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November 2019 Briefing – Pathology

Here are what the editors at HealthDay consider to be the most important developments in Pathology for November 2019. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Antimicrobial Resistance Patterns Examined for Adult, Peds HAIs

WEDNESDAY, Nov. 27, 2019 (HealthDay News) — In two reports published online Nov. 25 in Infection Control & Hospital Epidemiology, authors present updated summaries of common pathogens and antimicrobial resistance patterns among health care-associated infections (HAIs) in adult and pediatric patients.

Abstract/Full Text 1 (subscription or payment may be required)

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Study Supports PSA Screening for Male BRCA2 Carriers

WEDNESDAY, Nov. 27, 2019 (HealthDay News) — Systematic prostate-specific antigen (PSA) screening is advised for men who are carriers of the BRCA2 mutation, which is associated with a higher incidence of prostate cancer, younger age at diagnosis, and clinically significant tumors, according to the interim results of a study published in the December issue of European Urology.

Abstract/Full Text

Household Environment Plays Role in MRSA Acquisition

WEDNESDAY, Nov. 27, 2019 (HealthDay News) — The household environment plays a key role in the acquisition of methicillin-resistant Staphylococcus aureus (MRSA) skin and soft tissue infection, according to a study published online Nov. 26 in The Lancet Infectious Diseases.

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Editorial (subscription or payment may be required)

U.S. Life Expectancy Dropped Since 2014 for Working-Age Adults

TUESDAY, Nov. 26, 2019 (HealthDay News) — U.S. life expectancy increased from 1959 to 2016 but has been decreasing since 2014, according to research published in the Nov. 26 issue of the Journal of the American Medical Association.

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Editorial (subscription or payment may be required)

Changes in Metabolic Syndrome Status Linked to MACE Risk

TUESDAY, Nov. 26, 2019 (HealthDay News) — Recovery from metabolic syndrome (MetS) is associated with a decreased risk for major adverse cardiovascular events (MACE), while increased risk is seen in association with MetS development, according to a study published online Nov. 26 in the Annals of Internal Medicine.

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Many Cancer Patients Interested in Pathology Consultations

TUESDAY, Nov. 26, 2019 (HealthDay News) — When surveyed, a majority of cancer patients expressed interest in participating in a patient-pathologist consultation program, according to a study recently published in the Archives of Pathology & Laboratory Medicine.

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Polio Vaccines Causing Polio Cases

MONDAY, Nov. 25, 2019 (HealthDay News) — More children worldwide are being paralyzed by polio viruses from vaccines than from viruses in the wild, according to new data.

AP News Article

More Information: WHO

Racial Differences Found in Gene Panels for Prostate Cancer Prognosis

MONDAY, Nov. 25, 2019 (HealthDay News) — For three commercial panels for prostate cancer prognosis, gene expression differs for European-American men (EAM) and African-American men (AAM), according to a study published online Nov. 22 in Cancer Epidemiology, Biomarkers & Prevention.

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Maternal Efavirenz May Up Risk for Microcephaly Among Offspring

MONDAY, Nov. 25, 2019 (HealthDay News) — In utero exposure to efavirenz is associated with an increased risk for microcephaly among children who are HIV-exposed but uninfected, according to a study published online Nov. 15 in The Lancet HIV.

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Editorial (subscription or payment may be required)

Threshold for Breast Cancer Recurrence Score Differs by Sex

THURSDAY, Nov. 21, 2019 (HealthDay News) — The Oncotype DX Breast Recurrence Score (RS) is associated with mortality at a lower threshold for men versus women with breast cancer, according to a study published online Nov. 20 in Clinical Cancer Research.

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Recommendations Developed for Multidrug-Resistant Tuberculosis

THURSDAY, Nov. 21, 2019 (HealthDay News) — In a new clinical practice guideline, published online Nov. 15 in the American Journal of Respiratory and Critical Care Medicine, recommendations are presented for the treatment of multidrug-resistant tuberculosis (MDR-TB).

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Employee Premiums, Deductibles Eating Larger Share of Income

THURSDAY, Nov. 21, 2019 (HealthDay News) — During the last decade, health care costs have eaten up a larger share of income for millions of middle-class Americans with employer coverage, according to Trends in Employer Health Care Coverage, 2008-2018, a Nov. 21 report from The Commonwealth Fund.

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H. Pylori Infection Must Be Wiped Out to Cut Gastric Cancer Risk

THURSDAY, Nov. 21, 2019 (HealthDay News) — Only complete eradication of Helicobacter pylori infection, not treatment alone, will reduce the risk for developing stomach cancer, according to a study recently published in Gastroenterology.

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Most Infants Susceptible to Measles by 3 Months of Age

THURSDAY, Nov. 21, 2019 (HealthDay News) — In an elimination setting, most infants are susceptible to measles by age 3 months, according to a study published online Nov. 21 in Pediatrics.

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Editorial (subscription or payment may be required)

Cervical Cancer Screening Remains Low in Women Ages 45 to 65 Years

TUESDAY, Nov. 19, 2019 (HealthDay News) — Cervical cancer screening rates are only about 70 percent among women ages 45 to 65 years, according to a study published online Nov. 1 in Preventive Medicine.

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Cancer Yield Similar for Dense Breast Ultrasound After DM, DBT

WEDNESDAY, Nov. 20, 2019 (HealthDay News) — There is no significant difference in breast cancer detection rates with dense breast ultrasound screening following digital mammography (DM) versus digital breast tomosynthesis (DBT), according to a study recently published in the American Journal of Roentgenology.

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Infection Likely Cause of One in Eight Stillbirths

WEDNESDAY, Nov. 20, 2019 (HealthDay News) — Most cases of infection-related stillbirth may be due to bacterial pathogens, according to a study published online Nov. 4 in Obstetrics & Gynecology.

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Endurance Exercise May Offer Vascular Benefit in Sickle Cell Disease

TUESDAY, Nov. 19, 2019 (HealthDay News) — Endurance exercise training may improve skeletal muscle microvasculature in patients with sickle cell disease (SCD), according to a study published online Nov. 19 in Blood.

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HbA1c Variability Linked to Cardiovascular Disease Risk

TUESDAY, Nov. 19, 2019 (HealthDay News) — For patients with newly diagnosed type 2 diabetes, visit-to-visit hemoglobin A1c (HbA1c) variability is associated with increased risks for cardiovascular disease and microvascular complications, according to a study published online Nov. 14 in Diabetes Care.

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Distribution of Self-Test Kits Can Up HIV Awareness

TUESDAY, Nov. 19, 2019 (HealthDay News) — Distribution of HIV self-tests among men who have sex with men (MSM) can increase testing and newly identified infections, according to a study published online Nov. 18 in JAMA Internal Medicine.

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Editor’s Note (subscription or payment may be required)

White House Wants Hospitals, Insurers to Provide Actual Costs of Care

MONDAY, Nov. 18, 2019 (HealthDay News) — New rules requiring hospitals and insurers to disclose the actual prices for common tests and procedures before they are performed have been proposed by the Trump Administration.

AP News Article

Studies Confirm Safety of 9-Valent HPV Vaccination

MONDAY, Nov. 18, 2019 (HealthDay News) — The safety of the 9-valent human papillomavirus vaccine (9vHPV) has been confirmed, according to two studies published online Nov. 18 in Pediatrics.

Abstract/Full Text – Shimabukuro (subscription or payment may be required)

Abstract/Full Text – Donahue (subscription or payment may be required)

Editorial (subscription or payment may be required)

Less Sleep Tied to Lower Bone Mineral Density in Women

MONDAY, Nov. 18, 2019 (HealthDay News) — Short sleep duration is associated with lower bone mineral density (BMD) and a higher risk for osteoporosis among postmenopausal women, according to a study published online Nov. 6 in the Journal of Bone and Mineral Research.

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Common TB Vaccine Associated With Lower Lung Cancer Rates

MONDAY, Nov. 18, 2019 (HealthDay News) — Childhood vaccination with the bacille Calmette-Guérin (BCG) vaccine is associated with a reduced risk for lung cancer, according to a study published online Sept. 25 in JAMA Network Open.

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CDC: Number of Vaping-Linked Lung Illnesses Up to 2,172

FRIDAY, Nov. 15, 2019 (HealthDay News) — The number of Americans stricken with a severe respiratory illness tied to vaping has now reached 2,172, the U.S. Centers for Disease Control and Prevention reported Thursday. That is a rise from the 2,051 case total from a week ago.

More Information: CDC

CNN Article

Some Progress Made in Slowing Antibiotic Resistance-Linked Deaths

FRIDAY, Nov. 15, 2019 (HealthDay News) — Progress has been made in slowing antibiotic resistance-associated deaths, but more than 2.8 million antibiotic-resistant infections occur each year in the United States, according to a report published by the U.S. Centers for Disease Control and Prevention.

Antibiotic Resistance Threats in the United States 2019

Higher Waist Circumference Tied to Increased Risk for Dementia

FRIDAY, Nov. 15, 2019 (HealthDay News) — Abdominal obesity is associated with a significantly increased risk for dementia, even after adjustment for general obesity, according to a study published online Nov. 5 in Obesity.

Abstract/Full Text

First Ebola Vaccine Approved by European Commission

THURSDAY, Nov. 14, 2019 (HealthDay News) — The world’s first Ebola vaccine has been approved by the European Commission, and it was quickly prequalified by the World Health Organization.

ABC News Article

Injecting Illegal Drugs Ups Risk for Death After Heart Surgery

WEDNESDAY, Nov. 13, 2019 (HealthDay News) — People who inject drugs (PWID) have shorter survival following cardiac surgery than non-PWID, according to a review published online Nov. 8 in BMC Infectious Diseases.

Abstract/Full Text

Patient, Graft Survival Excellent for Twin Kidney Transplant

TUESDAY, Nov. 12, 2019 (HealthDay News) — Among identical-twin kidney transplants, patient and kidney graft survival rates are excellent, according to a study published online Oct. 9 in the American Journal of Transplantation.

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Many Multiple Sclerosis Patients Considering Stem Cell Transplant

FRIDAY, Nov. 8, 2019 (HealthDay News) — Many multiple sclerosis (MS) patients are considering autologous hematopoietic stem cell transplantation (aHSCT) as a treatment option, according to a study published in the January 2020 issue of Multiple Sclerosis and Related Disorders.

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Test of Vascular Function May Predict Solid-Tumor Cancer Risk

THURSDAY, Nov. 7, 2019 (HealthDay News) — Microvascular endothelial dysfunction is associated with an increased risk for solid-tumor cancer, according to a study published online Oct. 31 in the European Journal of Preventive Cardiology.

Abstract/Full Text

CDC: Number of Vaping-Linked Lung Illnesses Tops 2,000

THURSDAY, Nov. 7, 2019 (HealthDay News) — The number of Americans stricken with a severe respiratory illness tied to vaping has now reached 2,051, the U.S. Centers for Disease Control and Prevention reported Thursday.

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Mailing HPV Kits to Underscreened Women Can Up Screening

WEDNESDAY, Nov. 6, 2019 (HealthDay News) — Mailing human papillomavirus (HPV) kits to underscreened women is associated with increased screening uptake but does not significantly increase precancer detection or treatment, according to a study published online Nov. 6 in JAMA Network Open.

Abstract/Full Text

Editorial

Women Less Likely to Receive Treatment for Myocardial Infarction

WEDNESDAY, Nov. 6, 2019 (HealthDay News) — Use of sex-specific diagnostic thresholds for myocardial infarction identifies more additional women than men with myocardial injury, but women are less likely to receive treatment, according to a study published in the Oct. 22 issue of the Journal of the American College of Cardiology.

Abstract/Full Text

FDA: Biotin Supplements Could Affect Results of Medical Tests

TUESDAY, Nov. 5, 2019 (HealthDay News) — Biotin supplements can interfere with the results of some critical lab tests, the U.S. Food and Drug Administration warned Tuesday.

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Seriously Ill Medicare Beneficiaries Face Financial Hardship

MONDAY, Nov. 4, 2019 (HealthDay News) — Seriously ill Medicare enrollees experience considerable financial distress, according to a report published in the November issue of Health Affairs.

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CRC Screening Recommended for Average-Risk Adults Age 50 to 75

MONDAY, Nov. 4, 2019 (HealthDay News) — Average-risk adults between the ages of 50 and 75 years should be screened for colorectal cancer, with the screening test selected based on discussion with patients, according to a guidance statement from the American College of Physicians published online Nov. 5 in the Annals of Internal Medicine.

Abstract/Full Text

Editorial (subscription or payment may be required)

Dr. Stephen Hahn Nominated to Head FDA

MONDAY, Nov. 4, 2019 (HealthDay News) — Radiation oncology expert Stephen Hahn, M.D., has been nominated as the new U.S. Food and Drug Administration commissioner.

CNN Article

Intensive BP Control in Elderly With HTN May Aid Brain Health

MONDAY, Nov. 4, 2019 (HealthDay News) — Intensive lowering of ambulatory blood pressure in older patients with hypertension reduced accumulation of small vessel disease in the white matter of the brain, according to a study published online Oct. 14 in Circulation.

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Coronary Calcium Score May ID CV Risk in Rheumatoid Arthritis

MONDAY, Nov. 4, 2019 (HealthDay News) — The Coronary Calcium Score (CCS) may be a useful tool in cardiovascular (CV) risk assessment among female patients with rheumatoid arthritis (RA), according to a study published in the October issue of the International Journal of Rheumatic Diseases.

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Recommendations Developed to Address Clinician Burnout

FRIDAY, Nov. 1, 2019 (HealthDay News) — In Taking Action Against Clinician Burnout, a new report published online Oct. 23 by the National Academies of Sciences, Engineering, and Medicine, recommendations are presented to address clinician burnout.

Taking Action Against Clinician Burnout

Many Oncologists Fail to Discuss Costs of Genomic Testing

FRIDAY, Nov. 1, 2019 (HealthDay News) — Only half of oncologists who discuss genomic testing with patients report that they often discuss the likely costs of testing and related treatments, according to a study published online Nov. 1 in the Journal of the National Cancer Institute.

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Hospitalizations May Hasten Cognitive Decline in the Elderly

FRIDAY, Nov. 1, 2019 (HealthDay News) — For older adults, a higher rate of hospitalizations is associated with more rapid cognitive decline, according to a study published online Oct. 15 in the Annals of Neurology.

Abstract/Full Text

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