Discontinuing Long-Term Opioids Tied to Overdose Risk

Tapering cuts risk for overdose among those with opioid use disorder

RSNA: Overweight Tied to Worse Brain Health in Preteens

Findings include worse brain white matter microstructural integrity, reduced cortical grey matter thickness, and decreased functional connectivity

RSNA: 20-Year Survival Shows Lung Cancer Screening Effective

Furthermore, consistency of lung cancer may be an important predictor of survival

Benefits of RT After Breast-Conserving Surgery Only Seen Within 10 Years

Findings seen at 30-year follow-up of patients who underwent breast-conserving surgery, systemic therapy for early-stage breast cancer

JYNNEOS Vaccination Provides Protection Against Mpox

Mpox incidence was 9.6 times as high among unvaccinated persons than among those who had received two vaccine doses

~10 Percent of Deaths Among Ever-Employed Linked to COPD in 2020

Industries with highest proportionate mortality ratios were mining, accommodation and food services, construction

Most Common Adverse Events With JYNNEOS Are Nonserious

Serious adverse events are rare in adults, and none have been identified among persons aged younger than 18 years

FDA Approves Bivalent COVID-19 Boosters for Children 6 Months and Older

Updated boosters protect against both the original strain of COVID-19 and highly contagious omicron variants

LASIK Should Carry Warnings of Possible Complications, FDA Says

New guidance says complications can include dry eyes, double vision, difficulty with night driving, chronic eye pain

MRI-Targeted Biopsy Beneficial for Men With Elevated PSA

Fewer men in experimental group received diagnosis of clinically insignificant prostate cancer

Tumor-Infiltrating Lymphocytes Up PFS in Advanced Melanoma

Significantly longer progression-free survival seen with infusion of tumor-infiltrating lymphocytes versus ipilimumab

Supplementation of Some Micronutrients May Improve CVD Outcomes

n-3 fatty acid supplementation may reduce CVD mortality, myocardial infarction, coronary heart disease events

RSNA: Deductible Payments May Discourage Breast Imaging

Deductible payments discouraged women from returning for diagnostic workup of abnormal screening results, caused them to skip screening

Perianal Disease, Stricturing or Penetrating Behavior Tied to Crohn Disease Outcomes

Findings in Brazil similar to those in countries with a high prevalence of Crohn disease

Faster Cognitive Decline Seen With Eating More Ultraprocessed Foods

Faster rates of global cognitive decline, executive function decline observed for those with ultraprocessed food consumption above first quartile

Cost of Parking at Cancer Center Adds to Patient Financial Burden

Significant positive association seen between daily cost of parking and cost of living in city and for cancer center address transit score

Exposure to Occupational Inhalable Agents Could Increase RA Risk

Markedly elevated risk seen for ACPA-positive RA with exposure to any occupational inhalable agents, smoking, high genetic risk score

Lifestyle Modification Can Reduce Proportion of IBD Burden

A considerable proportion of ulcerative colitis, Crohn disease cases could be prevented by adherence to low modifiable risk score, healthy lifestyle

Risk Factors for Sleep-Related Suffocation, Infant Death Identified

Adjusted odds highest for sleep-related suffocation, unexplained infant death for infants not sharing room with mother, caregiver

Educational Intervention Increases Use of Pulse Oximeter Ear Probes

Educational intervention and making ear probes available in critical care setting increases compliance with manufacturer guidelines

More Frequent Scans Not Linked to Improved Survival After Lung Cancer Surgery

More frequent surveillance not linked to longer recurrence-free, overall survival in pathologic stage I non-small cell lung cancer

Intervention Delivered Via Web-Based Platform Ups BP Control

Rate of BP control significantly higher after 12 months of multicomponent intervention, with reduction in SBP of −10.1 mmHg

Statin Use Linked to Reduced Risk for Intracerebral Hemorrhage

Risk reduced for lobar and nonlobar intracerebral hemorrhage; greater reductions seen with prolonged use ≥5 years

COVID-19 Vaccine Prevents Against Reinfection

Findings show protection for all variant periods

FDA Food Safety Program Needs a Revamp: Panel

Program needs an overhaul with greater attention paid to strong leadership and a more proactive culture

Paxlovid Soon Will Not Be Free for Americans

At this point, about 6 million Americans have taken free Paxlovid doses

SGLT-2i Use Before COVID-19 May Reduce Adverse Outcomes in Diabetes Patients

SGLT-2is associated with lowest probability for adverse outcomes followed by glucagon-like peptide-1 receptor agonists, metformin

2019 to 2020 Saw Drop in Number, Rate of Twin Births

Number of twin births declined 7 percent compared with 3 percent decline in singleton births

Persistent Pain in Seniors Linked to Decline in Physical Function

However, those with persistent pain were no more likely to experience cognitive decline

Healthier Diets Cut ASCVD Risk by 10 Percent in Eight Weeks

Results similar for DASH or fruit and vegetable diets versus typical American diet

Minority Children Less Likely to Have Surgery Than White Children

Authors hope findings will reduce disparities in surgical access for minority children and raise awareness among clinicians

Three-Year Interval Feasible for Stool-Based CRC Screening in Low-Risk People

At three years, test identified more advanced precancerous lesions than expected

Fewer Postpartum Visits Occurred During Pandemic

Largest declines seen among Black individuals, young people, and those without insurance

Online Heart Transplant Resources Overly Complex

Resources require high literacy levels and often lack translation to other languages

Team Care With Clinical Decision Support System Beneficial for T2DM Patients

Significantly greater decreases seen in HbA1c levels, LDL-C levels, and systolic BP for team-based care with versus without CDSS

Dapagliflozin Reduces Hospitalizations Among Patients With CKD

Reduction seen in rate of admissions due to cardiac disorders, renal and urinary disorders, metabolism and nutrition disorders, neoplasms

Increase in Overdose Mortality Greater Among the Pregnant in 2020

Overdose mortality increased about 81 percent from 2017 to 2020 among pregnant and postpartum women

Study Explores Impact of FDA Approval of Aducanumab on Trial Participation

Individuals who were independently aware of the FDA decision demonstrated reduced willingness to participate

Educational Attainment No Worse for Children With T1DM

Children in most optimal HbA1c quintile had substantially better educational attainment, while those in least optimal quintile had worse attainment

Facial Scars Do Not Affect Perceived Attractiveness, Confidence

However, scar located on lower lid mid subunit perpendicular to facial tension lines was rated as less attractive

More States Are Allowing Pharmacists to Prescribe Birth Control

Easier access to birth control helps women who live far from a health care provider or have difficulty obtaining appointments

Bromocriptine Quick Release Beneficial for Teens With T1DM

Improvements seen in blood pressure and central and peripheral aortic stiffness and pressure hemodynamics in teens with type 1 diabetes

Review Links Hearing Aid Devices With Reduced Cognitive Decline

Furthermore, use of devices linked to 3 percent improvement in cognitive test scores in the short term

2013 to 2017 Saw Significant Drop in U.S. Melanoma Mortality Rates

Significant reduction seen in mortality rate from 2013 to 2017, after the introduction of new treatments in 2011 (most after 2013)

Cryoablation More Effective for Some Early-Stage Renal Cell Carcinomas

Increased cancer-specific mortality seen with heat-based thermal ablation versus cryoablation for tumor size 3.1 to 4 cm

Legalization of Medical Marijuana Beneficial for Cancer Patients

Reduction seen in rate of one or more opioid days and in the rate of one or more pain-related hospital events

Bevacizumab, Aflibercept Compared for Neovascular AMD

At the end of one year, likelihood of being weaned off treatment was higher for eyes treated with aflibercept versus bevacizumab

CVD Risk Increased for Adolescent, Young Adult Cancer Survivors

Odds are disproportionately increased with annual household income <$50,000; are reduced with performance of MVPA

Race, Ethnicity Not Linked to Timely Treatment of Peripartum HTN

However, Black, Asian, Hispanic women all more likely than White women to experience severe hypertension requiring treatment

Poor Sleep Tied to Urinary, Prostate Symptoms

Association especially strong among the elderly male population

Dynamically Updating Models Can Improve Prediction of COVID-19 Survival

Drift in model calibration performance was detected immediately, with minor fluctuations in discrimination

HIV Care Services Resilient During COVID-19 Pandemic

Decrease seen in HIV tests performed, persons prescribed PrEP, HIV diagnoses in quarter 2 of 2020, but partial rebound observed in Q3

41.6 Percent of Adults Have Serology Indicative of Past COVID-19 Infection

25.5 percent of those whose serology indicated past infection reported not having been vaccinated, with higher rates seen in young, Black adults

Feds Urge Vaccination as ‘Tripledemic’ Hits More Americans

Vaccination will be key to keeping patients healthy through the winter holidays

Pfizer Asks FDA to Approve Tweaked COVID-19 Booster as Third Shot for Under 5s

Though children aged 5 years and older and adults need only two doses to complete a primary series, younger children need three doses

Bacteria Risk Spurs Recall of 8 Million Laundress Products

Eleven customers have reported Pseudomonas infections; company investigating possible connection to the recalled products

FDA: No Useful Monoclonal Antibody Treatments Left Against New COVID-19 Variants

Immunocompromised patients can still receive convalescent plasma

United States to End Mpox Public Health Emergency in January

More than 29,000 Americans contracted the virus and 17 died during an outbreak that started earlier this year

Study Looks at Extent of Residual Lung Abnormalities After COVID-19 Hospitalization

Posthospitalization prevalence of residual lung abnormalities estimated at 11.7 percent in sensitivity analyses

Prevalence of Methamphetamine-Related Heart Failure Increasing

MethHF linked to significant morbidity, including worse heart failure symptoms compared with non-methamphetamine-related heart failure

Supraphysiological Oxygen During Surgery Linked to Organ Damage

Odds of acute kidney injury, myocardial injury, lung injury increased for those exposed to supraphysiological oxygen

RSNA: New AI Algorithm Predicts 10-Year Cardiovascular Risk From Chest X-Ray

Performance similar to the standard atherosclerotic cardiovascular disease risk score

PTSD, Psychiatric Disorders Tied to Higher Risk for Severe COVID-19 Outcomes

Findings seen even when accounting for sociodemographic factors, comorbidities, and smoking

Personalized Counseling May Overcome Non-Follow-Up After Positive FIT Test

Lack of knowledge, decision-making difficulties among factors identified with non-follow-up

No Significant Association Found for ADHD Meds, CVD Risk

Meta-analysis shows no significant associations for children, adolescents, or adults, for female patients, or for those with preexisting CVD

Sleeve Gastrectomy Compared to Gastric Bypass for Teens With Obesity

Sleeve gastrectomy tied to lower health care utilization, but five-year death, complications, reoperation, revision similar to gastric bypass

Risk for Breast Cancer Up for Women With Benign Breast Disease

Excess risk for breast cancer remains elevated through 20 years for women with benign breast disease on screening

Cannabis Use Among Pregnant Women More Likely With Legalization

Smoking cannabis during pregnancy fourfold more likely under medical and adult-use legalization frameworks

Herpes Zoster Linked to Increased Risk for Cardiovascular Disease Events

Long-term risks for stroke and coronary heart disease increased for individuals with history of herpes zoster versus those with no history of herpes zoster

Outcomes Examined for Cannabis Users After Lower-Extremity Bypass

Cannabis use linked to reduced graft patency, increased amputation, and increased opioid use after lower-extremity bypass

Preexisting Type 2 Diabetes Tied to Later Stage of Cancer Diagnosis

Increased risk seen for nonscreenable cancers

988 Mental Health Hotline Back in Business After Daylong Outage

Hotline started in July with mental health counselors working around the country and has answered about 8,000 calls a day since then

More Biosimilars Marketed in Germany, Switzerland Than U.S.

Monthly treatment costs of biosimilars were higher in the United States than corresponding costs in Germany, Switzerland

Predictors of Diabetes in Chronic Pancreatitis Identified

Type 2 diabetes risk factors were predominant for diabetes occurring before chronic pancreatitis

Environmental Sustainability Not Prioritized in Dialysis Facilities

Few facilities report having environmental sustainability strategy in place or undertaking sustainability audits

Airway Inflammation, Emphysema More Common in Marijuana Smokers

In age-matched analysis, marijuana smokers had higher rates of bronchial thickening, bronchiectasis, mucoid impaction than tobacco-only smokers

Impaired Glucose Homeostasis Seen With Exposure to Artificial Light at Night

Prevalence ratio of 1.28 found for diabetes with highest versus the lowest quintile of exposure to light at night

Vaginal Birth After C-Section Tied to Later Pelvic Floor Surgery

Heightened risk seen particularly for surgery for pelvic organ prolapse and urinary incontinence

Lecanemab Reduced Markers of Amyloid in Early Alzheimer Disease

Moderately less decline seen in cognition and function at 18 months with lecanemab versus placebo

Fewer Parents Talking to Child’s Regular Provider About Vaccines

Conversations less often about flu or COVID-19 vaccines versus school-required vaccines

On World AIDS Day, White House Announces Plan to End Epidemic by 2030

Global goals include reaching UNAIDS targets for reducing new infections and reaching targets for all age, gender, and population groups

First FDA-Approved Fecal-Based Treatment Helps Fight C. difficile

Rebyota is prepared from human stool donated by qualified individuals

FDA Moves to Ease Restrictions on Gay Men Giving Blood

Administration says it expects to issue updated draft guidance in the coming months

CDC Will Test New Areas for Polio in Wastewater

Agency says information could be used to target vaccination efforts and rapidly increase coverage if needed

Awareness of the Link Between Alcohol, Cancer Is Low

Adjusted predicted probabilities of being aware of alcohol-cancer link higher for those believing alcohol increases heart disease risk

Nutritional Supplements May Have Role in Hair Loss Treatment

Potential benefit seen for multiple supplements, including omegas 3 and 6 with antioxidants, zinc, pumpkin seed oil

Deferiprone Not Beneficial for Newly Diagnosed Parkinson Disease

Greater decrease seen in nigrostriatal iron content with deferiprone, but more patients have symptom progression leading to initiation of dopaminergic therapy

Subjective Cognitive Decline Tied to Incident Dementia in Black, Latinx Individuals

SCD associated with increased rates of incident dementia over time in multiracial population, Latinx, non-Latinx Black individuals

Buprenorphine Use in Pregnancy May Reduce Risk for Adverse Neonatal Outcomes

Risk for preterm birth, small size for gestational age, low birth weight lower for those receiving buprenorphine versus methadone

RSNA: Corticosteroid Injections Appear to Worsen Knee Osteoarthritis

Corticosteroids linked to progression of knee OA based on whole-organ magnetic resonance imaging scores, KL grade

Six Additional Weeks of Rivaroxaban Reduces Recurrent VTE

Risk for recurrent venous thromboembolism reduced for patients with isolated distal DVT receiving six additional weeks of rivaroxaban

Benzodiazepine Exposure in Pregnancy Does Not Up Risk for ADHD, Autism

No significantly increased risk seen for ADHD or ASD with exposure to benzodiazepines during first, second, third trimester

Extended-Release Morphine Does Not Reduce Breathlessness in COPD

One week of extended-release morphine does not significantly reduce the intensity of worst breathlessness

Causal Effect Observed for Diastolic Blood Pressure on Neuroticism

No significant causal effects were identified for other blood pressure traits with psychological states

RSNA: Lasting Benefit Seen for Hydrodissection in Carpal Tunnel Syndrome

Improvement in mean Boston Carpal Tunnel Questionnaire persisted at weeks 12 and 24; lasting reduction seen in median nerve cross-sectional area

Clinician Nudge Ups Initiation of Statin Prescribing in Primary Care

Clinician nudge alone or in combination with a patient nudge increases initiation of statin prescribing versus usual care

Overactive Bladder Common in Postacute COVID-19 Syndrome

COVID-19 may lead to new or worsening urinary symptoms in men and women

2000 to 2020 Saw Increase in Drug Overdose Death Rates in Seniors

For men aged 65 to 74 and 75 years or older, drug overdose death rates were higher for non-Hispanic Black men

Skills-Training Program Beneficial for Teen Drivers With ADHD

Program reduces frequency of long glances and lessens variation in lane position compared with control program

Use of New-to-Market Neurologic Medications Reported to Be Low

Use of most new-to-market meds was <20 percent; costs for these medications were substantially larger

Temporal Improvement Seen in Standard of Care for Hospitalized COVID-19 Patients

Outcomes improved from Adaptive COVID-19 Treatment Trial-2 to ACTT-3, although potential explanatory factors were similar

Quality Improvement Collaborative Improving Cancer Screening Postpandemic

National Return-to-Screening collaborative linked to improvements in cancer screening compared with prepandemic, pandemic periods

Convection-Enhanced Delivery of Topotecan Active in Glioblastoma

Catheter pump system capable of CED of topotecan well tolerated and active in recurrent glioblastoma

Increase Seen in Years of Life Lost Per COVID-19 Death in 2021

YLL increased 35.7 percent per COVID-19 death in 2021 versus 2020 as median age of COVID-19 deaths decreased

Coping Strategies Linked to Distress, QOL in Caregivers of Stem Cell Recipients

Caregivers with approach-oriented coping strategy have less anxiety and depression symptoms, better quality of life

Second Death in Trial of Experimental Alzheimer Drug Raising Concerns

Doctors suspect that by stripping away amyloid deposits, lecanemab weakens blood vessels and leaves them vulnerable to bleeds

Medical Masks Similar to N95 Respirators for Preventing COVID-19

No significant difference seen with medical masks versus N95 respirators for health care personnel providing care to COVID-19 patients

Lower Frequency of Adding Salt to Food Linked to Lower CVD Risk

Lowest CVD risk seen for those who combined a DASH-style diet with lowest frequency of adding salt to food

Risk of Uterine Diseases, Cancers Up With Tamoxifen Treatment

After adjustment for confounding variables, risk of endometrial cancer was increased almost fourfold with tamoxifen treatment

Mean Length of Preclinical Detectable Phase of Glaucoma >10 Years

Mean length was 10.7 years by the prevalence/incidence method and 10.1 years by the Markov chain Monte Carlo model method

Cerebral Palsy Risk Up With Exposure to Maternal Unintentional Injury In Utero

Higher risk of cerebral palsy in offspring seen for severe injuries that resulted in hospitalization, delivery within one week from injury

Combination Treatment Beneficial in Albuminuric CKD

7.4 year gain in event-free survival for 50-year-old patients with combo therapy with ACEi/ARB and SGLT2 inhibitors

Melanoma Diagnosis Linked to Increased Risk of Prostate Cancer

More than twofold increased risk of prostate cancer seen for men with first melanoma diagnosed 10 to 15 years before study recruitment

Antidepressants Have Small Benefit for Pain, Function in OA

However, total adverse events occur more often in patients receiving antidepressants versus placebo

Geographic Distribution of Dimorphic Mycoses Expanding in U.S.

Diagnosis and testing should be considered in patients with suggestive illness in regions that are hyperendemic for dimorphic mycoses

Left Digit Bias Seen in Acceptance of Organs for Donation

5.4 percent decrease seen in probability of any organ placement at age 70 versus 69 years

More Than One-Quarter of U.S. Adults Have Heard of MyPlate

During 2017 to March 2020, only 8.3 percent of U.S. adults had tried to follow the recommendations of MyPlate

Demographic Disparities Seen in Firearm Fatality Rates

Maximum rates of firearm homicides higher among non-Hispanic Black and Hispanic versus White men

Lead Toxin Concerns Spur Recall of Toddler Sippy Cups

Portion of cup that contains lead was not tested in a safety lab because it was not meant to be exposed under normal use

New COVID-19 Variant XBB Gaining Ground Among Americans

New omicron subvariant is taking hold in the United States, health officials say, though it does not look more severe than its predecessors

Monkeypox Renamed Mpox Amid Racism Concerns

Virus has been called monkeypox since 1958, when it was first observed in Denmark in research monkeys

Clinical Report Addresses Need for POCUS Guidelines for NICU

Hospital-wide POCUS committee should be established, have oversight responsibilities for implementation and QA of POCUS program

FDA Approves First Gene Therapy for Adults With Hemophilia B

Benefits include decreased need for routine factor IX replacement prophylaxis and reduction in annualized bleeding rate

QOL Up With Pembrolizumab Versus Ipilimumab, HDI in Resected Melanoma

Quality of life favored the pembrolizumab arm versus standard-of-care arm receiving ipilimumab, high-dose interferon α 2b

Vitamin D Supplementation Does Not Influence Growth in Children

No influence seen on height for age, BMI for age, waist-to-height ratio, percentage body fat, fat mass, fat-free mass, or Tanner scores

Asthma Exacerbations Up After Relaxation of COVID-19 Restrictions

Relaxation of restrictions coincided with increasing incidence of COVID-19, non-COVID-19 ARI, severe asthma exacerbations

Cervical Cancer Incidence Up Among Women Ages 30 to 34 Years

Findings similar across most races and cancer stages from 2012 to 2019

Benzodiazepines Tied to Drug Overdose in Young People With Sleep Disorders

Findings even stronger for young people with a recent opioid prescription

E-Cigarettes, Vaping Tied to Higher Cavity Risk

Authors say dental-medical history should include e-cigarette, vaping use

Robotic Resection Cuts Perioperative Morbidity With Liver Cancer

Overall survival and cumulative incidence of death related to tumor recurrence similar to open resection

Conceiving Within Three Months of Pregnancy Loss Safe

Risk for adverse pregnancy outcomes not increased for those conceiving within three months after miscarriage, induced abortion

Studies Compare Various Treatments for COVID-19

Sotrovimab effective compared with molnupiravir; second study shows no effect for angiotensin receptor blockers in terms of illness severity

High Sugar Consumption Affects Aging in Childhood Cancer Survivors

Risk for aging-related health conditions increased with consumption of more total sugar, added sugar, and sugar-sweetened beverages

Higher Carotid Plaque Burden Seen With Persistent Asthma

Persistent asthma linked to carotid plaque, total plaque score, even after adjustment for baseline interleukin-6, CRP

Changes in Metabolic Syndrome Linked to Alteration in Risk for Gout

Among young male adults, those with MetS at three health checkups had nearly fourfold increased risk for incident gout

Five-Year Relative Survival 59.6 Percent in Lower-Risk Myelodysplastic Syndromes

Five-year overall survival 47.3 percent in patients with lower-risk myelodysplastic syndromes

Acupuncture Helps Alleviate Back/Pelvic Pain During Pregnancy

Researchers find acupuncture has no observable severe adverse influences on newborns

Bariatric Surgery Cuts CVD Risk in Patients With Obesity, NAFLD

Findings seen versus nonsurgical care among individuals with severe obesity and nonalcoholic fatty liver disease

Morning Exercise Tied to Larger Cuts in Cardiovascular Disease Risk

Physical activity in the morning reduces risk for CVD, regardless of total activity level; findings more evident in women

Flu Shots Cut Some Cardiac Complications in Patients With Heart Failure

Less pneumonia, fewer cardiovascular events, deaths, hospitalizations seen during peak flu season

Adherence to Quality Indicators Low in Chronic Myeloid Leukemia

Compliance with diagnostic and therapeutic indicators was 83 and 78 percent, while compliance with monitoring indicators was lower

ACR: Genicular Nerve Block Offers Short-Term Pain Relief for Knee OA

Improvements seen in pain scores for patients receiving genicular nerve block at two, four, eight, and 12 weeks

Serum 25(OH)D Levels Linked to Diabetes in African-Americans

Risk for diabetes lower with higher 25(OH)D in Jackson Heart Study and Multi-Ethnic Study of Atherosclerosis

Oncogenic Variants Identified in ~10 Percent With Appendix Cancer

Mutations identified in MUTYH, in the MLH1 gene, and in other cancer predisposition genes

Education Interacts With Genetic Variants to Increase Myopia Risk

Genotype by education interaction identified for five genetic variants, with increased effect for university-level education

USPSTF Recommends Screening for Latent TB Infection

Task force recommends screening asymptomatic adults at increased risk for latent TB infection

Flavonol Intake Linked to Slower Decline in Global Cognition

Beneficial associations seen for dietary intakes of total flavonols and several flavonol constituents

Decrease Noted in Lung Cancer Cases Over Past Five Years

However, screening of high-risk individuals for lung cancer is still low at 5.8 percent nationally

Outreach Messages Up Well-Child Visits, Vaccination Completion

Rates of scheduling and completion of well-child visits increased regardless of whether messages were standard or tailored

Adults Lack Knowledge About Signs of Pancreatic Cancer

Pancreatic Cancer Action Network survey revealed knowledge gaps exist across ages, genders

7.7 Million Deaths Associated With 33 Bacterial Pathogens in 2019

Deaths associated with these pathogens comprised 13.6 percent of all global deaths, 56.2 percent of all sepsis-related deaths

Cognitive Scores Lower for Children With Iron Deficiency

Cognitive scores were lower in iron-deficient children after intervention, despite improvement in serum ferritin

Low HDL-C Linked to Coronary Heart Disease Risk in White Adults

High HDL-C is not protective against coronary heart disease in either White or Black adults

Significant Treatment Attrition Rate Seen in Multiple Myeloma

In patients receiving autologous stem cell transplant, 57.6 percent advanced to second-line treatment, 32.6 percent to third-line

Measuring Vertebral Arteries Can Clarify Pathology of Transient Vascular Vertigo

Different results of MV ratio and cVEMP seen between TVV cases with and without central nervous system symptoms

Isolated Nail Psoriasis Does Not Increase Risk for Metabolic Syndrome

Both metabolic syndrome components and related medical conditions seen at similar rates between patients with, without isolated nail psoriasis

Treatment Without ADT Delays Initiation of Systemic Therapy in Prostate Cancer

Metastasis-directed therapy can delay initiation of systemic therapy in patients with solitary oligorecurrent metastatic lesion

Thermal Images Differentiate Healed From Unhealed Wounds

Thermal images taken in home settings at week 0 can discriminate healed from unhealed leg venous ulcer wounds

More Than 12 Percent Develop De Novo Postpartum Hypertension

Risk for developing dn-PPHTN was increased for those aged 35 years or older, with caesarean delivery, for current or former smokers

MRI-Guided Focused Ultrasound Thalamotomy Aids Essential Tremor Over Five Years

Overall improvement in quality-of-life measures sustained, without any progressive or delayed complications

Disparities Seen in Treatment of Middle Ear Infections in U.S. Children

Socially disadvantaged children less likely to receive treatment for recurrent or suppurative otitis media

Youth Suicides Up With Shortage of Mental Health Professionals

Mental health workforce shortage linked to increased suicide rate and increased youth firearm suicide rate

PRIORIX, M-M-R II Vaccines Interchangeable for MMR

Either PRIORIX or M-M-R II may be administered in any situation in which MMR vaccine is indicated

Many With Psychosis Have Long-Term Functional Morbidity

Researchers found that few individuals with psychotic disorders have participated in vocational training

Most Pivotal Trials of New Drugs Recruit From Low-, Middle-Income Countries

Percentage of participants recruited from low-, middle-income countries was 8, 36, and 17 percent for cancer, cardiovascular, neurology trials

Vitamin D Supplements Do Not Reduce Asthma Exacerbations Overall

Supplements reduce risk among children with low serum 25(OH)D and have beneficial effects in children with atopic dermatitis, allergic rhinitis

ACR: Opioids Raise Risk for VTE in Patients With Rheumatoid Arthritis

However, opioids and NSAIDs carry similar cardiovascular, mortality risks for RA patients

CDC: Flu Has Started Early and With a Punch

United States has already seen 38,000 hospitalizations for flu; hospitals also treating high numbers of patients with RSV and COVID-19

Study Explores Weight Terminology That Youth Prefer, Dislike

Differences in youth preferences and emotional reactions seen across sex, sexual orientation, race/ethnicity, and weight status

Treatment-Related Adverse Events of Antibody Drug Conjugates Identified

Overall incidence of treatment-related adverse events was 91.2 percent and included lymphopenia, nausea, neutropenia

Guidance Provided for Identifying, Managing CP in Primary Care

A patient- and family-centered care team should be established by engaging pediatricians with the family and specialists

ACR: Long-Term Safety Demonstrated for Anifrolumab in Lupus

Exposure-adjusted incidence rates of serious adverse events 8.5 versus 11.2 per 100 patient-years for anifrolumab versus placebo

ACR: Low-Dose Hydroxychloroquine Tied to More Hospitalizations for Lupus Flares

Both weight-based and non-weight-based low-dose HCQ associated with increased hospitalizations for SLE

Sleep Dysregulation Ups Risk for Inflammatory Bowel Disease

Short sleep duration and daytime napping associated with Crohn disease and ulcerative colitis

COVID-19 Not Tied to Worse Inflammatory Bowel Disease Outcomes

Findings based on primary composite outcome of IBD-related hospitalization or surgery with 394 days of median follow-up

Manifestations of Vertigo Described in Pregnancy

Pregnancy can exacerbate certain conditions, including Meniere disease and benign paroxysmal positional vertigo

Stable Neurodevelopment Seen for Most Children With Familial High Risk for Schizophrenia

12.8 percent of children with familial high risk for schizophrenia, bipolar disorder transition to different neurocognitive subgroup

Demand for Mental Health Care Outpacing Capacity

Psychologists report increases in those seeking care for anxiety, depression, substance use and no capacity for treating new patients

FDA Approves First Drug to Delay Onset of Type 1 Diabetes

Tzield targets the autoimmune issues that drive the disease, rather than its symptoms

New Pfizer Booster Shot Shows Protection Against Emerging Omicron Variants

In early data, new Pfizer COVID-19 boosters marshal antibodies against newer omicron variants

FDA: Patients Should Be Cautious When Using Online Pharmacies to Buy Meds

Red flags include pharmacies that do not require a doctor's prescription or have a licensed pharmacist to answer questions

Despite Pleas From Pediatric Groups, Biden Balks at Declaring RSV a Health Emergency

Emergency declaration would have allowed a more flexible response by pediatric practices and for FEMA assistance

New Tool Can Predict Individual’s Dementia Risk

Risk score model yielded nearly 100 percent prediction accuracy of 13-year dementia risk

Subretinal Drusenoid Deposits Linked to High-Risk Vascular Disease in AMD

Presence of HRVD can be identified in model including SDD, high-density lipoprotein with accuracy of 78.5 percent

Cancer Screening and Detection Remain Below Prepandemic Levels

Lower screening rates for cervical, breast, and colorectal cancers suggest 'pattern of forgone care,' according to researchers

ACR: Holding Methotrexate for Just a Week After Flu Vaccine Works for RA Patients

Authors say immune response similar for patients holding methotrexate for one week or two weeks

Impact of Climate Change on Neurologic Health Reviewed

Associations seen for temperature extremes and variability with stroke, migraines, hospitalization in dementia, MS exacerbations

IHD, Stroke Risk Up for Offspring Born to Moms With Preeclampsia

Association mainly independent of preterm or SGA birth, may be partly explained by unmeasured familial factors

Rate of Adverse Physical Effects High With Ayahuasca Use

69.9 percent of sample reported acute physical health effects; 2.3 percent reported need for subsequent medical attention

Artificial Intelligence-Aided Colonoscopy Does Not Increase Cancer Detection

AIAC group had lower adenoma and polyp detection rates; lower median number of adenomas, polyps detected per colonoscopy

Shorter Regimen of Radiotherapy Safe for Soft Tissue Sarcoma

Findings with preoperative radiotherapy administered to dose of 42.75 Gy in 15 fractions for three weeks

Seroprevalence to SARS-CoV-2 Has Increased Over Time

Global seroprevalence from infection or vaccination reached 59.2 percent by September 2021

FDA Oversight of Clinical Trials Described as ‘Grossly Inadequate’

Article describes inadequate oversight relating to development of COVID-19 vaccines and predating the pandemic

Suicidality, Self-Harm Up for Children With Gender Dysphoria

Prevalence of suicidality, self-harm increased for children with gender dysphoria-related diagnoses in 2016, 2019

Preterm Birth Rate Up in 2021 to 15-Year High

Rates increased for women of all races, earning nation D+ grade, according to the March of Dimes

AHA: Consciousness, Awareness May Occur During Cardiac Arrest

Normal EEG consistent with consciousness emerged as long as 35 to 60 minutes into CPR despite marked cerebral ischemia