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May 2020 Briefing – Pediatrics

Here are what the editors at HealthDay consider to be the most important developments in Pediatrics for May 2020. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Physician’s Briefing Weekly Coronavirus Roundup

Here is what the editors at Physician’s Briefing chose as the most important COVID-19 developments for you and your practice for the week of May 25 to 29, 2020. This roundup includes the latest research news from journal studies and other trusted sources that is most likely to affect clinical practice.

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Outcomes Equal for AYA Hodgkin Therapy at Peds, Adult Centers

FRIDAY, May 29, 2020 (HealthDay News) — For adolescent and young adult (AYA) patients with Hodgkin lymphoma (HL), treatment strategies differ, but outcomes are equivalent with treatment at pediatric and adult centers, according to a study published online May 22 in Cancer Medicine.

Abstract/Full Text

Infection Risk Up in Month After CAR T-Cell Immunotherapy

FRIDAY, May 29, 2020 (HealthDay News) — For children and young adults receiving CD19 chimeric antigen receptor (CAR) T-cell infusion (CTI), infection rates increase in the first month after treatment and then decrease, according to a study published in the May issue of Open Forum Infectious Diseases.

Abstract/Full Text

Parents Facing Higher Levels of Stress During Pandemic

THURSDAY, May 28, 2020 (HealthDay News) — Individuals, particularly parents, are coping with extreme stress related to the COVID-19 pandemic, according to the results of a survey released May 21 by the American Psychological Association (APA).

Press Release

9.5 Percent Uninsured in U.S. From January Through June 2019

WEDNESDAY, May 27, 2020 (HealthDay News) — A total of 9.5 percent of persons were uninsured from January through June 2019, according to a report published online May 28 by the National Center for Health Statistics.

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Links Found Between Leaders of Medical Associations, Industry

THURSDAY, May 28, 2020 (HealthDay News) — There are extensive financial relationships between leaders of U.S. professional medical associations and industry, according to a study published online May 27 in The BMJ.

Abstract/Full Text

Editorial

Parents Struggling to Provide for Families During Pandemic

WEDNESDAY, May 27, 2020 (HealthDay News) — The COVID-19 pandemic poses risks to children’s health, well-being, and development as parents struggle to provide for their families, according to a survey released by the Urban Institute.

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Only One in Four U.S. Hospitals With ICUs Have Tele-ICU Services

WEDNESDAY, May 27, 2020 (HealthDay News) — In 2018, half of U.S. hospitals had the capacity to conduct telehealth-based outpatient visits, while only one in four had tele-intensive care unit (tele-ICU) capabilities, according to a research letter published online April 30 in the Annals of Internal Medicine.

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USPSTF: Little Evidence Interventions Prevent Illicit Drug Use in Youth

TUESDAY, May 26, 2020 (HealthDay News) — The U.S. Preventive Services Task Force (USPSTF) concludes that current evidence is inadequate for assessing the balance of benefits and harms of primary care interventions for preventing illicit drug use among children, adolescents, and young adults. These findings form the basis of a final recommendation statement published in the May 26 issue of the Journal of the American Medical Association.

Evidence Report

Final Recommendation Statement

Three Trajectories of Picky Eating Identified in Children

TUESDAY, May 26, 2020 (HealthDay News) — Three stable trajectories of picky eating have been identified in childhood from ages 4 to 9 years, with maternal feeding behaviors associated with picky eating, according to a study published online May 26 in Pediatrics.

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Air Filters Shown to Improve Breathing in Children With Asthma

TUESDAY, May 26, 2020 (HealthDay News) — Daily use of a fine particulate matter air filtration device can significantly improve airway mechanics and reduce airway resistance in children with asthma, according to a study recently published in JAMA Pediatrics.

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Physician’s Briefing Weekly Coronavirus Roundup

Here is what the editors at Physician’s Briefing chose as the most important COVID-19 developments for you and your practice for the week of May 18 to 22, 2020. This roundup includes the latest research news from journal studies and other trusted sources that is most likely to affect clinical practice.

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CDC: COVID-19 Not Spread Easily From Contaminated Surfaces

FRIDAY, May 22, 2020 (HealthDay News) — COVID-19 spreads swiftly between people but is not easily caught from contaminated surfaces, according to updated information from the U.S. Centers for Disease Control and Prevention.

Washington Post Article

More Information: CDC

U.S. Government Seeks Deal With Private Industry to Boost Supply of Medical Equipment

FRIDAY, May 22, 2020 (HealthDay News) — In an effort to prevent the United States from again struggling to have enough medical supplies in a pandemic, the federal government is seeking to make a five-year deal with U.S. manufacturers.

AP News Article

Johns Hopkins University

U.S. Offers $1.2 Billion to Drug Company for COVID-19 Vaccine Research

FRIDAY, May 22, 2020 (HealthDay News) — The U.S. Department of Health and Human Services said Thursday it would provide up to $1.2 billion to AstraZeneca to develop a potential COVID-19 vaccine from a lab in Oxford, England.

The New York Times Article

No SARS-CoV-2 ID’d in Asymptomatic Pregnant Women in Los Angeles

FRIDAY, May 22, 2020 (HealthDay News) — At the Cedars-Sinai Medical Center in Los Angeles, none of 80 asymptomatic women admitted to the labor and antepartum units tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), according to a research letter published online May 19 in Obstetrics & Gynecology.

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Cardiac Decompensation Seen in Children Following COVID-19

FRIDAY, May 22, 2020 (HealthDay News) — Children may experience acute cardiac decompensation due to a severe inflammatory state (multisystem inflammatory syndrome in children or MIS-C) following infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), according to a study published online May 17 in Circulation.

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Weight in Adolescence Tied to Early-Onset Type 2 Diabetes

FRIDAY, May 22, 2020 (HealthDay News) — Obesity in adolescence significantly increases the risk for incidence of type 2 diabetes in early adulthood in both sexes, according to a study published online April 22 in Diabetes Care.

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Clinical Genetic Testing for Autism Remains Very Low

FRIDAY, May 22, 2020 (HealthDay News) — Only 3 percent of patients with autism spectrum disorder (ASD) report having received all recommended clinical genetic testing, according to a research letter published online May 13 in JAMA Psychiatry.

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CDC Says Test All Newborns of Mothers With Confirmed, Suspected COVID-19

THURSDAY, May 21, 2020 (HealthDay News) — All babies born to women with confirmed or suspected COVID-19 should be tested, according to U.S. Centers for Disease Control and Prevention guidelines issued Wednesday.

CNN Article

More Information: CDC

CDC: Live Poultry Linked to Salmonella Cases in 28 States

THURSDAY, May 21, 2020 (HealthDay News) — Live poultry, such as chicks and ducklings, in backyard flocks have caused Salmonella infections that have sickened 97 people in 28 states, the U.S. Centers for Disease Control and Prevention said Wednesday.

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Musculoskeletal Malformations Up With Fluconazole in Pregnancy

THURSDAY, May 21, 2020 (HealthDay News) — Use of oral fluconazole for treatment of vulvovaginal candidiasis in the first trimester of pregnancy is associated with musculoskeletal malformations, but not with oral clefts or conotruncal malformations, according to a study published online May 20 in The BMJ.

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Risk for Autism Spectrum Disorder Up With Affected Aunt, Uncle

THURSDAY, May 21, 2020 (HealthDay News) — The risk for autism spectrum disorder (ASD) is increased for children with an aunt or uncle with ASD, according to a study recently published in Biological Psychiatry.

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Decrease Seen in Child Vaccination Coverage During COVID-19

WEDNESDAY, May 20, 2020 (HealthDay News) — There has been a decrease in child vaccination coverage in almost all milestone age cohorts during the COVID-19 pandemic, according to research published in the May 18 early-release issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.

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Some Children With COVID-19 Require Admission, PICU Care

WEDNESDAY, May 20, 2020 (HealthDay News) — Some children with COVID-19 require admission and intensive care, according to a study published online May 11 in The Journal of Pediatrics.

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High BMI in Childhood May Up Risk for Bladder Cancer as Adult

WEDNESDAY, May 20, 2020 (HealthDay News) — Childhood body mass index (BMI) is positively associated, while childhood height is inversely associated, with the risk for bladder cancer (BC) in adulthood, according to a study published online May 19 in the Annals of Human Biology.

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CDC: Number of Births, General Fertility Rate in U.S. Down in 2019

WEDNESDAY, May 20, 2020 (HealthDay News) — The number of births and general fertility rate decreased from 2018 to 2019, according to a May Vital Statistics Rapid Release report, a publication from the U.S. Centers for Disease Control and Prevention.

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11.2 Percent of Pediatric Cancer Patients Positive for SARS-CoV-2

WEDNESDAY, May 20, 2020 (HealthDay News) — Among pediatric cancer patients, overall morbidity of COVID-19 is low, according to a research letter published online May 13 in JAMA Pediatrics.

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15 Percent of Pregnant Women With COVID-19 Experience Severe Disease

TUESDAY, May 19, 2020 (HealthDay News) — Fifteen percent of pregnant women with COVID-19 have severe disease, according to a case series published online May 18 in the American Journal of Obstetrics & Gynecology.

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Cord Blood Does Not Improve Socialization Skills in Autism

TUESDAY, May 19, 2020 (HealthDay News) — A single infusion of cord blood (CB) does not improve socialization skills or reduce autism symptoms among children with autism spectrum disorder (ASD), according to a study published online May 19 in The Journal of Pediatrics.

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28 Million-Plus Surgeries Could Be Canceled Due to COVID-19

TUESDAY, May 19, 2020 (HealthDay News) — Worldwide, more than 28 million elective surgeries could be canceled or postponed during the 12 weeks of peak disruption due to COVID-19, according to a study published online May 12 in the British Journal of Surgery.

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Factors ID’d for Positive SARS-CoV-2 Test Result in Primary Care

TUESDAY, May 19, 2020 (HealthDay News) — Sociodemographic factors associated with the risk for a positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) test result include deprivation, population density, and ethnicity, according to a study published online May 15 in The Lancet Infectious Diseases.

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Editorial

Corticosteroids for IBD May Up Risk for Severe COVID-19

TUESDAY, May 19, 2020 (HealthDay News) — For patients with inflammatory bowel disease (IBD) and COVID-19, risk factors for severe disease include increasing age, comorbidities, and systemic corticosteroids, according to a study published online May 18 in Gastroenterology.

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Spending on Primary Care Continues to Lag in the U.S.

TUESDAY, May 19, 2020 (HealthDay News) — Spending on inpatient services, specialty care, and prescriptions together accounted for about two-thirds of the increase in total U.S. health care spending from 2002 to 2016, according to a research letter published online May 18 in JAMA Internal Medicine.

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Burnout Comparable Between Millennial, Gen X Residents, Fellows

TUESDAY, May 19, 2020 (HealthDay News) — Millennial and Generation X medical residents and fellows experience similar rates of burnout and have similar levels of empathy, according to a study published online May 5 in Academic Psychiatry.

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Social Distancing Policies Reduced COVID-19 Growth Rate

MONDAY, May 18, 2020 (HealthDay News) — The impact of four widely adopted social distancing policies reduced the daily growth rate of COVID-19 across U.S. counties, according to a report published online May 14 in Health Affairs.

Abstract/Full Text

Experimental COVID-19 Vaccine Appears Safe, Triggers Immune Response

MONDAY, May 18, 2020 (HealthDay News) — An experimental vaccine against COVID-19 appears to be safe and to trigger an immune response, according to results of the first human clinical trial of a COVID-19 vaccine.

The New York Times Article

Sleep Problems in Infancy May Be Tied to Autism Diagnosis

MONDAY, May 18, 2020 (HealthDay News) — Sleep-onset problems in the first year of life may precede an autism spectrum disorder (ASD) diagnosis in children at higher risk for ASD, according to a study published online May 7 in The American Journal of Psychiatry.

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Most Physicians Have Seen False-Negative COVID-19 Test Results

MONDAY, May 18, 2020 (HealthDay News) — Most physicians believe they have seen false-negative results for a COVID-19 diagnostic test, according to the results of a recent survey.

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Cough May Not Appear in Young Children With COVID-19

MONDAY, May 18, 2020 (HealthDay News) — Young children with COVID-19 may not present with respiratory symptoms, according to a case report published online May 12 in Frontiers in Pediatrics.

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No Improvements Seen in Meeting AAP Vitamin D Intake Guidelines

MONDAY, May 18, 2020 (HealthDay News) — Since 2009, there has been no improvement in meeting the American Academy of Pediatrics (AAP) guidelines for vitamin D intake, according to a study published online May 18 in Pediatrics.

Abstract/Full Text

Editorial

Physician’s Briefing Weekly Coronavirus Roundup

Here is what the editors at Physician’s Briefing chose as the most important COVID-19 developments for you and your practice for the week of May 11 to 15, 2020. This roundup includes the latest research news from journal studies and other trusted sources that is most likely to affect clinical practice.

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NIH: Large-Scale Testing of Some COVID-19 Vaccines Could Start in July

FRIDAY, May 15, 2020 (HealthDay News) — A number of COVID-19 vaccines under development “look pretty promising” and one or two could be ready for large-scale testing by July, the director of the U.S. National Institutes of Health says.

AP News Article

Distracted Driving Laws Tied to Fewer Teen Crash Fatalities

FRIDAY, May 15, 2020 (HealthDay News) — Distracted driving laws within the United States help reduce fatalities for teenagers, according to a study published online May 15 in Pediatrics.

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Autism in Childhood May Up Risk for Later Eating Disorders

FRIDAY, May 15, 2020 (HealthDay News) — Greater autistic social traits in childhood could be a risk factor for the development of disordered eating in adolescence, according to a study published online May 3 in the Journal of Child Psychology and Psychiatry.

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Kawasaki-Like Disease Incidence Up After Start of SARS-CoV-2

THURSDAY, May 14, 2020 (HealthDay News) — The incidence of Kawasaki-like disease increased after the start of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic in the Bergamo province of Italy, according to a study published online May 13 in The Lancet.

Abstract/Full Text

Editorial

Doctors Should Watch for Pediatric Inflammatory Syndrome With COVID-19

WEDNESDAY, May 13, 2020 (HealthDay News) — American physicians should watch for a dangerous inflammatory syndrome in children that may be linked to COVID-19 infection, the U.S. Centers for Disease Control and Prevention says in an alert.

CNN Article

Plan in Place to Up Production of Prefilled Syringes for Future COVID-19 Vaccine

WEDNESDAY, May 13, 2020 (HealthDay News) — A deal for hundreds of millions of syringes that could be used to quickly administer a possible vaccine against COVID-19 has been reached between the U.S. government and a private company.

NBC News Article

PM2.5 Linked to Later Mortality in Certain Pediatric, AYA Cancers

WEDNESDAY, May 13, 2020 (HealthDay News) — For pediatric and adolescent and young adult (AYA) patients with specific cancers, continued exposure to fine particulate matter (PM2.5) is associated with later mortality, according to a study published online May 13 in Cancer, Epidemiology, Biomarkers & Prevention.

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Children of Mothers With Mental Illness Less Likely to Receive Vaccines

WEDNESDAY, May 13, 2020 (HealthDay News) — Children whose mothers have mental illness are significantly less likely to receive vaccinations through age 5 years, according to a study published online April 24 in the European Journal of Epidemiology.

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Dexrazoxane Preserves Cardiac Function in Pediatric Leukemia

TUESDAY, May 12, 2020 (HealthDay News) — For pediatric patients with acute myeloid leukemia (AML), dexrazoxane preserves cardiac function without affecting survival, according to a study published online April 28 in the Journal of Clinical Oncology.

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Organic Pollutant Exposure May Up Celiac Disease Risk in Children

TUESDAY, May 12, 2020 (HealthDay News) — In children, the odds of celiac disease are increased in association with persistent organic pollutant (POP) exposure, according to a study published online May 11 in Environmental Research.

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Severe Illness Reported in Some Children With COVID-19

TUESDAY, May 12, 2020 (HealthDay News) — Severe illness from COVID-19 infection occurs in some children, most of whom have significant preexisting comorbidities, according to a study published online May 11 in JAMA Pediatrics.

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Pediatric Vaccine Ordering Has Decreased During COVID-19

TUESDAY, May 12, 2020 (HealthDay News) — After the COVID-19 emergency declarations, there was a decrease in pediatric vaccine ordering, according to research published in the May 8 early-release issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.

Abstract/Full Text

ACR Issues Statement on Return of Routine Radiology Services

MONDAY, May 11, 2020 (HealthDay News) — In an American College of Radiology statement, published online May 6 in the Journal of the American College of Radiology, recommendations are presented for re-engagement of routine radiology care during the COVID-19 pandemic.

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2007 to 2016 Saw Increase in Peds ED Visits for Mental Health

MONDAY, May 11, 2020 (HealthDay News) — From 2007 to 2016, pediatric emergency department visits remained stable, but visits for all mental health disorders increased 60 percent, according to a study published online May 11 in Pediatrics.

Abstract/Full Text

Editorial

Physician’s Briefing Weekly Coronavirus Roundup

Here is what the editors at Physician’s Briefing chose as the most important COVID-19 developments for you and your practice for the week of May 4 to 8, 2020. This roundup includes the latest research news from journal studies and other trusted sources that is most likely to affect clinical practice.

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FDA Slashes Number of Approved Chinese Makers of N95 Masks

FRIDAY, May 8, 2020 (HealthDay News) — The number of mask makers in China approved to make N95-type masks for U.S. health care workers was slashed from 80 to 14 by the U.S. Food and Drug Administration on Thursday.

MarketWatch Article

Symptomatic COVID-19 Infection Fatality Rate 1.3 Percent in U.S.

FRIDAY, May 8, 2020 (HealthDay News) — The overall infection fatality rate (IFR) among symptomatic COVID-19 cases (IFR-S) in the United States is estimated at 1.3 percent, according to a report published online May 7 in Health Affairs.

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Asthma, COPD Medication Adherence Up During Pandemic

FRIDAY, May 8, 2020 (HealthDay News) — Medication adherence for asthma and chronic obstructive pulmonary disease (COPD) has increased during the COVID-19 pandemic, according to a study published online May 3 in the Journal of Allergy and Clinical Immunology: In Practice.

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Previous Pregnancy Complication Ups Risk for Preterm Delivery

FRIDAY, May 8, 2020 (HealthDay News) — Risk for preterm delivery is higher in pregnant women who have experienced preeclampsia, placental abruption, stillbirth, neonatal death, or small for gestational age in a term first pregnancy, according to a study published online April 29 in The BMJ.

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Doubt Cast on Notion That New Strain of COVID-19 Is More Infectious

THURSDAY, May 7, 2020 (HealthDay News) — A new study suggesting that COVID-19 has mutated to become even more infectious should be viewed with skepticism, former U.S. Food and Drug Administration head Scott Gottlieb, M.D., said Wednesday.

CNBC Article

New York State Reports Cases of Pediatric Inflammatory Syndrome Tied to COVID-19

THURSDAY, May 7, 2020 (HealthDay News) — The New York State Department of Health issued an advisory on May 6 regarding cases of pediatric multisystem inflammatory syndrome potentially associated with COVID-19.

More Information

AHA Statement

Microstructural Differences Detected on Brain MRI in PANS

THURSDAY, May 7, 2020 (HealthDay News) — Children with pediatric acute-onset neuropsychiatric syndrome (PANS) have cerebral microstructural differences in multiple brain structures, including the deep gray matter structures, according to a study published online May 4 in JAMA Network Open.

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Link Found Between Body Size in Childhood, Later Life Disease

THURSDAY, May 7, 2020 (HealthDay News) — Large adult body size contributes to the association between genetically predicted larger body size in childhood and coronary artery disease and type 2 diabetes later in life, according to a study published online May 6 in The BMJ.

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New Coronavirus Strain More Contagious, Scientists Say

WEDNESDAY, May 6, 2020 (HealthDay News) — A new, mutated strain of the coronavirus that causes COVID-19 has become dominant and appears to be more contagious than the strain that spread during the early stages of the pandemic, scientists report.

Los Angeles Times Article

Human Trials of Experimental COVID-19 Vaccine Begin in U.S.

WEDNESDAY, May 6, 2020 (HealthDay News) — Human trials on an experimental COVID-19 vaccine began in the United States on Monday, Pfizer and the German pharmaceutical company BioNTech said.

The New York Times Article

Health Care Workers at Risk From Mental Burden of COVID-19

WEDNESDAY, May 6, 2020 (HealthDay News) — Health care workers and younger people have an increased risk for a psychological impact from COVID-19, according to a study published online April 14 in Psychology, Health & Medicine.

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Fewer Children Enrolling in Pediatric Cancer Trials

WEDNESDAY, May 6, 2020 (HealthDay News) — Just one in five pediatric cancer patients enroll in clinical trials, down from 40 to 70 percent during the 1990s and 20 to 25 percent in the early 2000s, according to a study published online April 23 in PLOS ONE.

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Whole-Body DW MRI Can Help Assess Pediatric Tumor Response

WEDNESDAY, May 6, 2020 (HealthDay News) — Whole-body diffusion-weighted (DW) magnetic resonance imaging (MRI) shows good agreement with 18 fluorodeoxyglucose (FDG) positron emission tomography (PET) for assessing tumor response to induction chemotherapy in children and young adults with lymphoma or sarcoma, according to a study published online May 5 in Radiology.

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Teen Obesity, T2DM, HTN May Lead to Early Vascular Aging

WEDNESDAY, May 6, 2020 (HealthDay News) — The presence of obesity, type 2 diabetes, and elevated systolic blood pressure (SBP) in adolescence accelerates the progression of risk factors that play a role in the development of early vascular aging, according to a study published online May 6 in the Journal of the American Heart Association.

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Lawnmower Injuries More Common in Children From Rural Areas

TUESDAY, May 5, 2020 (HealthDay News) — From 2005 to 2017, 1,302 lawnmower injuries were identified in the United States, with higher rates in rural areas, according to a study published in the May 1 issue of the Journal of the American Academy of Orthopaedic Surgeons.

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USPSTF Recommends Hep B Screening for Those at Increased Risk

TUESDAY, May 5, 2020 (HealthDay News) — The U.S. Preventive Services Task Force (USPSTF) recommends screening adolescents and adults at increased risk for hepatitis B virus (HBV) infection. These findings form the basis of a draft recommendation statement published online May 5 by the USPSTF.

Draft Evidence Review

Draft Recommendation Statement

Comment on Recommendation Statement

Variation Seen in COVID-19 Tests, Hospitalization, Deaths Across NYC

TUESDAY, May 5, 2020 (HealthDay News) — There is considerable variation in the rates of COVID-19 testing, hospitalization, and deaths across New York City boroughs, according to a research letter published online April 29 in the Journal of the American Medical Association.

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Recommendations Made for PPE Use by HCPs in COVID-19 Care

MONDAY, May 4, 2020 (HealthDay News) — In guidelines from the Infectious Diseases Society of America, recommendations are presented for personal protective equipment (PPE) use by health care providers (HCP) in caring for suspected or known COVID-19 patients.

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Guidelines Issued for Managing Eosinophilic Esophagitis

MONDAY, May 4, 2020 (HealthDay News) — Recommendations are presented for the management of eosinophilic esophagitis (EoE) in clinical practice guidelines published in the May issue of Gastroenterology.

Guidelines (subscription or payment may be required)

Technical Review (subscription or payment may be required)

More Mental Health Visits Tied to Lower Rates of Youth Suicide

FRIDAY, May 1, 2020 (HealthDay News) — The odds of suicide decrease among youths who have more mental health visits, according to a study recently published in JAMA Pediatrics.

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Physician’s Briefing Weekly Coronavirus Roundup

Here is what the editors at Physician’s Briefing chose as the most important COVID-19 developments for you and your practice for the week of April 27 to May 1, 2020. This roundup includes the latest research news from journal studies and other trusted sources that is most likely to affect clinical practice.

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Contact Tracing Can Cut Time to Case Isolation in SARS-CoV-2

FRIDAY, May 1, 2020 (HealthDay News) — Contact tracing can reduce the time to case isolation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), according to a study published online April 27 in The Lancet Infectious Diseases.

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