USPSTF Advises Fluoride Dental Varnish for Young Children

Fluoride supplementation recommended for children 6 months and older if water supply does not contain enough fluoride

FDA Approves Emergency Use of Pfizer Vaccine for Those Aged 12 to 15

Vaccination side effects comparable to those seen in trial participants ages 16 to 25 years

Gene Therapy Promising for SCID Due to ADA Deficiency

High overall, event-free survival seen at 24 and 36 months for severe combined immunodeficiency due to ADA deficiency

Antibody Response Lags After Second Vaccine Dose in Transplant Recipients

Fifty-four percent of solid organ transplant recipients had antibody response after two doses of SARS-CoV-2 mRNA vaccine

Depot Buprenorphine Improves Outcomes in Opioid Dependence

Improvement seen in treatment satisfaction and several secondary end points for depot buprenorphine versus sublingual buprenorphine

Any Initial Bone Fracture Ups Risk for More Fractures in Older Women

All types of initial bone fractures associated with increased risk for subsequent fractures among postmenopausal women

Blacks, Hispanics Underrepresented in U.S. Surgical Leadership

Little progress made in increasing diversity for leadership positions in academic surgery in the U.S. from 2013 to 2019

Vaccination Rates Low Among Lupus Patients on Medicaid

Acute care use for vaccine-preventable illnesses potentially could be avoided with greater use of outpatient care, vaccination in SLE patients

Risks for Suicide, Self-Harm Up for Adult ICU Survivors

Factors include previous depression or anxiety, previous PTSD, invasive mechanical ventilation

Guidance Issued for Managing CVST After COVID-19 Vaccination

CVST with thrombocytopenia reported after COVID-19 vaccine with adenoviral vector; management similar to heparin-induced thrombocytopenia

USPSTF Advises Applying Fluoride Dental Varnish for Young Children

Fluoride supplementation recommended for children 6 months and older if water supply does not contain enough fluoride

Impaired First-Phase Ejection Fraction Tied to COVID-19 Mortality

Mortality increased in unadjusted, adjusted analyses for patients with impaired first-phase ejection fraction

Longitudinal CV Risk Inversely Linked to Cognitive Performance

Elevated systolic BP, high serum total cholesterol, obesity from childhood linked to worse midlife cognitive performance

Pre-TKA Vitamin D Deficiency May Adversely Affect Outcomes in Postmenopausal Women

Potential risk factors for moderate-to-severe knee pain after TKA include vitamin D deficiency, smoking, high BMI

Fauci Says Relaxed Indoor Masking Rules Could Be on the Way

Right now, the CDC says that even vaccinated people should still wear masks in indoor public spaces

Oral Microbiome Differs With Rheumatoid Arthritis

Those with early RA or at risk for RA show higher abundance of proinflammatory species

Nitrate in Drinking Water Tied to Spontaneous Preterm Birth Risk

Association seen for nitrate concentrations in tap water below the federal regulatory limit

App Could Analyze Eye-Gaze Patterns to ID Autism in Toddlers

Area under receiver operating characteristic curve for discriminating ASD from non-ASD was 0.90 using multiple gaze features

Internal Medicine Residency, Fellowship Applications Up During Pandemic

Authors say increase may be due to lower barriers for virtual interviews

Neurodevelopmental Disabilities Described for Children Born Preterm

Children born at 24 to 26, 27 to 31, and 32 to 34 weeks have considerable rates of moderate/severe disabilities at age 5

Rehab + Vagus Nerve Stimulation May Restore Arm Function After Stroke

Arm function improved for patients who had moderate-to-severe arm weakness at least nine months after ischemic stroke

In-Hospital Mortality Low for Pregnant Women With COVID-19

In-hospital mortality also lower for pregnant versus nonpregnant women admitted to ICU, receiving mechanical ventilation

Risk for Overdose Up With Opioid Prescriptions After Dental Procedure

Study finds increased risk for overdose among patients who fill an opioid prescription and their family members

Comprehensive Med Reviews Do Not Cut Unplanned Hospitalizations

Among older adults with and without postdischarge follow-up, incidence of unplanned hospital visits within 12 months did not differ with CMRs versus usual care

CDC Revises Website Info on How COVID-19 Spreads

Virus most commonly caught by standing near someone who is infected and when virus particles land on the face or are inhaled

Poll Finds Many Parents Hesitant to Get Younger Children Vaccinated

Only 29 percent of parents of children younger than 18 years of age said they would get their child vaccinated 'right away'

U.S. Likely to Achieve July 4 COVID-19 Vaccination Target, but Challenges Remain

Vaccine hesitancy may hamper efforts to achieve immunity in 70 to 85 percent of the total U.S. population

Pharmacy Access Varies by Racial, Ethnic Neighborhood Composition

Persistently fewer pharmacies located in Black and Hispanic/Latino neighborhoods than White or diverse neighborhoods

Removing Race Adjustment Could Up Prevalence of CKD in Blacks

Some Black medication users reclassified to lower eGFR for which dose adjustment or discontinuation is recommended

Sugar-Sweetened Drinks May Up Early-Onset CRC Risk in Women

Risk for EO-CRC increased with each serving per day during adulthood and during adolescence at ages 13 to 18 years

Link Between Drug Prices, Out-of-Pocket Spending Explored

No link found overall, but among those who pay any drug deductible or coinsurance, out-of-pocket spending increased with change in list prices

Dexamethasone Does Not Increase Risk for Surgical-Site Infection

Dexamethasone reduces risk for nausea and vomiting after nonurgent, noncardiac surgery without increasing incidence of surgical-site infection

Mediterranean Diet May Protect Against Memory Decline

Higher MeDi adherence linked to larger mediotemporal gray matter volume, better memory, less amyloid and pTau181 pathology

Response to COVID-19 Vaccine Positive in Patients With IBD

Antibody response in IBD patients, including those receiving biologic therapy at the time of vaccination, similar to that of controls without IBD

Physicians Report Sharing Office Visit Notes Beneficial Overall

While time concerns declined after implementation, half of the clinicians reported being less candid in their documentation

2.4 Million ED Visits in ≥65s Due to Unintentional Falls

More than 90 percent of emergency department visits, hospitalizations from selected nonfatal injuries in 2018 were due to unintentional falls

Physician’s Briefing Weekly Coronavirus Roundup

Here is what the editors at Physician's Briefing chose as the most important COVID-19 developments for you and your practice for the week of...

Dual Use of E-Cigarettes + Smoked Products Ups Risk for Respiratory Symptoms

Elevated risk for symptoms such as wheezing, nocturnal dry cough higher with dual use than for use of either product type alone

Low Bone Mineral Density Prognostic for Atherosclerotic CVD

Independent association found for lower BMD at lumbar spine, femur neck, total hip with higher risk for ASCVD events

Self-Reported Concussions Up for U.S. Teens From 2016 to 2020

FRIDAY, May 7, 2021 (HealthDay News) -- Between 2016 and 2020, there was an increase in the estimated percentage of U.S. eighth-, 10th-, and...

Many Oncology Patients Are Lonely During COVID-19

Those categorized as lonely have higher levels of social isolation, higher symptom severity scores for all symptoms

Pfizer to Seek Approval in Fall for COVID-19 Vaccine Use in Children Aged 2...

Company also plans to apply to the FDA this month for full approval of the vaccine for use in people ages 16 to 85 years

Biden Administration to Back Lifting of COVID-19 Vaccine Patents

Global health activists note that patent holders must also share technical know-how and personnel

CDC Gives Cruise Ship Lines Guidelines for Simulated Voyages

Agency outlines how inspections of cruise ships will be conducted during simulated and restricted passenger voyages

Exercise, Liraglutide Combo Superior for Weight Loss Maintenance

Weight loss greater compared with exercise alone, and decrease in body fat percentage greater compared with either strategy alone

Medication May Ease ADHD Symptoms in Preschool-Aged Children

Symptoms are reduced in a majority of preschool-aged children who initiate therapy with α2-adrenergic agonists or stimulants for ADHD

Lower Kidney Function May Up Dementia Risk in Older Adults

In addition, steeper decline in eGFR within one year associated with higher dementia risk

Four-Month Rifapentine Regimen With Moxifloxacin Noninferior for TB

Rifapentine-based regimen with moxifloxacin noninferior to six-month control regimen of rifampin, isoniazid, pyrazinamide, ethambutol

HPV Vaccination Rates Low for Young Adults

Rates low for 18- to 21-year-olds reporting vaccination at any age or initiating in young adulthood

AI Model Detects Normal, Abnormal Findings on Brain MRI

Model, which was trained on data from one institution and tested on data from a second institution, had area under the curve of 0.78

Factors ID’d Putting Youth on High-Risk Trajectory After First Opioid Rx

Differences between the two trajectories persist in opioid fills, misuse beyond 12 months

Cannabis Use Disorder in Pregnancy Tied to Worse Infant Outcomes

Concurrent tobacco use and minority race/ethnicity status further worsen outcomes with cannabis use disorder during pregnancy

Nocturnal Arousal Burden Linked to Long-Term CV, Overall Mortality

Arousal burden linked to significantly increased all-cause, CV mortality among women; link less clear for men

Efficacy of BNT162b2 mRNA COVID-19 Vaccine Lower in Patients With CLL

Second study shows lower neutralizing antibody titers against SARS-CoV-2 after the first dose among elderly patients with multiple myeloma

Vaccination, NPI Compliance Needed to Prevent COVID-19 Surges

Accelerated decline in nonpharmaceutical intervention adherence could undermine vaccine-related gains

Two Doses of BNT162b2 SARS-CoV-2 Vaccine Highly Effective

Real-world study shows vaccine effectiveness of 97.2 percent against COVID-19-related hospitalization, 96.7 percent against COVID-19-related death

Psychological Well-Being Worse for Children During COVID-19

After the end of in-person instruction, increase seen in frequency of youth mental health concerns, including loneliness

Canada Approves Pfizer COVID-19 Vaccine for Children Ages 12 to 15

Chief medical adviser at Health Canada says evidence is that the vaccine is safe and effective in the younger age group

Peloton Recalls Treadmills Following Child’s Death, Numerous Injuries

So far, the CPSC is aware of 72 reports of adults, children, pets, and objects being pulled under the rear of the treadmill

CDC: Provisional Number of Births Decreased in 2020

In 2020, more New York City residents gave birth out of the city; increases more pronounced for non-Hispanic White women

Erythropoietin May Up Risk for Hip Fracture in Hemodialysis Patients

Risk for hip fracture increased with EPO doses of 50 to 149, 150 to 299, and ≥300 versus <50 units/kg/week

Exposure to Ambient Air Pollutants May Up BP in Children, Teens

Long-term exposure to PM with diameter ≤2.5 µm, PM with diameter ≤10 µm, and NO2 linked to systolic BP values

Topical Corticosteroid Use in Pregnancy Not Tied to SGA, LBW

Risks for small for gestational age or low birth weight not increased with exposure to potent or very potent topical corticosteroids

COVID-19-Associated Cancer Screening Deficit Quantified in U.S.

Absolute deficit in screening estimated at 3.9, 3.8, and 1.6 million for breast, colorectal, and prostate cancers, respectively

COVID-19 Vaccine Hesitancy Found for 20 Percent on Hemodialysis

Increased odds of vaccine hesitancy seen for patients aged 18 to 44 years, Black and Native Americans or Pacific Islanders, women

Universal Multigene Panel Test in CRC IDs Heritable Mutations

Sequencing results from universal panel changed cancer treatment for roughly one in 10 colorectal cancer patients

Gender Disparities Seen in Care for Younger Patients With ASCVD

Women with premature atherosclerotic cardiovascular disease receive less optimal care than men

SLNB, RT Not Tied to Better Outcomes in Older Women With Breast Cancer

Receipt of sentinel lymph node biopsy or radiotherapy not associated with improved locoregional recurrence-free or disease-free survival

Biden Sets New Goal of Vaccinating 70 Percent of Americans by July 4

So far, more than 56 percent of American adults have received at least one dose of a COVID-19 vaccine; more than 106 million fully vaccinated

Gender Gap in Orthopedics Remains Largely Unchanged

As of April 2020, only 8 percent of orthopedic surgeons nationally are women

Gender-Affirming Surgery Tied to Better Mental Health

Among transgender and gender-diverse adults, undergoing at least one type of gender-affirming surgery related to lower psychological distress

Risk for Severe COVID-19 Increases With BMI Above 23

Risks increased for admission to hospital, death, and ICU admission; risks up for younger people and Blacks versus Whites

Many Americans Wrong About Sun’s Skin Cancer Dangers: Poll

Survey results show Generation Z and millennials have the greatest misunderstandings about sun exposure

More Parity in Breast Reconstruction Seen With Medicaid Expansion

Increases in breast reconstruction rates among non-Hispanic Black women associated with Medicaid expansion

FDA Plans to Approve Pfizer Vaccine for Those Aged 12 Years and Older

Pfizer's trial in adolescents showed its vaccine worked as well in teens as it does in adults

ACP Issues Guideline on High-Flow Nasal Oxygen for Respiratory Failure

HFNO suggested for initial or postextubation management of acute hypoxemic respiratory failure in hospitalized adults

NYC, NJ, and Connecticut to Ease COVID-19 Capacity Restrictions

Yesterday, Florida ended all restrictions; however, half of Oregon has been shut back down

Adding Aspirin May Up Risk for Patients on DOAC for A-Fib/VTE

Among patients with a-fib and/or VTE, about one-third received ASA in addition to a DOAC with no clear indication for ASA

U.K. to Ease Lockdown Measures by June 21

British population has received at least one vaccine dose, while roughly a quarter have received two shots

Many Patients Prefer Stool-Based Colorectal Cancer Screening Tests

Multitarget stool DNA test, fecal immunochemical test, or guaiac-based fecal occult blood test preferred over colonoscopy

USPSTF: Evidence Lacking for Use of Vitamins for CVD, Cancer Prevention

Task force recommends against use of beta-carotene, vitamin E for prevention of cardiovascular disease or cancer in adults

12 Cases of CVST Reported for Ad26.COV2.S Vaccine in the U.S.

Time from vaccination to symptom onset varied from six to 15 days; initial presentation was headache in 11 cases

HPV Vaccination Rates Suboptimal Within Ages 9 to 12 Years

For most of the study period, higher rates of HPV vaccination initiation and up-to-date rates were seen for non-Hispanic Blacks, Hispanics

Women Physicians Delay Childbearing Versus Nonphysicians

Physicians more likely to experience childbirth at older ages; have same cumulative probability of childbirth as nonphysicians

Child Abuse Hotline Volume Up During Pandemic

Caller type shifted during pandemic, including increase in text reports from children

Early-Life Exposure to Antibiotics Linked to Atopic Dermatitis

Exposure in utero and during first year of life linked to increased risk for atopic dermatitis; attenuated in sibling-control analysis

Cryoablation Promising for Early Breast Cancer

Almost all patients and physicians report satisfaction from cosmetic results; overall recurrence rate 2.06 percent

More Medical Errors Reported for Nurses With Poor Physical, Mental Health

Likelihood of having better physical health up for nurses who perceived that worksite was very supportive of well-being

Effect of COVID-19 on Breast Cancer Treatment Examined

More patients with estrogen receptor-positive, HER2-negative breast cancer treated with neoadjuvant endocrine therapy due to COVID-19

ACP Advises Point-of-Care Ultrasound to Aid Diagnosis of Dyspnea

POCUS suggested in addition to standard diagnostic pathway for patients in ED, inpatient setting when diagnosis is uncertain

Risk Factors ID’d for COVID-19-Related Death in Diabetes

Risk for COVID-19-related death up in association with male sex, older age, preexisting comorbidities, insulin use

Rate of Planned C-Section on Maternal Request Stable in Canada

Women with planned CDMR for low-risk pregnancies may have lower risk for adverse outcomes compared with those with planned vaginal delivery

Anxiety-Related Adverse Event Clusters ID’d After Janssen Vaccine

Rate of syncope was 8.2 per 100,000 doses after Janssen COVID-19 vaccination versus 0.05 per 100,000 after flu shots

Mortality Risk Up for Fragmented Care After Complex Cancer Surgery

Mortality higher for patients readmitted to outside hospital rather than index hospital after hepatopancreatobiliary or gastric cancer surgery

Farxiga Approved to Reduce Risk for CKD Progression

SGLT2 inhibitor approved for patients with CKD to prevent kidney function decline, kidney failure, CV death, hospitalization for heart failure

Occult Brain Mets Detected in Patients With Advanced Renal Cancer

Asymptomatic brain metastases incidentally diagnosed in about 4 percent of patients with mRCC during clinical trial screening

FDA Approves Higher-Dose Naloxone Hydrochloride Nasal Spray

8-mg dose of naloxone hydrochloride nasal spray now approved with 2-mg and 4-mg doses

Congenital Heart Disease Surgery Tied to Later Hypertension

During 10 years of follow-up, younger age at index surgery and more complex surgery particularly linked to higher risk for developing hypertension

Congo Ebola Outbreak Declared Over

It has been 42 days with no new cases since the last survivor tested negative and was discharged from Ebola treatment unit

Risk for Kidney Stones Increased During, After Pregnancy

Risk increased during second and third trimesters; peak in risk found at zero to three months after delivery, followed by decrease in risk

Many in Japan Strongly Oppose Olympics

Japanese nurses and doctors say nation's already overloaded health system cannot cope with extra pressure the Games will bring

Side Effects of BNT162b2, ChAdOx1 nCoV-19 Vaccines Quantified

Systemic side effects for 13.5 and 22.0 percent after first, second dose of BNT162b2; 33.7 percent after first dose of ChAdOx1 nCoV-19

Mental Health, Other Conditions Up for Teens With Autism

Teens with autism more likely to receive mental health services and to have an unmet medical or mental health need

Mean Cumulative Incidence of Tick Bite ED Visits 49 Per 100,000

Incidence highest in Northeast at 110 per 100,000 emergency department visits and among pediatric patients aged 0 to 9 years

Review: Meds to Lower BP May Cut Risk for Major CV Events

Findings show reduction in major cardiovascular events for those without and with previous CVD, even with normal systolic BP

Nonmedical Cannabis Users 50+ Not Likely to Discuss Use With Doctor

Authors say all older adults should be screened for cannabis and other substance use as part of routine care

Physician’s Briefing Weekly Coronavirus Roundup

Here is what the editors at Physician's Briefing chose as the most important COVID-19 developments for you and your practice for the week of...

ART Ups Life Expectancy for HIV+ in Latin America, Caribbean

Life expectancy gains seen for people living in low-income and middle-income regions in Latin America and the Caribbean, including Haiti

Pandemic Tied to Mental Health Concerns in Pregnant, Postpartum Women

Excessive information seeking doubles the odds of elevated posttraumatic stress and anxiety/depression

Supply Steady for Existing Patients Receiving Opioids During COVID-19

Opioid prescriptions for opioid-naive decreased then rebounded, while buprenorphine initiation remained lower

COVID-19 Deaths Continue to Decline in the United States

Still, more Americans need to get vaccinated, experts urge

Calcium Scores From Low-Dose Lung CT Can Predict CVD Mortality

Prediction model based on vascular calcification identified on low-dose CT outperformed model based on participant characteristics

Brazil Second Country to Record More Than 400,000 COVID-19 Deaths

April was the country's deadliest month of the pandemic, with thousands of deaths daily

FDA Says Do Not Drink ‘Real Water’ Brand Alkaline Water

As of April 26, there had been 11 probable cases and one suspected case of acute nonviral hepatitis in Nevada

Consumers Warned About Bed Rails That Pose Entrapment, Asphyxia Risk

Some models can allow a person to get trapped between the bed rail and mattress or within portions of the rail itself

Fertility Concerns Impact Treatment Decisions in Breast Cancer

One-third of young women with breast cancer indicated that fertility concerns affected decisions relating to endocrine therapy

CDC: Cruise Ships Can Soon Resume Sailing in U.S. Waters

Companies that meet certain stipulations will be allowed to return to U.S. waters by midsummer

Safety, Efficacy of Vadadustat Explored for CKD

Vadadustat did not meet noninferiority margin for MACE in patients with NDD-CKD, but did for patients with DD-CKD

Vaccination Linked to Drop in COVID-19 Hospitalization in ≥65s

Vaccine effectiveness against COVID-19 hospitalization estimated at 94 percent for full vaccination with Pfizer-BioNTech, Moderna vaccines

Incidence of Postpartum Hemorrhage Lower With Tranexamic Acid

For women undergoing cesarean section, prophylactic use of tranexamic acid results in lower risk for postpartum hemorrhage

FDA Poised to Ban Menthol Cigarettes

Agency said it will also seek to ban menthol and other flavors in mass-produced cigars

Neighborhood Socioeconomic Status Linked to Stroke Outcomes

Higher nSES associated with better function, better biopsychosocial health, fewer depressive symptoms in moderate-to-severe stroke

COVID-19 Pill Could Be Available Later This Year: Pfizer CEO

If clinical trials are successful and the FDA approves the drug, it could be available across the United States later in 2021

Unsafe Sleep Factors Common in Sudden Unexpected Infant Deaths

82 percent of the cases categorized as unexplained; 72 percent of SUIDs occurred in unsafe sleep environment

Many Americans Have COVID-19 Vaccine Preferences

Most (36 percent) prefer Pfizer, followed by Moderna at 19 percent and Johnson & Johnson at 17 percent

Peripheral Nerve Stimulation May Cut Pain After Orthopedic Surgery

Pain scores, opioid consumption reduced in first postoperative week with percutaneous peripheral nerve stimulation versus sham treatment

Urinary Incontinence Surgery in Women Not Tied to Pelvic Cancer

At a median follow-up of 8.5 years, no increased risk for pelvic malignancy seen following mesh or nonmesh SUI surgery

Delayed Antibiotic Prescribing Safe for Respiratory Tract Infection

No differences seen in follow-up symptom severity for delayed versus immediate antibiotics or for delayed versus no antibiotics

Genetics May Predict Vasomotor Symptoms in Menopause

However, impact of genetic variants may vary across racial/ethnic groups

Many U.S. Colleges Will Mandate Vaccines on Campus Next Fall

Schools that are not requiring vaccinations are instead offering incentives to encourage students to get their shots

Consider Meds for Persistent Stage 1 HTN at Six Months

Consideration should be given to addition of meds for adults not meeting BP goals after six months of lifestyle therapy

Assessing HDL Anti-Inflammatory Capacity May Aid CV Risk Prediction

HDL anti-inflammatory capacity associated with cardiovascular disease events independent of cholesterol efflux capacity

No Signal of Facial Paralysis Found for mRNA COVID-19 Vaccines

No signal of disproportionality of facial paralysis seen for broad or narrow definitions versus other viral vaccines, influenza vaccines alone

HHS Issues Guidelines Expanding Access to Buprenorphine Treatment

Eligible practitioners who are registered to prescribe controlled substances are exempt from certain statutory certification requirements

QTc Interval Prolonged in Some Hospitalized With COVID-19

QTc prolongation seen in association with age 80 years and older, severe chronic kidney disease, elevated hs-troponin levels

Hand Hygiene Compliance Rates Peaked >90 Percent in March 2020

Across all units, compliance decreased from daily peak of 92.8 percent on March 29 to a daily nadir of 51.5 percent on Aug. 15, 2020

Exposure to Secondhand Smoke May Raise Risk for Oral Cancer

Higher risk for oral cancer with longer duration of exposure to secondhand smoke further supports possible causal link

Unhealthy Lifestyle Only Explains Part of Health Disparities of Poor

Overall lifestyle only explained 3 to 12.3 percent of the excess risks

Younger Age at T2DM Onset Linked to Subsequent Dementia Risk

Every five-year younger age at onset of type 2 diabetes linked to hazard ratio of dementia of 1.24 at age 70 years

White House to Propose Menthol Cigarette Ban

Also anticipated is a ban on menthol and other flavors in mass-produced cigars, including small cigars

Outcomes of MitraClip for Secondary Mitral Regurgitation Reported

No difference seen across mitral valve gradient quartiles for two-year composite end point of all-cause mortality, heart failure hospitalization

$100 Savings Bonds Offered to Young People in West Virginia Who Get COVID-19 Shot

Bond offer will apply retroactively to those who have already received a COVID-19 vaccine

Cannabis Use Disorder Tied to Spine Surgery Complications

Surgical patients with concurrent cannabis use disorder had higher rates of inpatient neurovascular, thromboembolic, and pulmonary complications

AAO/HNS Issue Guideline for Opioid Use After Otolaryngologic Surgery

Recommendations aim to improve postoperative pain control while reducing the risk for opioid use disorder

ED Staff Reported Poor Mental Health During Early Pandemic

Almost half reported exhaustion, burnout, while one in five indicated PTSD symptoms

Failure to Rescue Drives Racial Disparity in Maternal Mortality

Failure to rescue decreased nationally from 1999 to 2017; however, disparities for five racial and ethnic groups persisted overall

Factors Tied to Severe COVID-19 in Children Identified

Hispanic, Black children overrepresented for COVID-19 infections, but not severe disease

Early-Life Exposure to Famine Linked to Increased Odds of RA

Odds ratios for rheumatoid arthritis increased for individuals exposed to famine in utero and at ages 0 to 3, 3 to 6, and 6 years or older

AGA Issues Guidelines on Intragastric Balloons for Managing Obesity

IGB therapy with lifestyle modification suggested for those with obesity who have failed conventional weight-loss strategies

USPSTF Reaffirms Benefit of Hypertension Screening for Adults

Screening for hypertension with office blood pressure measurement recommended for adults aged 18 years and older

CDC Says Vaccinated Can Shed Masks Outside, Except in Crowds

Even unvaccinated individuals may go without masks when walking, jogging, or biking outdoors with household members

AstraZeneca Sued by EU Over Vaccine Shipment Delays

European officials say AstraZeneca broke its contract when it said it would deliver only a third of the 300 million doses promised by end of June

Increasing BMI Ups Risk for Second Cancer After Breast Cancer

Increased risks seen for any second cancer, obesity-related cancer, second breast cancer, second ER-positive breast cancer

Eleven Novel Loci Identified for Rheumatoid Arthritis

Total of 615 plausible effector genes include targets of drugs approved for RA and repurposable drugs

Preeclampsia Linked to Increased Stroke Risk in Later Life

Association only evident when adjustment was made for all vascular risk factors over the life course

Shift Work Linked to Increased Risk for COVID-19 Illness

Associations seen for shift work, irregular or permanent shift work, day-shift work, irregular or permanent night-shift work

Rapid Antigen Test Can ID Contagious People in SARS-CoV-2 Outbreak

Percentage positive agreement was 95 percent for BinaxNOW with virus culture for ID of replication-competent virus

Carboplatin Alone Not Adequate for Ovarian Cancer in Frail Seniors

Worse survival than with combination carboplatin-paclitaxel regimens for vulnerable older patients with ovarian cancer

Racial/Ethnic Disparities Identified in Ophthalmology Trials

Black and Hispanic or Latinx participants are underrepresented in clinical trials for drugs for AMD, OAG, DR

Baseline Patient Characteristics May Predict Psoriasis Course

Among patients with plaque phenotype, high disease activity, and scalp lesions, 52 percent developed severe disease

Wildfire Air Pollution Tied to Uptick in Visits for Dermatitis, Itch

Increased health care utilization seen for pediatric and adult patients

Transient Improvement Found in Sedentary Time in CKD With Intervention

Maximum reduction in sedentary duration and increase in number of steps/day seen at week 20, attenuated by week 24

Female Sex, Work Culture Biggest Contributors to Physician Burnout

Compared with electronic health record usage at an academic medical center, clinician sex and work culture contributed more to burnout

Steroids Unrelated to Psychological Reactions in Pediatric ALL

Low-quality evidence suggests type/dose of steroid not linked to adverse psychological reactions, possibly associated with sleep problems

VTE Risk High in Cancer Patients Receiving Immune Checkpoint Inhibitors

History of VTE predicts VTE occurrence; VTE occurrence linked to increased mortality

FDA Holds Meeting to Review Merits of Approved Cancer Drugs

Three-day meeting prompted by what FDA officials call an 'unprecedented level of drug development' in recent years

CDC Issues Updated Summer Camp Guidelines

When activities must be indoors, spaces should be well ventilated and windows should be kept open

COVID-19 Vaccinations Now Mandatory for Houston Methodist Hospital Workers

In March, health system gave vaccinated workers an extra $500 and warned that at some point the shots would no longer be voluntary

EU Will Allow Fully Vaccinated U.S. Tourists

No word on a timeline on when exactly tourist travel might open up or details on how it would occur

U.S. Will Help India in Fight Against COVID-19: Biden

United States is 'working around the clock' to immediately send drug treatments and rapid diagnostic COVID-19 testing kits to India

Bimekizumab Tops Secukinumab for Plaque Psoriasis

In second study, bimekizumab showed noninferiority and superiority to adalimumab for moderate-to-severe disease

Millions of Americans Have Missed Their Second COVID-19 Vaccine Dose: CDC

Local health authorities struggling to make sure that those who get their first shot also get their second

AHA Offers Guidance for CVD Risk in Breast, Prostate Cancer

Patients with breast, prostate cancer who are receiving hormonal therapy more likely to develop cardiovascular risk factors

Lower Incomes Increase Cancer Worry, Anxiety During Pandemic

Worry, anxiety up with lower annual income for Medicaid-insured women receiving gynecologic oncology care during March 15 to April 15, 2020

Probiotic With Low-Dose Iron Studied in Pregnant Women

Iron status improved in healthy pregnant women randomly assigned to Lactiplantibacillus plantarum 299v product versus placebo

Intraabdominal Fat Ups Health Risks in Absence of Obesity

Interventions investigated to reduce these adipose tissue depots, with lifestyle interventions as effective as medications (or more so)

Noncalcified Coronary Plaque Up for People Living With HIV

Calcified coronary plaque prevalence lower among PLWH without known cardiovascular disease versus healthy volunteers without HIV

Hearing Loss Tied to Less Physical Activity in Older Adults

Mild and moderate-or-greater hearing is equivalent to 5.84 and 7.28 years of aging, respectively

Tocilizumab Preserves Lung Function in Early Systemic Sclerosis

Stabilization of lung function independent of the extent of quantitative radiographic interstitial lung disease or fibrosis at baseline

Younger Age at First Drug Use Tied to Faster Transition to Substance Use Disorder

Past-year substance use disorder higher for adolescents than young adults at all examined time frames since first use

Physician’s Briefing Weekly Coronavirus Roundup

Here is what the editors at Physician's Briefing chose as the most important COVID-19 developments for you and your practice for the week of...

FDA Moves to Resume Use of J&J COVID Vaccine

Johnson & Johnson has agreed with the U.S. Food and Drug Administration to add a warning label to the vaccine

Pfizer and Moderna Vaccines Effective Against New NYC Variant​

Studies add to growing evidence that the two vaccines protect against all coronavirus variants identified so far

Psoriasis Incidence in the United States Remains Steady

New diagnosis of psoriasis increases with age, is similar between sexes, and is greatest among Whites

FDA Approves Immunotherapy for dMMR Endometrial Cancer

Jemperli approved for dMMR endometrial cancer that progressed after platinum-containing chemotherapy treatment

CDC: Salmonella Outbreak Linked to Jule’s Cashew Brie​

Two people hospitalized; no deaths reported

Few SARS-CoV-2 Vaccine Breakthrough Infections Reported at SNFs

22 infections identified among 12 residents and 10 staff members at 15 skilled nursing facilities; no facility-associated secondary transmission reported

Single-Dose Ad26.COV2.S Effective Against COVID-19

Also effective against cases in South Africa, which mainly comprised infections caused by the 20H/501Y.V2 variant

Claim Rates ID’d for Musculoskeletal Disorders From Overexertion

Work-related musculoskeletal disorder claims from overexertion among construction workers were highest for those aged 35 to 44 years

Severe Maternal Morbidity, Mortality Up With COVID-19 in Pregnancy

Asymptomatic women with COVID-19 diagnosis only have increased risks for maternal morbidity and preeclampsia

Opportunistic Mobile ECG Detects A-Fib in American Indians

New atrial fibrillation was detected in 1.5 percent of patients screened versus 0.3 percent of controls, who did not undergo screening

One-Quarter in Ocular HTN Treatment Study Developed Visual Field Loss

20-year cumulative incidence of primary open angle glaucoma was 45.6 percent after adjustment for exposure time

CSVD Severity Up for Minority Intracerebral Hemorrhage Survivors

Minority ICH survivors have greater global cerebral small vessel disease and hypertensive arteriopathy burden on MRI

Sacituzumab Govitecan Treats Metastatic Triple-Negative Breast Cancer

Progression-free, overall survival prolonged with sacitizumab govitecan versus single-agent chemotherapy

Survivors of Adolescent, Young Adult Cancer Face Financial Hardships

Hardships include forgoing care and medication nonadherence due to cost

Margin-Positive Surgery Still Beneficial in Pancreatic Cancer

Survival benefit seen for surgery, even with R1/R2 resection margins compared with chemotherapy alone for stage II pancreatic cancer

Air Pollution, Exercise Combined Affect CVD Risk in Young Adults

Increased physical activity with high exposure to air pollution may increase risk for cardiovascular disease

No Obvious Safety Signals ID’d for mRNA COVID-19 Vaccine in Pregnancy

Adverse neonatal outcomes included preterm birth and small for gestational age; no neonatal deaths reported