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Incidence and prevalence highest in Northern Europe, North America; lowest in Southern Europe, Asia, Middle East

Incidences of major adverse cardiovascular events, cancers higher with tofacitinib versus TNF inhibitor; criteria for noninferiority not met

Real-world data support the use of remdesivir for hospitalized COVID-19 patients receiving no oxygen or low-flow oxygen

All-cause inpatient admissions 2.8 times more likely, death 1.5 times more likely during foot ulcer episodes versus period after healing

Lower respiratory infections accounted for >1.5 million deaths associated with resistance, making it the most burdensome syndrome

Reporting rates 3.83 per million vaccine doses for Ad26.COV2.S versus 0.00855 per million for mRNA-based vaccines

Promoting low-dose CT screening among mostly nonsmoking women increased detection of early-stage, but not late-stage, lung cancers

No such increased risk seen with Sinovac inactivated virus vaccine

Evidence currently inadequate for assessing the balance of benefits and harms of screening for atrial fibrillation in asymptomatic adults

ACIP recommends PCV20 alone or PCV15 in series with PPSV23 for all aged 65 years and older or younger adults at risk