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May 2019 Briefing – Hematology & Oncology

Here are what the editors at HealthDay consider to be the most important developments in Hematology & Oncology for May 2019. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

2007 to 2017 Saw Decline in Number of U.S. Pathologists

FRIDAY, May 31, 2019 (HealthDay News) — The U.S. pathologist workforce decreased in both absolute and population-adjusted numbers from 2007 to 2017, according to a study published online May 31 in JAMA Network Open.

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Lupus Manifestations Appear to Differ by Race, Ethnicity

FRIDAY, May 31, 2019 (HealthDay News) — Clinical manifestations of systemic lupus erythematosus (SLE) vary by racial and ethnic groups, according to a study published online May 22 in Arthritis Care & Research.

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Excess Cause-Specific Mortality Tied to Chronic Proton Pump Inhibitor Use

FRIDAY, May 31, 2019 (HealthDay News) — Taking proton pump inhibitors (PPIs) is associated with an excess of cause-specific mortality, according to a study published online May 30 in The BMJ.

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Guidelines Updated for Radiotherapy After Prostatectomy

FRIDAY, May 31, 2019 (HealthDay News) — Clinical guidelines on adjuvant and salvage radiotherapy after radical prostatectomy have been updated, according to the American Society for Radiation Oncology and the American Urological Association.

Adjuvant and Salvage Radiotherapy after Prostatectomy: ASTRO/AUA Guideline

Mammogram Benefits Seen as More Important Than Harms

THURSDAY, May 30, 2019 (HealthDay News) — Generally, women perceive the potential benefits of mammograms as more important than the potential harms, according to a study published in the June issue of Preventive Medicine.

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Pediatric Nurse Practitioner Shortage Looming

THURSDAY, May 30, 2019 (HealthDay News) — There is a looming critical shortage of pediatric nurse practitioners (PNPs), according to a white paper published in the May-June issue of the Journal of Pediatric Health Care.

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High Costs Associated With Physician Burnout in U.S.

THURSDAY, May 30, 2019 (HealthDay News) — High costs are associated with physician turnover and reduced clinical hours attributed to burnout, according to a study published online May 28 in the Annals of Internal Medicine.

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Ibrutinib, Venetoclax Active in High-Risk, Seniors With CLL

THURSDAY, May 30, 2019 (HealthDay News) — For high-risk and older patients with previously untreated chronic lymphocytic leukemia (CLL), the combination of ibrutinib and venetoclax is an active regimen, according to a study published in the May 30 issue of the New England Journal of Medicine.

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Early-Onset CRC Rising Fastest for Whites in Western States

THURSDAY, May 30, 2019 (HealthDay News) — Whites in western states are experiencing the most rapid increase in early-onset colorectal cancer (CRC), according to a study published online May 29 in the Journal of the National Cancer Institute.

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Daratumumab Cuts Risk for Progression in Multiple Myeloma

WEDNESDAY, May 29, 2019 (HealthDay News) — For patients with newly diagnosed multiple myeloma, the addition of daratumumab to lenalidomide and dexamethasone is associated with a reduced risk for disease progression or death, according to a study published in the May 30 issue of the New England Journal of Medicine.

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Global Burden of Serious Health-Related Suffering to Double by 2060

WEDNESDAY, May 29, 2019 (HealthDay News) — The global burden of serious health-related suffering is set to increase 47 percent by 2060, according to a study published online May 22 in The Lancet Global Health.

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Reading Visit Notes May Improve Medication Management

WEDNESDAY, May 29, 2019 (HealthDay News) — Reading clinical notes can help patients to understand why medications are prescribed and improves medication adherence for some patients, according to a brief research report published online May 28 in the Annals of Internal Medicine.

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Hip Fracture Linked to Increased Risk for Death in T2DM Patients

WEDNESDAY, May 29, 2019 (HealthDay News) — For patients with type 2 diabetes, hip fracture is associated with an increased risk for death, according to a study published online May 21 in the Journal of Diabetes Investigation.

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Incidence Rates for Aggressive Uterine Cancers on the Rise

WEDNESDAY, May 29, 2019 (HealthDay News) — Hysterectomy-corrected uterine cancer incidence rates show that nonendometrioid carcinoma rates have been increasing among all women, according to a study published online May 22 in the Journal of Clinical Oncology.

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Cancer Consultation Low in Noncurable Pancreatic Adenocarcinoma

TUESDAY, May 28, 2019 (HealthDay News) — Many patients with noncurable pancreatic adenocarcinoma do not have a specialized cancer consultation and most do not receive cancer-directed therapy, according to a study published online May 27 in CMAJ, the journal of the Canadian Medical Association.

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AI Model Can Improve Accuracy of Lung Cancer Screening

TUESDAY, May 28, 2019 (HealthDay News) — Deep learning models can improve the accuracy of lung cancer screening, according to a study published online May 20 in Nature Medicine.

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First PI3K Inhibitor Approved for Metastatic, Advanced Breast Cancer

TUESDAY, May 28, 2019 (HealthDay News) — Piqray (alpelisib) tablets were approved for the treatment of hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative, PIK3CA-mutated, advanced or metastatic breast cancer in combination with fulvestrant, the U.S. Food and Drug Administration announced Friday.

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Obstructive Sleep Apnea Linked to Cancer Diagnosis in Women

FRIDAY, May 24, 2019 (HealthDay News) — Obstructive sleep apnea (OSA) is associated with cancer diagnosis, especially among women, according to a research letter published online May 20 in the European Respiratory Journal.

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U.S. Incidence of Pediatric Thyroid Cancer on the Rise

FRIDAY, May 24, 2019 (HealthDay News) — From 1973 to 2013, there was an increase in the incidence rates of pediatric thyroid cancer, with marked increases from 2006 to 2013, according to a study published online May 23 in JAMA Otolaryngology-Head & Neck Surgery.

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Statin Use With Colorectal Cancer Lowers Risk for Early Death

FRIDAY, May 24, 2019 (HealthDay News) — Use of statins before or after colorectal cancer (CRC) diagnosis is linked to a lower risk for premature death, from either cancer or other causes, according to a review published online May 8 in Cancer Medicine.

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U.S. Lawmakers Say WHO Opioid Guidelines Too Lax

THURSDAY, May 23, 2019 (HealthDay News) — The World Health Organization’s pain care guidelines contain false claims about the safety of prescription opioid painkillers and should be withdrawn, two U.S. lawmakers say.

AP News Article

Blood Donor Screening Data IDs Familial Hypercholesterolemia

THURSDAY, May 23, 2019 (HealthDay News) — Data from a blood donor screening program could represent a novel strategy for identifying familial hypercholesterolemia (FH), according to a study published online May 22 in JAMA Cardiology.

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Suboptimal Diet Accounted for >80,000 Cancer Cases in 2015

WEDNESDAY, May 22, 2019 (HealthDay News) — In 2015, more than 80,000 cancer cases were associated with suboptimal diet in U.S. adults, according to a study published online May 22 in JNCI: Cancer Spectrum.

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CDC: Cancer Death Rates Decreased, Heart Disease Deaths Rose

WEDNESDAY, May 22, 2019 (HealthDay News) — Cancer death rates declined for adults aged 45 to 64 years from 1999 to 2017, while heart disease death rates decreased to 2011 and then increased, according to the May 22 National Vital Statistics Reports, a publication from the U.S. Centers for Disease Control and Prevention.

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Adverse Liver Outcomes Up With Diagnosis of NAFLD/NASH

WEDNESDAY, May 22, 2019 (HealthDay News) — The risks for cirrhosis and hepatocellular carcinoma (HCC) are increased for patients with a recorded diagnosis of nonalcoholic fatty liver disease (NAFLD)/nonalcoholic steatohepatitis (NASH), according to a study published online May 20 in BMC Medicine.

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Bill Would Raise U.S. Legal Age to Buy Tobacco to 21

TUESDAY, May 21, 2019 (HealthDay News) — A bill to raise the minimum age for buying any type of tobacco product, including electronic cigarettes, from 18 to 21 years was introduced Monday by Senate Majority Leader Mitch McConnell.

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More Information: CDC

Homemade Sunscreen Recipes Commonly Shared, Offer Low Protection

TUESDAY, May 21, 2019 (HealthDay News) — There is widespread public interest in and acceptance of homemade sunscreens, even though they often do not offer sufficient protection from ultraviolet radiation, according to a study published online May 20 in Health Communication.

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Octogenarians With Acute Myeloid Leukemia Have Poor Survival

TUESDAY, May 21, 2019 (HealthDay News) — Octogenarians with acute myeloid leukemia (AML) have a one-month mortality rate of 41 percent and overall survival (OS) of 1.5 months, according to a research letter published in the June issue of the American Journal of Hematology.

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Fracture Risk Tool Useful for Women on Aromatase Inhibitors

TUESDAY, May 21, 2019 (HealthDay News) — The FRAX fracture risk tool can stratify fracture risk equally well among women receiving aromatase inhibitor (AI) therapy for breast cancer and nonusers of AI therapy, according to a study published online May 9 in the Journal of Bone and Mineral Research.

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Clinical Drug Diversion Costly to Health Care Organizations

TUESDAY, May 21, 2019 (HealthDay News) — U.S. health care organizations lost nearly $454 million due to clinical drug diversion in 2018, according to the 2019 Drug Diversion Digest, released by Protenus Inc.

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Access to Care Worse for Sexual-Minority Cancer Survivors

MONDAY, May 20, 2019 (HealthDay News) — Sexual-minority cancer survivors have worse access to care and higher odds of poor quality of life (QOL), according to a study published online May 20 in Cancer.

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Cancer Screening Less Likely Among Current Smokers

FRIDAY, May 17, 2019 (HealthDay News) — Current smokers are less likely to receive guideline-concordant screening studies for breast, prostate, and colorectal cancer versus never smokers, according to a study published online May 17 in JAMA Network Open.

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Hormone Therapy in Transgender Women Ups Breast Cancer Risk

MONDAY, May 20, 2019 (HealthDay News) — Transgender women receiving hormone treatments are at greater risk for developing breast cancer than cisgender men, according to a study published online May 15 in The BMJ.

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Many Lives Could Be Saved if All Hospitals Had Grade A Rating

FRIDAY, May 17, 2019 (HealthDay News) — More than 50,000 lives could be saved if all hospitals had an avoidable death rate equivalent to “A” grade hospitals, according to an updated report prepared for The Leapfrog Institute.

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Private Insurers Pay 241 Percent of What Medicare Would Pay

FRIDAY, May 17, 2019 (HealthDay News) — Prices paid to hospitals for privately insured patients in 2017 averaged 241 percent of what Medicare would have paid, with wide variation in prices among states, according to a report published by the RAND Corporation.

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Quitting Smoking Lowers Risk for Bladder Cancer Postmenopause

FRIDAY, May 17, 2019 (HealthDay News) — Among postmenopausal women, former smokers have a reduced risk for bladder cancer within the first 10 years of cessation, which continues to decline over time but remains elevated compared with never smokers, according to a study published in the May issue of Cancer Prevention Research.

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Colorectal Cancer Incidence Increasing in Younger Adults

FRIDAY, May 17, 2019 (HealthDay News) — Colorectal cancer incidence is increasing among young adults in certain high-income countries, according to a study published online May 16 in The Lancet Gastroenterology & Hepatology.

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First Anticoagulant Approved for Preventing VTE Recurrence in Children

FRIDAY, May 17, 2019 (HealthDay News) — Fragmin (dalteparin sodium) injection has been granted the first approval for subcutaneous use in preventing recurrence of symptomatic venous thromboembolism (VTE) in children aged 1 month or older, the U.S. Food and Drug Administration announced.

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FDA Approves Venetoclax for Chronic Lymphocytic Leukemia

THURSDAY, May 16, 2019 (HealthDay News) — Venetoclax (VENCLEXTA) has been approved to treat adult patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma, the U.S. Food and Drug Administration announced yesterday.

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Avelumab + Axitinib Approved for Treatment of Renal Cell Carcinoma

THURSDAY, May 16, 2019 (HealthDay News) — Avelumab (BAVENCIO) was approved this week for first-line treatment of advanced renal cell carcinoma (RCC) in combination with axitinib, the U.S. Food and Drug Administration announced.

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North Carolina Sues Electronic Cigarette Maker JUUL

THURSDAY, May 16, 2019 (HealthDay News) — North Carolina is suing electronic-cigarette manufacturer JUUL for allegedly marketing its products to children and misleading the public about the health risks of the products. This lawsuit is the first filed by a state over JUUL’s alleged marketing toward teens, CNN reported.

CNN Article

Recs Updated for TB Screening, Treatment in Health Care Workers

THURSDAY, May 16, 2019 (HealthDay News) — Guidelines have been updated for screening and treatment for tuberculosis (TB) infection among health care personnel, according to research published in the May 17 issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.

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AI Model Uses Serial Imaging to Predict Lung Cancer Tx Response

THURSDAY, May 16, 2019 (HealthDay News) — For patients with locally advanced non-small cell lung cancer (NSCLC), deep-learning networks integrating computed tomography (CT) scans at multiple time points can improve clinical outcome predictions, according to a study published online April 22 in Clinical Cancer Research.

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Two-Thirds of Sunscreens Fail Safety Tests

WEDNESDAY, May 15, 2019 (HealthDay News) — Nearly two-thirds of sunscreens that were analyzed failed safety tests proposed by the U.S. Food and Drug Administration, the Environmental Working Group said Wednesday.

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California Couple Awarded $2 Billion in Roundup Lawsuit

TUESDAY, May 14, 2019 (HealthDay News) — An elderly California couple who said their cancer was caused by Monsanto’s weed killer Roundup was awarded just over $2 billion by a jury in Oakland on Monday.

CNN Article

Some Cervical Cancer Screening Strategies More Cost-Effective

TUESDAY, May 14, 2019 (HealthDay News) — A cervical cancer screening strategy that involves cytologic testing every three years from ages 21 to 29 years and then continuing cytologic testing or switching to low-cost high-risk human papillomavirus (hrHPV) testing every five years is reasonable, according to a study published online May 13 in JAMA Internal Medicine.

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T2Bacteria Panel Accurately IDs Bloodstream Infections

MONDAY, May 13, 2019 (HealthDay News) — The T2Bacteria Panel can rapidly and accurately diagnose bloodstream infections (BSIs), according to a study published online May 14 in the Annals of Internal Medicine.

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Patients Find Note Reading Important for Health Management

MONDAY, May 13, 2019 (HealthDay News) — Patients find note reading important for their health management and are rarely troubled by what they read, according to a study published in the May issue of the Journal of Medical Internet Research.

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Higher Risk for Cancer, Mortality Seen With Pediatric-Onset IBD

MONDAY, May 13, 2019 (HealthDay News) — Individuals with pediatric-onset inflammatory bowel disease (pIBD) have an increased risk for cancer and mortality, according to a study published online May 9 in Alimentary Pharmacology & Therapeutics.

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Health Professionals Supportive of Medicinal Cannabis

FRIDAY, May 10, 2019 (HealthDay News) — Health professionals are generally supportive of medicinal cannabis use but report a lack of knowledge about its use, according to a review published online May 6 in PLOS ONE.

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Rate of Ordering Cancer Screening Tests Decreases During Clinic Day

FRIDAY, May 10, 2019 (HealthDay News) — As the clinic day progresses, the rate of clinician ordering of breast and colorectal cancer screening tests decreases, according to a study published online May 10 in JAMA Network Open.

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Whole-Body MRI Accurate for Staging Colorectal Cancer, NSCLC

FRIDAY, May 10, 2019 (HealthDay News) — Whole-body magnetic resonance imaging (WB-MRI) could be a quicker alternative to multimodality staging of colorectal cancer and non-small cell lung cancer (NSCLC), according to two studies published online May 9 in The Lancet Gastroenterology & Hepatology and The Lancet Respiratory Medicine.

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Doctors Aware of Patient Difficulties Affording Medical Care

FRIDAY, May 10, 2019 (HealthDay News) — Physicians are aware of patients’ difficulty with affording medical care and consider out-of-pocket costs in their decision making, according to an article published in a supplement to the May 7 issue of the Annals of Internal Medicine.

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New Recommendations Developed for Breast Cancer Screening

FRIDAY, May 10, 2019 (HealthDay News) — New recommendations have been developed for breast cancer screening based on a life-years-gained model; the American Society of Breast Surgeons (ASBrS) official statement was published online May 3.

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ACS Sets Goal to Cut Cancer Mortality 40 Percent by 2035

THURSDAY, May 9, 2019 (HealthDay News) — The American Cancer Society (ACS) has set a goal of a 40 percent reduction in overall cancer mortality by 2035, according to a study published online May 8 in CA: A Cancer Journal for Clinicians.

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2018 Saw More Employed Physicians Than Self-Employed

THURSDAY, May 9, 2019 (HealthDay News) — In 2018, employed physicians outnumbered self-employed physicians, according to a report from the American Medical Association (AMA).

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Fifteen Million Patients Will Need First-Course Chemo in 2040

THURSDAY, May 9, 2019 (HealthDay News) — An estimated 15.0 million patients will require first-course chemotherapy in 2040, with delivery requiring 100,000 cancer physicians, according to a study published online May 8 in The Lancet Oncology.

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CDC: Uninsurance Levels Did Not Change Significantly in 2018

THURSDAY, May 9, 2019 (HealthDay News) — In 2018, the percentage of U.S. individuals who were uninsured was not significantly different from the numbers in 2017, although uninsurance increased among adults aged 45 to 64 years, according to a report published online May 9 by the U.S. Centers for Disease Control and Prevention National Center for Health Statistics.

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Mammo-Based Deep Learning Model Assesses Breast Cancer Risk

THURSDAY, May 9, 2019 (HealthDay News) — Mammography-based deep learning (DL) breast cancer risk models are more accurate than models that consider traditional risk factors and breast density, according to a study published online May 7 in Radiology.

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Risk for Cancer Increased in Men, Women With T2DM

THURSDAY, May 9, 2019 (HealthDay News) — Men and women with type 2 diabetes (T2D) have an increased risk for overall cancer and some site-specific cancers, according to a study published online May 9 in the Journal of Diabetes.

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Prices Will Soon Be Included in TV Drug Ads

WEDNESDAY, May 8, 2019 (HealthDay News) — In response to public demands for action to control drug costs, the top U.S. health official says TV advertisements for prescription drugs will soon have to include prices.

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In 2015 to 2016, 45.8 Percent of U.S. Population Used Rx Drugs

WEDNESDAY, May 8, 2019 (HealthDay News) — In 2015 to 2016, 45.8 percent of the U.S. population used prescription drugs within the past 30 days, according to a May data brief published by the U.S. Centers for Disease Control and Prevention National Center for Health Statistics (NCHS).

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Patent Foramen Ovale Ups Ischemic Stroke in Those With PE

WEDNESDAY, May 8, 2019 (HealthDay News) — For patients with symptomatic pulmonary embolism (PE), the frequency of recent ischemic stroke is higher in those with patent foramen ovale (PFO), according to a study published online May 7 in the Annals of Internal Medicine.

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Test Predicts Benefit of Chemo in ER+, HER2− Breast Cancer

WEDNESDAY, May 8, 2019 (HealthDay News) — EndoPredict (EPclin) is prognostic for distant recurrence (DR) in women with estrogen receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer, according to a study published online April 30 in Breast Cancer Research and Treatment.

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Oral Aspirin Does Not Up FIT Test Sensitivity for ID’ing CRC

WEDNESDAY, May 8, 2019 (HealthDay News) — Administration of a single dose of oral aspirin prior to fecal immunochemical testing does not increase test sensitivity for detecting advanced colorectal neoplasms, according to a study published in the May 7 issue of the Journal of the American Medical Association.

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Efforts Needed to Ensure Publication of All Trials

TUESDAY, May 7, 2019 (HealthDay News) — Efforts are needed to ensure all completed large trials are reported, according to a research letter published online May 7 in the Annals of Internal Medicine.

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External Reference Pricing Could Cut Drug Costs in U.S.

TUESDAY, May 7, 2019 (HealthDay News) — The average price for single-source brand-name drugs is higher in the United States than in other countries, indicating that external reference pricing could reduce costs, according to a study published in the May issue of Health Affairs.

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Cardiorespiratory Fitness Tied to Lower Risk for Lung Cancer, CRC

MONDAY, May 6, 2019 (HealthDay News) — Higher cardiorespiratory fitness (CRF) is associated with a lower risk for incident lung and colorectal cancer and with a lower risk for all-cause mortality among those diagnosed with lung and colorectal cancer, according to a study published online May 6 in Cancer.

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Cardio-Oncology Services Growing in Number and Demand

FRIDAY, May 3, 2019 (HealthDay News) — Cardio-oncology is an emerging discipline and subspecialty in response to the rapidly growing number of patients with comorbid cardiovascular disease and cancer and the complexity of these conditions, according to a review published in the May 7 issue of the Journal of the American College of Cardiology.

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Model Predicts Progression Risk for Rare Type of Lymphoma

FRIDAY, May 3, 2019 (HealthDay News) — A publicly available model can identify patients with asymptomatic Waldenström macroglobulinemia (AWM) at high risk for progression, according to a study published online April 16 in the Journal of Clinical Oncology.

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Lifetime Risk for Brain Mets Up in Elderly With Three Common Cancers

FRIDAY, May 3, 2019 (HealthDay News) — Elderly patients with lung cancer, breast cancer, or melanoma are at increased risk for brain metastases (BMs) later in life, according to a study published online May 3 in Cancer Epidemiology, Biomarkers & Prevention.

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More Than Half of U.S. Adults Have Medical Financial Hardship

FRIDAY, May 3, 2019 (HealthDay News) — Medical financial hardship affects more than half of adults in the United States, according to a study published online May 1 in the Journal of General Internal Medicine.

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Implementing Surgical Safety Checklist Reduces Mortality

FRIDAY, May 3, 2019 (HealthDay News) — There has been a significant reduction in surgical mortality during the last decade in Scotland that is partially attributable to the implementation of the World Health Organization Surgical Safety Checklist, according to a study published online April 16 in the British Journal of Surgery.

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FDA: Breast Implants Linked to Cancer Can Still Be Sold in U.S.

THURSDAY, May 2, 2019 (HealthDay News) — A type of breast implant linked to cancer can still be sold in the United States, the U.S. Food and Drug Administration said Thursday.

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ASTRO: Prior Authorization Obstacles Delaying Treatment

THURSDAY, May 2, 2019 (HealthDay News) — Prior authorization obstacles are delaying patient access to radiation oncology treatments, according to a survey released by the American Society for Radiation Oncology.

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Cervical Adenocarcinoma Rates Increased in Some Populations

THURSDAY, May 2, 2019 (HealthDay News) — Many populations have increasing or stabilized incidence trends in cervical adenocarcinoma (AC), according to a study published in the June issue of Preventive Medicine.

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EPA Says Weed Killer in Roundup Is Safe

WEDNESDAY, May 1, 2018 (HealthDay News) — Despite thousands of lawsuits from people claiming that the weed killer glyphosate caused their cancer, the U.S. Environmental Protection Agency said Tuesday that the active ingredient in Roundup is safe.

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Medicaid Reimbursement for Breast Radiation Varies by State

WEDNESDAY, May 1, 2019 (HealthDay News) — Coverage and payment rates for radiation oncology services under Medicaid vary considerably by state, according to a study published online March 31 in the International Journal of Radiation Oncology • Biology • Physics.

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E-Cigarette Use Similar for Pregnant, Nonpregnant Women

WEDNESDAY, May 1, 2019 (HealthDay News) — The prevalence of current cigarette smoking is lower among pregnant women, while prevalence of current electronic cigarette smoking is equivalent for pregnant and nonpregnant women of reproductive age, according to a research letter published online April 29 in JAMA Pediatrics.

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