Home News Cancer News Overweight and Obesity May Up Risk for Several Common Cancers

Overweight and Obesity May Up Risk for Several Common Cancers

Among overweight, obese patients, cancer risk 12 percent greater compared with general population

THURSDAY, Feb. 6, 2020 (HealthDay News) — Hospital-diagnosed overweight and obesity is associated with an increased risk for several common cancers, according to a study recently published in the Journal of Internal Medicine.

Sigrid Bjerge Gribsholt, M.D., Ph.D., from Aarhus University Hospital in Denmark, and colleagues examined the overall cancer incidence and specific site-related cancer incidences among patients with hospital-diagnosed overweight and obesity versus the general Danish population.

The researchers found 20,706 cancers among 313,321
patients diagnosed with overweight and obesity (median age, 43 years; median follow-up, 6.7 years) versus 18,480 cancers expected (standardized incidence ratio [SIR], 1.12; 95 percent confidence interval [CI], 1.11 to 1.14). The SIR associated with overweight and obesity was even higher among patients with comorbidities, including type 2 diabetes (SIR, 1.18; 95 percent CI, 1.13 to 1.23) and alcoholism-related diseases (SIR, 1.62; 95 percent CI, 1.45 to 1.82). The SIR was 1.31 (95 percent CI, 1.28 to 1.34) for cancers identified as obesity-related, including pancreatic (SIR, 1.38; 95 percent CI, 1.27 to 1.49) and postmenopausal breast cancer (SIR, 1.14; 95 percent CI, 1.09 to 1.19). Additionally, elevated SIRs were seen for obesity/overweight status and hematological (SIR, 1.24; 95 percent CI, 1.18 to 1.29) and neurological cancers (SIR, 1.19; 95 percent CI, 1.11 to 1.27). In contrast, SIRs were not significant for immune-related cancer (1.01; 95 percent CI, 0.97 to 1.05), malignant melanoma (0.88; 95 percent CI, 0.82 to 0.95), and hormone-related cancers other than postmenopausal breast cancer (0.88; 95 percent CI, 0.85 to 0.92).

“Concomitant comorbidities, including diabetes and alcoholism-related diseases, further increased the cancer risk,” the authors write.

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