Vaccination Protects Against Death From SARS-CoV-2 Delta Variant

Scotland cohort study shows vaccination with ChAdOx1 nCoV-19, BNT162b2 highly effective for preventing deaths caused by delta variant

Intestinal Ultrasound Informs Management of IBD

In 60 percent of patients, IUS had impact on disease management, with change in medication in 47.8 percent

Fluvoxamine Cuts Hospitalizations in High-Risk COVID-19 Outpatients

Rate of high-risk COVID-19 outpatients needing prolonged emergency care or transfer to tertiary hospital lower with fluvoxamine versus placebo

Sotrovimab Cuts Risk for COVID-19 Progression in High-Risk Patients

Interim analysis shows lower risk for progression with sotrovimab versus placebo among high-risk patients with mild-to-moderate COVID-19

Parkinson Disease Mortality Up in U.S. From 1999 to 2019

Increases seen across all age groups, both sexes, various racial/ethnic groups, different urban/rural classifications

Itepekimab Bests Placebo for Moderate-to-Severe Asthma

Incidence of events indicating loss of asthma control lower with itepekimab monotherapy in phase 2, proof-of-concept trial

ACS: Surgery May Follow Initial Antibiotic Therapy for Appendicitis

At one and two years, 40 and 46 percent of patients initially receiving antibiotics underwent subsequent appendectomy

Isolated Small Fiber Neuropathy Increasing in Incidence

Patients with small fiber neuropathy did not self-identify as disabled, but many have multiple comorbidities

All-Cause Mortality Rates Up for Recently Pregnant Women

2015 to 2019 saw increase in all-cause mortality rates, mortality for drug/alcohol poisoning

Self-Reported Cataract Surgery Linked to All-Cause Mortality

After multiple adjustments, self-reported cataract surgery predicted 36 percent elevated risk for vascular-related mortality

Black Women With Breast Cancer Face Barriers to Genetic Counseling

In nationwide survey, a majority of U.S. breast oncologists report that Black women encounter more barriers to genetic counseling, testing

Cascade Testing Proposed for Siblings of Newborns With Cancer Genes

Surveillance for siblings of newborns with pathogenic variants in cancer genes could reduce rare child cancer deaths

Lifetime Excess Weight Linked to Subclinical Myocardial Injury

People with BMI trajectories of stable overweight or obesity have elevated levels of cardiac troponin I, a marker of subclinical myocardial injury

Cost-Sharing Waivers Did Not Cover All COVID-19 Hospital Care in 2020

Mean out-of-pocket spending was $3,840 for privately insured patients with COVID-19 hospitalizations

Autism Spectrum Disorder Tied to Higher Risk for Self-Harm

Meta-analysis shows tripled risk for self-injurious behavior and suicidality

For Dialysis Recipients, Antibody Response Lowest With Ad26.COV2.S

Patients receiving attenuated adenovirus vaccine more likely to have no seroconversion, no detectable or diminished IgG response

Cell Culture-Derived Influenza Vaccine Efficacious in Children

Vaccine efficacy consistent in subgroups according to age, sex, race, and previous influenza vaccination

Seven Best Diagnostic Criteria ID’d for Childhood Psoriasis

Presence of two or more of these criteria has a sensitivity and specificity of more than 70 percent, the authors say

Merck Allows Poor Nations to Make COVID-19 Pill

Royalty-free license means companies in 105 countries can sublicense the formulation for antiviral pill molnupiravir and start making it

Immunocompromised May Need Fourth COVID-19 Shot: CDC

Small studies have shown that fully vaccinated immunocompromised people account for ~44 percent of breakthrough cases leading to hospitalization

Impact of Dietary Interventions Inconsistent in Rheumatoid Arthritis

Dietary interventions combined with omega-3 supplementation may provide additional benefit

Suicide Risk Up After Cancer Diagnosis in Rural, Poor Counties

Risk highest in the first year after diagnosis, but remains higher in those living in the lowest-income counties

C-Sections Up Among Women With Mood, Anxiety Disorders

Predicted probability of primary cesarean section was 3.5 percentage points higher for those with versus without disorders

Maternal Exposure to Cleaning Products Tied to Offspring Asthma

Occupational exposure to indoor cleaning products at preconception, time of conception/pregnancy may increase asthma risk for child

Overweight Tied to More Respiratory Symptoms in Milder COVID-19

In a cohort of mostly outpatients with COVID-19, those with overweight or obesity had more symptoms, especially cough and shortness of breath

Predictors Explored for Response to UVB Phototherapy in Psoriasis

Higher body mass index and positive smoking status predict poorer phototherapy response

Pain, Fatigue in Rheumatoid Arthritis Tied to Sitting, Standing Time

Longitudinal and bidirectional associations seen for pain and fatigue with more sedentary time, less standing time

2000 to 2018 Saw Increase in Incidence of Pancreatic Cancer

Incidence increased for men and women; relative increase greater for women versus men aged younger than 55 years

FDA Advisors Approve Emergency Use of Pfizer Vaccine in Children 5 to 11

Vote was nearly unanimous at 17 to 0, with one abstention; FDA expected to make a final ruling in a matter of days

Non-COVID-19 Mortality Not Increased After COVID-19 Vaccination

Adjusted relative risks reduced for non-COVID-19 mortality after receipt of Pfizer-BioNTech, Moderna, Janssen vaccines

Fetal Mortality Drops to Historic Low of 5.70 Per 1,000 in 2019

Fetal mortality rate was lower than 2018 for deaths occurring at 20 to 27 weeks, no different for deaths occurring at 28 or more weeks

Biden Admin Offers Details of Vaccination Requirements for Foreign Travelers

New policy comes as the Biden administration eases restrictions that ban nonessential travel from several dozen countries

White House Takes More Steps to Up Supply of Rapid At-Home COVID-19 Tests

Tests will be be particularly useful during flu season because the tests can help distinguish between the flu and COVID-19

Trader Joe’s Salami Snacks Tied to 20 Salmonella Cases in Eight States

Three people have been hospitalized, but no deaths have been reported

USPSTF: Evidence Lacking for Open-Angle Glaucoma Screening

Current evidence is insufficient for assessing the balance of benefits and harms of screening adults without signs or symptoms of glaucoma

USPSTF: Evidence Lacking for Screening Seniors for Visual Acuity

Current evidence is insufficient for assessing the balance of benefits and harms of screening asymptomatic ≥65s in primary care setting

ACS: Length of Stay for Surgical Patients Dropped From 2014 to 2019

Rate of postdischarge complications for surgical patients increased from 44.6 to 56.5 percent during the same time period

ACS: Attitudes Toward CRC Screening Changed During Pandemic

Use of fecal occult blood test up during pandemic; more than half of respondents willing to do at-home FOBT in lieu of colonoscopy

Belimumab Promising in Combination Therapy for Refractory Lupus

Lower serum IgG anti-dsDNA antibody levels seen at 52 weeks with belimumab rather than placebo given after rituximab

Adding Interferon Beta-1a to Remdesivir No Better for COVID-19

For hospitalized adults with COVID-19, time to recovery did not differ with interferon beta-1a plus remdesivir versus remdesivir alone

USPSTF Presents New Approach to Sex, Gender in Recommendations

Task force will use inclusive approach to identify issues related to sex, gender in guideline development; will use gender-neutral language

ACS: Surgery May Benefit Men With Stage IV Breast Cancer

Patients receiving systemic therapy, surgery, and radiation have survival advantage over systemic therapy alone

ACS: Telemedicine Lung Cancer Screenings Offered During Pandemic

Distribution of Lung-RADS results did not differ for lung cancer screenings with telemedicine versus in-person visit

AI Algorithms Can Use ECG Data to ID Ventricular Dysfunction

Novel deep learning models can quantify left, right ventricular dysfunction using electrocardiogram data

Severe COVID-19 Outcomes Not Up During Delta Predominance

No increase in proportion of patients admitted to ICU, receipt of invasive mechanical ventilation, death while hospitalized

Many Pregnant Women Not Receiving Recommended Care

Findings show even patients adhering to prenatal care receive an average of six of eight guideline-based services

Moderna Says Its COVID-19 Vaccine Works Well in Children Aged 6 to 11

Trial included more than 4,700 children who received two shots of the vaccine 28 days apart

Walmart Recalls Room Spray Due to Rare and Deadly Bacteria

The four cases of melioidosis illness occurred in Georgia, Kansas, Texas, and Minnesota; two patients have died

Overweight Less Likely in Infants With More Sleep, Fewer Awakenings

Odds of infant overweight from 1 to 6 months lower with increase in nighttime sleep duration, decrease in number of waking bouts

Suicide Risk Up for Long-Term Survivors of Childhood Cancer

Suicide risk significantly elevated for survivors alive beyond the age of 28 years; risk was lower for women than men

Statins May Be Tied to Lower Risk for COVID-19 Death

Statin treatment tied to moderately lower COVID-19 mortality in large population study accounting for preexisting health conditions and other factors

More Than Half of U.S. Infants Born in High-Volume Obstetric Hospitals

Yet, more than one-third of U.S. obstetric hospitals are low-volume with <500 births/year

PCPs Not Routinely Recommending Early Behavioral Treatment for ADHD

Only 11 percent of preschoolers with ADHD diagnosis or symptoms received referrals for parent training in behavior management

Neuroimaging Soon After Trauma May Predict Stress Response

Three clusters replicated in samples with variety of trauma types; clusters showed different patterns of posttrauma symptoms

Geriatrics-Focused Risk Factors ID’d for COVID-19 Death

Indicators other than age alone can be used to determine prognosis in older adults hospitalized with COVID-19

3 Percent of U.S. Cancer Cases Attributable to Physical Inactivity

Population-attributable fraction varied from 3.9 percent for urinary bladder cancer to 16.9 percent for stomach cancer

Proton Pump Inhibitor Use Tied to Less Severe Periodontal Disease

Patients with periodontitis who use proton pump inhibitors have fewer teeth with elevated probing depths for the gap between teeth and gums

Physician’s Briefing Weekly Coronavirus Roundup

Here is what the editors at Physician's Briefing chose as the most important COVID-19 developments for you and your practice for the week of...

Quitting at Younger Age Cuts Most Smoking-Associated Cancer Mortality Risk

Starting to smoke at any age linked to increased cancer mortality rate ratio, with increased rate ratio for starting at younger age

BNT162b2 Effectively Prevents Pediatric COVID-19 Hospitalization

Two doses of Pfizer-BioNTech vaccine highly effective for preventing hospitalization among children aged 12 to 18 years

Michigan Data Show Routine Vaccinations Plummeted in Early Pandemic

Authors say catch-up vaccinations of doses missed throughout the pandemic needed to stem outbreaks of vaccine-preventable diseases

Delta Variant Subtype on Rise in United Kingdom

A small number of AY.4.2 cases have also been reported in Denmark and the United States

Pfizer Says Lower Dose of Its COVID-19 Vaccine Protects Younger Children

Dose used in trial that included more than 2,200 children was 10 mcg, while the adult dose is 30 mcg

>86.0 Percent of U.S. Adults Exceed CDRR Sodium Intake Goal

No significant linear trends seen from 2003 to 2016 for U.S. adults overall for unadjusted or energy intake-adjusted mean sodium intake

CDC Signs Off on Moderna, J&J Boosters, Backs Mix ‘n’ Match Shots

Agency plans to release guidance early next week about who might benefit from choosing one booster over another

BNT162b2 Highly Effective Against Delta Variant in Teens

At seven to 21 days after second dose, estimated effectiveness was 90 percent against infection, 93 percent against symptomatic COVID-19

mRNA Vaccine More Effective Booster to ChAdOx1 nCoV-19

Heterologous ChAdOx1 nCoV-19/mRNA prime-boost vaccination more effective than homologous ChAdOx1 nCoV-19/ChAdOx1 nCoV-19

Dysglycemia Risk Up for Women With PCOS, Regardless of BMI

Combined oral contraceptive pill use associated with reduced dysglycemia risk for women with PCOS

Depression May Worsen Survival in Advanced Non-Small Cell Lung Cancer

Two-year trajectory of depression symptoms significantly linked to cancer survival; association for anxiety not significant

Avoid Intensification of Diabetes Meds at Discharge in Older Adults

For older adults hospitalized with common medical conditions, intensifying diabetes meds at time of discharge shows little benefit

FDA Approves Moderna, J&J Booster Shots, Backs Mix ‘n’ Match Vaccines

Agency's decision is one of the last steps toward a full rollout of booster shots to eligible Americans

Impact of 2014 Policy Change Examined for Pediatric Kidney Transplants

Racial/ethnic disparities in time from dialysis initiation to transplantation mitigated by 2014 Kidney Allocation System

Increasing Dairy Intake Can Cut Falls, Fractures for Seniors

Intervention to increase calcium and protein intake using dairy foods beneficial for institutionalized older adults

Poisoning Related to Ivermectin Exposure for COVID-19 Described

In August 2021, 21 calls were received by Oregon Poison Center; six people were hospitalized for toxic effects resulting from use

Fibrosis Stages F3, F4 in NAFLD Linked to Higher Mortality Risk

Incidence of all-cause mortality increased with increasing fibrosis stage; increase also seen in liver-related complications

One in Six With Arthritis Have Attended Self-Management Class

69.3 percent of those with arthritis report ever receiving health care provider physical activity counseling

Lanifibranor Reduces Disease Activity in Nonalcoholic Steatohepatitis

In phase 2b trial, more patients with active NASH had reduction in disease activity score with lanifibranor versus placebo

Pfizer Vaccine Booster Restores Nearly Full Protection, Company Says

Trial is the first randomized, controlled COVID-19 vaccine booster study to provide efficacy results

High-Dose Constraint-Induced Movement Therapy Beneficial for Cerebral Palsy

Regardless of constraint type, high-dose CIMT consistently produced pattern of greatest short- and long-term gains

U.S. Has Shared 200 Million COVID-19 Vaccines With Other Countries

Donations include more than 120 million surplus doses from the U.S. stockpile

Lifetime Physical Activity Not Linked to Risk for ALS

Heavy occupational work intensity may increase ALS risk; survival in newly diagnosed ALS patients worse with inactivity, highest activity level

Salmonella Outbreak in 37 States Linked to Imported Onions

So far, there have been 129 hospitalizations, but no deaths

Delta Variant May Increase Risk for Poor Pregnancy Outcomes

Experts recommend COVID-19 vaccination for pregnant women to mitigate severe perinatal morbidity, mortality

High Exposure to Phthalates Tied to Early Death

Authors estimate roughly 100,000 premature deaths among older Americans each year and a $40 billion annual U.S. economic burden

One in Six Youth in the United States Is Obese

Robert Wood Johnson Foundation calls on policymakers to prioritize children's health and equity

In 2020, More Than One in Five Adults Received Mental Health Treatment

16.5 percent had taken prescription medication and 10.1 percent received counseling or therapy in previous 12 months

Flu Cases Already Up 23 Percent This Season: Walgreens

Significant increase shown by the company's analysis of its own data reflects the historically low levels of flu last year

Study IDs Pregnancy Complications in the U.S. Tied to the Pandemic

Higher risks for gestational hypertension, poor fetal growth, preeclampsia seen in pregnant women with commercial health insurance

Doctors Report That Kidney Grown in Pig Worked in a Human

Kidney came from pig genetically engineered to grow an organ with a low risk for being rejected by the human body

Many Minority, Women Cardiologists Face Discrimination

Across racial and ethnic groups, most cardiologists report satisfaction with their careers

Mixed Results Seen With eHealth Program for Cancer Survivors

Those with moderate-to-high engagement in text/web intervention showed greater self-efficacy for managing cancer-related issues

Long-Term Bone Loss Studied in Postmenopausal Women

Lower baseline BMI and greater increase in BMI appear to be protective against postmenopausal bone loss

Eating Nuts May Cut Recurrence in Breast Cancer Survivors

Compared with no nut intake, higher nut intake linked to improved disease-free survival in long-term breast cancer survivors

Psoriatic Arthritis May Up Risk for Preterm Birth, C-Section

Risk for preterm birth increased with antirheumatic treatment for psoriatic arthritis -- particularly biologics -- during pregnancy

ACG Updates Clinical Guidelines for Benign Anorectal Disorders

Anorectal biofeedback therapy recommended in defecation disorders; biofeedback also recommended in proctalgia syndrome

AHA Provides Strategies to Improve BP Medication Adherence

Interventions for effective med adherence include patient education and counseling, simplification of treatment regimens

Cigarette Sales Increased During COVID-19 Pandemic

Estimated difference between observed and expected cigarette sales indicated monthly excess of 0.34 packs/capita

White House Announces COVID-19 Vaccination Plan for Young Children

Rather than mass vaccination sites, Biden administration plans to have pediatric shots delivered in settings parents know and trust

Patient Satisfaction High With Telemedicine in Radiation Oncology

No difference seen in satisfaction scores between office and telemedicine consultations for routine radiation oncology practice

Varenicline Combo, Extension No Better for Quitting Smoking

Combining varenicline with nicotine patch, extending treatment from 12 to 24 weeks did not increase smoking cessation rates

FDA Approves First Interchangeable Biosimilar for Inflammatory Diseases

Cyltezo is first interchangeable monoclonal antibody for RA, psoriatic arthritis, ankylosing spondylitis, Crohn disease, ulcerative colitis, chronic plaque psoriasis

Sodium Content of Processed Foods Varies by Type, Country

Twofold to threefold differences seen across different countries, with highest sodium levels in processed meat and fish products in China

Mobile Tech Program Helps Adults Control High Blood Pressure

Greater engagement with self-management program linked to lower systolic BP over time, lower risk for very high BP

Short Hospital Stays for Births More Common During Pandemic

No increase seen in infant rehospitalizations within seven days after earlier discharge to home for healthy, term infants

Cases of Takotsubo Syndrome Up in Middle-Aged, Older Women

Majority of cases (88.3 percent) seen in women, especially those aged 50 years or older; incidence higher in middle-aged men than younger men

More Than Half of COVID-19 Survivors Have Postacute Sequelae

Most common sequelae include functional mobility impairments, pulmonary abnormalities, and mental health disorders

Preterm Delivery May Up Risk for Chronic Hypertension in Women

Risk for hypertension increased within first 10 years after delivery and remained elevated at least 40 years later

AI Model Helps Triage Breast MRIs in Women With Dense Breasts

Deep learning model dismissed 39.7 percent of MRI examinations without lesions from women with extremely dense breasts

Women Working as Family Docs Report High Career Satisfaction Overall

Women are less satisfied with certain aspects of their career, including pay, personal time, administrative tasks

FDA Eases Access to Cheaper Over-the-Counter Hearing Aids

Proposal would create a category of hearing aids that could be sold directly to consumers, without medical exam or audiologist fitting

USPSTF: Evidence Lacking for Screening for Eating Disorders

Evidence insufficient to evaluate the benefits and harms of screening for eating disorders in adolescents and adults

FDA Expected to Allow Mix ‘n’ Match COVID-19 Vaccines

Agency will not recommend one vaccine over another but may say it is preferable to use same booster as the vaccine

Maternal Cholesterol in Pregnancy Tied to AMI Severity in Adult Offspring

Increased maternal cholesterol levels during pregnancy linked to greater severity of acute myocardial infarction in adult offspring

U.S. Pediatricians, Psychiatrists Declare ‘Emergency’ in Child Mental Health

Groups urge policymakers to increase funding to ensure all families can access mental health services

2016 to 2018 Saw 181,227 TBI-Related Deaths in United States

In 43 states, suicide was leading cause of TBI-related deaths; in other states, main causes were unintentional falls, motor vehicle crashes

Prevalence of Binge Drinking in Past 30 Days 16.6 Percent in 2018

Prevalence was higher for men than women, increased with income, and varied from 10.5 percent in Utah to 25.8 percent in Wisconsin

Biologic Therapies Available for Pediatric Patients With Asthma

Pediatricians should refer patients to a pediatric subspecialist to identify candidates for biologic therapy and select the appropriate medication

Antithrombotic Therapy Not Helpful for COVID-19 Outpatients

Major adverse cardiopulmonary outcomes not reduced with aspirin, apixaban versus placebo for clinically stable COVID-19 outpatients

Potential Safety Concern for Guillain-Barré Syndrome ID’d for Ad26.COV2.S

Based on preliminary findings for presumptive GBS, overall observed-to-expected rate ratio estimated to be 4.18 for 42-day window

Menstrual Cycle Length in Perimenopause May Predict Atherosclerosis

Changes in menstrual cycle length may help identify groups at greater or lesser risk for atherosclerosis after menopause

Risk Factors ID’d for Conversion From RIS to Multiple Sclerosis

For radiologically isolated syndrome, younger age, spinal cord lesions, gadolinium-enhancing lesions at time of index scan tied to increased risk

U.S. Spending Up for Cancer Drugs Lacking Evidence of Survival Benefit

From 2017 to 2019, Medicare spending on 10 accelerated approval drugs with lack of overall survival benefit increased to $569 million

Model Suggests Earlier Breast Cancer Screenings for U.S. Black Women

Initiating screening 10 years earlier in Black women could reduce Black-White disparities in breast cancer mortality by 57 percent

Social Vulnerability May Increase Premature CVD Mortality

Relative risks for premature CVD mortality varied considerably according to demographic characteristics, including ethnicity and rurality

EPA Plans New Strategy Against Toxic ‘Forever Chemicals’

Per- and polyfluoroalkyl substances are used in products ranging from cookware to carpets to firefighting foam

Legionnaires’ Disease Outbreak Hits Long Island, New York

As of Saturday, one patient had died, two remained hospitalized, and seven had been released from the hospital

Disparities Found in Vaccination Coverage by Age 24 Months Before COVID-19

Disparities in coverage for race/ethnicity, poverty status, health insurance status seen among children born in 2017 to 2018

Inbox Time Linked to Reduced Odds of Physician Turnover

And increase in mean total messages received per day seen for physicians during March 2020 to June 2021

Analogs, Pen Devices Dominate Ambulatory Insulin Use in U.S. Adults

Uptake of newer insulin products increased from 2016 to 2020 for ambulatory use in U.S. adults with type 2 diabetes

Physician’s Briefing Weekly Coronavirus Roundup

Here is what the editors at Physician's Briefing chose as the most important COVID-19 developments for you and your practice for the week of...

Helmet Use Cuts Head Injuries in Youth in ATV, Dirt Bike Crashes

Helmet use among youth involved in ATV, dirt bike crashes reduces odds of intracranial injury, moderate or severe traumatic brain injury

Intranasal Oxytocin Therapy No Better for Children With ASD

No difference seen in change in Aberrant Behavior Checklist modified Social Withdrawal subscale score with oxytocin versus placebo

Key Elements ID’d for Transition to Adult Care for Kawasaki Disease

Key element for successful health care transition is structured intervention, including planning, transfer, integration into adult care

Pregnancy Outcomes Examined in Women With Congenital Heart Disease

Maternal complications, neonatal morbidity and mortality were significantly elevated, but absolute rates were low

High Mortality for Psych Disorders Worse During the Pandemic

COVID-19 standardized mortality rates were elevated across nine psychiatric conditions including learning disabilities, eating disorders

2021 USPSTF Guidance Expands Eligibility for Lung Cancer Screening

Newly eligible population includes individuals aged 50 to 54 years, more women, more racial and ethnic-minority groups

Incidence Rates of SARS-CoV-2 Similar for Children, Adults

More infections asymptomatic among children, with 52 percent asymptomatic among those aged 0 to 4 years versus 12 percent in adults

Therapeutic-Dose LMWH Cuts Thromboembolism, Deaths in COVID-19

Reduction in venous thromboembolism, arterial thromboembolism, and deaths seen in high-risk patients in non-ICU, but not ICU, settings

60 Percent of Americans Will Delay or Skip Flu Shot This Year: Survey

FRIDAY, Oct. 15, 2021 (HealthDay News) -- Experts are warning that the upcoming flu season could be severe as social distancing measures are relaxed...

FDA Panel Recommends Approval of Johnson & Johnson Booster Shot

The booster shot is recommended for anyone 18 years and older, to be given at least two months after the first dose

2015 to 2019 Saw Downward Trend for Buprenorphine Misuse

0.7 million of 2.4 million U.S. adults misused buprenorphine in 2019; motivations for misuse include being hooked, physical pain relief

Vaccinated Foreign Travelers Can Enter United States Beginning Nov. 8

Foreign air travelers to the U.S. are required to have full vaccination, proof of negative test before boarding, and follow-up negative test within three days of entering U.S.

Biden Administration to Invest $100 Million to Ease Health Care Worker Shortage

Funding will be invested in program that helps find primary care doctors for communities struggling to recruit and keep them

Despite Pressures of Pandemic, U.S. Nursing School Enrollment Climbs

Enrollment in bachelor's, master's, and doctoral nursing programs increased 5.6 percent from 2019 to 2020

Higher Dietary Intake of ALA May Lower Mortality Risk

Higher dietary intake of alpha linolenic acid linked to reduced risk for mortality from all causes, cardiovascular disease, coronary heart disease

Women Underrepresented in Stroke Clinical Trials

Greatest differences seen for trials of intracerebral hemorrhage stroke type, nonacute interventions, and rehabilitation interventions

Hybrid Closed-Loop Therapy Beneficial for Children With T1D

At six months, glycemic control improved in children, teens with type 1 diabetes receiving HCL intervention versus conventional therapies

Convalescent Plasma Unlikely to Improve Outcomes in Severe COVID-19

Likelihood of improvement in organ support-free days low in critically ill adults with COVID-19 receiving convalescent plasma

Obesity May Up Length of Stay, Mortality for COVID-19 Patients in ICU

Twofold higher risk for composite outcome of death or length of stay ≥14 days seen in obese COVID-19 patients admitted to the ICU

Trial of Labor Tied to Better Delivery Outcomes in Transplant Recipients

Trial of labor rather than scheduled cesarean delivery linked to better neonatal outcomes among kidney, liver transplant recipients

Lyme Disease Often Diagnosed Later Among Black Patients

Differences in the recognition of the manifestations of Lyme disease by physicians or by patients may contribute to later diagnosis

Skin Cancer App Fails to Identify Rare, Aggressive Cancers

Sensitivity and specificity for detecting Merkel cell carcinoma and amelanotic melanoma was 79.4 and 37.7 percent, respectively

Poor Oral Health Tied to Greater Severity of COVID-19

Subgroup analysis suggests that poor oral health may increase severity of COVID-19 in patients with cardiovascular diseases

Predictors of Smell Recovery ID’d in COVID-19 Patients

Age less than 40 years, nasal congestion at the time of COVID-19 infection positively associated with recovery of smell

Nonmelanoma Skin Cancers Larger Among Hispanic Patients

Mohs micrographic surgery defect sizes larger for Hispanic/Latino patients than for non-Hispanic White patients

FDA Panel Supports Moderna Booster Shot for Older Adults, People at High Risk

Panelists recommended half-dose booster shot six months after the second shot

Former FDA Chief Robert Califf a Contender to Head Agency Again

FDA has not had a permanent head for more than eight months, is being overseen by Acting Commissioner Janet Woodcock

CDC Reports Record High 12-Month Drug Overdose Death Toll

Record-high 96,779 drug overdose deaths reported from March 2020 to March 2021

FDA Warns Against Using At-Home Dermal Filler ‘Pens’

Serious adverse events have been reported in connection with dermal filler use, such as permanent damage to the skin, lips, and eyes

FDA Authorizes First E-Cigarette

Antismoking advocates say the authorization 'leaves our nation's youth at an undue risk of addiction'

ASA: Intraoperative Acupuncture May Help Cut Post-TKA Opioid Use

Acupuncture was applied to ipsilateral ear during total knee arthroplasty; all patients discontinued opioids by postoperative day 30

Risk Prediction Model Developed for Breast Cancer in Black Women

Model developed for use in primary care setting to predict breast cancer risk in U.S. Black women

Too Few At-Risk Seniors Monitor Blood Pressure at Home

Poll shows health care providers should encourage regular monitoring for older adults with hypertension or other chronic conditions requiring blood pressure control

Laser Treatment No Aid for Postmenopausal Vaginal Symptoms

No difference found in symptoms, quality of life, or histological findings between laser or sham treatment

Marine Omega-3 Supplements Tied to Higher Atrial Fibrillation Risk

Risk appeared to be greater in trials testing >1 g/day dosing

Myocarditis Reported After BNT162b2 Vaccination in Israel

Estimated incidence highest among males 16 to 29 years; second study shows highest standardized incidence ratio for males 16 to 19 years

Depression, Anxiety in U.S. Adults More Severe During Pandemic

Depression and anxiety severity scores increased among U.S. adults from August to December 2020, followed by decrease through mid-2021

FDA Expert Panel to Weigh Approval of Moderna, Johnson & Johnson Booster Shots

Panel will consider whether third Moderna shot should contain half the original dose, best timing for second shot of single-dose J&J vaccine

FDA Reduces Recommended Salt Levels in Americans’ Food

The new, voluntary guideline aims to reduce average sodium intake from 3,400 to 3,000 mg per day in the next 2.5 years

COVID-19 Infection Risk Drops With Increasing Immunity Within Family

Risk for COVID-19 infection progressively lower for nonimmune family members as number of family members with immunity increases

Baby Cereal Sold at Walmart Recalled for Elevated Levels of Arsenic

Three lots of Parent's Choice Rice Baby Cereal recalled after testing above the guidance for naturally occurring inorganic arsenic

ASA: Spinal Anesthesia Not Superior for Hip Fracture Surgery

Composite outcome of survival and recovery of ambulation at 60 days similar with spinal anesthesia, general anesthesia in older adults

U.S. to Reopen Borders to Vaccinated Travelers From Canada, Mexico

This action effectively completes the reopening of the United States to tourism, ushering in a new phase in the pandemic recovery

ASA: Dexamethasone Use During Cancer Surgery May Reduce Mortality

Intraoperative administration of dexamethasone linked to reduced 90-day mortality after surgery to remove solid tumors

FDA Questions Strength of Johnson & Johnson Booster Shot Data

Agency says key test used by the company to measure immune response from booster shot six months after the original shot likely not sensitive enough

Mononucleosis As Child, Teen May Up Later Multiple Sclerosis Risk

Infectious mononucleosis during childhood may be a risk factor for subsequent MS diagnosis, independent of shared familial factors

Use of Enzyme-Inducing Antiseizure Meds May Up Long-Term CVD Risk

Increase in risk for incident cardiovascular disease reaches clinical significance approximately 10 years from first exposure

Antibody Response to BNT162b2 Reported in Pediatric Transplant Recipients

Positive antibody titers seen in 73.3 percent of pediatric solid organ transplant recipients who provided titers at one month after the second dose

GI Bleeding Up for New Users of Rivaroxaban

Compared with other DOACs, rivaroxaban linked to higher rates of GI bleeding overall and in an analysis restricted to patients with atrial fibrillation

Increases in Major Depressive Disorder, Anxiety Reported Due to COVID-19

Increase of 27.6 percent seen in cases of major depressive disorder globally; 25.6 percent increase reported in anxiety disorders

AAP: Magnets, Electronics Foreign Body Ingestion Up During COVID-19

No increase found in foreign body ingestions overall, but proportion of magnets and electronics FBI increased significantly

Accelerometers ID Sleep Patterns Associated With Mental Illness

Accelerometry provides a scalable way to objectively measure sleep patterns in psychiatric research and practice, the authors say

USPSTF Advises Against Starting Aspirin in ≥60s to Prevent CVD

For adults aged 40 to 59 years with 10 percent or greater 10-year CVD risk, decision to initiate aspirin should be individualized

California Expands Access to Free Menstrual Products in Schools

Several other states are also considering or require free menstrual products in public schools

42 Percent of Breast Cancer Patients Report Cannabis Use

Cannabis used for symptom relief including pain, insomnia, anxiety, stress; 49 percent of users believe cannabis can treat cancer

Climate Change Is World’s Most Pressing Health Problem: WHO

WHO report and open letter signed by health professionals outline major climate issues affecting public health

ASA: Symptomatic COVID-19 Tied to More Emergency Deliveries

Pregnant COVID-19-positive women, regardless of symptoms, more likely to have a cesarean delivery

Merck Asks FDA to Approve First COVID-19 Antiviral Pill

Molnupiravir could be major advance because it reaches more high-risk patients than the monoclonal antibody treatments now being used

Adverse Neonatal Outcomes Up for COVID-19-Positive Parturients

Composite neonatal adverse outcome incidence increased from healthy to asymptomatic to symptomatic women

ASA: Standing Oral Acetaminophen Before Tonsillectomy Cuts IV Usage

Additional benefits include reducing variability and significant cost savings

Antenatal Depression Linked to Preterm Birth, Low Birth Weight

Untreated depression during pregnancy linked to adverse birth outcomes with even stronger associations seen for African American women

AAP: More Burn Injuries Reported for Children During Pandemic

Average number of burn-injured patients admitted per month increased; peak in difference between 2019 and 2020 seen in July

CDC Urges Flu Shots as Survey Shows Half of Americans Do Not Plan on...

Severity of the upcoming flu season is unclear, but other respiratory infections have already returned

Functional Iron Deficiency Linked to CV Disease, Mortality

Significant associations seen for functional iron deficiency with coronary heart disease, cardiovascular mortality, all-cause mortality

Infection Risk Does Not Seem to Differ Among Biologics for Psoriasis

Differential risk for serious infection or respiratory tract infection, including SARS-CoV-2, not seen among biologics used to treat psoriasis

COVID-19 Delta Variant Tied to More Hospitalizations in Pregnant Patients

One-fourth of pregnant patients diagnosed at a public Texas hospital between Aug. 29 and Sept. 4 admitted for severe illness

Being Over 40 With T1DM Ups Risk for COVID-19-Related Hospitalizations

Children and younger individuals with type 1 diabetes had better outcomes and milder disease

Protection Against SARS-CoV-2 Wanes Months After BNT162b2 Vaccination

Declines seen in humoral responses, effectiveness against SARS-CoV-2 infection, within several months after the second dose