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October 2019 Briefing – Pathology

Here are what the editors at HealthDay consider to be the most important developments in Pathology for October 2019. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Close to 1,900 Cases of Vaping-Linked Lung Illness Reported, CDC Says

THURSDAY, Oct. 31, 2019 (HealthDay News) — The number of Americans stricken with a severe, sometimes fatal lung illness tied to vaping has now reached 1,888, the U.S. Centers for Disease Control and Prevention reported Thursday. That is a rise from the 1,604 case total from a week ago.

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Gilteritinib Superior in Relapsed, Refractory FLT3-Mutated AML

THURSDAY, Oct. 31, 2019 (HealthDay News) — For relapsed or refractory acute myeloid leukemia (AML) with mutations in the FMS-like tyrosine kinase 3 gene (FLT3), treatment with a selective FLT3 inhibitor, gilteritinib, results in significantly longer survival and a greater percentage of patients with remission than salvage chemotherapy, according to a study published in the Oct. 31 issue of the New England Journal of Medicine.

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Common Sites of Bone Erosion in Rheumatoid Arthritis ID’d on US

THURSDAY, Oct. 31, 2019 (HealthDay News) — Joint recesses with bone erosion are more likely to exhibit greater severity of joint inflammation on ultrasound (US) examination, according to a study published online Oct. 25 in the Journal of Clinical Ultrasound.

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Cognitive Ability in Childhood Linked to Cognitive Scores at 70

THURSDAY, Oct. 31, 2019 (HealthDay News) — Childhood cognitive ability is associated with cognitive scores, including the Preclinical Alzheimer Cognitive Composite (PACC), more than 60 years later, according to a study published online Oct. 30 in Neurology.

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J&J Says No Asbestos Detected in New Tests of Baby Powder

WEDNESDAY, Oct. 30, 2019 (HealthDay News) — No asbestos was detected in 15 new tests of the same bottle of Johnson & Johnson’s Baby Powder previously found to contain asbestos by the U.S. Food and Drug Administration, the company said Tuesday.

CBS News Article

J&J Press Release

AI Model Helps ID Those at Risk for Familial Hypercholesterolemia

WEDNESDAY, Oct. 30, 2019 (HealthDay News) — The FIND FH model can successfully identify individuals with familial hypercholesterolemia (FH) from a scan of large, diverse health care encounter databases, according to a study published online Oct. 21 in The Lancet Digital Health.

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CDC: U.S. Life Expectancy Up Slightly, Mortality Lower in 2017

WEDNESDAY, Oct. 30, 2019 (HealthDay News) — Life expectancy has increased slightly in the United States, and mortality is lower than in 2007, according to a report published Oct. 30 by the U.S. Centers for Disease Control and Prevention National Center for Health Statistics.

Health, United States, 2018

Hypoglycemia Increases Risk for Sudden Cardiac Arrest in T2DM

WEDNESDAY, Oct. 30, 2019 (HealthDay News) — Hypoglycemic episodes may increase the risk for ventricular arrhythmia (VA) and sudden cardiac arrest (SCA) among patients with type 2 diabetes, according to a study published online Oct. 26 in Diabetes/Metabolism Research and Reviews.

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Cancer Screening Rates Lower Among Women With Diabetes

TUESDAY, Oct. 29, 2019 (HealthDay News) — Women with diabetes have lower rates of breast, cervical, and colorectal cancer screening compared with women without diabetes, according to a review published online Oct. 24 in Diabetologia.

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CDC: Most Patients With Vaping-Related Lung Injury Report THC Use

TUESDAY, Oct. 29, 2019 (HealthDay News) — Most patients with electronic cigarette, or vaping, product use-associated lung injury (EVALI) reported use of tetrahydrocannabinol (THC)-containing products in the three months preceding symptom onset, according to research published in the Oct. 28 early-release issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.

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Facebook Launches Preventive Health Tool

TUESDAY, Oct. 29, 2019 (HealthDay News) — A new tool designed to help guide preventive care for heart disease, cancer, and seasonal flu was launched in the United States Monday by Facebook.

CNN Article

Readmissions Up for Preexisting HAIs With Home Discharge

TUESDAY, Oct. 29, 2019 (HealthDay News) — Discharge to a skilled nursing facility (SNF) is associated with fewer avoidable readmissions for preexisting health care-associated infections (HAIs) compared with home discharges, according to a study published online Oct. 23 in the Journal of the American Geriatrics Society.

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Outcomes Poor With Medical Care From Fraud, Abuse Perpetrators

MONDAY, Oct. 28, 2019 (HealthDay News) — Receiving medical care from fraud and abuse perpetrators (FAPs), subsequently excluded from Medicare, is associated with higher rates of all-cause mortality and emergency hospitalization, according to a study published online Oct. 28 in JAMA Internal Medicine.

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HPV DNA Identified in Oral Cavity of 6.2 Percent of Teen Girls

FRIDAY, Oct. 25, 2019 (HealthDay News) — Human papillomavirus (HPV) DNA is detected in the oral cavities of about 6.2 percent of sexually active female adolescents, according to a study published online Oct. 25 in JAMA Network Open.

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AI Model Based on US Classifies Thyroid Nodules by Genetic Risk

FRIDAY, Oct. 25, 2019 (HealthDay News) — A model developed through automated machine learning uses ultrasonographic images to classify indeterminate thyroid nodules as having low or high genetic risk, according to a study published online Oct. 24 in JAMA Otolaryngology-Head & Neck Surgery.

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Delay of Surgery for DCIS Ups Risk for Invasive Breast Cancer

FRIDAY, Oct. 25, 2019 (HealthDay News) — For each month of delay between diagnosis and surgery for ductal carcinoma in situ (DCIS), there is slightly worse survival and an increase in risk for invasive disease, according to a study published online Sept. 27 in the Annals of Surgical Oncology.

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CDC: Cases of Vaping-Linked Lung Illness Now Top 1,600

THURSDAY, Oct. 24, 2019 (HealthDay News) — More than 1,600 Americans have now been struck by a severe, sometimes fatal, lung illness tied to vaping, the U.S. Centers for Disease Control and Prevention reported Thursday.

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Regional Brain Atrophy ID’d in Patients With History of TBI

THURSDAY, Oct. 24, 2019 (HealthDay News) — Individuals with a history of traumatic brain injury (TBI) have regional brain atrophy, especially in the ventral diencephalon, putamen, and pallidum, according to a study recently published in the Journal of Alzheimer’s Disease.

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Serum Elaidic Acid Levels Tied to Dementia, Alzheimer Disease

WEDNESDAY, Oct. 23, 2019 (HealthDay News) — Higher serum levels of elaidic acid, an objective biomarker for industrial trans fat, are associated with an increased risk for developing all-cause dementia and Alzheimer disease, according to a study published online Oct. 23 in Neurology.

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Neurodegenerative Disease Deaths Up in Former Soccer Players

WEDNESDAY, Oct. 23, 2019 (HealthDay News) — Former soccer players have an increased risk for mortality from neurodegenerative diseases, according to a study published online Oct. 21 in the New England Journal of Medicine.

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Lung Transplant With Ex Vivo Lung Perfusion Feasible

WEDNESDAY, Oct. 23, 2019 (HealthDay News) — Use of ex vivo lung perfusion (EVLP)-treated lungs increases the number of patients undergoing transplantation with comparable long-term outcomes, according to a study published online Oct. 9 in JAMA Surgery.

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More Choices, Lower Premiums for ACA Consumers Next Year

TUESDAY, Oct. 22, 2019 (HealthDay News) — There will be more health insurance choices and a slight decrease in premiums for many consumers next year under the Affordable Care Act, according to the Trump administration.

AP News Article

Expert Second Opinions Up Reliability of Melanoma Diagnosis

TUESDAY, Oct. 22, 2019 (HealthDay News) — Second opinions rendered by dermatopathologists improve the reliability of melanocytic lesion diagnosis, although there is still discordance among pathologists, according to a study published online Oct. 11 in JAMA Network Open.

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Long-Term Lung Function Declines Even for Prior Low-Intensity Smokers

TUESDAY, Oct. 22, 2019 (HealthDay News) — Compared with never-smokers, former smokers and low-intensity current smokers have accelerated lung function decline, according to a study published online Oct. 9 in The Lancet Respiratory Medicine.

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Antiviral Antibodies ID’d in CSF of Acute Flaccid Myelitis Cases

MONDAY, Oct. 21, 2019 (HealthDay News) — Enterovirus (EV)-specific antibodies have been identified in the cerebrospinal fluid (CSF) of pediatric cases of acute flaccid myelitis (AFM) versus controls, according to a study published online Oct. 21 in Nature Medicine.

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Lower Birth Weight May Protect Against Allergies

MONDAY, Oct. 21, 2019 (HealthDay News) — Intrauterine growth restriction protects against allergic diseases, according to a review published online Oct. 12 in the Journal of Allergy and Clinical Immunology.

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Long Sleep Duration Linked to Cognitive Decline in Hispanics

MONDAY, Oct. 21, 2019 (HealthDay News) — Long sleep duration predicts seven-year cognitive decline among U.S. Hispanic/Latino patients, according to a study published online Oct. 9 in Alzheimer’s & Dementia.

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Johnson & Johnson Recalls Baby Powder Due to Presence of Asbestos

FRIDAY, Oct. 18, 2019 (HealthDay News) — A shipment of baby powder has been recalled by Johnson & Johnson after U.S. authorities found asbestos in it.

The New York Times Article

Occupational Use of Disinfectants May Up Risk for Developing COPD

FRIDAY, Oct. 18, 2019 (HealthDay News) — Regular use of chemical disinfectants among nurses may be a risk factor for developing chronic obstructive pulmonary disease (COPD), according to a study published online Oct. 18 in JAMA Network Open.

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Risk for Secondary Primary Cancer Varies With Lymphoma Stage

FRIDAY, Oct. 18, 2019 (HealthDay News) — The risk for secondary primary malignancies (SPMs) varies based on stage of diffuse large B-cell lymphoma (DLBCL) at diagnosis, according to a study published online Sept. 11 in Cancer.

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Exposure to Secondhand Smoke Linked to Choroidal Thinning in Children

FRIDAY, Oct. 18, 2019 (HealthDay News) — Exposure to secondhand smoking is associated with choroidal thinning among children aged 6 to 8 years, according to a study published online Oct. 17 in JAMA Ophthalmology.

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Prediagnostic Colonoscopy Cuts Colorectal Cancer Death Risk

THURSDAY, Oct. 17, 2019 (HealthDay News) — The risk for colorectal cancer death drops with an increasing number of prediagnostic colonoscopies, largely due to fewer advanced cancers at time of diagnosis, according to a study recently published in BMC Cancer.

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Risk, Severity of CTE Increase With Years of Football Played

THURSDAY, Oct. 17, 2019 (HealthDay News) — The risk and severity of chronic traumatic encephalopathy (CTE) increase with the number of years playing American football, according to a study published online Oct. 7 in the Annals of Neurology.

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Risk for Cancer Incidence, Mortality Increased With Psoriasis

WEDNESDAY, Oct. 16, 2019 (HealthDay News) — Patients with psoriasis have an increased risk for developing or dying from cancer, according to a review published online Oct. 16 in JAMA Dermatology.

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Maternal Lead Exposure Tied to Obesity Risk in Offspring

WEDNESDAY, Oct. 16, 2019 (HealthDay News) — Maternal elevated lead exposure is associated with an increased risk for intergenerational overweight or obesity (OWO), independent of postnatal blood lead levels, according to a study published online Oct. 2 in JAMA Network Open.

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Close to 1,300 Cases of Vaping-Linked Illness Now Identified

THURSDAY, Oct. 10, 2019 (HealthDay News) — The number of Americans sickened with a severe lung injury tied to vaping just keeps rising, U.S. health officials said Thursday.

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CDC: Seasonal Influenza Viruses Circulating in Southern Hemisphere

THURSDAY, Oct. 10, 2019 (HealthDay News) — Seasonal influenza viruses are circulating widely in the Southern Hemisphere, but influenza activity is currently low in the United States, according to research published in the Oct. 11 issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.

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Multigene Testing for All Breast Cancer Patients Cost-Effective

THURSDAY, Oct. 10, 2019 (HealthDay News) — Unselected, multigene testing for all patients with breast cancer would be cost-effective in the United Kingdom and the United States, according to a study published online Oct. 3 in JAMA Oncology.

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Screening for Bacterial Vaginosis in Pregnancy Not Advised

WEDNESDAY, Oct. 9, 2019 (HealthDay News) — The U.S. Preventive Services Task Force (USPSTF) recommends against screening for bacterial vaginosis in pregnant women who are not at increased risk for preterm delivery; for pregnant women at increased risk for preterm delivery, the balance of benefits and harms cannot be determined. These findings form the basis of a draft recommendation statement published online Oct. 8 by the USPSTF.

Draft Evidence Review

Draft Recommendation Statement

Comment on Recommendation Statement

Medicare Fraud-Prevention Rules to Be Revised

WEDNESDAY, Oct. 9, 2019 (HealthDay News) — Revision of decades-old Medicare rules meant to prevent fraud has been proposed by the Trump administration.

AP News Article

2000 to 2015 Saw Increase in Medicare GME Payments

WEDNESDAY, Oct. 9, 2019 (HealthDay News) — Medicare graduate medical education (GME) payments increased significantly from 2000 to 2015, according to a study published online Oct. 7 in JAMA Internal Medicine.

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2017 to 2018 Saw Increases in Chlamydia, Gonorrhea, Syphilis

TUESDAY, Oct. 8, 2019 (HealthDay News) — During 2017 to 2018, there were increases in the rates of chlamydia, gonorrhea, and syphilis, according to a report published online Oct. 8 by the U.S. Centers for Disease Control and Prevention.

Sexually Transmitted Disease Surveillance 2018

Hydroxychloroquine Blood Levels Predict Retinopathy Risk in Lupus

TUESDAY, Oct. 8, 2019 (HealthDay News) — Hydroxychloroquine (HCQ) blood levels are useful in predicting retinopathy among patients with systemic lupus erythematosus (SLE), according to a study published online Sept. 18 in Arthritis & Rheumatology.

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Testosterone, Estradiol Levels May Play Role in Sex Differences in Asthma

TUESDAY, Oct. 8, 2019 (HealthDay News) — Sex hormones seem to play a role in known sex differences in asthma in adults, with the effects modified by obesity, according to a study published online Sept. 16 in the American Journal of Respiratory and Critical Care Medicine.

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Burnout Linked to Poor Quality Care in Published Literature

TUESDAY, Oct. 8, 2019 (HealthDay News) — In the published literature, burnout in health care professionals is frequently associated with poor-quality care, but the effect size may be smaller than reported, according to data from a systematic review published online Oct. 8 in the Annals of Internal Medicine.

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Cost of Waste in U.S. Health System Estimated

TUESDAY, Oct. 8, 2019 (HealthDay News) — The estimated cost of waste in the U.S. health care system varies from $760 to $935 billion, according to a special communication published online Oct. 7 in the Journal of the American Medical Association.

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Data Suggest Viral Etiology for Pediatric Acute Flaccid Myelitis

MONDAY, Oct. 7, 2019 (HealthDay News) — Surveillance data for acute flaccid myelitis (AFM) suggests a viral etiology, according to a study published online Oct. 7 in Pediatrics.

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Hysterectomy Technique Tied to Poorer Uterine Cancer Outcomes

MONDAY, Oct. 7, 2019 (HealthDay News) — Uncontained power morcellation is associated with a higher mortality risk in women with occult uterine sarcoma, especially in those with occult leiomyosarcoma, according to a study published online Sept. 16 in the Journal of Clinical Oncology.

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Guideline for Community-Acquired Pneumonia Updated

MONDAY, Oct. 7, 2019 (HealthDay News) — In an updated official clinical practice guideline from the American Thoracic Society and Infectious Diseases Society of America, published in the Oct. 1 issue of the American Journal of Respiratory and Critical Care Medicine, recommendations are presented for the diagnosis and management of community-acquired pneumonia (CAP).

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Survey: Many U.S. Adults Not Planning to Get Flu Vaccine

FRIDAY, Oct. 4, 2019 (HealthDay News) — Many U.S. adults, including some at the highest risk for the flu and pneumonia, do not plan to get preventive vaccines, according to a survey conducted by NORC at the University of Chicago on behalf of the National Foundation for Infectious Diseases.

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Cases of Serious Vaping-Linked Lung Injury Now Top 1,000

THURSDAY, Oct. 3, 2019 (HealthDay News) — The number of Americans sickened with a severe lung illness tied to vaping continues to climb, U.S. health officials said Thursday.

Press Release: CDC

NEJM Research Letter

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