Home News General Health News Nilvadipine Increases Cerebral Blood Flow in the Hippocampus

Nilvadipine Increases Cerebral Blood Flow in the Hippocampus

CBF did not significantly change in posterior cingulate cortex, other regions of interest in Alzheimer disease

MONDAY, June 17, 2019 (HealthDay News) — For patients with mild-to-moderate Alzheimer disease, treatment with nilvadipine lowers systolic blood pressure and increases cerebral blood flow (CBF) in the hippocampus, according to a study published online June 17 in Hypertension.

Daan L.K. de Jong, from the Radboud University Medical Center in Nijmegen, Netherlands, and colleagues conducted a preplanned substudy within a randomized, placebo-controlled study to examine how six months of treatment with nilvadipine would affect CBF in 58 patients with mild-to-moderate Alzheimer disease. Patients were randomly allocated to either nilvadipine or placebo (29 in each group).

The researchers found that treatment with nilvadipine lowered systolic blood pressure (Δ = −11.5 [95 percent confidence interval (CI), −19.7 to −3.2] mm Hg; P < 0.01), while whole-brain gray-matter CBF remained stable with treatment (Δ = 5.4 [95 percent CI, −6.4 to 17.2] mL/100 g/min; P = 0.36). In the hippocampus, CBF increased (left: Δ = 24.4 [95 percent CI, 4.3 to 44.5] mL/100 g/min; P = 0.02; right: Δ = 20.1 [95 percent CI, −0.6 to 40.8] mL/100 g/min; P = 0.06). CBF did not change significantly in the posterior cingulate cortex (Δ = 5.2 [95 percent CI, −16.5 to 27.0] mL/100 g/min; P = 0.63) or other regions of interest.

“This high blood pressure treatment holds promise as it doesn’t appear to decrease blood flow to the brain, which could cause more harm than benefit,” a coauthor said in a statement. “Even though no medical treatment is without risk, getting treatment for high blood pressure could be important to maintain brain health in patients with Alzheimer’s disease.”

One author disclosed a pending patent for nilvadipine.

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