Certain Dietary Patterns May Raise Risk for Developing IBD

Carnivorous pattern linked to increased risk for ulcerative colitis; Western dietary pattern linked to increased risk for Crohn disease

Incidence, Prevalence of Pediatric IBD Increasing Globally

Incidence and prevalence highest in Northern Europe, North America; lowest in Southern Europe, Asia, Middle East

CV, Cancer Risk Up With Tofacitinib for Rheumatoid Arthritis

Incidences of major adverse cardiovascular events, cancers higher with tofacitinib versus TNF inhibitor; criteria for noninferiority not met

Remdesivir May Benefit Adults Early in COVID-19 Course

Real-world data support the use of remdesivir for hospitalized COVID-19 patients receiving no oxygen or low-flow oxygen

Likelihood of Hospital Admission Up During Foot Ulcer Episodes

All-cause inpatient admissions 2.8 times more likely, death 1.5 times more likely during foot ulcer episodes versus period after healing

4.95 Million Deaths Linked to Antimicrobial Resistance in 2019

Lower respiratory infections accounted for >1.5 million deaths associated with resistance, making it the most burdensome syndrome

Thrombosis, Thrombocytopenia Syndrome Up After Ad26.COV2.S

Reporting rates 3.83 per million vaccine doses for Ad26.COV2.S versus 0.00855 per million for mRNA-based vaccines

More Steps Per Day May Cut Risk for Incident Diabetes in Seniors

Stronger association seen for moderate- to vigorous-intensity steps per day than for light-intensity steps per day

Third mRNA Vaccine Dose Ups Effectiveness Against Hospitalization

Vaccine effectiveness against COVID-19 hospitalization increased with third dose in those with, without immunocompromising conditions

Vitamin D Supplementation Linked to Reduction in Autoimmune Disease

Vitamin D supplementation, with or without omega-3 fatty acids, linked to reduced risk for autoimmune disease

Moderna Begins Testing Booster Shot Aimed at Omicron

New study will focus on a single omicron-specific booster dose in about 600 adults

Alterations in Gut Microbiome ID’d in Postacute COVID-19 Syndrome

Higher levels of Ruminococcus gnavus, Bacteroides vulgatus, lower levels of Faecalibacterium prausnitzii observed in patients with PACS

Scientists Watch, Worry About New ‘Stealth’ Version of Omicron Variant

The variant, called BA.2, has genetic traits that make it somewhat more difficult to detect

Cumulative Exposure to Pesticides Linked to Risk for COPD

Prevalence ratios for chronic obstructive pulmonary disease increased with ever exposure, high cumulative exposure to pesticides at work

Hospital Defends Decision to Deny Heart Transplant to Unvaccinated Man

Other U.S. hospitals have also faced criticism for denying transplants to patients who were not vaccinated against COVID-19

Young Have Greatest Burden of Distant Colorectal Adenocarcinoma

Largest increases in distant-stage proportion for rectal-only seen for 20- to 29-year-old non-Hispanic Blacks, Hispanics

Among Young Adults, More Women Than Men Have Ischemic Strokes

Significantly more ischemic strokes seen in women than men among those aged 35 years and younger, but not among 35- to 45-year-olds

COVID-19 Vaccination Not Linked to Fecundability in Men, Women

SARS-CoV-2 infection associated with short-term transient decline in fertility for men

Screening Nonsmokers May Up Lung Cancer Overdiagnosis, Spurious Survival Rates

Promoting low-dose CT screening among mostly nonsmoking women increased detection of early-stage, but not late-stage, lung cancers

Risk for Carditis Tied to Second Dose of Pfizer-BioNTech COVID-19 Vaccine

No such increased risk seen with Sinovac inactivated virus vaccine

USPSTF: Evidence Still Lacking for Atrial Fibrillation Screening

Evidence currently inadequate for assessing the balance of benefits and harms of screening for atrial fibrillation in asymptomatic adults

Omicron Linked to Increase in COVID-19 Cases, Lower Disease Severity

Mean length of stay and percentages admitted to ICU, receiving invasive mechanical ventilation, dying lower during omicron

Recommendations Simplified for Pneumococcal Vaccination

ACIP recommends PCV20 alone or PCV15 in series with PPSV23 for all aged 65 years and older or younger adults at risk

Risk for Early-Onset Sepsis Low for Infants With Low-Risk Delivery

Risk for early-onset sepsis low among infants of all gestational ages born with low-risk delivery characteristics

Casirivimab + Imdevimab Prevents Progression to Symptomatic COVID-19

For asymptomatic SARS-CoV-2-positive individuals living with infected household contact, combo cuts incidence of symptomatic COVID-19

Septic Shock Linked to Mortality in Hematologic Malignancies

Mortality rate increases with increasing sequential organ failure assessment score on admission, respiratory failure, maximum lactate level

ACG Issues Guidelines for Managing Acute-on-Chronic Liver Failure

Preferred approach described for managing ACLF, now emerging as a major cause of mortality in patients with cirrhosis, chronic liver disease

Children’s Hospital Admissions Reduced After March 2020

Fewer hospital admissions reported for respiratory, severe invasive, and vaccine-preventable infections

Psychotropic Medication Use Linked to Mortality in Cardiac Patients

Patients with symptoms of anxiety significantly more likely to use psychotropic medications after hospital discharge

Skyrizi Approved for Psoriatic Arthritis

Approval based on two Phase 3 trials showing more than 50 percent of patients receiving Skyrizi achieved ACR20 response at 24 weeks

~7 Percent of Lung Transplants Due to COVID-19 Respiratory Failure

Three-month survival 95.6 percent among patients who underwent lung transplant during August 2020 to September 2021

Booster Shots More Effective During Omicron Emergence Period

And vaccine effectiveness lower during omicron with receipt of two doses, but higher after booster dose

Nurse Work Environment Affects Patient Outcome

Surgical patients in hospitals with good nurse environment less likely to be admitted to ICU, have 30-day mortality

More Than 1 Million U.S. Children Diagnosed With COVID-19 in Single Week

Since the start of the pandemic, more than 10.6 million children have tested positive for COVID-19

Biden Administration Withdraws Vaccine Mandate for Large Employers

Supreme Court said mandate went too far in imposing such a sweeping requirement on employers

Weight Loss May Not Aid Fertility Treatment in Obese Women

Weight loss before infertility treatment in obese women not associated with improvement in healthy live birth rate

Nutrient-Laden Snacks Can Meaningfully Cut Cholesterol

Consumption of a suite of ready-to-eat bioactive foods tied to 8.8 percent drop in LDL cholesterol in four weeks

Screening Nonsmokers May Up Lung Cancer Diagnosis, Survival Rates

Promoting low-dose CT screening among mostly nonsmoking women increased detection of early-stage, but not late-stage, lung cancers

Flu Vaccine Effective Against Life-Threatening Illness in Children

Vaccine effectiveness 75 percent during 2019 to 2020 season, when vaccine-mismatched viruses predominated

Blood Biomarkers May Help Assess Need for Lung Cancer Screening

Blood test based on four-marker protein panel combined with risk prediction model may improve assessment of risk for lung cancer

Managing Pulmonary Embolism in Primary Care Feasible for Some Patients

About 21 percent of adults diagnosed with acute PE in primary care sent home; few experienced adverse events within 30 days

Children’s Use of Helmets Low During Sledding

Parents report much higher use of helmets during snowmobiling, skiing/snowboarding

Prognostic Index May ID CLL Patients Who Will Not Need Treatment

Novel prognostic index CLL-WONT identifies patients with chronic lymphocytic leukemia who are at low risk for ever requiring treatment

Self-Help Aids Quality of Life for People With Psoriasis

Findings show modest, but significant, benefit from either compassion-based or mindfulness-based self-help

Fatigue Common Even With Early Rheumatoid Arthritis

Those presenting with fatigue early likely to see it persist

No Evidence of Malignant, Sustained Arrhythmias Seen After COVID-19

Palpitations common, but corresponded with sinus rhythm or sinus tachycardia

Proportion of Minorities Low in Internal Medicine Residency Programs

Proportion of internal medicine applicants and matriculants who identify as underrepresented in medicine remained low during 2010 to 2018

Pfizer Begins Testing COVID-19 Vaccine Targeted to Omicron

New U.S. study will assess the updated, omicron-targeted vaccine for use as a booster or for primary vaccinations

Omicron Shows Signs of Ebbing as U.S. Cases Fall, Hospitalizations Level Off

More states have now reported they have passed their peaks in new cases, and new cases have begun to drop nationally

EU Eases COVID-19 Travel Rules Within the Bloc for Fully Vaccinated

Announcement made a day after the WHO said the spread of the omicron variant could change the pandemic from overwhelming to manageable

Free N95 Masks Begin Arriving in U.S. Pharmacies

Masks already set up for distribution at some Hy-Vee and Meijer grocery stores in the Midwest

FDA Limits Use of Two COVID-19 Antibody Treatments

Treatments made by Regeneron and Eli Lilly performed well against earlier variants, but not against omicron

Allopurinol Not Tied to Higher Mortality for Patients With Gout and CKD

Allopurinol initiation, achieving target serum urate levels, allopurinol dose escalation not associated with increased mortality

Stable Body Mass Index Tied to Slower Cognitive Decline in Older Adults

Findings seen regardless of whether a person has normal, overweight, or obese BMI at baseline

Ad26.COV2.S, mRNA Boosters Immunogenic After Ad26.COV2.S

Compared with homologous booster, heterologous booster with mRNA-based vaccine yielded larger increase in binding antibodies

Microbiome Therapeutic Beats Placebo for Recurrent C. difficile

Investigational oral live microbiome therapeutic superior to placebo in patients with three or more episodes of C. difficile infection

Overall, Night Shift Work Not Tied to Higher Lymphoma Risk

However, nonlinear association seen between night shifts and chronic lymphocytic leukemia

Frailty Mars Outcomes After aHSCT in Lymphoid Malignancies

Links found for frailty with in-hospital mortality, prolonged length of stay for patients with NHL, HL, MM undergoing aHSCT

Black Patients More Likely to Have Negative Descriptors in Notes

Compared with White patients, Black patients have 2.54 times the odds of having at least one negative descriptor in EHR

MRI of Hand, Foot May Predict RA in Undifferentiated Arthritis

MRI-detected tenosynovitis independently associated with progression to rheumatoid arthritis

FDA May Limit Use of Two COVID-19 Antibody Treatments

Treatments made by Regeneron and Eli Lilly performed well against earlier variants, but not against omicron

Risk for Cancer Increased After VTE for Patients With Psoriasis

Standardized incidence ratio was 3.0 during first year of follow-up after VTE and decreased to 1.5 during subsequent years

England to Lift Travel Restrictions for Vaccinated Visitors

Mask mandates to be lifted this week, as England relies on vaccinations and testing to keep the virus in check

Vaccination, Previous Infection Protect Against COVID-19

During period of delta predominance, protection was lower among vaccinated persons without previous COVID-19 diagnosis

Opioid Overdose Antidote Urged for Schools After Student’s Fentanyl Death

In response to the incident, Hartford officials pledged to ensure that all city schools are stocked with naloxone

Pandemic Having Major Impact on Pediatric Oncology Providers

51 percent of institutions cite decreased clinical staff availability; HCPs experiencing psychological distress, financial concerns

Risks Discussed for Alternative Peripartum, Neonatal Practices

Vaginal seeding has no known benefits and may expose neonates to vaginal pathogens; umbilical nonseverance has no clear benefit

Combo Immunotherapy Ups Survival in Advanced Liver Cancer

Overall survival, but not progression-free survival, improved with tremelimumab plus durvalumab versus sorafenib for unresectable HCC

Adding Immunotherapy to Chemo Ups Survival in Advanced Biliary Tract Cancer

Overall survival, progression-free survival prolonged in those receiving durvalumab versus placebo in addition to gemcitabine and cisplatin

Prevalence of Coronary Heart Disease Largely Unchanged From 2011 to 2018

However, some small but significant increases and decreases seen in specific geographic areas

Delay to Admission From ED Tied to Increase in 30-Day Mortality

Statistically significant linear increase observed in mortality from five hours after time of arrival at emergency department up to 12 hours

Closed-Loop System Improves Glycemic Control in Young Children With T1DM

Percentage of time with glucose level in target range higher during closed-loop period versus sensor-augmented pump therapy period

Physician’s Briefing Weekly Coronavirus Roundup

Here is what the editors at Physician's Briefing chose as the most important COVID-19 developments for you and your practice for the week of...

Semaglutide Superior to Liraglutide for Weight Loss

Findings reported for subcutaneous treatment in overweight, obese adults also using diet, physical activity

Risk for Diabetes Increased for Pediatric Patients With COVID-19

Increased incidence of diabetes seen among patients aged younger than 18 years after acute COVID-19 infection versus those without COVID-19

One-Third of Pregnant Women Report Mental Distress During Pandemic

Health behavior impacts showed a dose-response relationship with mental health distress

Prolonged TV Watching Ups Blood Clot Risk

35 percent higher risk for venous thromboembolism seen with watching more than four hours of TV daily

Myopia Progressed Faster in Children Under COVID-19 Lockdowns

Exploratory analysis shows link between optical defocus treatment and slower progression of myopia in school-aged children

Blacks Increased Telemedicine Use for Surgical Consults

Findings seen in second phase of the pandemic; no significant racial differences seen during the beginning of the pandemic

Vaccine Effectiveness Against Symptomatic COVID-19 Wanes

But protection against COVID-19 hospitalization, death after two doses of BNT162b2 or CHAdOx1-S is more durable

COVID-19 Rapid Test Makers Struggling to Meet Demand

However, government's order for the free test kits is in addition to existing supply and does not interfere with existing orders

Brain Imaging May ID THC-Linked Impairment in Cannabis Users

Measurement of prefrontal cortex oxygenated hemoglobin concentration with functional near-infrared spectroscopy may detect THC impairment

COVID-19 Boosters Keep Older Americans Out of Hospitals: CDC

Chances of hospitalization for COVID-19 more than 40 times higher for those who are unvaccinated than for those with full vaccination and booster

Biosimilars Could Cut Spending for Biologic Therapy in the U.S.

Increased market growth of biosimilars that are similar to brand-name biologic agents has the potential to reduce spending on prescription drugs

Peanut Oral Immunotherapy at Younger Age Ups Desensitization in Children

More children who received immunotherapy met the primary outcome of desensitization and remission criteria

Breast Cancer Survivors Face Higher Risk for Hypertension, Diabetes

Risk for hypertension even higher for those receiving left-sided radiation therapy, endocrine therapy

Same-Day Discharge Increasing for Hip, Knee Arthroplasty

Faster increase seen for total hip arthroplasty, while total knee arthroplasty has slightly higher odds of complications

Nearly Half of U.S. Adults Gained Weight During First Year of Pandemic

Significant predictors of pandemic weight gain were psychological distress, prepandemic weight, and children at home

U.S. Insurers Could Spend Millions for Ivermectin Rx for COVID-19

Claims data for private insurance and Medicare Advantage plans show spike in inappropriate ivermectin prescriptions for COVID-19

Long-Term Outcomes Described for Survivors of Childhood ALL

Life challenges more negatively impacted in younger, female, relapsed patients; socializing more positively impacted in older patients

Nomogram May Help Predict Survival in Primary Intestinal NHL

Prediction accuracy of the nomogram higher than that of Ann Arbor Stage for primary intestinal non-Hodgkin lymphoma patients

Emergency Department Interventions Cut Opioid Rx Rates

However, no reduction observed in prescribed opioid quantity

Fourth Vaccine Dose May Up COVID-19 Immunity in Kidney Transplant Recipients

Fourth dose of mRNA vaccine increased antispike IgG titers in some kidney transplant recipients with weak serologic response after three doses

COVID-19 Proning Teams Benefit From Wound Care Specialist Nurse

Findings show inclusion significantly cuts odds of pressure injuries in patients hospitalized with severe COVID-19

Health Care Utilization Highest in First 30 Days After COVID-19 Diagnosis

Previously hospitalized patients had twice the health care utilization of nonhospitalized COVID-19 patients

Recommendations Updated for Recombinant Zoster Vaccine

Two doses of RZV recommended for adults 19 years and older who are immunocompromised due to disease or therapy

No Significant Increase Seen in Fetal Mortality Rates From 2019 to 2020

Rates for three largest race and Hispanic-origin groups did not significantly change; increase in rates reported in one state, decline reported in two states

Prophylactic Antibiotics Not Needed Before Invasive Dental Procedures

No evidence of temporal association seen between invasive dental procedure and late prosthetic joint infection

Suicide Attempts Increased Among U.S. Adults From 2008 to 2019

But authors say use of mental health services is not increasing among those who attempt suicide

Significant Health Benefits Seen With Meeting ATS Air Quality Standard

Compared with meeting EPA standards alone, this would prevent 11,850 more deaths, 25,400 more morbidities

AI Model May Predict COVID-19 Outcomes for Critically Ill

Machine learning model incorporates data from 14 proteins derived from a single blood sample to predict survival in patients with COVID-19

2021 USPSTF Lung Cancer Screening Criteria Expand Eligibility

Compared with 2013 USPSTF criteria, more patients eligible for lung cancer screening with less racial disparity in access

BNT162b2 Vaccine Effective Against Severe COVID-19 in Adolescents

Two doses highly effective against COVID-19-related hospitalization and critical illness for those aged 12 to 18 years

AAN Position Statement Addresses Consent Issues in Acute Stroke

Inability to fulfill elements of decisional capacity coupled with need for rapid treatment decisions complicates consent

WHO Says Worst of Pandemic Could Ease This Year if Vaccine Inequities Erased

Fewer than 10 percent of people in lower-income countries have received one dose of COVID-19 vaccine

Biden Plans to Send 400 Million N95 Masks to Americans for Free

Move follows updated mask guidance issued by the CDC late last week

COVID-19 Restrictions Eased in England

As of Jan. 27, COVID-19 passes will no longer be needed to enter large-scale events, use of face masks in public schools will no longer be required

Racial, Ethnic Disparities Seen in mAb Treatment for COVID-19

Monoclonal antibody treatment used infrequently among all racial, ethnic groups; Hispanics received mAbs less often than non-Hispanics

Specialist-Led Model of Care Can Improve CVD Prevention in Psoriasis

Dermatologists and patients with psoriatic disease approve of a specialist-led model of care

Cardiac Outcomes Good for Children With COVID-19-Related MIS-C

All deformation parameters on echocardiogram recovered within first week, including LV global longitudinal strain, peak left atrial strain

FDA Approves Rinvoq for Treatment of Atopic Dermatitis

Approval indicated for those 12 years and older with atopic dermatitis that has not responded to previous treatment

Gap Between Retinal Age, Chronological Age Tied to Mortality

An increase in the gap between retinal age and chronological age, known as the retinal age gap, may increase the risk for mortality

Disparities Seen in Air Pollution Exposure Across the U.S.

Exposure to air pollution greater for certain racial/ethnic groups, low-income groups

Ethnic Disparities Seen in Enrollment for a Clinical Trial​

29 percent of patients deemed appropriate for intervention were Hispanic compared with 52 percent of those deemed not appropriate

More Kidneys From Deceased Donors With AKI Being Transplanted

Procurement and transplant of stage 3 AKI kidneys has increased, but discard rate is still high

ACP Issues Two Guidelines for Acute Left-Sided Colonic Diverticulitis

Guidelines address diagnosis and management, use of diagnostic colonoscopy in complicated disease, and interventions to prevent recurrence

Guideline Issued for External Beam RT in Primary Liver Cancers

EBRT strongly recommended as potential first-line therapy for patients with HCC confined to liver who are not candidates for curative therapy

Unnecessary RT Given Near End of Life in Metastatic Cancer

Guideline-nonconcordant radiotherapy given to substantial proportion of Medicare beneficiaries with metastatic cancer near the end of life

USPSTF: Individualize Counseling for Primary Prevention of CVD

For adults without known CVD risk factors, individualize the decision to refer to behavioral counseling to promote healthy diet, physical activity

Epstein-Barr Virus Suspected as Cause of Multiple Sclerosis

Risk for MS increased 32-fold following EBV infection, but not following infection with other viruses, including cytomegalovirus

Adding a P2Y12 Inhibitor Does Not Improve Outcomes in COVID-19

Adding a P2Y12 inhibitor to a therapeutic dose of heparin does not improve outcomes among non-critically ill patients hospitalized for COVID-19

Global Burden of Chronic Lymphocytic Leukemia Up From 1990 to 2019

Incidence higher for men versus women, adults older than 70 years, and individuals living in high social-demographic index regions

Survival Increase Seen for Adults With Relapsed Ph+ ALL

From 2000 to 2019, overall survival progressively improved for patients with Philadelphia-positive ALL who had posttransplant relapse

COVID-19 Cases Surge Again in U.S. Nursing Homes

During the week ending Jan. 9, U.S. nursing homes reported more than 32,000 cases and 645 deaths among their residents

White House Launches Website for Free Home COVID-19 Tests a Day Ahead of Schedule

Early launch due to 'beta testing'; website currently working at 'limited capacity' ahead of official Wednesday debut

COVAX Program Has Now Sent 1 Billion Vaccines to Poorer Nations

Thirty-six of the organization's 194 member countries have still only vaccinated 10 percent of their populations

Too Soon to Tell if Omicron Will End Pandemic: Fauci

There are suggestions that omicron could result in COVID-19 transitioning from a pandemic to an endemic situation

Preschool Intervention Can Achieve Sustained Lifestyle Changes

Achieving sustained changes requires multidisciplinary teams, multidimensional educational programs, multilevel interventions

Factors ID’d for Eventual Surgery in Patients With Appendicitis

Presence of an appendicolith increases risk for undergoing appendectomy after starting antibiotic therapy for acute appendicitis

Long-Term Medication Usage After Bariatric Surgeries Compared

Patterns of medication use for obesity-related comorbidities slightly more favorable following gastric bypass versus sleeve gastrectomy

Secondhand Vape Exposure Linked to Respiratory Symptoms

Young adults with secondhand vape exposure have increased odds of bronchitic symptoms, shortness of breath

Comprehensive Approach Advised for Managing CV Risk in T2DM

In addition to managing all cardiovascular risk factors, providers must consider social determinants of health

3 Percent of Youth Testing Positive for COVID-19 in ED Have Severe Outcomes

Age, underlying chronic illness, and symptom duration tied to severe outcomes

Fosfomycin Not Noninferior to Comparators for Bacteremic UTI

Fosfomycin not noninferior to ceftriaxone or meropenem for bacteremic urinary tract infection due to multidrug-resistant E. coli in adults

Preventive Aspirin Should Be Based on Benefit, Not Age

Authors urge primary care physicians to make case-by-case basis decisions based on benefit-to-risk

Physician’s Briefing Weekly Coronavirus Roundup

Here is what the editors at Physician's Briefing chose as the most important COVID-19 developments for you and your practice for the week of...

Mental Health Improves With Access to Gender-Affirming Hormones

Access to GAH during adolescence, adulthood linked to lower odds of past-year suicidal ideation versus desiring but not accessing GAH

Insurance Coverage for Acupuncture Up From 2010 to 2019

However, most costs are paid out of pocket

Amid U.S. Blood Shortage, New Pressure to Ease Donor Rules for Gay Men

Easing the rules would result in a 2 to 4 percent increase -- 345,400 to 615,300 more pints of blood -- in the nation's annual blood supply

Senate Committee Backs Califf Nomination to Head FDA

Among those who voted against Califf's nomination were Democrats who expressed concerns about his links to pharmaceutical companies

Some Menopause Symptoms Tied to Cognitive Impairment

Severe depressive and sexual symptoms of menopause associated with worse cognitive performance

Supreme Court Blocks Biden’s Vaccine Mandate for Large Employers

Mandate was a crucial component of the White House plan to tackle the COVID-19 pandemic

Data Support Lowering Age for CRC Screening to 45 Years

For those aged 45 to 49 years, 32 percent had any neoplasia, 7.5 percent had advanced premalignant lesions, 0.58 percent had CRC

WHO Living Guideline Updated for Drug Treatment of COVID-19

JAK inhibitor baricitinib strongly recommended for the treatment of severe or critical COVID-19

Regular Exercise Linked to Slower Deterioration in Parkinson Disease

Regular physical activity levels linked to slower deterioration of postural and gait stability, activities of daily living, processing speed

NCCN Endorses Full COVID-19 Vaccination for Cancer Patients

The NCCN Advisory Committee supports the strong preference for mRNA vaccines and offers guidance on the timing of vaccination

Rural, Urban Disparities Seen for Quality of Home Health Care

Rural home health care agencies perform better on process measures; urban agencies perform better on outcome measures

Men With More Breakups, Years Lived Alone Have Higher Inflammation

No similar findings seen for middle-aged women

New Device Safe, Effective for Treating Brain Aneurysms

Woven EndoBridge device effective for treating ruptured and unruptured aneurysms in all intracranial locations

Donepezil Tied to Risk for Overactive Bladder

Risk for overactive bladder varies across individual cholinesterase inhibitor drugs

Overall Breast Cancer Incidence Decreased From 1999 to 2018

Incidence increased from 2004 to 2018, and among non-Hispanic Asian or Pacific Islander women and those aged 20 to 39 years

Sitting, Inactivity Increase Death Risk Among Cancer Survivors

Risk for both all-cause and cancer-specific death increased for cancer survivors with combination of prolonged sitting and inactivity

Survey Highlights Difficulties of Living With Bipolar Disorder

Struggles include finding the right medication and medication side effects

Kidney Failure Risk Equation Bests eGFR for Predicting ESKD

KFRE score >20 percent had similar specificity, higher sensitivity for predicting end-stage kidney disease than eGFR <20 mL/min/1.73 m2

Statin Use May Be Safely Continued During Pregnancy

Higher risk seen for low birth weight and preterm birth with statins, but no tie to congenital anomalies

Hip Fracture Risk Up With Drug Holiday From Risedronate Versus Alendronate

After three or more years of therapy, drug holidays from risedronate versus alendronate linked to 18 percent increase in hip fracture risk

White House May Soon Offer ‘High-Quality’ Masks to Americans

One option being discussed is to distribute the masks at community sites

Pediatric Antibiotic Prescribing Dropped During Pandemic

Decrease in antibiotic prescriptions in pediatric primary care driven by reduced volume of visits for respiratory tract infections

U.S. Military Medical Personnel Being Deployed to Ease Shortages

More than 1,000 will begin arriving at hospitals nationwide starting next week

Incidence of Advanced Lung Cancer Continues to Decline in the U.S.

During 2014 to 2018, incidence continued to increase slowly for female breast cancer, remained stable for prostate cancer

Real-World, Rapid COVID-19 Testing Shows Few False Positives

Cluster of false-positive results likely the result of manufacturing issues, rather than implementation

Consuming Olive Oil May Reduce Mortality Risk in U.S. Adults

Replacing butter, margarine, mayonnaise, dairy fat with olive oil linked to reductions in total, cause-specific mortality

Response to Radiotherapy for Prostate Cancer Better in Black Men

Outcomes better for Black men compared with White men in clinical trials of definitive radiotherapy for localized prostate cancer

School Absences Common Among Pediatric Critical Care Survivors

Also, work absences common for primary caregivers after critical care hospitalization of child for acute respiratory failure

Pfizer Says Omicron-Specific Vaccine Ready by March

Pfizer also working to improve its current COVID-19 vaccine 'to address any future variant of potential concern, if needed'

Dense Breasts, High BMI May Interact to Up Breast Cancer Risk

Positive additive interaction linked to increased risk for breast cancer particularly in postmenopausal women

Selected Procedures May Be Performed by Surgical Residents Alone

Patient outcomes similar for certain procedures performed by residents alone, attending surgeons alone, residents assisted by attending surgeons

N95 Respirators Can Be Reprocessed Using Vaporized Hydrogen Peroxide

All reprocessed N95 respirators met primary end points of function and effectiveness; no change reported in filtration efficiency

Nearly 600,000 U.S. Children Had COVID-19 Last Week

Since the start of the pandemic, nearly 8.5 million U.S. children have tested positive for COVID-19

U.S. May Soon See Sharp Drop in Omicron Cases, Experts Say

One model suggests number of daily reported cases in the U.S. will top out at 1.2 million by Jan. 19 and then fall sharply

Myopia Progression May Continue in Young Adults Into Late 20s

Myopia incidence from age 20 to 28 years was 14 percent

BinaxNOW Test Catches COVID-19 Infection in Many People, Study Shows

Earlier preliminary studies had raised questions about whether rapid antigen tests might be less sensitive to omicron than other variants

Depression Up in Pediatric, Adult Hidradenitis Suppurativa Patients

Prevalence of depression increased among adults and children with hidradenitis suppurativa

White House to Give Schools 10 Million Free COVID-19 Tests Every Month

First shipments are expected later this month

Recreational Marijuana Legalization Tied to More Pediatric ED Visits

Increased frequency, severity of ED visits for cannabis exposure in children tied to legalization of commercial cannabis edibles in Ontario

Removing Race May Up Equity in Preemptive Listing for Kidney Transplant

Race coefficients applied to calculation of eGFR in non-Black transplant candidates to demonstrate more equitable preemptive listing

Aquatic Exercise Cuts Pain, Disability From Low Back Pain

Improvements show long-term effect up to 12 months following a three-month intervention

Two Doses of BNT162b2 Vaccine Protect Against MIS-C

Two doses of Pfizer-BioNTech vaccine have estimated effectiveness of 91 percent against MIS-C in children aged 12 to 18 years

COVID-19 Survivors Overestimate Lingering Taste Impairment

Authors say validated psychophysical tests can better identify true burden of chemosensory dysfunction

U.S. COVID-19 Hospitalizations Pass Last Winter’s Peak

Surge in cases has overwhelmed hospitals nationwide, and about one-quarter face critical staffing shortages

Intrathecal Morphine + Oral Gabapentin Aids Pain Management

Combination improved pain management for teens undergoing spinal fusion for scoliosis

U.S. Insurers Must Cover Eight COVID-19 At-Home Tests a Month: White House

Under the plan, people who provide insurance information at certain pharmacies will be able to get the tests with no out-of-pocket costs

Weight Loss Tied to Earlier Death in Older Women

However, grip strength and physical functioning were tied to lower risk for death, regardless of weight

Red Cross Says U.S. Blood Supply at Dangerously Low Level

People who have received COVID-19 vaccines can donate blood and platelets as long as they are symptom-free

Young Adults With Cancer Facing Psychological Distress During Pandemic

High psychological distress tied to lower quality of life, social isolation, impaired cancer care

Americans Should Avoid Travel to Canada: CDC

Agency has placed Canada under a Level 4 travel health notice, which is the highest category

Multicomponent Strategy Ups Buprenorphine Use for Opioid Use Disorder in ED

However, wide variation seen in provider uptake

In Breakthrough Transplant, Man Receives Genetically Modified Pig Heart

The Maryland heart patient is still doing well three days after the procedure was performed

Mindfulness Plus Brain Stimulation May Ease Chronic Migraine

Mindfulness practices combined with active rather than sham transcranial direct-current stimulation showed greater benefit

ADA Updates Standards of Medical Care in Diabetes for 2022

Updates include recommendation to screen for prediabetes and diabetes in all people starting at age 35 years

Breastfeeding May Reduce Maternal Cardiovascular Risk

Among parous women, risks for CVD, coronary heart disease, stroke, fatal CVD reduced for those who ever, versus those who never, breastfed

COVID-19 Incidence Up With Exposure to Airborne Pollutants

Long-term exposure to low levels of air pollutants linked to increased incidence of COVID-19 in city in Northern Italy

Children’s Behavior at Home Worse During Remote Learning

Children experiencing hybrid learning have better outcomes than with remote learning, worse behavior than with in-person learning

FDA Warns Against Using At-Home COVID-19 Test Swabs in the Throat

Throat swabs are common in some countries, but most self-tests in the United States require nasal samples

Factors at Midlife May Predict Health Trajectory in Women

Factors linked to health declines include higher BMI, lower level of education, current smoking, osteoarthritis, depression, CVD

Medicare May Rethink Premium Hike for Pricey Alzheimer Drug

Announcement comes shortly after Aduhelm maker Biogen cut the price of the drug by about half, from $56,000 to $28,000 a year

COVID-19 Vaccination Linked to Small Change in Menstrual Cycle Length

Difference in change in cycle length between vaccinated and unvaccinated cohorts less than one day in adjusted models

Amid COVID-19 Test Shortages, Price Gouging Is on the Rise

Attorney General offices around the country have reported receiving complaints or hearing stories of price gouging

Use of Certain Prescription Meds Linked to COVID-19 Mortality

Discontinuation of ACE-I, ARB, metformin associated with elevated risk for death among hospitalized COVID-19 patients

Mindfulness-Based Cognitive Therapy Beneficial in Migraine

Headache-related impairment did not improve, but headache frequency reduced and psychological functioning improved