Home News General Health News Polygenic Risk Score Reliably Predicts Coronary Artery Disease

Polygenic Risk Score Reliably Predicts Coronary Artery Disease

PRS predicts prevalent CAD but does not perform as well for predicting incident, recurrent CAD

TUESDAY, June 11 2019 (HealthDay News) — Genome-wide polygenic risk scores (PRS) can predict coronary artery disease (CAD), according to a study published online June 11 in Circulation: Genomic and Precision Medicine.

Noting that two recently derived genome-wide PRS have shown high specificity and sensitivity to identify CAD cases in European-ancestry participants from the U.K. Biobank, Florian W√ľnnemann, Ph.D., from the Montreal Heart Institute, and colleagues calculated both PRS (GPSCAD and metaGRSCAD) in French-Canadian individuals from three cohorts totaling 3,639 prevalent CAD cases and 7,382 controls. The impact of the founder French-Canadian familial hypercholesterolemia deletion (LDLR delta > 15kb deletion) was estimated on CAD risk in one of these cohorts; this estimate was used to calibrate PRS impact.

The researchers confirmed the ability of both PRS to predict prevalent CAD comparable to the original reports (area under the curve [AUC], 0.72 to 0.89). Consistent with previous estimates, the PRS identified about 6 to 7 percent of individuals at CAD risk similar to that for carriers of the LDLR delta > 15kb mutation. For predicting incident or recurrent CAD, the PRS did not perform as well (AUC, 0.56 to 0.60), possibly due to confounding as more than three-quarters (76 percent) of participants were on statin treatment.

“Using the polygenic risk score, even in a normal population, we can find people whose risk is as high as those who have [familial hypercholesterolemia],” a coauthor said in a statement.

Abstract/Full Text (subscription or payment may be required)

Copyright © 2019 HealthDay. All rights reserved.