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T2DM Linked to Worse Cognitive Performance After Stroke

No significant difference found in cognitive function for those with impaired, normal fasting glucose levels

FRIDAY, May 15, 2020 (HealthDay News) — In a stroke population, type 2 diabetes (T2D), but not impaired fasting glucose, is associated with worse cognitive performance, according to a study published online May 14 in Stroke.

Jessica W. Lo, from the University of New South Wales in Sydney, and colleagues examined the impact of impaired fasting glucose and T2D on cognitive performance in a stroke population of 1,601 participants from seven international observational studies. Fasting glucose levels (FGL) during hospitalization were used to define three groups: T2D (FGL ≥7.0 mmol/L), impaired fasting glucose (6.1 to 6.9 mmol/L), and normal (<6.1 mmol/L). Standardized neuropsychological test scores were used to derive domain and global cognition Z scores. The correlations between glucose status and cognitive performance were assessed at three and six months after stroke.

The researchers found that compared with patients with normal FGL, those with T2D had significantly poorer performance in global cognition (standard deviation [SD], −0.59; 95 percent confidence interval, −0.82 to −0.36; P < 0.001) and in all domains. For patients with impaired fasting glucose and those with normal FGL, no significant difference was seen in global cognition (SD, −0.10; 95 percent confidence interval, −0.45 to 0.24; P = 0.55) or in any cognitive domain.

“This emphasizes the importance of interventions to prevent the progression of prediabetes to diabetes mellitus in stroke patients,” the authors write.

Several authors disclosed financial ties to the pharmaceutical industry.

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