Most Immunosuppressive Meds Not Tied to Worse COVID-19 Outcomes

Except for rituximab, no increased risk seen for in-hospital death or mechanical ventilation for those on long-term immunosuppressive therapy

Concurrent Zoster, Flu Vaccines Tied to Lower Subsequent Flu Vaccine Uptake

Patients may misattribute adverse effects commonly caused by the zoster vaccine to the influenza vaccine

PSA Testing Rates Up in the U.S. After Change in Guidance

Prostate-specific antigen testing rates increased for men aged 40 to 89 years following 2017 revision of USPSTF recommendation on screening

Early Childhood Feeding Problems Tied to Developmental Delays

Authors say young children with multiple eating problems may benefit from screening for developmental delay

Many Hospitals Lack All-Trans Retinoic Acid for Treating Leukemia

Only 14 percent of hospitals that referred patients with acute promyelocytic leukemia had ATRA readily available

Discrimination Has Pervasive Adverse Links to Mental Health

Adverse mental health, substance use, and poor well-being reported for young adults with interpersonal discrimination

Almost One-Third of Mumps Cases in U.S. Occur in Children, Teens

Median of 87 percent of the pediatric patients each year had previously received one or more MMR vaccine dose

Simulation Can Improve Time to First Shock in IHCA

Online education and code simulation improves performance of intensive care unit nurses when responding to in-hospital cardiac arrests

Days of Extreme Heat Linked to Increased Risk for ED Visits

Risk increased for emergency department visits for any cause and for heat-related illness, renal disease, mental disorders

AI-Augmented System Aids Classification of Colorectal Polyps

Compared with standard microscopic assessment, AI-augmented digital system improves accuracy of classification of polyps by pathologists

Hospitals Lag in Sexual Harassment Policies

Findings reveal few of the top U.S. medical centers have policies addressing harassment of physicians and staff by patients

Childhood Vaccination Schedule Not Linked to Type 1 Diabetes

Recommended immunization schedule is not positively associated with the incidence of type 1 diabetes in children

Colorectal Cancer Risk Up for Patients With Psoriasis

In subgroup analysis according to sex, increased risk for CRC seen for female, but not male psoriasis patients

FDA Approves Imaging Drug That Can Help Surgeons Spot Ovarian Cancers

Drug is designed to improve surgeon's ability to detect ovarian cancer while operating on a patient

FDA Panel Mulls Merck COVID-19 Antiviral Pill

Expert panel will vote later Tuesday on whether to recommend authorizing the drug for high-risk patients

Old Spice, Secret Antiperspirants Recalled Due to Benzene

Proctor & Gamble said that it has not received any reports of harm from the recalled products

Omicron Variant Spurs New York Officials to Recommend Masking Indoors

So far, there are no confirmed cases of the omicron variant in New York City, according to the health commissioner

Higher Habitual Coffee Intake May Slow Cognitive Decline

Higher baseline coffee consumption also linked to slower Aβ-amyloid accumulation during a 126-month study period as shown on brain MRI scans

Pfizer to Seek FDA Approval of Boosters for Teens Ages 16 to 17

Move to expand booster availability comes as President Joe Biden tries to keep Americans calm about omicron

Telehealth Programs Benefit Obese Adults With Knee OA

Education and exercise program, with and without dietary intervention, better than education only for knee osteoarthritis

Regeneron Says Its Antibody Cocktail Likely Weakened by Omicron Variant

No direct data yet available testing the new variant's resistance to immunity from monoclonal antibodies and vaccines

Smartphone Wound Follow-Up Increases Odds of Early SSI Diagnosis

Patients in smartphone group had reduced community care attendance, better experiences accessing care after abdominal surgery

Colchicine No Benefit Over Supportive Care for COVID-19

No significant reduction reported in mortality, ventilatory support, ICU admission, length of stay, serious adverse events; increase seen in adverse events, diarrhea

AAV Gene Transfer Feasible for the Treatment of Hemophilia A

In a phase 1-2 trial, 16 of 18 men had sustained expression of factor VIII after gene transfer with adeno-associated viral vector (SPK-8011)

ATS: Consider FEɴᴏ Test for Optimizing Asthma Treatment

The use of FENO testing in addition to usual care is suggested for patients with asthma in whom treatment is being considered

Decline in Infectious Conjunctivitis During COVID-19 Pandemic

Decrease in emergency department encounters for nonallergic conjunctivitis after adoption of public health measures to curb COVID-19

SARS-CoV-2 Infection Up >90 Days Since Second BNT162b2 Dose

Individuals who tested positive for SARS-CoV-2 had significantly longer time elapsed since vaccine injection

FDA Approves Livtencity for Posttransplant Cytomegalovirus

Livtencity is indicated for posttransplant CMV that does not respond to available antiviral treatments

Intermetatarsal Bursitis ID’d in Clinically Suspect Arthralgia

IMB for 23 percent with CSA; patients with IMB also have increased likelihood of subclinical synovitis, tenosynovitis

Genetic Links Between Schizophrenia, CVD Explored

Genetic correlations between schizophrenia and CVD close to zero, but schizophrenia liability may increase heart failure risk

Psychedelic Microdosers Report Health and Wellness Motivations

Among adults citing mental health concerns, those who microdose psychedelic substances report less depression, anxiety, and stress

Bariatric Surgery Cuts Hepatic Steatosis in Obesity and T2DM

Similar decline in liver fat fraction seen for sleeve gastrectomy, Roux-en-Y gastric bypass from surgery to one-year follow-up

Merck’s COVID-19 Pill Appears Effective, but May Pose Pregnancy Risks: FDA

Given safety concerns, FDA scientists said Merck has agreed the drug will not be used in children.

Biden Pushes Vaccines, Masks as Best Defense Against Omicron Variant

News reports out of South Africa noted that COVID-19 cases from omicron have resulted in mostly mild symptoms

Vaccine Makers Already Testing Their Shots Against Omicron Variant

So far, existing vaccines have proven effective against prior coronavirus variants, including the delta variant

Thanksgiving Weekend Brought New COVID-19 Concerns: the Omicron Variant

On Saturday, the CDC issued a statement stressing that 'no cases of this variant have been identified in the U.S. to date'

Cervical Cancer Deaths Down Following HPV Vaccine Introduction

Reductions in cervical cancer incidence, mortality in the U.S. greater for those aged 15 to 24 years than those aged 25 to 29, 30 to 39 years

Aspirin Use Tied to Incident Heart Failure in At-Risk Adults

Aspirin use associated with increased risk for incident heart failure among individuals with or without a history of cardiovascular disease

MRI Markers May Signal Brain Changes from Repeated Head Impacts

Antemortem white matter hyperintensities linked to white matter pathologies seen at autopsy among athletes exposed to repetitive head injury

Conventional IVF Noninferior to PGT-A for Live-Birth Rate

Cumulative live-birth rate with use of conventional IVF noninferior to that for embryo selection with preimplantation genetic testing for aneuploidy

Young Veterans With Mild TBI Show Premature Cognitive Aging

In young veterans with traumatic brain injury, performance on some cognitive tests similar to that of older adults with early Parkinson disease

Sulfur Microbial Diet May Increase Risk for Colorectal Cancer

Sulfur microbial diet features high intakes of low-calorie drinks, red meats, processed meats and low intakes of fruits, vegetables, whole grains

Risk for Psoriasis Reduced After Tonsillectomy

Among patients with rheumatoid arthritis, the risk for psoriasis was increased after tonsillectomy

Prevalence of Primary Sclerosing Cholangitis in IBD Explored

Prevalence of primary sclerosing cholangitis in patients with inflammatory bowel disease is about 2 percent

RSNA: CT Imaging for Cancer Down During COVID-19 Peak in 2020

In post-COVID-19 peak period in 2020, CT volume still down for cancer screening and initial workup with inconsistent recovery for active cancer

Physician’s Briefing Weekly Coronavirus Roundup

Here is what the editors at Physician's Briefing chose as the most important COVID-19 developments for you and your practice for the week of...

Enterovirus D68 Detections Lower Than Expected in 2020

382 EV-D68 detections in respiratory specimens from patients <18 in 2018, number dropped to six in 2019, 30 in 2020

Kraft Recalls Powdered Drinks Over Metal, Glass Concerns

The problem with the glass and metal pieces occurred during production

CVS Health, Walmart, and Walgreens Played Role in Opioid Crisis: Ohio Jury

Case is the first time the retail side of the drug industry has been held accountable in the U.S. opioid crisis

Six Proteins Upregulated Years Before Ulcerative Colitis Diagnosis

Inflammatory proteins predicted ulcerative colitis; four of these proteins significantly up-regulated in healthy twin siblings

Pandemic Had Greater Effect on Work-Life Balance for Female Physicians

A sizable gender gap evident for risk of depression and anxiety

Device Apps Aid Memory in Older Adults With Impaired Cognition

Digital voice recorder or smartphone apps can improve prospective memory function, QOL in older adults with mild cognitive disorders

Caregivers of Childhood Cancer Survivors Concerned About COVID-19 Vaccines

Concerns, expressed early in the rollout, included lack of safety and efficacy data, particularly in children with cancer

Low-to-Moderate Caffeine Intake Not Tied to Maternal Health Risk

Limited caffeine intake, within recommended amounts, during the second trimester associated with lower risk for gestational diabetes

AI-Based Analysis of ECG May Help Assess A-Fib Risk

Predictive utility comparable for CHARGE AF clinical risk score, artificial intelligence-enabled analysis of 12-lead electrocardiogram

Dasatinib Beneficial in Type 2 Diabetes

Patients treated with dasatinib had mean reduction in serum glucose concentration and relative decrease in body weight

COVID-19 Positivity Lower for Some With Psychiatric Disorders

Patients with schizophrenia, mood disorders, anxiety disorders have increased odds of COVID-19 mortality

Risk for Stroke, Dementia Down With Coffee, Tea Consumption

Lowest hazard ratio for incident stroke, dementia seen for two to three cups of coffee, three to five cups of tea, combined intake of four to six cups/day

Incidence of Atrial Fibrillation Up After Breast Cancer Diagnosis

Breast cancer stage strongly linked to development of AF; new-onset AF after breast cancer diagnosis linked to increased cardiovascular mortality

Housework Tied to Higher Cognitive Function in Older Adults

Associations of housework with physical function and sensorimotor performance were intensity-dependent

U.S. COVID-19 Cases, Hospitalizations on the Rise Just Before Thanksgiving

There has been an 18 percent increase in the seven-day average of reported COVID-19 infections in the United States

RSNA: Changes on Breast MRI Suggest Systemic Effects of LNG-IUD Use

Higher ACR category on dynamic contrast-enhanced breast MRI seen in 23 of 48 women with versus without intrauterine device in place

As Vaccine Deadline Passes, 95 Percent of Federal Workers Have Gotten Shots

Only about 59 percent of the general population are fully vaccinated, according to CDC data

Performance of ESC 0/1-, 0/2-, 0/3-Hour Algorithms for AMI Compared

European Society of Cardiology 0/1-, 0/2-hour algorithms have higher sensitivities and negative predictive values than 0/3-hour algorithm

Biden Plan Will Spend $1.5 Billion to Boost Health Worker Supply

The pandemic has exacerbated health care disparities for minorities and underserved communities

Recurrent VTE Rate Higher Than Expected for Subsegmental PE

Prospective cohort study restricted to patients with low-risk subsegmental pulmonary embolism managed without anticoagulation

Guidance Updated on Treating Motor Symptoms in Early Parkinson Disease

Levodopa preferred as initial dopaminergic therapy for motor symptoms in patients with early Parkinson disease

Outpatient Gabapentin Rarely Used for Approved Indications

Concomitant use of central nervous system-depressant drugs listed for 58.4 percent of off-label gabapentin visits

Exposure to 17-OHPC in Utero Linked to Cancer Risk in Offspring

Risk for any cancer increased in association with first-trimester exposure; risk increased with number of injections

Cre8 EVO Stents Noninferior for PCI in Diabetes Patients With CAD

Cre8 EVO stents noninferior to Resolute Onyx stents for target-lesion failure composite outcome at one year

Many Psychiatric Patients Are Getting Risky Drug Gabapentin ‘Off-Label’

By Amy Norton HealthDay Reporter MONDAY, Nov. 22, 2021 (HealthDay News) -- Most prescriptions for the medication gabapentin are for unapproved uses -- and many...

AHA: High Sodium, Low Potassium Intake Linked to Higher CV Risk

Higher sodium excretion, lower potassium excretion, higher sodium-to-potassium ratio linked to higher cardiovascular risk

30 Percent of Hospital-Based Health Care Personnel Unvaccinated

COVID-19 vaccination coverage increased from 36.1 to 60.2 percent from January to April 2021, then slowed, reaching 70.0 percent as of Sept. 15

Structured Exercise Aids Recovery From Breast Cancer Surgery

U.K. study shows upper-limb disability at one year reduced with exercise versus usual care after nonreconstructive breast cancer surgery

Annual Mammography Not Cost-Effective Beyond 75 Years

Extending biennial mammography from age 75 to 80 years is cost-effective, but the absolute number of deaths averted is small

Very Low-Energy Diets With Meal Replacements Effective for T2DM Weight Management

Low-carbohydrate no better for weight loss than higher-carbohydrate, low-fat diets; no difference seen for high-protein, Mediterranean diets

Smartphone Intervention Feasible for Severe Mental Illness

Large effect sizes seen for Beck Depression Inventory, Recovery Assessment Scale, Rosenberg Self-Esteem Scale

Risk for Incident Dementia Up With Pro-Inflammatory Diet

Individuals in highest versus lowest diet inflammatory index tertile were three times more likely to develop dementia

Pfizer Says Its COVID-19 Vaccine Provides Full Protection to Adolescents

Pfizer will submit these new data to the FDA as it seeks full approval of the vaccine for youth ages 12 to 15 years

Sacubitril-Valsartan Does Not Cut Risk for Death, Heart Failure After MI

Sacubitril-valsartan not linked to reduced incidence of death from cardiovascular causes or incident heart failure versus ramipril

Endovascular Treatment Alone Not Beneficial for European Stroke Patients

EVT alone was neither noninferior nor superior to intravenous alteplase plus EVT for functional outcome at 90 days

Blacks, Hispanics Still Underrepresented in Cancer Clinical Trials

Odds of participation up for Blacks, Hispanics in breast, lung, prostate cancer trials in 2015 to 2019 compared with 2000 to 2004

Growing Evidence Links Pentosan Polysulfate Sodium, Maculopathy

Specific retinal conditions proportionately more common for PPS users versus users of other interstitial cystitis, bladder pain drugs

Use of Technology Assistance Rising for Total Knee Arthroplasties

Odds of complications at 90 days requiring readmission lower with computer-assisted navigation, robotic-assistance TKAs

Risk for Stillbirth Elevated for Deliveries With COVID-19

Adjusted relative risk for stillbirth higher in deliveries with COVID-19 in pre-delta and delta periods, with stronger link during delta period

Physician’s Briefing Weekly Coronavirus Roundup

Here is what the editors at Physician's Briefing chose as the most important COVID-19 developments for you and your practice for the week of...

Concern About School Shootings Tied to Anxiety, Panic in U.S. Teens

Associations for depressive symptoms vary by race/ethnicity

Vials Found in Lab Contained Vaccine, Not Smallpox Virus: CDC

Federal officials were alerted that the vials were found by a laboratory worker while cleaning out a freezer in the facility

FDA Approves Both Pfizer, Moderna Boosters for All Adults

Any adult who received a second dose of either vaccine at least six months earlier should be able to get a booster as soon as this weekend

New Review Claims First COVID-19 Patient Was Wuhan Market Vendor

While paper will rekindle debate over whether the pandemic resulted from animal-to-human transfer, it likely will not settle the issue

Ethical Considerations Explored for Aducanumab in Alzheimer Disease

Grounds insufficient to offer aducanumab for moderate, advanced Alzheimer dementia or patients without biomarker evidence of brain ß-amyloid

ICU Bed Occupancy During COVID-19 Linked to Increase in Excess Deaths

If ICU bed use reached 75 percent capacity nationwide, an excess of 12,000 deaths would be expected two weeks later

Access to Care Disrupted for Young Adults With Diabetes in COVID-19

Young adults with diabetes also report lower intention of receiving COVID-19 vaccination compared with those 60 years or older

Caregivers More Likely to Have Subjective Cognitive Decline

Caregivers with SCD more likely than caregivers without SCD to report frequent mental distress, history of depression

Concerns Raised About COVID-19 Chronic Olfactory Dysfunction

Research needed on how to treat olfactory dysfunction lasting six months or longer as a symptom of long-term COVID-19

AHA: Risk-Benefit of Mitral Valve Surgery Plus Tricuspid Annuloplasty Studied

For mitral valve surgery plus TA, risk for primary end-point event lower at two years, but risk for permanent pacemaker implantation higher

AHA: Oral Milvexian Promising for Prevention of VTE

In patients undergoing knee arthroplasty, postoperative incidence of venous thromboembolism lower with milvexian versus enoxaparin

Patients Hospitalized With COVID-19 Less Likely to Be Vaccinated

Decreased likelihood of vaccination also seen in association with death, mechanical ventilation among patients hospitalized with COVID-19

AHA: Risk for Heart Disease Up for Young Black Adults in the U.S.

Comparison of cohorts of hospitalized young, Black adults from 2007 and 2017 shows higher rates of risk factors for CVD

New Symptoms ID’d That May Indicate Pancreatic Cancer

Additional symptoms can be used to update QCancer, a risk prediction model that helps physicians identify patients at high risk for cancer

Fewer Deaths Reported With Enrollment in COVID-19 Remote Monitoring

Remote monitoring service, COVID Watch, reduced deaths at 30 and 60 days and was associated with presentation to emergency department sooner

Only Half of Teens Receive Minimum Standards for Sex Education

Disparities exist in receipt of information by gender, race, and location of instruction

Strong Opioids No Better for Pain After Surgery for Fracture

No difference seen in Numerical Pain Rating Scale mean pain score for patients receiving strong versus mild opioids

Atopic Dermatitis Linked to Shorter Stature in Early Childhood

Associations of atopic dermatitis with height and BMI decreased by age 14 and 5.5 years, respectively

Positive SARS-CoV-2 Test Result Linked to Psychiatric Morbidity

However, risk for incident psychiatric morbidity was similar for those with negative SARS-CoV-2 test result and was higher with influenza

AHA: Better Management of High Cholesterol Needed in Young Adults

A substantial number of young adults with moderate or severe hypercholesterolemia do not achieve guideline-directed reductions in LDL-C

AHA: Women With Disabilities Have Poorer Diets, Face Food Insecurity

Findings seen among women of reproductive age with self-reported disability

Trial Begins of Nasal Vaccine for Alzheimer Disease

Phase 1 trial will include 16 patients ages 60 to 85 years who have early, symptomatic Alzheimer disease but are otherwise in good health

Vials With Smallpox Labels Found at Vaccine Lab in Pennsylvania: CDC

Vials were found by a laboratory worker while cleaning out a freezer in a facility that conducts vaccine research

Nearly 10 Percent of Younger Children Have Gotten First COVID-19 Vaccine Dose

Children who get their first shot by the end of the week and their second one three weeks after will be fully vaccinated by Christmas

Moderna Asks FDA to Approve Its Booster Shot for All Adults

Moderna booster is half the dose of the initial vaccination series: 50 mcg versus 100 mcg

Bariatric Surgery May Cut Risk for Adverse Outcomes in NASH

Risk for adverse liver and cardiovascular outcomes lower among patients with obesity and advanced fatty liver who undergo bariatric surgery

Number of Elderly on U.S. Liver Transplant List Rising

Outcomes for elderly patients receiving liver transplants also improving

Muscle Mass Tied to Vasomotor Symptoms in Women at Menopause

Authors say health care providers should consider screening menopausal women without hot flashes for age-related loss of muscle mass

Hypertension May Increase Risk for Late-Onset Epilepsy

After adjustment for prevalent and interim stroke, risk for developing epilepsy increased almost twofold

Smoking Linked to Fatal Event as First Sign of CVD

Smoking associated with earlier onset of cardiovascular disease, by 5.1 years for men and 3.8 years for women

Many Stroke Survivors Continue to Smoke

Stroke survivors less likely than cancer survivors to quit smoking

CDC: More Than 100,000 Americans Died From Drug Overdoses in One Year

Figure is almost 30 percent higher than the previous year, when 78,000 overdose deaths were reported

Effects of Fasting-Mimicking Diet Studied in Cancer Patients

Fasting-mimicking diets induce metabolic and immunologic changes that might enhance the effects of standard antineoplastic therapy

CDC Investigating Case of Monkeypox in Traveler From Nigeria

Symptoms of monkeypox are similar to but milder than symptoms of smallpox

Most Teens, Young Adults Knowledgeable About Sun Protection

While most report sunscreen use, substantial number also report having had sunburns

White House to Spend Billions to Boost COVID-19 Vaccine Supply

The goal of the plan is to produce at least 1 billion doses a year beginning in the second half of 2022

Minorities Less Likely to Undergo MRI After Elevated PSA Test

Disparities in subsequent MRIs more pronounced at higher PSA thresholds

FDA Could Approve Pfizer Booster Shots for All Adults This Week

More than 30 million Americans have already gotten booster shots

Prior Bariatric Surgery May Protect Against Severe COVID-19 Outcomes

Among COVID-19-positive adults, outcomes better for those with prior bariatric surgery versus those eligible for bariatric surgery

FDA Approves Virtual Reality System to Ease Back Pain

EaseVRx system uses number of cognitive behavioral therapy methods to achieve pain relief

Noncontrast CT Can ID Candidates for Mechanical Thrombectomy

For stroke patients with late-presenting large-vessel occlusion, 90-day outcomes similar with selection by noncontrast CT, MRI, CTP

Suicide Risk Varies Among Lesbian, Gay, and Bisexual Adults

Suicide risk influenced by intersection of sexual identity with other factors, including age, gender, race/ethnicity

Review Profiles Open-Access Datasets With Skin Cancer Images

Darker skin types underrepresented among publicly available skin image datasets used to inform skin cancer diagnosis

Liver Transplant Outcomes Worse for Nonoverweight NAFLD Patients

Outcomes worse before and after liver transplant for nonoverweight versus overweight/obese adults with nonalcoholic fatty liver disease

9.6 Percent of People of All Ages Uninsured in First Half of 2021

Among adults aged 18 to 64 years, 14.0 percent were uninsured, 21.6 percent had public coverage, 66.3 percent had private health coverage

Some Cirrhosis Patients Given Opioid Rx at Outpatient Visits

Authors say primary care providers in particular need more education on the potential harms of opioids in patients with liver disease

Two Doses of 10 μg BNT162b2 Safe, Efficacious in 5- to 11-Year-Olds

BNT162b2 vaccine had favorable safety profile in 5- to 11-year-olds similar to that seen in other age groups

Higher Serum Iron May Up Liver Cancer Risk in NAFLD Patients

Increased risk for hepatocellular carcinoma also seen with higher transferrin saturation levels in patients with nonalcoholic fatty liver disease

Pfizer Asks FDA for Emergency Approval of Its COVID-19 Antiviral Pill

Request comes shortly after clinical trial testing the drug was halted early due to overwhelming evidence of its effectiveness

ASN: Steroids Best Placebo in High-Risk IgA Nephropathy

But dose reduced because of increased incidence of serious adverse events with full-dose methylprednisolone

CDC Warns of E. Coli Outbreak Linked to Baby Spinach

Illness reported in Indiana, Iowa, Michigan, Minnesota, Missouri, Ohio, South Dakota; two hospitalizations but no deaths reported

ASN: Ellipsys Percutaneous Fistula Durable for Hemodialysis Access

High rate of fistula use, low rates of secondary procedures and complications seen at five years

Salmonella Outbreak Linked to Salami Sticks Rises to 31 Cases in 10 States

There have been six hospitalizations reported, but no deaths

ACR: Risk Factors ID’d for Hydroxychloroquine-Related Retinopathy

Independent risk factors for HCQ retinopathy include higher doses, longer duration of use, chronic kidney disease, and Asian race

Pfizer COVID-19 Pill to Be Made, Sold Cheaply in 95 Poor Countries

Countries included in licensing deal mostly in Africa and Asia and account for more than half of the world's population

Flu Vaccine Coverage Suboptimal for Medicare Beneficiaries

Uptake of vaccination higher among beneficiaries with versus without high-risk conditions; missed opportunities for vaccination are common

Progress Made in Reducing Depression During Internship

Increases in sleep hours and use of mental health services, decrease in work hours occurred in parallel to decrease in depressive symptoms

ASN: Model Predicts Benefit of SGLT2 Inhibitors for Adults With T1DM

Steno Type 1 Risk Engine predicts substantial reduction in risks for CVD, ESKD with SGLT2i as adjunct therapy for type 1 diabetes

ACAAI: Many Parents Unaware of Guidelines to Prevent Peanut Allergy

Less than half of parents and caregivers report being told by a physician to introduce child to peanut-containing foods by 11 months of age

BP Control Lower for Current Smokers, Especially Men

Rates of BP control lower for current smokers; 45.5 percent of men had blood pressure >180 and/or >100 mm Hg

ACR: Lupus Patients Can Have Low Immune Response to COVID-19 Vaccines

However, overall disease activity does not appear to change after vaccination

ACR: Total Hip Arthroplasty Up for Those Under Age 21

Frequency of THA for osteonecrosis increased, while frequency of THA for inflammatory arthritis decreased from 2000 to 2016

SSRIs Linked to Reduced Relative Risk for Mortality in COVID-19

Relative risks for mortality significantly reduced for any SSRI, fluoxetine, and fluoxetine or fluvoxamine

QFR-Guided Percutaneous Coronary Intervention Improves Outcomes

One-year clinical outcomes improved with quantitative flow ratio for lesion selection versus standard angiography guidance

Prior SARS-CoV-2 Infection Ups Protection for Vaccinated

Prior infection linked to lower risk for breakthrough infection among individuals vaccinated with BNT162b2 or mRNA-1273

Protocol Examined for Returning Results in Genomic Research

Among participants in a biobank found to be carrying pathogenic or likely pathogenic variants, 76.3 percent unaware of these research results

Bilateral Oophorectomy Before Menopause Linked to MCI

In cross-sectional study, bilateral oophorectomy before age 46 linked to poorer performance on cognitive tests 30 years later

AHA: Use of Cardiac Rehab Low in Adults With Heart Failure

Rate of enrollment increased after Medicare expansion in 2014, but absolute enrollment rate in cardiac rehabilitation for HF patients still low

Pricey Alzheimer Drug Drives Spike in Medicare B Premium: Officials

New premium will be $170.10 a month, and the $21.60 boost is the biggest increase ever in dollar amount, but not in percentage terms

AHA: Sacubitril/Valsartan No More Beneficial for Chronic Advanced CHF

No benefit seen versus valsartan for reducing NT-proBNP levels for patients with chronic advanced heart failure and reduced ejection fraction

Federal Court Backs Stay on COVID-19 Vaccine Mandate for Large Businesses

Legal challenges against the mandate have been filed by at least 27 states in at least six federal appeals courts

ASN: PPI Use May Up Risk for AKI After Cardiac Surgery

Adults receiving proton pump inhibitors have increased risk for acute kidney injury requiring dialysis following cardiac surgery

Wealthier Parents More Likely to Get COVID-19 Vaccines for Young Children

47 percent with annual incomes ≥$100,000 willing to get their child vaccinated versus only 34 percent of those with incomes less than $50,000

Federal Judge Overturns Texas Ban on School Mask Mandates

Judge said ban violated the 1990 Americans With Disabilities Act because it put children with disabilities at risk

More Than 2 Million COVID-19 Home Test Kits Recalled Due to False-Positive Results

35 reports of false-positive results sent to the FDA, but no deaths have been reported

Physician’s Briefing Weekly Coronavirus Roundup

Here is what the editors at Physician's Briefing chose as the most important COVID-19 developments for you and your practice for the week of...

Biden Announces New Lung Health Program for U.S. Veterans

Program will begin with a focus on lung and breathing problems but will expand as science identifies potential new connections

Estimated Coverage With Measles Vaccine Down in 2020

Annual number of estimated measles deaths decreased 94 percent during 2000 to 2020, representing 31.7 million deaths averted

ASN: Daprodustat Noninferior to ESAs for Treating Anemia in CKD

Randomized, open-label, phase 3 trials conducted in patients with chronic kidney disease undergoing, not undergoing dialysis

Many Adults Unaware of Exocrine Pancreatic Insufficiency

Additionally, survey shows many U.S. adults suffer from gastrointestinal symptoms without seeking care

ASN: Chlorthalidone Aids BP Control in Patients With CKD and HTN

For patients with stage 4 chronic kidney disease and poorly controlled hypertension, addition of low dose of chlorthalidone improves BP control

Ambient Temperatures Linked to Hospitalization for Renal Diseases

For each 1-degree Celsius increase in daily mean temperature, estimated risk for hospitalization for renal diseases increased by 0.9 percent

CTA May ID Pattern for Slow-Progressing Ischemic Stroke

Symmetric collaterals on CTA common in patients with large vessel occlusion stroke, highly specific for small 24-hour ischemic core volume

Therapeutic Heparin May Benefit Moderately Ill COVID-19 Inpatients

Among those with increased D-dimer levels, no reduction seen in primary composite outcome at 28 days, but odds of death decreased

Biden to Nominate Former FDA Head Robert Califf to Lead Agency Again

If confirmed by the Senate, Califf will direct an agency responsible for more than $2.8 trillion worth of food, medical products, and tobacco

Air Pollution Exposure Linked to Pneumonia in Children

Exposure to PM2.5 above 10.75 µg/m3 associated with residence in area with high risk for community-acquired pneumonia in children

Physical Activity Not Tied to Development of Knee Osteoarthritis

No association found for measurement of physiological energy expenditure or time spent in recreational physical activity with risk for knee OA

Prenatal Perfluoroalkyl Substances Tied to Risk for Preeclampsia

Maternal exposure to PFDA and PFOS tied to higher odds of late-onset preeclampsia; findings not significant for early-onset preeclampsia

Depressive Symptoms Increased During Migraine Headache

Prospective diary study shows no evidence of acute depressive symptomatology as an early warning sign for upcoming migraine attack

Diabetes Patients Less Often Perceive Atrial Fibrillation Symptoms

Those with diabetes and a-fib have worse quality of life and more cardiac and neurological morbidities than those without diabetes

Oral Nadolol Feasible for the Treatment of Infantile Hemangiomas

Randomized clinical trial shows oral nadolol noninferior to oral propranolol for treatment of infantile hemangiomas

ACR: Certain Serious Infections Down for Psoriatic Arthritis Patients

Hospital discharges for psoriatic arthritis patients with sepsis, skin and soft tissue infections, and UTIs down from 2012 to 2017 in the U.S.

CPAP, HFNO Not Tied to Greater SARS-CoV-2 Air, Surface Contamination

Another small study suggests cough poses higher risk for aerosol emission from the respiratory tract than CPAP, HFNO

2000 to 2019 Saw Decline in Sepsis-Related Death Rates for ≥65s

Increase in sepsis-related death rates with age, with rate about five times higher for adults aged 85 years or older versus 65 to 74 years

Nearly 900,000 U.S. Children Under 12 Have Gotten Their First COVID-19 Shot

But some experts say that demand could begin to recede in only a matter of weeks

Patient Blood Management Program May Reduce Use of Transfusions

Absolute risk reduction of 6 percent seen for transfusions in hospitalized adults after implementation of PBM at large academic medical center

Oklahoma Supreme Court Overturns $465 Million J&J Opioid Ruling

It is not clear how the decision will affect similar cases nationwide, since most public nuisance laws are state-specific

Longitudinal Analysis of PRISm Conducted in Large Adult Population

Preserved ratio impaired spirometry associated with increased risks for breathlessness and cardiovascular disease

Pfizer Asks FDA to Approve Booster Shots for All U.S. Adults

With its application, the company included early results of a study that involved 10,000 people

ACR: COVID-19 Vaccine Not Tied to Severe Rheumatic Disease Flares

Seropositivity lags after vaccination in those with rheumatic diseases but improves after second dose

Link Between Migraine, Complete Mental Health Explored

Association between migraine, complete mental health attenuated after adjustment for physical health, mental health problems

ACR: Cycling JAK Inhibitors Feasible for Difficult-to-Treat RA

One-year outcomes similar for cycling JAK inhibitors versus switching to a biologic drug

Sleep Onset Timing Linked to Risk of Developing CVD

Lowest cardiovascular disease incidence seen in association with sleep-onset time of 10.00 p.m. to 10.59 p.m.

Psychoneurological Distress Up With Nasal Septum Deviation

Patients with NSD from Korean Health Insurance Service database have increased incidence of anxiety, depression, migraine

Statin Use Not Linked to COVID-19 Mortality in Hospitalized Patients

Statin use associated with increased relative risk for severe disease among hospitalized patients with COVID-19

Smoking, Alcohol Intake Tied to Age-Related Macular Degeneration

Findings based on mendelian randomization for genetically predicted smoking initiation, alcohol intake