Statin Use Not Tied to Cognitive Decline, Dementia in Seniors

No association seen for statin use versus nonuse with dementia, MCI, or changes in cognitive function over time

Untreated Sleep Apnea Tied to COVID-19 Infections, More Severe Cases

However, positive airway pressure therapy tied to lower rates of infection

Older Age, Black or Hispanic Race Tied to Higher Risk for Colorectal Cancer

Findings seen in a large study of veterans undergoing diagnostic colonoscopy

New Protocol Aims for Early Extubation in Cardiac Surgery Patients

Faster progression to extubation does not increase risk for reintubation or other adverse events

Clinical Benefit of Epic Sepsis Model in Question

External validation study shows poor performance for proprietary sepsis prediction model in hospitalized patients

Poll: Many ‘High-Risk’ Americans Unconcerned About Skin Cancer

AAD survey revealed that 49 percent of respondents were more worried about avoiding sunburn than preventing skin cancer

Respiratory Virus Detections Decreased During COVID-19

Monthly antibiotic prescriptions for respiratory tract infections decreased 79 percent during pandemic period

Preventive Aspirin Use Up for Seniors With Versus Without Diabetes

Among those with diabetes, likelihood of using aspirin did not differ for older versus younger (60 to 69 years) age categories

COVID-19 Vaccines Do Not Interfere With Male Fertility

No significant decreases seen in any sperm parameters following two doses of an mRNA COVID-19 vaccine

Guidelines Updated for Managing BP in CKD Patients Not on Dialysis

Standardized office BP measurement preferred for management of high BP, with target of <120 mm Hg for systolic BP

AHA Advises OSA Screening for Those With CV Risk, Conditions

Screening for obstructive sleep apnea recommended for those with resistant/poorly controlled HTN, pulmonary HTN, recurrent a-fib

Myocarditis-Like Illness Reported After COVID-19 Vaccination

Case series describes seven cases in males younger than 40 years; all patients' symptoms were resolved by the time of hospital discharge

Outcomes Examined for Primary Nephrotic Syndrome in Adults

Significant variation observed for risk for developing end-stage kidney disease according to etiology of nephrotic syndrome

Stereotactic Body Radiotherapy Aids Spinal Metastasis Pain

Complete response rate improved compared with conventional external beam radiotherapy

Certain Antihypertensive Agents May Aid Cognition in Elderly

Memory recall better for up to three years with blood-brain barrier-crossing renin-angiotensin drugs versus nonpenetrant counterparts

Incidence Rates of Pediatric Cancers Vary by Race, Ethnicity

Variation seen by single year of age, including lower incidence of acute lymphoblastic leukemia in Blacks, especially at 1 to 7, 16 to 20 years

AAP: Screen All Children for Risk for Sudden Cardiac Arrest, Death

Because no single screening strategy can detect all conditions associated with SCA, CPR training in the community is important

Convalescent Plasma May Cut Deaths in Hematologic Cancer and COVID-19

Lower 30-day mortality seen in hospitalized adults, including those admitted to ICU, requiring mechanical ventilation

Underlying Medical Conditions Up Risk for Severe COVID-19 in Children

Risk factors include type 1 diabetes, cardiac and circulatory congenital anomalies, and obesity, as well as prematurity

Distinct Molecular Subtypes of RSV Bronchiolitis Identified

Four biologically and clinically meaningful endotypes identified; asthma risk higher for endotype B compared with endotype A

In 11 States, Seniors’ Low Vaccination Rates a ‘Powder Keg’ for New Cases

In states where vaccination rates are low, seniors who have not gotten a shot pose a public health risk as social-distancing restrictions are stripped away

Higher-Dose DHA in Pregnancy Tied to Fewer Early Preterm Births

Rate of early preterm births lower with 1,000 mg versus 200 mg per day; greater effect seen for women with low DHA status at baseline

Blood Shortage Causes Surgery Delays in New England

While periodic, localized blood shortages are not uncommon, this shortage is 'unprecedented in its scope'

Investigation Starts in Five States After Imported Dog Develops Rabies

At least 12 people were exposed to the dog, which was among 33 dogs and one cat that arrived in Chicago from Azerbaijan

Local Fans Now Allowed to Attend Tokyo Olympics

Fans will not be allowed to cheer, must wear masks, and are being told to go straight home afterward

Obesity Tied to Long-Term COVID-19 Complications

Increases seen for hospital admission, mortality, need for diagnostic medical tests occurring 30+ days after positive COVID-19 test

Pandemic Tied to Worsening of Teens’ Mental Health

However, pandemic also tied to decrease in substance use among both boys and girls

Long-Term Disparities in Respiratory Health Persist in the U.S.

Benefits of improved air quality and reduced smoking have not been equally distributed according to socioeconomic status

Paternal Depression May Linger After Child Discharged From NICU

Authors say there is need for increased attention to paternal mental health during infant NICU stay and after discharge to home

Eptinezumab Speeds Pain, Symptom Relief From Migraine Attack

Headache pain, most bothersome symptom resolved more quickly with IV infusion of eptinezumab versus placebo during migraine attack

Presumed Sudden Cardiac Death Rates Up for Individuals With HIV

Among individuals with versus without known HIV infection, sudden cardiac death due to occult drug overdose was more common

16.3 Percent of Pregnant Women Have Had COVID-19 Vaccine

Receipt of vaccine highest for women aged 35 to 49 years and for Asian and White versus Hispanic and Black women

Physician’s Briefing Weekly Coronavirus Roundup

Here is what the editors at Physician's Briefing chose as the most important COVID-19 developments for you and your practice for the week of...

Privacy Concerns Examined Regarding Use of Mobile Health Apps

28.1 percent of apps provided no privacy policies; 47 percent of user data transmission complied with privacy policy

U.S. to Spend $3.2 Billion to Help Develop Antiviral Pills for COVID-19

Oral medications patients take when symptoms first appear are being tested, but initial results are not expected for several months

Many at High Priority for Kidney Transplant Not on Waitlist

Nonlisted patients disproportionally African American, lack commercial insurance, or reside in lower-income communities

TB Outbreak May Be Linked to Bone Repair Product

Aziyo Biologics recalling 154 containers of the bone putty that includes human cells and is used in a range of orthopedic procedures

Rare Events of ITP Associated With ChAdOx1 Vaccine

Small increased risk for idiopathic thrombocytopenic purpura seen after first dose with estimated incidence of 1.13 cases per 100,000 doses

European Union Opens Doors to American Travelers​

Decision is nonbinding and each EU nation can decide how to regulate visitors

Diabetes, Sleep Disturbances Up Risk for Early Death

Having both conditions poses greater risk than either condition alone

Patients in Bind as Brain Cancer Drug Price Rises to $1,000 Per Pill

Company's decision means there is one less option in a limited number of approved chemotherapies

Few Clinicians Talk About Bariatric Surgery With Obese Patients

But having this discussion is associated with more weight loss and higher odds of bariatric surgery

Genetic Predisposition + High Caffeine Intake Ups Risk of Increased Intraocular Pressure

High caffeine intake not associated with increased risk for higher IOP or glaucoma, overall; among those with genetic risk, caffeine consumption increases risk of glaucoma

New Gene Variants Identified That May Raise Risk for ALS

Mutations identified in TP73 in ALS patients; mutations caused abnormal differentiation, apoptosis in myoblast differentiation assay

Hypothermia Does Not Cut Deaths in Patients With Coma After Cardiac Arrest

At six months, no reduction seen in death, severe disability or worse for those managed with hypothermia versus normothermia

Risk Factors for PHACE Syndrome ID’d in Infantile Hemangiomas

Surface area of 25 cm2 or more, involvement of three or more locations linked to increased risk

Red Cross Warns of Severe Blood Shortage

Hospitals' need for blood on the rise as they deal with many patients who delayed care due to the COVID-19 pandemic

Ahead of Tokyo Olympics, Japan Eases COVID-19 Restrictions

Experts say it is crucial to accelerate the vaccine rollout for the Olympics to be safe

CureVac’s COVID-19 Vaccine Only 47 Percent Effective

Vaccine's efficacy is the lowest reported so far by a COVID-19 vaccine maker

U.S. Supreme Court Strikes Down Challenge to Affordable Care Act

Ruling did not address whether the Obama-era law can continue without a provision that requires Americans obtain insurance or pay a penalty

U.S. Buys 200 Million Extra Moderna Vaccine Doses, as Possible Booster Shots

It is not clear yet whether, or when, booster shots might be necessary

Mean Out-of-Pocket Spending >$3,000 for Childbirth Episodes

Spending exceeded $5,000 for 17.1 percent of episodes and exceeded $10,000 for 1 percent of episodes

Persistent Racial/Ethnic Disparities in Drowning Death Rates

Rate of drowning higher among American Indian/Alaska Natives and Black persons than all other racial/ethnic groups

Patients Do Not Improve Activity Level After Hip Replacement

Findings despite surgery success in aiding pain, physical performance

Mental Illness, Multimorbidity, SUD Up for Methamphetamine Users

Those with past-year methamphetamine use also more likely to have each combination of paired outcomes or all three outcomes

Combining Low-Salt, DASH Diets May Reduce Cardiac Damage

Combination of diets shows reductions in cardiac biomarkers for injury and strain, while DASH diet alone cuts inflammation

Severity of Multiple Sclerosis Symptoms Tied to Race/Ethnicity

African American, Hispanic American race/ethnicity associated with greater disability, symptom severity in multiple sclerosis

Adjuvant RT May Aid Men at High Risk for Death From Prostate Cancer

Adjuvant RT versus early salvage RT may lower the risk for all-cause mortality in men with adverse pathology at radical prostatectomy

Factors ID’d for Unnecessary Preoperative Testing for Low-Risk Surgery

About half of patients receive one or more routine tests before lumpectomy, laparoscopic cholecystectomy, or inguinal hernia repair

Accelerometer-Derived Physical Activity Tied to Drop in Risk for A-Fib

Significant reductions seen in risks for atrial fibrillation, stroke with guideline-adherent physical activity assessed with accelerometer

Survival Examined for Early-Onset Colorectal Cancer

Survival advantage greatest for diagnosis at age 35 through 39 years with stage I or II disease versus diagnosis at age 51 to 55 years

Coronavirus Delta Variant Classified ‘Variant of Concern’ by CDC

The variant, also known as B.1.617.2, was identified in India in December and had been detected in 54 countries by June

European Union to Lift Restrictions on U.S. Travelers

The United States has yet to say when it will reciprocally lift its ban on EU travelers

New York Lifts Pandemic Restrictions

Gov. Andrew Cuomo announced an immediate end to all state-mandated restrictions in all commercial and social settings

FDA Approves StrataGraft for Deep Partial-Thickness Thermal Burns

Data show StrataGraft helps reduce the amount of healthy skin needed for grafting

Disparities in COVID-19 Vaccination ID’d Among Health Employees

At MetroHealth System, probability of vaccination up for employees older than 44 years, men, Whites, and Asians

Bariatric Surgery Beneficial for Class 1 Obesity

Individuals undergoing RYGB or sleeve gastrectomy lost up to 20 percent of their initial BMI; many had remission from T2DM, HTN, hyperlipidemia

Higher BMI Linked to Increased Risk for Developing Psoriasis

Hazard ratio increased for overweight, obese class 1, obese class 2/3 compared with those with BMI <25.0 kg/m2

Strict Rest May Slow Recovery From Sports-Related Concussion

Persisting symptoms lasting longer than typical time frame may be due to interaction of postinjury symptoms with biopsychosocial factors

Modifiable Cardiovascular Risk Factors Linked to Severity of COVID-19

Strategies that improve cardiovascular health may also improve outcomes for people following COVID-19

Nonsurgical Knee Arthritis Care Varies Geographically

Greater use of nonsurgical care associated with lower rates of total knee arthroplasty

SARS-CoV-2 Antibodies Identified Before Cases Recognized in U.S.

Nine seropositive blood specimens ID'd from Jan. 2 to March 19, 2020; seven prior to first confirmed cases in five states

Financial Toxicity More Prevalent for ASCVD Than Cancer Patients

Odds up for any difficulty paying medical bills, inability to pay bills, cost-related meds nonadherence, food insecurity with ASCVD versus cancer

Stressors of Integrating Work, Life Higher for Female Faculty

Since COVID-19, faculty more likely to consider leaving, reducing employment, especially female faculty members

California Lifts Most COVID-19 Restrictions

However, reopening does not mean the pandemic is over, and some public health measures will still be in place for 'mega events'

Obesity-Related Outcomes Up for Metabolically Healthy Obese

Those with MHO had increased rates of diabetes, ASCVD, heart failure versus metabolically healthy without obesity

MIS-C Incidence 316 Persons Per 1 Million SARS-CoV-2 Infections

Incidence was higher in Black, Hispanic or Latino, and Asian or Pacific Islander persons versus Whites

Hemodialysis Patients Have Antibody Response to COVID-19 Vaccine

But few kidney transplant recipients develop anti-spike SARS-CoV-2 antibodies after second mRNA vaccine dose

More Than One in Four Adults With CVD Currently Smoke

From wave 1 to 4 of PATH, <5 percent decrease seen in cigarette use and 0.5 percent increase found in e-cigarette use

Heart Attack, Stroke Care Rebound During Pandemic

Biggest, latest COVID-19 surge did not show declines in stroke, heart attack presentation as seen early in the pandemic

Links Explored for ADHD Meds, Externalizing Symptoms, Child Suicidality

ADHD medications may moderate the association between externalizing symptoms and risk for suicidality in children

ED Visits for Leiomyomas Increased From 2006 to 2017

However, admission rate decreased during same period; admission was least likely for uninsured patients

AHA Says Up Physical Activity for Mildly Elevated BP, Cholesterol

Assess and prescribe physical activity for all patients, including those with elevated BP, cholesterol who are at mild-moderate risk

Prenatal Exposure to Ultrafine Particles Tied to Child Asthma

Sex differences seen in sensitive windows, with highest risk for asthma seen for females exposed to higher levels of UFPs in late pregnancy

Weight Control Product Use in Adolescence Ups Risk for Later Eating Disorder

Findings seen among teens followed for 10 years into early adulthood

1980 to 2017 Saw Improved Survival for Acute Myeloid Leukemia

Survival improved across calendar periods for all age groups except for patients aged ≥70 years

$5.1 Billion Effort to Eradicate Polio Announced

There were 1,226 cases of polio worldwide in 2020, compared with 138 in 2018

Demographic Disparities in Proximity to Stroke Care Identified

Disparities greater in nonurban areas; in both urban and rural areas, tracts with more uninsured people and a larger proportion of American Indians were farther from stroke centers

UnitedHealthcare Delays New Policy on Emergency Department Visits

After backlash from major hospital and doctor groups, company has put new policy about reimbursement for nonurgent care on hold

Inhaled Nitrous Oxide Explored for Treatment-Resistant Depression

In phase 2 trial, 25 percent nitrous oxide comparable to 50 percent nitrous oxide for reducing symptoms, but with fewer adverse effects

Stem Cell Transplant Reviewed for Peripheral T-Cell Lymphoma

Three- and five-year overall survival similar with allogeneic or autologous HSCT, but transplant-related mortality higher with allogeneic HSCT

COVID-19 Cases, Deaths Down in Seniors After Vaccine Introduction

Lower rate ratios for COVID-19 cases, ED visits, hospital admission, and deaths comparing oldest age group with younger adults

Review IDs Reasons for Disparities in Headache Treatment

Factors that contribute to disparities include racism, socioeconomic status and insurance status, geographic disparities

Neurological, Neuropsychiatric Symptoms Common in COVID-19

Symptoms with the highest prevalence included anosmia, weakness, fatigue, dysgeusia, myalgia, and depression

Recent Decline Seen in Diabetes Control Among U.S. Adults

After a long period of progress, glycemic and blood pressure control declined while lipid control plateaued in adults with diabetes

Houston Methodist Suspends Nearly 200 Workers Who Refuse COVID-19 Vaccines

Nearly 25,000 workers met Monday's deadline to be fully immunized, but 178 failed to do so and were suspended

American Academy of Neurology Says Police Must End Use of Neck Restraints

At a minimum, law enforcement and policymakers should classify neck restraints as a form of deadly force

Arsenic Levels Trigger Recall of Beech-Nut Infant Cereal

No illnesses related to the recalled products have been reported, according to the company

Child Drownings in U.S. Pools, Spas Are on the Rise

Child drownings remain the leading cause of unintentional death among U.S. children ages 1 to 4

U.S. to Send 500 Million COVID-19 Vaccine Doses to Countries Desperate for Shots

First 200 million doses will be sent out this year, with 300 million more shared in the first half of next year

Heart Transplant Outcomes Comparable in Advanced Age

Five-year mortality did not differ for adults aged ≥70 years and <70 years after adjustment for relevant confounders

FETO Beneficial for Severe Left Congenital Diaphragmatic Hernia

Studies examine benefits of fetoscopic endoluminal tracheal occlusion for severe, moderate left diaphragmatic hernia

Breast Cancer Risk Up With Inflammatory Potential of Diet

Women in highest quintile of inflammatory score of the diet had significantly increased risk, especially premenopausal women

ASCO: Sotorasib Targets KRAS p.G12C-Mutated NSCLC

Objective response seen in 37.1 percent of patients with previously treated KRAS p.G12C-mutated non-small cell lung cancer

Second-Opinion Strategy Analyzed for Cutaneous Melanocytic Lesions

Decision-analytic model shows selective second-opinion strategy could increase diagnostic accuracy, decrease population-level costs

Diets Compared for Mild-to-Moderate Crohn Disease in Adults

Rate of symptomatic remission at week 6 similar for Mediterranean diet, specific carbohydrate diet in randomized trial

Cardiac Monitor Implant Detects A-Fib in More Stroke Patients

Rate of incident AF over 12 months higher with implant versus usual care with external cardiac monitoring in patients with ischemic stroke

United Nations: Urgent Global Action Needed to End AIDS

Assembly's 193 member nations commit to efforts such as reducing annual new HIV infections, annual AIDS-related deaths

Expiration Date Looming for Millions of J&J COVID-19 Vaccine Doses

Research into extending the shelf life of the one-dose vaccine is ongoing

State Department Eases Travel Advisories for Dozens of Countries

Japan, France, Italy, Spain, Greece, Switzerland, Canada, and Mexico no longer in the 'Do Not Travel' category

Vaccinations More Urgent as Variant That Crippled India Shows Up in the U.S.

However, vaccines do appear to work well against this variant of the coronavirus

Barriers to Physician Skin Exam ID’d for Young Melanoma Survivors

Barriers to health care access linked to increased odds of suboptimal physician skin examination adherence

Osteoarthritis May Be Linked to Increased Risk for Subsequent Parkinson Disease

Highest increased risk for developing Parkinson disease seen among those with knee or hip osteoarthritis

Nintendo Wii Therapy Benefits Children With Cerebral Palsy

Systematic review and meta-analysis show improvement in functional balance and dynamic balance among children with cerebral palsy

Alcohol Intake Inversely Linked to Fecundability

During luteal phase, moderate and heavy drinking are associated with reduction in fecundability versus no alcohol intake

Gap Between Mortality in Rural and Urban Areas Has Increased

Difference increased in age-adjusted mortality rates between large metropolitan areas, rural areas from 1999 to 2019

Real-World Study Shows Power of Pfizer, Moderna Vaccines to Prevent COVID-19

Symptomatic and asymptomatic infection reduced by 81 percent after partial vaccination and by 91 percent after full vaccination

Mortality Increased for Racial/Ethnic Minorities With TBI

Hazard ratio for in-hospital mortality 2.21 for minority patients after adjustment for injury type, probability of survival, operative status

COVID-19 Vaccine Patent Rules Reconsidered by World Trade Organization

Idea backed by more than 60 countries, including the United States

India to Provide Free COVID-19 Shots for All Adults

So far, just over 222 million vaccines have been given in India; less than 5 percent of its population has been fully vaccinated

ASCO: Pembrolizumab Ups DFS in High-Risk Resected Clear-Cell RCC

Estimated DFS rate 77.3 and 68.1 percent at 24 months with pembrolizumab versus placebo; benefit consistent across subgroups

Decline in Births Linked to COVID-19 Pandemic Societal Shutdown

However, prospective modeling using electronic medical records suggests a birth volume surge will occur in summer 2021

Diet to Induce Weight Loss Can Reduce BP in Type 2 Diabetes

69 of 78 participants on treatment for hypertension stopped all or some antihypertensive and diuretic meds

AGA Issues Recommendations for Moderate-to-Severe Crohn Disease

Anti-TNFα recommended over no treatment for induction and maintenance of remission for adult outpatients

Severe Glycemic Events in T1D May Raise Risk for Dementia

Dementia risk increased more than sixfold for older adults with T1D who experienced severe episodes of hypoglycemia and hyperglycemia

Cataract Surgeries Down in Those Diagnosed With Alzheimer Disease

Authors say patients with Alzheimer disease would still be expected to benefit from cataract surgery

Earlier Screening Urged for Relatives of Prostate Cancer Patients

Men with family history of prostate cancer reach the screening risk threshold up to 12 years earlier than men in the general population

Switching to Plant Protein for Dinner May Reduce CVD Risk

Consuming low-quality carbohydrates and animal protein at dinner versus breakfast linked to increased CVD risk

ASCO: Adding Olaparib Slows High-Risk Early Breast Cancer

Higher rates of invasive disease-free survival seen in adjuvant setting for HER2-negative early-stage disease with germline BRCA1 or BRCA2 mutations

New HIV Infections in the U.S. Continued to Drop in 2019

Most infections attributable to male-to-male sexual contact; increase seen in proportion of infections among Blacks, Hispanics

SARS-CoV-2 RNAemia Infrequent in Blood Donors

Estimated prevalence of SARS-CoV-2 RNA reactive donations 1.16/100,000; no infectivity seen in inoculated permissive cell cultures

FDA Warns Against Use of Implantable Heart Device

The agency says the Medtronic HVAD system should no longer be used because it increases risk for neurological problems, death

Adults With Schizophrenia Have Higher Risk for Suicide

Younger adults with schizophrenia, those with history of suicide attempts or self-injury at especially high risk

After Editor-in-Chief’s Resignation, JAMA Journals Outline Steps to Address Racism

AMA will take steps to promote diversity, equity, inclusion within the medical society and its journals

Prenatal Acetaminophen Exposure May Up Risk for ADHD, Autism

However, no link seen between postnatal exposure and later symptoms in childhood

Salmonella Outbreak Linked to Raw Frozen Breaded Chicken Products: CDC

Eight people have been hospitalized; no deaths have been reported

e-ECE: Autoantibodies in Pregnancy Tied to Adult-Onset T1DM

Detection of ICA, GADA, IA2A autoantibodies in women with gestational diabetes linked to decreased T1DM-free survival time, time to diagnosis

New Drug For Vaginal Yeast Infections Approved by FDA

Brexafemme offers an alternative to Diflucan but at greater cost

e-ECE: Testosterone Therapy Mitigates NAFLD in Obese Men With FH, T2D

Testosterone undecanoate therapy reduces NAFLD grade in obese men with functional hypogonadism and type 2 diabetes

Functionally Impaired Older Adults May Use/Misuse Cannabis, Rx Drugs

Higher risk seen for medical cannabis use and prescription opioid and tranquilizer/sedative use and misuse

Testing for STIs in the U.S. Dropped During Early Pandemic

Low point in testing for chlamydia and gonorrhea seen in early April 2020, raising the possibility of many missed cases

Financial Penalties for Dialysis Centers Do Not Increase Performance

Performance-based financial penalties not associated with improvement in total performance scores, specific measures

Mastocytosis and Hymenoptera Venom Allergy Profiled in the U.S.

Mastocytosis occurs more often among U.S. patients with hymenoptera venom anaphylaxis versus general population

CGM Tied to Better Glycemic Control in Insulin-Treated Diabetes

Improvement in HbA1c, reduction in ER visits and hospitalizations for hypoglycemia seen in insulin-treated patients with diabetes

Benefits of Deep Brain Stimulation Persist in Parkinson Disease

Reductions in time spent with dyskinesia, time spent in the off state, and in dopaminergic drugs sustained for more than 15 years

Transplant Referral Less Likely For Dialysis Patients at For-Profit Facilities

Rates of starting evaluations within six months of referral and wait-listing within six months similar at for-profit, nonprofit centers

Recommended Vaccines Associated With Few Serious Adverse Events

No increased risk for autism found following MMR in children; no evidence of intussusception or diabetes seen with rotavirus vaccine

Immediate Kangaroo Mother Care Aids Low-Birth-Weight Infants

Reduced 28-day mortality seen for infants with birth weight of 1.0 to 1.799 kg who received immediate versus delayed kangaroo mother care

ASCO: COVID-19 Infections, Deaths Not Up With  Breast Cancer Chemo

Risk for death following SARS-CoV-2 infection increased with advanced-stage disease, higher comorbidity, but not receipt of chemotherapy

Drug-Induced Immunosuppression Examined in U.S. Adults

Drug-induced immunosuppression, particularly from oral corticosteroids, may limit response to COVID-19 vaccine

WHO Approves Second Chinese COVID-19 Vaccine

Emergency use authorization based on data showing two doses of Sinovac are about 50 percent effective

J&J’s Appeal in $2 Billion Verdict Rejected by U.S. Supreme Court

Supreme Court will not hear J&J's appeal over ruling in favor of women who said they developed ovarian cancer from using talc products

Depressive Symptoms Linked to Rapid Kidney Function Decline

Baseline depressive symptoms positively linked with decline in kidney function for Chinese adults with normal kidney function

Asthma Flares Down Among Black, Hispanic Patients During Pandemic

Greatest decrease seen for those previously working outside of the home and in those without 'allergic-type' inflammation

ATS Guideline Addresses Testing for Viral Pathogens in CAP

Nucleic acid-based testing for noninfluenza pathogens suggested for hospitalized patients who have severe CAP or are immunocompromised

NIH Starts Trial Assessing ‘Mix & Match’ COVID-19 Vaccine Approach

Individuals who received J&J, Moderna, or Pfizer-BioNTech vaccine will receive single booster dose of Moderna vaccine 12 to 20 weeks later

Delaying Surgery Linked to Worse Outcomes for NSCLC

Risk for recurrence increased with surgical delay beyond 12 weeks; overall survival improved with surgery within 12 weeks

First Human Case of H10N3 Bird Flu Reported in China

The China National Health Commission says risk for large-scale spread in humans is low

BNT162b2 Vaccine Safe, Effective for Teens Aged 12 to 15 Years

Vaccine efficacy was 100 percent; no cases of COVID-19 with onset of seven or more days after dose 2 seen among BNT162b2 recipients

Most Severe Effects of PIMS-TS Resolved at Six Months

Findings generally favorable for patients with pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2

ASCO: Oncologists Underestimate Patient Use of Complementary Medicine

Furthermore, oncologists and patients differ in their opinions of modalities offering benefits, boost to quality of life

Cardiac-Related Calls to EMS Down, OHCA Up During COVID-19

Decrease in calls to emergency medical services and increase in out-of-hospital cardiac arrest persisted after initial wave

Tai Chi Helps Reduce Central Obesity in Adults ≥50 Years

Reductions in waist circumference seen in tai chi and conventional exercise groups compared with control group

ASCO: Incidence of Cervical Cancer Has Decreased in the United States

Other HPV-related cancers have increased in recent years; incidence of anal and rectal cancer expected to surpass cervical cancer

Microvascular Angina Linked to Major Adverse CV Events

In multivariable analyses, hypertension, previous history of coronary artery disease were predictors of MACE

JAMA Journals Editor-in-Chief Steps Down After Deputy’s Racism Comments

AMA investigating how podcast and tweet, which contained controversial statements, were developed, reviewed, and published

Arthroplasty, Arthrodesis Outcomes for Ankle Arthritis Examined

Better functional improvement seen with total ankle arthroplasty at 48 months after surgery for end-stage ankle arthritis

CDC Updates COVID-19 Guidelines for Summer Camps

Masks no longer required for campers, staff who are fully vaccinated

Food Allergy Training, Action Plans Suggested for Schools, Day Care

Site-wide food prohibitions or allergen-restricted zones are not suggested, except in special circumstances

WHO Says New Coronavirus Variants to Be Named Using Greek Alphabet

With new public labeling system, governments may be more willing to disclose newly detected variants

Osteoporosis, Low Bone Density May Contribute to Hearing Loss

Magnitude of elevated risk similar among women who did and did not use bisphosphonates

Some Prisons Highly Successful in Vaccinating Inmates

Success in prisons could convince some in the general public to get vaccinated

AHA Issues Statement on Central Retinal Artery Occlusion

Acute CRAO is a medical emergency and patients should be immediately triaged to an emergency department

Excess Pericardial Fat May Increase Risk for Heart Failure

High pericardial fat volume linked to twofold increase in risk for women, 53 percent increase in risk for men

Diabetes Care Lacking in Low-, Middle-Income Countries

Of adults with diabetes in a pooled sample from 55 LMICs, 4.6 percent self-report meeting need for all treatments recommended

Healthy Behaviors Independently Linked to Lower Dementia Risk

For those with familial dementia, risk for dementia is reduced with three or more healthy behaviors

Physician’s Briefing Weekly Coronavirus Roundup

Here is what the editors at Physician's Briefing chose as the most important COVID-19 developments for you and your practice for the week of...

Number of Smokers Continuing to Rise Worldwide

And, most smokers start smoking before age 25 years, with 82.6 percent initiating between ages 14 and 25 years

Many Americans Confused About Sunscreens: Poll

AAD poll highlights common misconceptions about sunscreen application

OCD Linked to Increased Risk for Ischemic Stroke

Risk elevated during follow-up, especially for middle-aged and elderly adults, compared with non-OCD controls

FDA Approves Tracer That Improves Detection of Advanced Prostate Cancer

Tracer is injected into the bloodstream and lights up metastatic prostate cancer cells during PET scan

Functional Decline Common in Adults Hospitalized for COVID-19

More than 40 percent of survivors were not assessed by physical medicine and rehab professionals during hospitalization

Breastfeeding Initiation Varies by Race/Ethnicity Across U.S.

Overall prevalence of breastfeeding initiation was 84.1 percent, with a range from 90.3 to 73.6 percent for infants of Asian, Black mothers

Poll Finds Herd Immunity in U.S. Possible by Summer

In latest KFF survey, 62 percent of respondents said they had received at least one dose of a COVID-19 vaccine

Review Shows COVID-19 Symptoms Often Linger

Median of 72.5 percent of patients experienced one or more persistent symptoms based on data from 16 studies

ED Presentations for Appendicitis, Miscarriage Down in Pandemic

During pandemic, initial reduction seen in ED visits for cholecystitis, ectopic pregnancy; reductions sustained for appendicitis, miscarriage

Several Nongenetic Factors Tied to Early-Onset Colorectal Cancer

Greater red meat intake, lower educational attainment, and heavier alcohol use up risk for early-onset colorectal cancer

ASCO: Nivolumab, Relatlimab Combo Slows Advanced Melanoma

Median progression-free survival of 10.1 versus 4.6 months seen among those receiving combo versus nivolumab alone, respectively

ACG Issues Guidelines for C. Diff Management in Adults

Authors recommend against probiotics for prevention of CDI; in those with CDI recurrence, FMT recommended to prevent further recurrence

Tdap Vaccination Tied to Lower Dementia Risk in Older Adults

Findings seen in two cohorts of older adults with different sociodemographic characteristics

AI Algorithm Aids Early Detection of Low Ejection Fraction

Diagnosis of low EF was increased with the intervention in the overall cohort, among patients with positive AI results

One Dose of BNT162b2 Inadequate for Hemodialysis Patients

Single mRNA vaccine dose often fails to elicit a humoral response; 57 percent of dialysis patients have undetectable anti-RBD IgG at four weeks

COVID-19 Vaccines May Give Protection for Years: Studies

Findings suggest that most people who have recovered from SARS-CoV-2 infection and were later vaccinated will not require booster shots

Providers Less Likely to Prescribe Statins in the Afternoon

Even for at-risk patients, primary care providers are less likely to prescribe during afternoon appointments

Guidelines Issued for Endoscopy of Surgically Altered Bowel

Multidisciplinary approach usually needed to address complexities in diagnosis and management of surgically altered bowel in IBD

Outcomes Poorer With Six Versus 12 Weeks of Antibiotics for PJI

Six weeks of therapy did not meet the criteria for noninferiority among patients with microbiologically confirmed prosthetic joint infections

Black Patients More Likely to Die From Triple-Negative Breast Cancer

Higher mortality risk partially explained by disparities in Black patients' receipt of surgery and chemotherapy

Nitrogen Dioxide Exposure May Up Risk for Parkinson Disease

However, no other significant associations seen between particulate matter and other air pollutants and Parkinson incidence

Portable PCR Platform Allows Rapid Diagnosis of Gonorrhea

Rapid test detects NG within 15 minutes and simultaneously determines whether strains are resistant to ciprofloxacin