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Findings seen for the high-risk population of teens with bipolar spectrum disorder

Authors say findings show gaps between practice and guideline-based care

More than twofold increase in risk seen for those treated with ≥200 mg/m² cumulative doxorubicin versus no doxorubicin

No significant improvement in progression-free, overall survival seen with addition of lenalidomide to cediranib

Environmental factors, including breastfeeding and visible damp, are associated with risk for infections

Screening with blood pressure measurements has substantial net benefits and is recommended throughout pregnancy

All four risk variants were predicted to be deleterious and were located in two immune pathways

After 2010, all invasive pneumococcal infection serotypes were those not included in 13-valent pneumococcal conjugate vaccine

Extended-release buprenorphine not cost-effective when transmucosal buprenorphine is available for treatment of OUD

More chronic conditions seen in late midlife for women with history of PBO with or without hysterectomy

Patients with more purulent sputum experience more exacerbations and more severe exacerbations

Likelihood of experiencing a serious medical outcome or being admitted to a health care facility was increased for children younger than 6 years

Safety concerns to consider for youth with diabetes who are restricting carbohydrates include growth deceleration, poor bone health

Ventilatory burden can also predict all-cause and cardiovascular disease mortality

Revaccination should be considered for patients with chronic HCV who do not respond to HBV vaccination

Double reading by one radiologist plus AI noninferior to standard-of-care double reading by two radiologists

Risk was increased for those receiving transfusion from donors who later developed multiple spontaneous intracerebral hemorrhages

However, overall 10-year colorectal cancer incidence relatively low in veterans younger than 50 years of age

Performance better than certified rater but not quite as good as expert neurologists

Authors say preventive efforts should focus on fathers, too

However, living in a greener area could help counteract this effect

Total annual economic burden of youth violence 17 percent higher in 2020 due to increase in youth homicides

No variation in risk for PCC seen based on number of vaccinations, but previous infection linked to reduced PCC risk

No between-group difference seen in BMI-standard deviation score, but significant difference seen in reduction of BMI-SDS ≥0.5

Normal EEG activity consistent with consciousness emerged as long as 35 to 60 minutes into CPR despite marked cerebral ischemia

Dose-response association seen for risk for stroke with number of head injuries, but no association seen for severity

Receipt of physical therapy within three months of presentation linked to reduced risk for subsequent falls

Daily use of cigarettes, e-cigarettes, and cannabis associated with both anxiety and depression

Early menarche, early menopause, shortened reproductive life span linked to increased risk, especially for NSCLC

Changes in office systolic BP of −14.1, −13.2, −6.9, and −4.1 mm Hg seen with 100, 50, 12.5 mg once daily of lorundrostat and placebo

Any β-blocker use cuts odds by nearly half, driven by nonselective β1-blockers

Proportion of stimulant involvement in fentanyl-involved overdose deaths increased in almost every state from 2015 to 2021

Combination of a patch and fast-acting nicotine replacement therapy also effective

Review showed that treating depression was associated with lower rates of sexual disorders

Long-term health-related quality of life consistently high up to 20 years after the event

Although relative dose intensity similar, pathologic complete response higher with intervention

Consumers should immediately stop using the recalled water bead kits and take them away from children

Vaccination linked to reduced odds ratio of COVID-19-related emergency department or urgent care encounter, outpatient visits

Intensity-modulated radiation therapy spares more normal tissue than 3D-conformal radiotherapy

Significant reductions seen in death with 1-point improvement in AUA Symptom Score, and in storage and voiding subscales

No difference seen in ongoing pregnancy versus hospital-controlled ovulation monitoring

High-protein, lean beef diet achieved similar weight loss, glucose control as normal-protein diet with no red meat

Findings based on meta-analysis involving more than 360,000 breast cancer survivors

Similar immune response and no increase in rate of reactogenicity events seen with coadministration versus COVID-19 vaccine alone

Respiratory and nonrespiratory complex chronic conditions, tracheostomy placement, LOS ≥14 days linked to readmission; one-year readmission probability was 30 percent

LH/FSH ratio and serum free testosterone reduced, while serum sex hormone-binding globulin increased with ≥45 days of diet

Low functional aerobic capacity, abnormal heart rate recovery, and low chronotropic index tied to noncardiovascular death

Incident hypertension, statin use higher with tenofovir alafenamide fumarate compared with tenofovir disoproxil fumarate

Proportion of visits delivered by nonphysicians varies across conditions, from 13.2 percent for eye disorders to 41.5 percent for respiratory infections

Teens whose parents drink frequently or binge drink have significantly higher odds of drinking

Loneliness, moderate-to-severe depression associated with greater odds of poor-to-fair health

One challenge is that women perceive their risk for HIV infection as low

Other benefits seen for improved maternal social support, infant-focused anxiety, and negative emotionality in infants

Black individuals exhibit higher frequency of delusions; Asian individuals have higher frequency of apathy

Findings seen in real-world patients with a range of chronic health conditions

Methylation score had sensitivity of 74 percent, specificity of 89 percent for adenocarcinoma in situ/adenocarcinoma

Seasonal variation of 1.4 mm Hg tied to nearly 5 percent variation in blood pressure control

Findings seen regardless of whether hypertension persists in seated position

Findings seen for transgender and gender-diverse individuals desiring testosterone therapy

Difference not explained by response times, rates of EMS termination of resuscitation, or rates of initiating CPR or automated external defibrillator

High-grade hypoattenuation thickening on follow-up CT after left atrial appendage occlusion associated with higher stroke risk

New booster targets the XBB.1.5 omicron subvariant, which is similar to the dominant variant now circulating

Individual patient data meta-analysis shows increased risk for dementia for those with untreated hypertension

Receipt of physical therapy and chiropractic care was low overall and lower across racial, ethnic minorities

Report highlights advances such as approval of 14 new anticancer therapeutics, expansion of use of 12 previously approved therapeutics

Factors associated with long-distance travel include low neurologist density, rural setting, and visits for ALS, nervous system cancer

Authors say screening may be recommended

A year after the U.S. Food and Drug Administration approved the devices, only a small fraction of people with hearing difficulties have bought one

The chemicals are already illegal in the European Union and other places around the world

Magnitude of positive association for four socioeconomic status categories with LE8 was greater for non-Hispanic Whites than minority groups

Prevalence of reporting clinician recommendation was lower for non-Hispanic Asian, Black, Hispanic versus White adults

>90 percent of total global IQ loss and cardiovascular disease deaths occurred in low-, middle-income countries

Shorter leucocyte telomere length also associated with smaller total brain volume, white matter volume, hippocampus volume

Significant, nonlinear association identified between time spent in sedentary behavior and incident dementia

Risk for all-cause death, nonfatal spontaneous myocardial infarction identified in overall cohort, those with high coronary artery calcium scores

Significant increase in risk seen for ER-positive breast cancer, but not ER-negative tumors

Furthermore, two-thirds with undiagnosed glaucoma had normal intraocular pressure

Panel's recommendation could prompt the FDA to pull all oral decongestants containing phenylephrine from store shelves

Significant improvements seen in symptoms on days 28 and 56; no synergistic effect seen for combination treatment

More medical imaging, including CT, fluoroscopy, angiography, nuclear medicine, reported for those with Down syndrome, especially in those younger than 1 year

Risk for death 3.49 times higher for those receiving no cancer treatment versus standard treatment or treatment with minor deviations

Among patients with ADRD receiving care from a home health agency, antipsychotic use was tied to less improvement in activities of daily living

Findings seen for 50 most common questions about false information, myths, and false and true contraindications

However, pediatric readiness does not eliminate Black mortality disparity for children's medical emergencies

Test able to quantify diagnostic status as well as individual levels of social disability, verbal ability, and nonverbal ability

Positive association seen after accounting for all measured lifestyle and sociodemographic factors

Interim data show vaccine effectiveness of 51.9 percent in five South American countries during their flu season

New booster targets the XBB.1.5 omicron subvariant, which is similar to the dominant variant now circulating

Back-to-back climate-related disasters have hampered blood collection efforts, and a summer shortfall has made the shortage worse

The services use a videophone device that transmits video and audio

Modest improvement seen in cough frequency, severity, and specific quality of life, but increase seen in treatment-, taste-related adverse events

Reduction seen in low-density coronary artery plaque volume with CPAP and with use of CPAP and GLP-1-mediated weight loss

Age-standardized rates increased among younger women and men and older women, while they declined in older men

Regardless of prognosis, panel deemed it appropriate to continue opioids, increase monitoring, and avoid opioid tapering

Greater associations seen for mothers with lower educational attainment, those whose pregnancies started in cold season

Shorter disease course with less mucosal disease seen on reinfection versus initial infection

NSAID use positively linked to VTE, with extra VTE events in those with concomitant high-, medium-risk contraception use

Significantly more children and adolescents with growing pains had headaches fulfilling criteria of migraine without aura, probable migraine

Reduction in need for anxiolytic drugs, antidepressants strongest for men and young and middle-aged adults

Death and stroke rates similar to those in patients with a similar clinical profile and predicted risk undergoing TAVR for native aortic valve stenosis

Hospitalizations from the One Chip Challenge have been reported across the country

Nearly half of patients report they do not believe their clinician considered their modality preferences when deciding on in-person versus virtual visit

Age-adjusted mortality rate increased for men versus women and Black versus White patients

However, disparities persisted among seniors in functional limitations and limitations in activities of daily living

Higher baseline hsCRP predicts poorer weight loss but has no effect on depression severity

Protective HLA-DRB1*04 subtypes bind strongly to aggregation-prone tau PHF6 sequence when acetylated at K311

Population attributable risk percentage for antepartum anemia and SMM highest for multiracial, Black, Hispanic patients

Higher intake of celluloses (E460 to E468) positively associated with higher risks for CVD and coronary heart disease

Combination approach better than statin monotherapy for all-cause mortality at one, three, and five years in acute coronary syndromes

Small improvements in femoral neck BMD coincided with significant reduction in incidence of hip fracture in men and women

Non-English-speaking patient callers to hospital are less likely to be provided with next steps to access cancer care

Two-thirds of health care providers agree with expanding recommendations for new PCV20

Associations between education, Medicaid, WIC participation, body mass index with T2DM were more pronounced among White individuals

CCB use also linked to thinner macular ganglion cell-inner plexiform layer, macular retinal nerve fiber layer thickness

The machines were recalled in June 2021 by the U.S. Food and Drug Administration

Since 2017, leading cause of HCC is NAFLD among women; increases in ALD- and NAFLD-HCC seen since 2015

The new booster targets the XBB.1.5 omicron subvariant, which is similar to the dominant variant now circulating

Main risk factors underlying early-onset cancers are dietary risk factors, alcohol consumption, and tobacco use

In a recent study, there was an increase in the percentage of patients discharged opioid-free

Findings seen among 16- to 30-month-old children referred to specialty autism clinics

Significant decrease seen in incidence of stage I melanomas but not other stages

Threefold increase reported in quarterly rate of cannabis-involved traffic injury ED visits during commercialization

Independent association seen for genetic liability to ADHD with risk for anorexia nervosa; bidirectional link noted to major depressive disorder

Attack frequency did not change over three years for people with benign recurrent vertigo, Meniere disease, or vestibular migraine

High-grade vesicoureteral reflux is crucial risk factor for recurrent febrile urinary tract infections in children

Benefit for incident CRC was duration-dependent, with significantly reduced risk after two or more years of use

Significant reductions were seen in dementia risk for rivaroxaban, apixaban, and dabigatran versus warfarin in network meta-analysis

History of TBI, TBI with loss of consciousness, older-age TBI linked to lower cognitive scores at age 70 years

Anti-PD-L1 agent induces sustained responses seen in about one-third of patients with advanced alveolar soft part sarcoma

CSF 48 panel plus existing biomarkers significantly improved diagnostic performance for outcomes studied

Almost all patients had remission of reflux symptoms after R-RYGB following sleeve gastrectomy

Urinary TNF-α and eotaxin levels can differentiate interstitial cystitis/bladder pain syndrome from other dysfunctions in men

Decreased vertigo severity, comorbidity burden, and absence of hearing loss tied to conservative treatment response

Relative risk for preterm mortality widened over time for nonsmokers, those with high levels of education

Variation in coverage seen by program, drug, and cardiovascular disease condition

Spike in severe cases seen in Florida and Georgia; regional increases usually predict the beginning of RSV season, according to CDC

Infections have been mostly seen in Gulf Coast states; infections in the Eastern United States have increased eightfold from 1988 to 2018

Scientists found the variant appears to be less concerning than initially thought, with data showing it is 60 percent less infectious than XBB.1.5 variants

Highest age-adjusted mortality rates seen for Black individuals, and greatest temporal increase found in American Indian and Alaska Native individuals

Quarterly percentage of deaths more than doubled with evidence of counterfeit pill use from July to September 2019 to October to December 2021

Overall survival did not differ, but significant interaction found between supplementation and NPM1 with survival

Diagnostic performance comparable for two test sets from the Personal Performance in Mammographic Screening scheme

OOP payments exceeded Amazon and GoodRx prices for 40 and 79 percent of prescriptions assumed to be in deductible phase

Comparable rates of in-hospital adverse events seen among seniors prescribed oral antipsychotics after major surgery

Prolonged length of stay is often due to need for skilled therapy or daily living support in medically ready patients

Risk for stroke hospitalization within 12 months of delivery higher for those who received infertility treatment versus spontaneous conception

Positive airway pressure treatment itself associated with less wheezing

However, clinical correlates of pathologic brain conditions are still uncertain

However, cannabis and cannabis-based medicines may aid certain clinical conditions

During extended treatment, bleeding risk was similar for apixaban and rivaroxaban

Smoking increased the risk for being hospitalized with a mental illness by 250 percent

Self-reported falls more common in women, but fall-related deaths more common in men

Simultaneously from 2009-2011 to 2019-2021, interest in hospital medicine gained popularity

Authors say mean treatment effect for hot flash frequency may only be 21 percent

Findings show low-dose aspirin also slows the increase in fasting plasma glucose over time among initially healthy older adults

Just over one-third of women experienced improvement in symptoms across treatment modalities

Similar patterns also observed in C-section-born infants

No significant improvement seen for relapse, but treatment was associated with side effects

Significant benefit seen as early as eight days compared with placebo

Teen, young adult users of e-cigarettes and cigarettes more likely to have severe, frequent ocular symptoms

Younger patients, African American patients appear to have more cost-related delays/nonadherence

Authors urge glycemia screening in younger men presenting with ED

Cadmium and lead levels significantly higher among exclusive marijuana users

Infants who eventually developed peanut allergies had lower gut microbiome diversity during their early years

Proposal would set minimum staffing to equivalent of three hours per resident per day, with just over a half hour of that time from a registered nurse

However, risk factors change depending on time from diagnosis and comorbidities

Analysis revealed two clusters of highly correlated psychosocial factors -- stress and strain

Findings persist for common surgeries when accounting for patient, procedure, surgeon, and other characteristics

Overall median annualized bleeding rate was 0 with concizumab

High levels of sulfate, vanadium, molybdenum in water supplies may increase the risk for nontuberculous mycobacteria pulmonary infections

Authors urge greater transparency of study results for drugs approved by the FDA

Lower treatment retention rates seen with 30-day, out-of-pocket costs ≥$150

Warning symptoms differed significantly between patients with sudden cardiac arrest and controls, but were sex-specific

Progression-free survival and overall survival prolonged with zolbetuximab plus CAPOX versus placebo plus CAPOX

Higher-performing and higher-staffed hospitals prepandemic were slower to decline, but all declined by Q4 of 2021

Biochemical recurrence does not meet the criteria to be a reliable surrogate endpoint for overall survival

Increased health care utilization seen up to 10 years before diagnosis with increases closer to diagnosis

Risk varies by age, atopic dermatitis severity, and inflammatory bowel disease subtype

Automated systems involved in large-scale eligibility review are causing entire households to be removed from Medicaid coverage, but children may still be eligible

The move would not legalize marijuana, but could move it from its Schedule I classification to a Schedule III

Selective serotonin reuptake inhibitor treatment tied to lower risk for maternal mental health problems and child externalizing behaviors across early childhood

Findings seen for visual acuity at 2.5 years of corrected age, but authors note that high loss to follow-up rate may have impacted findings

Subcutaneous anchor securement system better than adhesive securement device for reaching end of need with a single PICC

ICU mortality lower compared with patients without obesity in multivariable and propensity score-matched analyses

Individuals experiencing recurrent injury are typically young and mostly male, Black, and uninsured

13-year findings reveal sedentary time from childhood through young adulthood associated with progressive left ventricular remodeling

Patients with unrecognized need for COVID-19 therapy appear to have higher odds of readmission, regardless of race

Those who survived COVID-19 had reduced mortality on days 181 to 365 and 366 to 730

Survivors of spontaneous intracerebral hemorrhage with statin exposure have a lower risk for any stroke, ischemic stroke

Comorbidities tied to higher rates of complications and postoperative morbidity

IgG anti-spike antibodies undetectable in ~20 percent with immunosuppression who had received three or more COVID-19 vaccines

Outcomes and treatment worse for patients hospitalized during weeks with a high hospital COVID-19 burden

Benefits seen for velopharyngeal insufficiency at 5 years of age

Findings based on 41 studies with data for children younger than 13 years old

American Heart Association says knowing levels is key to preventing recurrent heart attack, stroke

The nasal spray version of naloxone will be available at select retailers for $44.99 for a box of two doses

Additionally, participation tied to greater retention of subsequent fluid intelligence

Patient benefits seen for all-cause mortality, implantation of a left ventricular assist device, or urgent heart transplantation

Three-year weight loss in older women tied to 33 percent lower odds of reaching age 90 years; association stronger for unintentional versus intentional weight loss

However, no association seen for social vulnerability index in early-life neighborhood