Booster Shots a Likely Reality for COVID-19-Vaccinated Americans

And, CDC has scheduled a new emergency hearing on the safety of J&J vaccine for April 23

Hemorrhagic Stroke + COVID-19 Doubles Risk for In-Hospital Mortality

In addition to increased risk for death, hospital and ICU lengths of stay are longer

Grandmaternal DDT Exposure Tied to Granddaughter Early Menarche, Obesity

o,p'-DDT exposure in normal-weight, but not overweight or obese, grandmothers linked to obesity in granddaughters

Risk-Based Approach Developed to Triage Mammography Use

Clinical indication and individual risk factors linked to breast cancer detection and could help triage mammography use

Chronic Adverse Effects From Anti-PD-1 Immunotherapies Common

About 43 percent of patients who receive anti-PD1 therapy for advanced melanoma have chronic immune-related adverse effects

Brain Activity May Play Role in ‘Broken Heart Syndrome’

Stress-related brain activity tied to higher risk for developing Takotsubo syndrome

Gens X and Y Show Worrisome Trend of Declining Health

Future increase in morbidity and mortality rates likely as younger generations age

Severe Mental Illness Tied to Higher Risk for Heart Attack Death

Those with severe mental illness also less likely to receive revascularization

ATA Issues Guidelines for Managing Anaplastic Thyroid Cancer

Evidence-based guidelines address diagnosis, evaluation, and treatment, including early multidisciplinary care team involvement

Response to One COVID-19 Vaccine Dose Strong in Previously Infected

Neutralizing antibody titer is higher after one dose of mRNA vaccine than after two vaccine doses in previously uninfected persons

Psilocybin Compared With Escitalopram for Depression

No difference seen in change in depression scores at six weeks for psilocybin plus placebo versus psilocybin plus escitalopram

Study Explores Oxytocin Use in Active Phase of Induced Labor

Discontinuation of oxytocin may lead to small increase in rate of cesarean section, decrease in fetal heart rate abnormalities

AAN: Neurological Manifestations Common in Children With PIMS-TS

Children with neurological involvement have higher peak inflammatory markers, are more likely to be ventilated

AAN: Race May Affect Response to Anti-CD20 Therapy for MS, NMOSD

B-cell repopulation occurs more often in African American versus White patients between six and 12 months after anti-CD20 infusion

Children With Worse Atopic Dermatitis More Likely to Have Learning Disabilities

Findings independent of socioeconomic characteristics, onset age, and other related disorders

Neighborhood Disadvantage Tied to Cognitive Decline in Older Adults

Cortical thinning partially mediates the association between neighborhood-level disadvantage and cognitive decline

AACR: Ovarian Cancer Patients at Higher Risk for Mental Illness

Increased risks for anxiety, depression, adjustment disorder especially high during first two years after diagnosis

Asthma Exacerbations, ED Admissions Decreased During Lockdown

Nonpharmaceutical interventions to reduce COVID-19 associated with reduction in admissions for COPD, asthma

Even Moderate Caffeine Intake in Pregnancy Tied to Smaller Babies

Consuming more than 50 mg of caffeine per day (the amount in about half a cup of coffee) linked to lower birth weight

ED Visits Down Dec. 2020 to Jan. 2021 Versus Prepandemic

Emergency department visits were 25 percent lower during December 2020 to January 2021 versus one year earlier

Routine Cancer Screenings Declined Significantly at Start of Pandemic

However, mammography and colonoscopy rates rebounded substantially by the end of July

U.S. Overdose Deaths Have Soared During COVID-19 Pandemic

Increase largely driven by illicitly manufactured fentanyl and other synthetic opioids

Thousands of Vaccinated People in U.S. Infected With COVID-19

New data are the first to indicate how effective COVID-19 vaccines are in real life

CDC Panel Says It Needs More Time to Study J&J Vaccine Clotting Cases

Advisers to the CDC say they do not have enough information or time to recommend how to proceed and they will meet again within 10 days

Suicide Rate Up for Nurses Versus General U.S. Population

Among women, suicide incidence was higher among nurses than the general population, with relative risk of 1.99

USPSTF Finds Evidence Insufficient for Vitamin D Screening

Evidence insufficient to ascertain benefits and harms of screening for vitamin D deficiency in asymptomatic adults

B.1.1.7 SARS-CoV-2 Variant More Transmissible but Not Linked to More Severe Illness, Death

Second study shows no change in symptoms, disease duration, reinfection rates with B.1.1.7, but reveals multiplicative increase in R1

Racial/Ethnic Disparities Vary in COVID-19 Hospitalization

Geographic and temporal differences ID'd in racial and ethnic disparities in COVID-19 hospitalization levels during 2020

Regular Physical Activity Cuts Risk for Severe COVID-19

Infected adults regularly meeting physical activity guidelines have lower risk for hospitalization, death

Study Explores Links Between Diet, Gut Microbiome, and Inflammation

Animal foods, sugar, processed foods tied to inflammatory gut microbiome, while plant-based foods tied to anti-inflammatory microbes

Insomnia Tied to Suicidal Thoughts, Worse Symptoms With Schizophrenia

Authors say that it is important for providers to assess sleep patterns in patients with schizophrenia

Work-Related Carpal Tunnel Syndrome Down From 2003 to 2018

Workers in construction, manufacturing jobs may be more susceptible to carpal tunnel than those working in office jobs

MRSA Colonization Linked to Increased Mortality Risk in Adults

Hazard ratio for mortality was 1.75 for community-dwelling adults aged 40 to 85 years colonized with MRSA

Three-Drug Regimen Treats Cystic Fibrosis in Younger Children

Elexacaftor/tezacaftor/ivacaftor well tolerated in children aged 6 through 11 years with cystic fibrosis and at least one F508del-CFTR allele

Excess Body Weight Tied to Higher Health Costs Across BMI Levels

Obesity associated with an estimated excess annual medical cost of $1,861 per person among U.S. adults

Firearm Injuries Up in Children Under 12 During COVID-19 Pandemic

Compared with prepandemic period, increases seen in risk for firearm injuries in young children and injuries inflicted by young children

CDC: U.S. STD Rate at Record High Again

In 2019, nearly 2.5 million Americans had an infection of chlamydia, gonorrhea, or syphilis

Moderna COVID-19 Vaccine 90 Percent Effective Six Months After Second Dose

Company also says vaccine is 95 percent effective against severe cases of the disease

Trump Ban on Clinic Abortion Referrals to Be Reversed​

Ban forced Planned Parenthood out of the federal family planning program called Title X

FDA to Set Limits on Toxic Elements in Baby Food

Agency said it will assess the science, set maximum acceptable levels, and monitor baby food makers' compliance

Rare Thrombosis, Thrombocytopenia Seen After AstraZeneca COVID-19 Vaccine

Reports document 16 reactions in young European patients following first dose of ChAdOx1 nCoV-19 vaccine

Excellent Outcomes Found for Neonates Born to SARS-CoV-2-Postive Moms

Most neonates fed unpasteurized expressed breast milk until discharge; 85 percent were breastfed postdischarge

Effects of Leisure Time, Work Activity on CV Events, Mortality Explored

Higher levels of leisure time, but not occupational, physical activity associated with decreased risk for cardiovascular events, death

AACR: Copanlisib + Rituximab Slows Relapsed Indolent Lymphoma

Significant reduction found in risk for disease progression/death for C+R versus placebo and rituximab

Nurse Work Environment Tied to Ischemic Stroke Outcomes

Better work environment associated with fewer readmissions and shorter length of stay

Prescribing Up for Drugs Associated With Falls in Older Adults

Concurrent rise seen in fall-related mortality in older adults in the United States from 1999 to 2017

New Criteria Aid Diagnosis of Traumatic Encephalopathy Syndrome

Diagnosis of TES requires exposure to repetitive head injury, core features of cognitive impairment/neurobehavioral dysregulation

Eating Fish Cuts Risk for Recurrence, Death in Those With CVD

Lower risk seen for major CVD, mortality with a minimal fish intake of 175 g (approximately two servings) weekly in those with vascular disease

ACG Updates Guidelines for Colorectal Cancer Screening

Recommendation strong for screening average-risk individuals from age 50 to 75 years; recommendation conditional for screening from age 45 years

FDA, CDC Call for Pause in J&J COVID-19 Vaccine After Six People Develop Clots

The six cases involved a cerebral venous sinus thrombosis and occurred in women between the ages of 18 and 48 years

COVID-19 Infection May Up Mortality in Surgical Patients

Authors recommend postponing surgery for patients with positive preoperative COVID-19 test result

Medicare Payment Patterns Examined for Hip Fracture Surgery

From 2005 to 2014, the ratio of Medicare reimbursements for hospital charges compared with surgeon charges has increased

WHO Urges Halt to Sale of Live Wild Animals at Food Markets

Agency says wild animals 'are the source of more than 70 percent of all emerging infectious diseases in humans'

Restrictions on Access to Abortion Pill Will Be Lifted During Pandemic

Decision means that health care providers in some states will be able to prescribe mifepristone via telemedicine and mail the pills to patients

Ground Turkey Linked to Salmonella Outbreak

Two people have been hospitalized, but no deaths have been reported

FDA OKs Marketing of First AI Device Used to Detect Lesions During Colonoscopy

The GI Genius identifies 'regions of interest' in real time to help clinicians determine where further assessment may be needed

Skin Reactions Usually Mild After COVID-19 Vaccination

Most common were delayed large local reactions, followed by local injection site reactions, urticarial eruptions, morbilliform eruptions

Blood Clot Risk High Following COVID-19 Hospitalization

However, anticoagulation cuts risk for major thromboembolic events by 46 percent

Dialysis Patients Develop Lower Antibody Response to Pfizer COVID-19 Vaccine

Response is lower than for individuals without kidney disease, and age affects response regardless of medical conditions

Banning Youth Use of Tanning Bed Would Be Cost-Effective

Ban could reduce the number of melanoma cases and decrease lifetime health care costs, despite compliance costs

AACR: Personalized Vaccine for Cancer Tolerated, Feasible

Vaccine well tolerated in 13 patients; vaccine showed potential benefit in patients with solid tumors, multiple myeloma in phase 1 trial

AACR: Healthy Lifestyle May Counter High Genetic Risk for Lethal Prostate Cancer

But adherence to healthy lifestyle not associated with decreased risk for overall prostate cancer

Thiazides May Up Risk for Skin Cancer in Older Adults

Increased exposure linked to significantly increased rates of incident keratinocyte carcinoma, melanoma in adults ≥66 years

Mortality Lower With PDE5i Treatment in Men With Stable CAD

Mortality risk lower with PDE5i treatment versus alprostadil treatment; similar links seen for MI, heart failure, CV mortality risks

Rumination Syndrome Often Missed or Misdiagnosed

Heartburn, regurgitation symptoms, particularly daytime regurgitation/reflux, may help identify patients with rumination syndrome

FDA to Decide ‘Quickly’ on Pfizer Request to Approve COVID-19 Vaccine for Children 12...

Currently, the FDA allows the Pfizer vaccine to be given to people 16 years and older

AHA Issues Statement on Central Retinal Artery Occlusion

Acute CRAO is a medical emergency and patients should be immediately triaged to an emergency department

Antibody Cocktail May Curb Infection in Unvaccinated Exposed to COVID-19

Drug company will ask FDA to expand the drug's EUA to allow it to be given for preventive purposes in 'appropriate populations'

Scammers Selling Fake COVID-19 Vaccination Cards

Fakespot, which identifies online retail scams, has pinpointed hundreds of different sellers of fake vaccination cards since the start of the year

Chinese COVID-19 Vaccines Not Very Effective: Official

Effectiveness of one vaccine at preventing symptomatic infections was found to be as low as 50.4 percent by researchers in Brazil

Several Racial/Ethnic-Minority Groups Underrepresented in Health Care Professions

Greater efforts needed to increase diversity in health care professions

Decrease Seen in Suicide Rate in the United States

Decrease seen despite concerns there would be more suicides due to the COVID-19 pandemic

Bariatric Surgery Cuts Cancer Risk With Obesity + Liver Disease

Risk reduction even greater for obesity-related cancers

Supply of J&J COVID-19 Vaccine to Drop 86 Percent Next Week

And, North Carolina has stopped administering Johnson & Johnson vaccines after at least 26 people experienced adverse reactions

Preterm Birth May Up Risk for Later Mental Health Issues

Prescription rates for psychotropic drugs during adolescence, young adulthood higher with preterm birth versus birth at term

First Living Donor Transplant of Lung Tissue to COVID-19 Patient Announced

Female recipient received lung tissue donated by her husband and son

Social Factors Affect Treatment for Mantle Cell Lymphoma

Unmarried, less-educated patients less likely to receive autologous hematopoietic cell transplantation

CDC: Risk for Catching Coronavirus From Surfaces Is Low

Agency says the risk for contracting the virus from a contaminated surface is less than 1 in 10,000

Cancer, Heart Disease Have Common Risk Factors

Age, sex, smoking status, 10-year atherosclerotic risk score, and natriuretic peptide concentrations tied to future cancer risk

Replacing TDF With TAF for HIV Tied to Adverse Metabolic Changes

Switch to tenofovir alafenamide linked to increase in body weight, development of obesity, worsening of serum lipid levels

Dietary Advice Poor for Mothers Breastfeeding Infants With Food Allergies

Researchers found dietary advice from providers to be inconsistent

Antibodies Persist Six Months After Second Dose of Moderna COVID-19 Vaccine

Neutralizing antibody titers significantly lower in those older than 55 years versus those 18 to 55 years of age

Blood Type Not Associated With COVID-19 Outcomes

No associations seen for disease susceptibility, severity, or outcomes for either White populations or diverse populations

Physician’s Briefing Weekly Coronavirus Roundup

Here is what the editors at Physician's Briefing chose as the most important COVID-19 developments for you and your practice for the week of...

Mortality Risk Up for Dialysis Patients in March to July 2020

Higher death rates seen in 2020 versus same time period in 2017 to 2019 among patients who were on dialysis or had a functioning transplant

In-Hospital SARS-CoV-2 Mortality Declined Throughout Pandemic

Authors say reductions in in-hospital mortality likely due to new therapies and improvements in clinical management of patients with SARS-CoV-2

Considerable Neurologic, Psychiatric Morbidity Reported After COVID-19

Estimated incidence of neurological or psychiatric diagnosis was 33.62 percent among 236,379 patients

Diabetes Tied to Mortality, CV Events in Chronic Coronary Syndrome

Diabetes linked to increased risks for primary outcome of cardiovascular death, MI, stroke and secondary outcomes

March 2020 to January 2021 Saw 23 Percent Jump in Mortality

Death rate was higher among non-Hispanic Blacks; 72.4 percent of excess deaths were attributed to COVID-19

Diet, Exercise Intervention Explored in Children With B-ALL

Reduction in fat gain not seen in overall cohort, but stratified analysis showed benefit among those overweight, obese at baseline

Having Visual, Hearing Impairments Linked to Dementia in Elderly

Dual sensory impairment, but not single sensory impairment, associated with increased prevalence of dementia

NIH Starts Trial Looking at Rare Allergic Reactions to COVID-19 Vaccines

Research will also address biological mechanism causing the reactions and whether there is a way to predict risk

Dose-Response Analysis Could Improve Peanut Allergy Labeling

The dose to elicit an allergic reaction in 1 percent of patients with peanut allergies is 0.052 mg of peanut protein

Special ACA Enrollment Window Brings Insurance to 500,000 Americans

Consumers who were already enrolled at the beginning of this year are also entitled to the increased financial aid

Oral COVID-19 Vaccine Being Tested

T cell oral vaccine targets the globe in the middle of the virus, a part less prone to mutation

Poll: Despite Pandemic’s Toll, Many Older Adults Do Not Have Living Wills

Only 7 percent of respondents said COVID-19 had motivated them to have a conversation with loved ones about their wishes if they became severely ill

Changes in Cancer Incidence, Deaths Expected by 2040

Most common cancers will be breast, melanoma, and lung, while most common cause of cancer-related death will remain lung

COVID-19 Cases Climb in the Midwest as British Variant Takes Hold in U.S.

Officials warn of fourth wave of COVID-19 cases this spring due to emergence of more contagious variants. easing of social distancing

Protocol Ups Referrals to Tobacco Quit Line in Rheumatology Clinics

Referrals took less than 90 seconds and increased 26-fold with staff usage of Quit Connect protocol

FDA Investigating Infections Tied to Reprocessing Urological Endoscopes

More than 450 medical device reports of patient infections, potential contamination recorded from Jan. 1, 2017, to Feb. 20, 2021

Benefit Suggested for Earlier Interventions in Infants With Cerebral Palsy

Data of limited quantity and quality suggest benefit from early interventions, with medium effect size for motor development

Poll: Public Lost Trust in CDC During COVID-19 Crisis

During recent survey period, trust in the CDC dropped about 10 percent

Arkansas Bans Gender-Confirming Treatments, Surgery for Transgender Youth

Under the ban, doctors cannot provide gender-confirming hormone treatment, puberty blockers, or surgery to anyone younger than 18 years

‘Double Mutant’ Coronavirus Variant Detected in US for First Time

Variant has two mutations that help the virus attach to cells and has been driving a surge of COVID-19 cases in India

Two Peaks in MIS-C Followed COVID-19 Peaks in the US

Lowest proportion of severe manifestations seen in patients aged 0 to 4 years, but 44.3 percent admitted for intensive care

Comfort Care Intervention Use for Ischemic Stroke Increased Over Time

CCI use still low but associated with significant decline in in-hospital mortality over time

COVID-19 Vaccination During Pregnancy May Protect Infant

The observed IgG transfer ratio demonstrates an infant antibody level about equal to maternal level

Majority of E-Cigarette Users Want to Quit

Former cigarette smokers have the highest levels of intention to quit and interest in quitting vaping

Stethoscope Remains Best Way to Monitor Fetal Distress During Labor

Review of 33 studies, including seven monitoring methods, shows no benefit from newer strategies

Strong Rebound in Mammography Volume Noted by July 2020

Rebound followed decrease in April 2020 versus prepandemic April 2019 level; rebound lower for Hispanic, Asian women

Risk for Acute Kidney Injury High With Protocol for Post-TKA Infection

AKI seen in 14 percent of patients treated with antibiotic-loaded bone cement spacer after resection of periprosthetic joint infection

Interval Cancers Down With Digital Breast Tomosynthesis

Interval cancer rate 1.6 per 1,000 women screened with DBT compared with 2.8 per 1,000 women screened with digital mammography

Chest CT Indicates Mortality Risk in COPD

Individuals with higher SAT index had lower risks for mortality, while higher IMAT index linked to higher mortality risk

‘Possible Link’ Found Between AstraZeneca COVID-19 Vaccine, Rare Blood Clots

EU agency experts reviewed several dozen cases and determined that such clots are 'very rare' side effects of the vaccine

Systemic Inflammatory Disease Tied to Mortality After MI in Young Adults

During follow-up, patients had increased risk for all-cause mortality

COVID-19 Funeral Assistance Program Announced by White House

Number of people who will be eligible is not known and neither is the program's cost

1999 to 2018 Saw Decline in Mean BP Among U.S. Children, Teens

However, authors warn that stagnation and possible increase in more recent years may indicate reversal of trend

Branded Rx Requests Up Medicare Costs by $1.6 Billion

Physician, patient requests account for almost one-third of branded dispensing

Mass COVID-19 Vaccinations May Help Protect Unvaccinated People

Researchers found that vaccination rates among adults reduced rates of infection among children younger than 16 years

Shelter-in-Place Orders Tied to Weight Gain

Findings regardless of geography or comorbidities and translate to 1.5 pounds per month

Few COVID-19 Infections Seen in Vaccinated Health Care Workers

Incidence of COVID-19 infection extremely low among fully vaccinated health care workers

New Coordinator Appointed for U.S. Global Response to COVID-19 Pandemic

Gayle Smith's duties will include harnessing U.S. knowledge and resources to increase COVID-19 vaccine production and distribution worldwide

Acupuncture Effective for Chronic Muscular Pain in Cancer Survivors

However, more adverse events seen with auricular acupuncture versus electroacupuncture

First U.S. Trachea Transplant Patient Breathing Freely

So far, patient has not had any complications or signs of rejection

Patient Navigation Services Cut Readmission in Adults With SUD

Readmissions and emergency department use reduced among hospitalized adults with comorbid substance use disorder

Walgreens Was Not Following COVID-19 Dose Timing Guidelines

CDC has asked Walgreens to use the recommended three-week period between doses

Persistent Midlife Loneliness May Up Later Dementia, AD Risk

However, transient loneliness compared with no loneliness during middle age appears to lower dementia risk

High Physical Activity, Low Air Pollution Exposure Cut T2DM Risk

However, habitual exercise reduces risk for type 2 diabetes regardless of level of exposure to particulate matter air pollution

Prevalence of Psychiatric Disorders High After Juvenile Detention

At 15 years after detention, 52.3 and 30.9 percent of men and women had one or more psychiatric disorders

No Increase Seen in Outpatient VTE for SARS-CoV-2-Positive Patients

Patients with positive SARS-CoV-2 test had higher 30-day incidence of hospital-associated, but not outpatient, VTE

Remote Cardiology Visits Tied to Less Prescribing, Diagnostic Testing

Findings seen for both video and telephone cardiovascular care visits compared with pre-COVID-19 in-person visits

Previously Infected May Only Need Single Dose of COVID-19 Vaccine

Spike-specific IgG antibody levels and ACE2 antibody binding inhibition responses similar to those in infection-naive after two doses

Increased CVD Risk With ß-Blockers for HTN in Veterans With HIV

Twenty-five percent experienced CVD event during follow-up; risk up for ß-blocker use but not with calcium channel blockers, diuretics

About 40,000 Children Have Lost a Parent to COVID-19

Three-fourths of children losing a parent to COVID-19 are teens; Black children disproportionately affected

Risk of Quitting Up for Medical Center Employees, Faculty During Pandemic

Lack of child care tied to consideration of leaving the workforce, lessening hours

Increase in Overall Costs With Use of Urgent Care Centers

Reduction in lower-acuity emergency department visits was offset by increase in urgent care center costs

Consuming Processed Meat Regularly May Up CVD, Mortality Risk

Higher intake of unprocessed red meat, poultry not tied to increased risks for mortality, major cardiovascular disease

Navajo Nation Curbs COVID-19 Cases

Tribe currently averaging about 11 new cases a day, compared with a peak of 250 in late November

Tislelizumab Plus Chemo Slows Advanced Squamous NSCLC

Progression-free survival significantly longer with tislelizumab plus chemotherapy versus chemotherapy alone

Utah Law Requires Fathers to Contribute to Pregnancy Costs

Father's financial obligation would include a pregnant woman's health insurance premiums and any pregnancy-related medical costs

2005 to 2015 Saw Increase in LOS for Pediatric ED Mental Health Visits

Increase in prolonged length of stay for pediatric mental health ED visits; no change in LOS for non-mental health visits

‘Vaccine Passports’ to Be Part of Britain’s Reopening Plan

Other proposals in the plan expected to be unveiled Monday include frequent mass testing with at-home test kits

Pregnant Women Show Robust Immune Response to COVID-19 Vaccine

And passage of antibodies through the placenta and breastmilk appears to confer immunity to newborns

Routine HPV Vaccination for Older Adults May Not Be Cost-Effective

Two microsimulation models used to examine cost-effectiveness of HPV vaccination for U.S. women and men aged 30 to 45 years

Substance Use Disorder Costs Topped $13 Billion for Hospitals in 2017

Costs of treatment and prevention could potentially be offset by cutting direct medical costs, authors say

Medicare Spending on Physician Services Down $9.4B During First Half of 2020

Declines seen regardless of service type, setting, or specialty, and state or region

Physician’s Briefing Weekly Coronavirus Roundup

Here is what the editors at Physician's Briefing chose as the most important COVID-19 developments for you and your practice for the week of...

CDC: Fully Vaccinated Americans Can Now Travel Safely

However, social distancing, mask-wearing, and hand-washing precautions should still be taken

Faster-Spreading COVID-19 Variant Expanding in United States

New study finds B.1.1.7 variant is 40 to 50 percent more transmissible than versions of the virus that were previously dominant

More Cases of Blood Clots Linked to AstraZeneca COVID-19 Vaccine

Britain's medical regulatory agency has received 30 reports of clotting events after people were vaccinated

Moderna Gets OK to Increase Doses in COVID-19 Vaccine Vials

Company expects to begin shipping the 15-dose vials within weeks

Biden Administration Kicks Off Campaign to Boost COVID-19 Vaccinations

The 'We Can Do This' campaign creates a 'community corps' of public health, athletic, faith, and other groups to spread the word about vaccines

Increase Seen in Co-Involvement of Opioids in Drug Overdose Deaths

From 2009 to 2019, increase in OD deaths involving cocaine and opioids faster than for those involving cocaine with no opioids

Screening May Improve Early Detection for Melanoma-Prone

Reduced thickness of melanoma lesions seen for patients receiving routine skin cancer screening, education about self-exam

More Advanced Cancer at Presentation Possible Effect of Pandemic

May be the result of treatment postponements and deferrals that were common at the beginning of the pandemic

Mortality, Readmission Low With COVID-19 Discharge on Home Oxygen

All-cause mortality rate 1.3 percent; 30-day readmission rate 8.5 percent among 621 patients discharged on home oxygen

Diabetes Mortality Rates Higher Among Blacks Than Whites

Rate ratios significantly higher in 11 cities; Black-White rate ratio about three times higher in Washington, D.C., than national rate ratio

Belly Fat Gain During Menopause May Elevate CVD Risk

Increases in visceral adipose tissue associated with subclinical atherosclerosis in the internal carotid artery

Benign Bone Tumors Commonly Detected on X-Rays in Children

Historical collection shows nonossifying fibromas detected in asymptomatic children had resolved in 37 percent at time of last radiograph

Benzodiazepines Up Risk for Nonfatal Drug-Related Poisoning in OUD

Risk partially mitigated by buprenorphine treatment

Cardiovascular Risk Factors Tied to Poor Pregnancy Outcomes

First-trimester cardiovascular risk factors also tied to hypertension years after delivery

Mobile Robotic System Perceived as Acceptable for Health Tasks

Survey suggests robotic system perceived as useful; patients report satisfaction with triage interview using mobile robotic system

EEG Abnormalities Common in Hospitalized COVID-19 Patients

Nonconvulsive seizures detected in 9.6 percent of patients with COVID-19 needing clinically indicated electroencephalogram monitoring

COVID-19 Was Third Leading Cause of Death in US in 2020

COVID-19 reported as underlying or contributing cause of death for 11.3 percent of deaths in 2020

Clinical Preventive Service Use Varies Across the United States

Insurance status is dominant factor linked to service use; use of nine of 10 services lower for uninsured

Pfizer/BioNTech COVID-19 Vaccine Highly Effective Six Months After Second Dose

Companies also announced that the vaccine is safe and effective in children as young as 12

Production Error at US Plant Ruins 15 Million Doses of J&J COVID-19 Vaccine

Situation will not impact doses of the Johnson & Johnson vaccine currently being delivered and used across the United States

FDA: Complications Up for Two Brands of Surgical Mesh Used in Breast Reconstruction

FlexHD and AlloMax brands lead to significantly higher rates of implant removal, reoperations, and infection within two years

Alcohol Consumption Linked to Lower Risk for Cataract Surgery

Findings seen in two large cohorts from United Kingdom; strongest protective association seen with wine consumption

Lower Thresholds Could ID Hypertension in More Pregnant Women

Reclassification of hypertension status could also identify more women at risk for preeclampsia, adverse fetal/neonatal events

Readmission, Mortality Up After Discharge for Acute COVID-19

Patients with COVID-19 also had significantly elevated rates of respiratory disease, diabetes, CVD compared with controls

Adjuvant Nivolumab Beneficial in Esophageal, GE Junction Cancer

Disease-free survival significantly longer in patients with resected esophageal, gastroesophageal junction cancer

Frequency of Acute Ischemic Stroke Low in COVID-19 Patients

Occurrence of acute ischemic stroke in COVID-19 is associated with increased risk for requiring long-term care

Weekly Semaglutide Bests Placebo for Greater Weight Loss

Semaglutide superior when used as an adjunct to intensive behavioral therapy and initial low-calorie diet among obese, overweight adults without diabetes

Global Maternal, Fetal Outcomes Worsened During COVID-19 Pandemic

Increase seen in stillbirth and maternal deaths, surgically managed ectopic pregnancies, and maternal depression

New OTC Rapid COVID-19 Test Approved by FDA

Test provides results in about 15 minutes and 'will be simple, even for people who have never tested themselves'

Tobacco Use Up During Early COVID-19 Lockdown

Inability to obtain lower-risk products drove some to turn to more readily available cigarettes

Community Exposures Tied to SARS-CoV-2 Seropositivity in HCWs

Workplace factors not linked to seropositivity for health care personnel

Upadacitinib Beats Placebo for Psoriatic Arthritis

Percentage of patients with ACR20 response significantly higher with upadicitinib versus placebo at week 12

Sotatercept Reduces Pulmonary Vascular Resistance in PAH

Decrease in pulmonary vascular resistance at 24 weeks greater with sotatercept versus placebo for pulmonary arterial hypertension

Pfizer Says Its COVID-19 Vaccine Is Very Effective in Kids as Young as 12

Vaccine triggered immune responses that were even more robust than those seen in young adults

Exercise May Slow Cognitive Decline in Some With Early Parkinson Disease

Higher physical activity related to slower APOE ε4-related cognitive decline in early Parkinson disease

Half of Parents Report Pandemic Negatively Impacting Teen Mental Health

Parents also report methods to improve mental health largely work

Osteoporosis Prevalence at Femur Neck, Lumbar Spine 12.3 Percent

Findings seen among adults 50 years and older in 2017 to 2018; prevalence of osteoporosis increased since 2007-2008 in women, not men

Prevalence of Cognitive Impairment Up in Normal-Tension Glaucoma

Linear trend identified between lower absolute cognitive scores in the NTG versus HTG cohort, but association not significant

Odds of MetS Lower With Adherence to Exercise, Diet Guidelines

Odds of metabolic syndrome reduced with adherence to guidelines; odds lowest for adherence to both guidelines

Aflibercept Cuts Vision-Threatening Complications of Diabetic Retinopathy

But no improvement in visual acuity seen with aflibercept versus sham for eyes with nonproliferative diabetic retinopathy

Tuberculosis Cases Largely Declined Across United States in 2020

20 percent relative reduction in TB cases reported to the CDC National Tuberculosis Surveillance System compared with 2019

Anxiety, Depression Common With Inflammatory Bowel Disease

Up to one-third of patients affected by anxiety symptoms and one-fourth affected by depression symptoms

Incidental Findings on Brain MRI Common in Children

21.1 percent had incidental findings; in 3.7 and 0.2 percent, nonurgent and urgent referral, respectively, were recommended

Physician Payment Source May Affect Evaluation for Black Lung Disease

Odds of classifying chest radiographs as negative for findings of pneumoconiosis increased when physician was hired by employer

Effectiveness of Anticoagulants Compared for Valvular A-Fib

Risks for ischemic stroke or systemic embolism, major bleeding events lower with DOACs overall as a class versus warfarin

Frequency Low for Dual Allergy to Cefazolin, Natural Penicillins

Evidence suggests that most patients with penicillin allergy history could safely receive cefazolin for surgical prophylaxis

Pandemic Lockdowns Tied to More Eating Disorder Symptoms

Exercise addiction fell following lockdown, but post-COVID-19 lockdown, exercise rates increased

US Study Confirms mRNA Vaccine Effectiveness Against SARS-CoV-2

Estimated mRNA vaccine effectiveness 90 percent for full immunization, 80 percent for partial immunization

COVID-19 Precautions Cut Transmission of Other Common Viruses

Flu and other common infections down 80 percent compared with similar time periods in previous years

Recurrent CHD Risk Up With Long Working Hours After First MI

Risk for recurrent coronary heart disease up for those working ≥55 hours/week; linear risk increase seen after 40 hours/week

​Biden, Top Health Officials Warn of Risk for Another COVID-19 Surge

As of Sunday, the seven-day average of new virus cases was about 63,000

First Cell-Based Gene Therapy Approved for Multiple Myeloma

Abecma indicated for patients with relapsed or refractory multiple myeloma who have received at least four previous types of therapy