically relevant depressive symptoms but no difference in mood scores seen with long-term use

Hyaluronic Acid Injection Use Increased for Knee Osteoarthritis in Seniors

Significant increase in utilization and associated costs seen among physicians' assistants and nurse practitioners

Efficacy of Bamlanivimab for COVID-19 May Vary With Antibody Status

Further study needed to determine whether bamlanivimab could benefit patients who are negative for endogenous neutralizing antibodies

Physician’s Briefing Weekly Coronavirus Roundup

Here is what the editors at Physician's Briefing chose as the most important COVID-19 developments for you and your practice for the week of...

Oropharyngeal Cancer Incidence, Mortality Up Among U.S. Men

Geographic differences seen, with notable rises in the Midwest and Southeast

Holidays Complicate Diabetes Management, Patients Report

Half of U.S. adults with diabetes say managing diabetes is more difficult during the holidays versus other times of the year

Women With Disabilities at Higher Risk for Poor Maternal Outcomes

Risk for severe maternal morbidities and maternal mortality higher for pregnant women who have disabilities, regardless of disability type

Percentage of Teens Reporting Drug Use Declined in 2021

Proportion of teens in grades 8, 10, and 12 reporting alcohol, marijuana use decreased significantly

mRNA COVID-19 Vaccine Less Protective in Elderly With Comorbidity

At ≥7 days after second dose, effectiveness of mRNA COVID-19 vaccine was 69 percent against infection, 86 percent against related death

Race/Ethnicity-Linked Differences Seen in Type 1 Diabetes Management

Insulin pump use higher among White versus Black and other Medicare beneficiaries

SAGE Detects Conversion From MCI to Dementia Early

The Self-Administered Gerocognitive Examination detects the conversion from mild cognitive impairment to dementia sooner than the MMSE

FDA Gives OK to Merck Antiviral At-Home COVID-19 Pill

Molnupiravir cut the risk for hospitalization and death in high-risk patients by 30 percent

FDA Approves New Drug to Help Control Severe Asthma

Tezspire is unique in that it only targets thymic stromal lymphopoietin, the molecule involved in airway inflammation

Microplastics in Human Feces Linked to Inflammatory Bowel Disease

Concentration of fecal microplastics higher in individuals with IBD versus healthy participants

13 Million Adults Delaying or Skipping Meds Due to Costs

Drug unaffordability is an issue regardless of insurance status and across private, public payers

Risk for Violence Perpetration Up for People With Schizophrenia

Review and meta-analysis show increased risk for violence perpetration for men and women with schizophrenia spectrum disorders

One-Third of Clinicians Still Offer Endometrial Scratching

Endometrial scratching still might be offered for psychological reasons

Overactive Bladder, Urinary Incontinence Common in Middle-Aged Women

Age and menopause status tied to increased urinary symptoms in women

COVID-19 Certification Mandates May Increase Vaccine Uptake

Country-specific information, such as prior vaccination uptake, vaccine hesitancy may influence the effect of COVID-19 certification mandates

Assisted Reproduction Not Tied to Psychiatric Illness in Offspring

Elevated risk for obsessive-compulsive disorder may be explained by differences in parental characteristics

Prostate Cancer Screening Declined Following 2012 USPSTF Guidance

In addition, rates of metastatic disease increased across all races, but particularly among Black men

ECG-Based Algorithm Predicts Long-Term Survival After Cardiac Surgery

Findings seen among patients with left ventricular ejection fraction >35 percent undergoing valve and/or coronary bypass surgery

High-Dose IV Iron Reduces MI in Patients on Hemodialysis

High-dose versus low-dose intravenous iron reduces myocardial infarctions in patients receiving maintenance hemodialysis

Omicron Now Accounts for 73 Percent of New COVID-19 Cases

Rate suggests there were more than 650,000 omicron infections in the United States last week

FDA Approves Pfizer Pill as First At-Home COVID-19 Treatment

Recent trial showed Paxlovid cut the odds for hospitalization and death by nearly 90 percent in high-risk people

First-Time Gun Owners Less Likely to Be White Men

From January 2019 to April 2021, 7.5 million U.S. adults became new gun owners

Fresh Express Salad Mixes Tied to Multistate Listeria Outbreak

Outbreak has caused 10 illnesses, one hospitalization, and one death

2019 to 2020 Saw 16.8 Percent Increase in U.S. Death Rate

Age-specific death rates increased for each age group 15 years and older; COVID-19 became third leading cause of death in 2020

U.S. Army Reports Progress on COVID-19 Vaccine That Fights All Variants

Animal studies have already shown new vaccine induces highly potent antibody responses against major variants

Public Stigma Toward Depression Decreased From 2006 to 2018

In general, change was inconsistent and sometimes regressive -- for example, for dangerousness for schizophrenia

Subclinical Synovitis May Precede Arthritis in Anti-CCP2+ Individuals

Anti-CCP3 antibodies were predictive for the development of ultrasound synovitis in anti-CCP2+ at-risk individuals

Axicabtagene Ciloleucel Slows Large B-Cell Lymphoma

Event-free survival prolonged with axi-cel versus standard care as second-line therapy for refractory, relapsed disease

Eight in 10 Oncologists See Mental Health Distress in Cancer Patients

Nine in 10 oncologists believe this mental health distress impacts health outcomes

Symptom Presentation Varies by SARS-CoV-2 Variant

During first wave of COVID-19, cough occurred first in the United States, while fever occurred first in China

3D Imaging Technique Aids Diagnosis of Aggressive Prostate Cancer

Proof-of-concept study shows 3D method improves assessment of glandular features over traditional pathology

ASH: Axicabtagene Ciloleucel Slows Large B-Cell Lymphoma

Event-free survival prolonged with axi-cel versus standard care as second-line therapy for refractory, relapsed disease

Radiation, Medical Oncology Faculty Lag in Diversity

Sex and racial and ethnic diversity increased a little over time but has not kept pace with the U.S. population

FDA Approves First-in-Class Treatment for Myasthenia Gravis

Vyvgart is the first neonatal Fc receptor blocker to be approved to treat generalized myasthenia gravis in patients testing positive for AChR antibody

Biogen Cuts Price of Controversial Aduhelm in Half

Drug shows promise in clearing brain plaques believed to play a role in Alzheimer disease

Serum Biomarkers Can Differentiate Psoriatic Arthritis, RA

Panel of serum protein biomarkers identified and evaluated for potential use in diagnostic testing for early-onset psoriatic arthritis

First Long-Acting Injectable Approved for HIV PrEP

Apretude, administered every two months, is approved in adults and adolescents at risk for HIV infection

Biden Outlines Measures to Fight Omicron, Pleads With Americans to Get Vaccinated

Included in the battle plan announced Tuesday are measures to distribute 500 million free rapid COVID-19 tests to the public

Factors ID’d for Severe GI Effects of SARS-CoV-2 in Children

Among children infected with SARS-CoV-2, 9.5 percent have severe GI effects, such as disseminated adenomesenteritis, appendicitis, pancreatitis

48 COVID-19 Cases Reported on World’s Largest Cruise Ship

Royal Caribbean said that those who tested positive were immediately isolated to prevent the spread of infection

Molnupiravir Cuts Risk for Severe COVID-19 Illness in Adults

Risk for hospitalization or death lower in at-risk adults with mild-to-moderate COVID-19 receiving oral therapy with molnupiravir versus placebo

Pediatricians Can Play Key Role in HIV Testing, Prophylaxis

All youth ages 15 years or older should be offered routine screening at least once; those at increased risk should be rescreened

Many Believe Dietary Supplements Cut Risk for Cancer Recurrence

Among adults diagnosed with breast, prostate, or colorectal cancer, 40 percent report using dietary supplements

Symptom Relief Cited for Cannabis Use During Pregnancy

Reasons reported for cannabis use similar for prepregnancy and lactation periods with emphasis on symptom management during pregnancy

Pandemic Worsened Mental Health, Social Risk in Minority Children

Depression/anxiety problems increased for urban, racial- and ethnic-minority children during versus six months before the pandemic

Opioid Rx Up, Non-Rx Therapy Down During the Pandemic

Nonpharmacologic therapy decreased, opioid prescribing increased for patients seeking treatment for pain management in 2020 versus 2019

Black Patients Not Represented in Breast Reconstruction Images Online

Lack of representation in social media photo postings may contribute to fewer Black patients seeking reconstructive surgery after mastectomy

Test-to-Stay Strategy Seems Effective for Saving In-Person Learning

Studies show secondary attack rate of 1.5 percent in Lake County, Illinois; no tertiary transmission in 20 identified outbreaks in Los Angeles