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June 2020 Briefing – Neurology

Here are what the editors at HealthDay consider to be the most important developments in Neurology for June 2020. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Brain Iron Concentrations Increased in Alzheimer Disease

TUESDAY, June 30, 2020 (HealthDay News) — Patients with Alzheimer disease (AD) have increased iron concentration in the deep gray matter and neocortical regions compared with healthy controls (HC), according to a study published online June 30 in Radiology.

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Progressive MS Linked to Faster Retinal Atrophy Than RRMS

TUESDAY, June 30, 2020 (HealthDay News) — Progressive multiple sclerosis (PMS) is associated with faster retinal atrophy than relapsing-remitting MS (RRMS), independent of age, according to a study published in the June issue of the Annals of Neurology.

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Incidence of VTE, Major Bleeding High in Primary CNS Lymphoma

MONDAY, June 29, 2020 (HealthDay News) — The incidence of venous thromboembolism (VTE) and major bleeding is high among patients with primary central nervous system lymphoma (PCNSL), according to a study published online June 23 in Leukemia & Lymphoma.

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Altered Mental Status Not Uncommon in Severe COVID-19

MONDAY, June 29, 2020 (HealthDay News) — Altered mental status is the second most common neurological presentation for patients with COVID-19, according to a study published online June 25 in The Lancet Psychiatry.

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Trump Administration Asks Supreme Court to Overturn Affordable Care Act

FRIDAY, June 26, 2020 (HealthDay News) — The Trump administration has asked the Supreme Court to overturn the Affordable Care Act (ACA).

Washington Post Article

Older Age, Obesity, Disability Tied to Severe COVID-19 in MS

FRIDAY, June 26, 2020 (HealthDay News) — For patients with multiple sclerosis (MS), age, obesity, and high Expanded Disability Severity Scale score (EDSS) are significantly associated with increased risk for severe COVID-19, according to a study published online June 26 in JAMA Neurology.

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CDC Updates List of Who Is at Highest Risk for COVID-19

FRIDAY, June 26, 2020 (HealthDay News) — The list of conditions that put people at risk for severe COVID-19 illness has been expanded by the U.S. Centers for Disease Control and Prevention.

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Women Have More Brain Changes Related to Alzheimer Disease

FRIDAY, June 26, 2020 (HealthDay News) — Cognitively normal women have increased Alzheimer disease endophenotype, with higher β-amyloid deposition, lower glucose metabolism, and lower gray and white matter volumes, according to a study published online June 24 in Neurology.

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Inflammatory Bowel Disease Linked to Subsequent Dementia

WEDNESDAY, June 24, 2020 (HealthDay News) — Inflammatory bowel disease (IBD) is associated with an increased risk for developing dementia, according to a study published online June 23 in Gut.

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ED Use Down for MI, Stroke, Hyperglycemic Crisis in COVID-19

WEDNESDAY, June 24, 2020 (HealthDay News) — Following declaration of the COVID-19 pandemic as a national emergency, there was a decrease in visits to the emergency department for myocardial infarction (MI), stroke, and hyperglycemic crisis, according to research published in the June 22 early-release issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.

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Safety Climate Perceptions Linked to Health Provider Stress

MONDAY, June 22, 2020 (HealthDay News) — Safety climate perceptions are associated with care practitioner-reported stress and job satisfaction, according to a study published in the May-June issue of the Journal of Healthcare Management.

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Reduced Circadian Rhythmicity Tied to Increase in Parkinson Disease

FRIDAY, June 19, 2020 (HealthDay News) — Reduced circadian rhythmicity is associated with an increased risk for incident Parkinson disease (PD), according to a study published online June 15 in JAMA Neurology.

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Cardioprotective Therapy Use Lower With Cancer History

THURSDAY, June 18, 2020 (HealthDay News) — Cardioprotective therapies, especially statins and antiplatelets, are underutilized in patients with a history of cancer (CaHx), according to a research letter published in the June 1 issue of JACC: CardioOncology.

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Court Rules Against Drug Price Disclosures in TV Ads

THURSDAY, June 18, 2020 (HealthDay News) — The U.S. government does not have the legal authority to force drug companies to disclose prices in their TV ads, a federal appeals court says.

AP News Article

Healthy Lifestyle May Lower Risk for Alzheimer Dementia

THURSDAY, June 18, 2020 (HealthDay News) — A healthy lifestyle is associated with a reduced risk for Alzheimer dementia, according to a study published online June 17 in Neurology.

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Mortality Up for Rural Versus Urban Stroke Patients

THURSDAY, June 18, 2020 (HealthDay News) — Compared with urban patients, rural patients with stroke are less likely to receive intravenous thrombolysis or endovascular therapy and are more likely to have higher in-hospital mortality, according to a study published online June 17 in Stroke.

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Globally, ~11 Percent of Children Live With One of Four Disabilities

WEDNESDAY, June 17, 2020 (HealthDay News) — Overall, 11.2 percent of the 2.6 billion children and adolescents worldwide had one of the following in 2017: childhood epilepsy, intellectual disability, vision loss, or hearing loss, according to a study published online June 17 in Pediatrics.

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Hormone Therapies Tied to Brain Changes in Menopausal Women

WEDNESDAY, June 17, 2020 (HealthDay News) — In recently menopausal women using hormone treatment (HT), circulating levels of pituitary-ovarian hormones are associated with changes in white matter hyperintensities (WMH), according to a study published online June 8 in Menopause.

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Hallucinations Tied to Mental Illness in Individuals With Seizures

TUESDAY, June 16, 2020 (HealthDay News) — Hallucinatory experiences in individuals with seizures are markers of high risk for mental health disorders and suicidal behavior, according to a study published online June 10 in Epilepsia.

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Therapeutic Hookworm Explored for Relapsing Multiple Sclerosis

TUESDAY, June 16, 2020 (HealthDay News) — For patients with relapsing multiple sclerosis (MS), treatment with hookworm appears to be safe, but it did not reduce the number of new/enlarging/enhancing lesions on brain magnetic resonance imaging (MRI) at month 9, according to a study published online June 15 in JAMA Neurology.

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Male Veterans Less Likely to Have Excellent, Good Hearing

FRIDAY, June 12, 2020 (HealthDay News) — Male veterans are significantly less likely to have excellent or good hearing and are significantly more likely to have a little or moderate trouble hearing, have a lot of trouble hearing, or be deaf compared with nonveterans, according to research published online June 12 in the National Health Statistics Reports, a publication from the U.S. Centers for Disease Control and Prevention.

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Sleep Apnea in Patients With T2DM Ups Risk for Comorbidities

FRIDAY, June 12, 2020 (HealthDay News) — Patients with type 2 diabetes who develop obstructive sleep apnea (OSA) are at higher risk for cardiovascular disease (CVD) and other diabetes-related complications, according to a study recently published in Diabetes Care.

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Stroke Risk Increased in African Americans Who Smoke Cigarettes

THURSDAY, June 11, 2020 (HealthDay News) — Current cigarette smoking is associated with stroke risk in blacks, with a dose-dependent pattern observed, according to a study published online June 10 in the Journal of the American Heart Association.

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Risk Factors for Suicide ID’d in Health Care Professionals

THURSDAY, June 11, 2020 (HealthDay News) — Modifiable and nonmodifiable risk factors for suicide have been identified among health care professionals, according to a study published online June 10 in JAMA Surgery.

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Worsened ADHD Behaviors Reported for Children During COVID-19

THURSDAY, June 11, 2020 (HealthDay News) — For children with attention-deficit/hyperactivity disorder (ADHD), parents reported worsened ADHD behaviors during the COVID-19 outbreak, with children’s and parents’ moods positively associated with behavior, according to research published online in the June issue of the Asian Journal of Psychiatry.

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Treatment Gap Remains in Stroke Care Between Men and Women

WEDNESDAY, June 10, 2020 (HealthDay News) — Pooled data from recent studies show that women with acute stroke are less likely to be treated with intravenous (IV) thrombolysis compared with men, according to a review published online June 10 in Neurology.

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Low-Dose Aspirin Lowers CVD Risk but Raises Bleeding Risk

WEDNESDAY, June 10, 2020 (HealthDay News) — Low-dose aspirin significantly lowers cardiovascular disease (CVD) risk but increases the risk for bleeding, according to a review published online June 2 in the British Journal of Clinical Pharmacology.

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Recent Cannabis Use Not Linked to Acute Ischemic Stroke

WEDNESDAY, June 10, 2020 (HealthDay News) — Recent cannabis use is not associated with acute ischemic stroke, according to a study published online June 3 in Neurology: Clinical Practice.

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Not Enough Evidence Exists to Support Cannabis for Parkinson Disease

TUESDAY, June 9, 2020 (HealthDay News) — More research is needed to determine the safety and efficacy of cannabis use for the treatment of Parkinson disease symptoms, according to a consensus statement released by the Parkinson’s Foundation.

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Vision, Balance Issues Common With Pediatric Concussions

TUESDAY, June 9, 2020 (HealthDay News) — Vision and balance issues are common in younger children with concussion, according to a study published online June 4 in The Journal of Pediatrics.

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Intracerebral Hemorrhage Incidence Rate Stabilizing

MONDAY, June 8, 2020 (HealthDay News) — In the past 30 years, rates of intracerebral hemorrhage (ICH) incidence have stabilized, according to a study published online June 8 in JAMA Neurology.

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Antiepileptic Drugs May Up Death Risk in Patients With Alzheimer Disease

FRIDAY, June 5, 2020 (HealthDay News) — Antiepileptic drugs (AEDs) are associated with a higher risk for mortality in patients with Alzheimer disease (AD), according to a study published online May 19 in Neurology.

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Delay in Treatment Seen for Acute Ischemic Stroke During COVID-19

WEDNESDAY, June 3, 2020 (HealthDay News) — A significant delay in treatment has been observed for patients with acute ischemic stroke during the COVID-19 pandemic, according to a study published online May 28 in the Journal of NeuroInterventional Surgery.

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Young With Intellectual Disability More Likely to Die of COVID-19

WEDNESDAY, June 3, 2020 (HealthDay News) — Age-related differences in COVID-19 trends are seen among those with intellectual and developmental disabilities (IDD), with a higher concentration of cases and increased case fatality in younger individuals with IDD, according to a study published online May 24 in the Disability and Health Journal.

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ABCDE Bundle Can Reduce Ventilation Time for ICU Patients

MONDAY, June 1, 2020 (HealthDay News) — Use of the awakening and breathing coordination, delirium monitoring/management, and early mobility (ABCDE) bundle can reduce ventilation time for patients admitted to the intensive care unit (ICU), according to a study recently published in AACN Advanced Critical Care.

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