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June 2019 Briefing – Hematology & Oncology

Here are what the editors at HealthDay consider to be the most important developments in Hematology & Oncology for June 2019. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Overall Survival Worse With Multiple Primary Melanomas

FRIDAY, June 28, 2019 (HealthDay News) — Patients with multiple primary melanomas have worse overall survival than those with a single primary melanoma, according to a study published online June 26 in JAMA Dermatology.

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Five-Year Survival Less Than 40 Percent in Seniors With DLBCL

FRIDAY, June 28, 2019 (HealthDay News) — Overall survival among older adults with diffuse large B-cell lymphoma (DLBCL) has improved over time, but five-year survival is less than 40 percent, according to a study published online June 12 in Leukemia & Lymphoma.

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Morning Preference Has Protective Effect on Breast Cancer Risk

FRIDAY, June 28, 2019 (HealthDay News) — Morning preference seems to have a protective effect on breast cancer risk, according to a study published online June 26 in The BMJ.

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Use of 3-D Mammography Rapidly Expanded 2015 to 2017

FRIDAY, June 28, 2019 (HealthDay News) — Adoption of 3-D mammography expanded rapidly in the United States in just a few years, particularly in areas with greater socioeconomic resources, according to a research letter published online June 24 in JAMA Internal Medicine.

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Review: HPV Vaccination Program Has Considerable Impact

FRIDAY, June 28, 2019 (HealthDay News) — The human papillomavirus (HPV) vaccination program has had a considerable impact, according to a study published online June 26 in The Lancet.

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Infections Tied to Subsequent Risk for Acute Ischemic Stroke

FRIDAY, June 28, 2019 (HealthDay News) — Different infection types, especially urinary tract infection (UTI), are associated with subsequent acute ischemic stroke, according to a study published online June 27 in Stroke.

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USPSTF Lung Cancer Screening Too Conservative for Blacks

THURSDAY, June 27, 2019 (HealthDay News) — Current U.S. Preventive Services Task Force (USPSTF) guidelines for lung cancer screening eligibility may be too conservative for African American smokers, according to a study published online June 27 in JAMA Oncology.

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Five-Year Overall Survival for Glioblastoma Persistently Low

THURSDAY, June 27, 2019 (HealthDay News) — The percentage of patients achieving five-year survival following a glioblastoma diagnosis remains both steady and low, according to a study published online June 19 in Mayo Clinic Proceedings.

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MSSP ACOs May Not Improve Spending, Quality of Care

WEDNESDAY, June 26, 2019 (HealthDay News) — After adjustment for the nonrandom exit of clinicians, the Medicare Shared Savings Program (MSSP) is not associated with improvements in spending or quality, according to a study published online June 18 in the Annals of Internal Medicine.

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Americans Concerned About Clinician Burnout

WEDNESDAY, June 26, 2019 (HealthDay News) — Nearly three-quarters of Americans are concerned about burnout among their clinicians, according to a survey released June 17 by the American Society of Health-System Pharmacists (ASHP).

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Combination Biopsy Strategy May Identify More Prostate Cancers

WEDNESDAY, June 26, 2019 (HealthDay News) — A lesion visible on magnetic resonance imaging (MRI) identifies a heightened risk for clinically significant prostate cancer in men undergoing first-time prostate biopsy, and a combination of targeted and systematic biopsy may improve the chances of detecting cancer, according to a study published online June 12 in JAMA Surgery.

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Mortality Not Higher With Transfusions From Female Donors

TUESDAY, June 25, 2019 (HealthDay News) — There is no increased risk for mortality among patients receiving red blood cell transfusions from female, previously pregnant, or sex-discordant donors, according to a study published in the June 11 issue of the Journal of the American Medical Association.

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Anesthesia Tied to Neurocognitive Impairment in Childhood ALL Survivors

TUESDAY, June 25, 2019 (HealthDay News) — Multiple exposures to general anesthesia may be associated with neurocognitive impairment and brain imaging abnormalities in long-term survivors of childhood acute lymphoblastic leukemia (ALL), according to a study published online June 20 in JAMA Oncology.

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Voxelotor Improves Hemoglobin Levels in Sickle Cell Disease

TUESDAY, June 25, 2019 (HealthDay News) — For individuals with sickle cell disease, 1,500 mg of voxelotor increases hemoglobin levels and reduces the incidence of worsening anemia compared with placebo, according to a study published in the June 14 issue of the New England Journal of Medicine.

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Cancer Survivors Have High Prevalence of Chronic Pain

TUESDAY, June 25, 2019 (HealthDay News) — Cancer survivors have a high prevalence of chronic pain, according to a research letter published online June 20 in JAMA Oncology.

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Nonchromosomal Birth Defects May Up Childhood Cancer Risk

MONDAY, June 24, 2019 (HealthDay News) — Children with nonchromosomal birth defects have a higher relative risk for cancer, though the absolute risk is still low, according to a study published online June 20 in JAMA Oncology.

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Adrenal Incidentalomas Rarely Grow, Change Hormone Function

MONDAY, June 24, 2019 (HealthDay News) — Nonfunctioning adrenal tumors (NFATs) or adenomas causing mild autonomous cortisol excess (MACE) rarely show clinically relevant changes in size or hormone function, according to research published online June 25 in the Annals of Internal Medicine.

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Drug Combo Slows Progression in Advanced Breast Cancer

MONDAY, June 24, 2019 (HealthDay News) — Treatment with a combination of alpelisib and fulvestrant prolongs progression-free survival among patients with PIK3CA-mutated, hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer, according to a phase 3 study recently published in the New England Journal of Medicine.

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Transfusion Dose Density Affects Myelodysplastic Syndrome Survival

MONDAY, June 24, 2019 (HealthDay News) — Transfusion dose density is an independent prognostic factor for progression-free survival (PFS) in patients with myelodysplastic syndromes treated with red blood cell transfusions (RBCTs), according to a study published online June 6 in Haematologica.

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Poor Oral Health Not Linked to Gastrointestinal Cancer Risk

FRIDAY, June 21, 2019 (HealthDay News) — Self-reported poor oral health is not associated with gastrointestinal cancer risk, although it may be associated with hepatobiliary cancer, specifically hepatocellular carcinoma, according to a study published online June 8 in the United European Gastroenterology Journal.

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Seniors Who Develop Cancer Have Better Memory, Slower Decline

FRIDAY, June 21, 2019 (HealthDay News) — Older individuals who develop cancer have better memory and slower memory decline than those who remain cancer-free, according to a study published online June 21 in JAMA Network Open.

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Study Reveals Lower Predictive Ability for Renal Cancer Models

FRIDAY, June 21, 2019 (HealthDay News) — Prospective validation of existing renal cell carcinoma (RCC) prediction models demonstrates a decrease in their predictive ability, according to a study published online June 19 in the Journal of Clinical Oncology.

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No Change Seen in Processed Meat Consumption by U.S. Adults

FRIDAY, June 21, 2019 (HealthDay News) — During the last 18 years, there has been no change in consumption of processed meats among U.S. adults, according to a study published online June 21 in the Journal of the Academy of Nutrition and Dietetics.

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First States to Expand Medicaid Had Largest Bump in Cancer Screening

FRIDAY, June 21, 2019 (HealthDay News) — The first states to expand Medicaid under the Affordable Care Act saw the largest increases in colorectal cancer (CRC) screening from 2012 to 2016, according to a study published in the July issue of the American Journal of Preventive Medicine.

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Restricting Blood Transfusions OK in Cardiac Surgery

THURSDAY, June 20, 2019 (HealthDay News) — For high-risk patients undergoing cardiac surgery with cardiopulmonary bypass, a restrictive approach to red blood cell transfusions leads to fewer transfusions than a liberal approach, with no increase in the risk for acute kidney injury (AKI), according to a study published online June 20 in the Journal of the American Society of Nephrology.

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Most Women Unaware Alcohol Poses Breast Cancer Risk

THURSDAY, June 20, 2019 (HealthDay News) — Women have poor awareness of alcohol’s role in breast cancer risk, according to a study published online June 17 in BMJ Open.

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New England Journal of Medicine Picks New Editor-in-Chief

THURSDAY, June 20, 2019 (HealthDay News) — The new editor-in-chief of the prestigious New England Journal of Medicine is Eric J. Rubin, M.D., Ph.D., who was selected after a worldwide search and plans to start in September, according to the Massachusetts Medical Society, which publishes the journal.

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Health Care Workers With ARIs Often Work While Symptomatic

THURSDAY, June 20, 2019 (HealthDay News) — Almost all health care workers (HCWs) with acute respiratory illness (ARI) report working at least one day while symptomatic, according to a study published online June 18 in Infection Control & Hospital Epidemiology.

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High Response Seen for Chemo in Seniors With High-Risk AML

THURSDAY, June 20, 2019 (HealthDay News) — A substantial proportion of older patients with high-risk acute myeloid leukemia (AML) treated with chemotherapy are long-term survivors, according to research published online June 7 in Cancer Medicine.

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Computer-Assisted Diagnosis Aids Detection of Glioma Growth

THURSDAY, June 20, 2019 (HealthDay News) — Computer-assisted diagnosis (CAD) can help physicians detect growth of low-grade gliomas, according to a study published online May 28 in PLOS Medicine.

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San Francisco Considering Banning Sales of E-Cigarettes

WEDNESDAY, June 19, 2019 (HealthDay News) — A ban on the sale and distribution of electronic cigarettes is being considered by San Francisco supervisors. If passed, it would be the first such ban by any city in the United States.

AP News Article

Hartford Courant Article

Surgeons’ Unprofessional Behavior Tied to Higher Complication Risk

WEDNESDAY, June 19, 2019 (HealthDay News) — Patients whose surgeons have higher numbers of coworker reports about unprofessional behavior may be at increased risk for postsurgical complications, according to a study published online June 19 in JAMA Surgery.

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Yogurt Consumption Linked to Reduced CRC Adenoma Risk in Men

WEDNESDAY, June 19, 2019 (HealthDay News) — Yogurt consumption is associated with a reduced risk for colorectal adenomas in men, according to a research letter published online June 18 in Gut.

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Prophylactic IVC Filters Worsen Outcomes for Bariatric Surgery

WEDNESDAY, June 19, 2019 (HealthDay News) — For patients undergoing bariatric surgery, use of prophylactic inferior vena cava filters (IVCFs) is associated with worse clinical outcomes and increased use of health care resources, according to a study published in the June 24 issue of JACC: Cardiovascular Interventions.

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Statins May Be Beneficial After Radiation to Thorax, Head, Neck

WEDNESDAY, June 19, 2019 (HealthDay News) — For cardiac patients with thorax and head or neck cancer, statin use after radiation therapy is associated with a significant reduction in stroke incidence and a trend toward reduced cardiovascular and cerebrovascular events, according to a study published online June 19 in the Journal of the American Heart Association.

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Many Surgeons Still Performing Inappropriate Vascular Access Sx

WEDNESDAY, June 19, 2019 (HealthDay News) — For patients with first-time permanent hemodialysis access placement, more than one-fifth of surgeons have arteriovenous graft (AVG) use rates exceeding the recommended best practice guideline of 34 percent, according to a study published online June 12 in JAMA Surgery.

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Cardiovascular AEs Common With Carfilzomib in Multiple Myeloma

WEDNESDAY, June 19, 2019 (HealthDay News) — For patients with relapsed multiple myeloma (MM), cardiovascular adverse events (CVAEs) are common with proteasome inhibitor therapy, particularly with carfilzomib, and are associated with inferior survival, according to a study published online June 12 in the Journal of Clinical Oncology.

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Recommendations Issued for Imaging Use in Multiple Myeloma

TUESDAY, June 18, 2019 (HealthDay News) — In a review published in the June 1 issue of The Lancet Oncology, recommendations are presented for use of newer imaging techniques for the diagnosis of multiple myeloma.

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Patterns of Inpatient Opioid Use Linked to Long-Term Use

TUESDAY, June 18, 2019 (HealthDay News) — Specific patterns of opioid administration to opioid-naive inpatients are associated with risk for long-term use after discharge, according to a study published online June 18 in the Annals of Internal Medicine.

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Adding Bevacizumab Improves Overall Survival in NSCLC

TUESDAY, June 18, 2019 (HealthDay News) — The addition of bevacizumab to carboplatin/pemetrexed is associated with improved overall survival among patients with advanced non-small cell lung cancer (NSCLC), according to a study published in the May issue of the Journal of the National Comprehensive Cancer Network.

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Overall Cancer Survival Rates Up Among Adolescents, Young Adults

TUESDAY, June 18, 2019 (HealthDay News) — Cancer survival has improved among adolescents and young adults (AYA), but survival disparities are reported, according to a study published online June 12 in JNCI Cancer Spectrum.

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Drug Makers Challenge New Rule Requiring Drug Prices in TV Ads

MONDAY, June 17, 2019 (HealthDay News) — Three large drug makers have launched a legal challenge against the Trump administration’s rule requiring the prices of drugs to be included in television ads.

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Triple-Negative Breast Cancer Varies by Birthplace for Black Women

MONDAY, June 17, 2019 (HealthDay News) — Among black women in the United States, the prevalence of triple-negative breast cancer varies by birthplace, according to a study published online June 13 in Cancer.

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High Soy Intake May Cut Fracture Risk in Younger Breast Cancer Survivors

MONDAY, June 17, 2019 (HealthDay News) — Higher soy consumption is linked to fewer osteoporotic fractures in younger breast cancer survivors, according to a study published online May 21 in JNCI Cancer Spectrum.

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Maine Legalizes Assisted Suicide

FRIDAY, June 14, 2019 (HealthDay News) — Maine has become the eighth state to legalize medically assisted suicide.

AP News Article

Cardiac Radiation Dose in NSCLC Predicts Mortality, Cardiac AEs

FRIDAY, June 14, 2019 (HealthDay News) — Cardiac radiation dose exposure is a modifiable cardiac risk factor for major adverse cardiac events (MACE) and all-cause mortality (ACM) in patients with non-small cell lung cancer (NSCLC), according to a study published in the June 18 issue of the Journal of the American College of Cardiology.

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Black Race Not Tied to Worse Prostate Cancer Mortality

FRIDAY, June 14, 2019 (HealthDay News) — After adjustment for nonbiological differences, black race is not associated with worse prostate cancer-specific mortality among men with nonmetastatic prostate cancer, according to a study published online May 23 in JAMA Oncology.

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FIGO 2018 Staging Ups Discrimination of Stage 1B Cervical Cancer

THURSDAY, June 13, 2019 (HealthDay News) — The Federation of Gynecology and Obstetrics (FIGO) 2018 staging schema improves discriminatory ability for women with stage IB cervical tumors, according to a study published online June 11 in Obstetrics & Gynecology.

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Increases in Red Meat Intake Linked to Increased Mortality

THURSDAY, June 13, 2019 (HealthDay News) — Increases in red meat consumption over eight years are associated with an increased mortality risk during the subsequent eight years, according to a study published online June 12 in The BMJ.

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HPV16 Antibodies Can Develop Long Before Throat Cancer Diagnosis

THURSDAY, June 13, 2019 (HealthDay News) — Seroconversion to human papillomavirus type 16 (HPV16)-E6 antibody positivity can occur decades before diagnosis of oropharyngeal squamous cell carcinoma (OPSCC), according to a study published online June 12 in the Annals of Oncology.

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Long-Term Opioid Prescribing Up Among Older Cancer Survivors

THURSDAY, June 13, 2019 (HealthDay News) — The rates of prolonged opioid prescribing remain high for older cancer survivors five or more years after cancer diagnosis, according to a study published in the May issue of the Journal of the American Geriatrics Society.

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Chemoradiation Does Not Up Survival in Endometrial Cancer

WEDNESDAY, June 12, 2019 (HealthDay News) — For patients with stage III or IVA endometrial cancer, chemotherapy plus radiation is not associated with improved relapse-free survival versus chemotherapy alone, according to a study published in the June 13 issue of the New England Journal of Medicine.

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Most Providers Unaware of Online Feedback About Themselves

WEDNESDAY, June 12, 2019 (HealthDay News) — Many health care providers in the United Kingdom have little direct experience with online feedback, rarely encourage it, and often view it as having little value for improving the quality of health services, according to a study published online June 2 in the Journal of Health Services Research & Policy.

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Nitrate Pollution of Tap Water May Cause Thousands of Cancer Cases

WEDNESDAY, June 12, 2019 (HealthDay News) — Nitrate pollution of drinking water has serious health and economic consequences, according to a study published online June 11 in Environmental Research.

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Approving Children’s Cancer Drugs Takes 6.5 Years Longer

WEDNESDAY, June 12, 2019 (HealthDay News) — For cancer drugs ultimately approved by the U.S. Food and Drug Administration, the median lag time from first-in-human to first-in-child trials is 6.5 years, according to a study published in the May issue of the European Journal of Cancer.

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Diagnostic Yield of Lynch Syndrome Screening Drops With Age

TUESDAY, June 11, 2019 (HealthDay News) — The incremental diagnostic yield of Lynch syndrome (LS) screening decreases substantially after age 70 to 75 years, according to a study published online June 11 in the Annals of Internal Medicine.

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Number of Cancer Survivors Set to Top 22 Million by 2030

TUESDAY, June 11, 2019 (HealthDay News) — The number of cancer survivors is projected to increase to more than 22.1 million by Jan. 1, 2030, based on growth and aging of the population alone, according to a study published online June 11 in CA: A Cancer Journal for Clinicians.

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Chemoimmunotherapy Regimen Approved to Treat DLBCL

MONDAY, June 10, 2019 (HealthDay News) — Polivy (polatuzumab vedotin-piiq), a novel antibody-drug conjugate, received approval to treat patients with diffuse large B-cell lymphoma (DLBCL) in combination with bendamustine and rituximab, the U.S. Food and Drug Administration announced today. The combination was approved for patients whose disease has progressed or returned after at least two previous therapies.

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Location of Body Fat Linked to Advanced, Fatal Prostate Cancer

MONDAY, June 10, 2019 (HealthDay News) — Specific fat deposits, body mass index (BMI), and waist circumference are associated with an increased risk for advanced and fatal prostate cancer, according to a study published online June 10 in Cancer.

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Access to Health Care Has Little Impact on Longevity

MONDAY, June 10, 2019 (HealthDay News) — Health care has modest effects on extending life expectancy in the United States, while behavioral and social determinants may have larger effects, according to a review published in the May/June issue of the Annals of Family Medicine.

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Mouth Rinse for HPV DNA May Be Biomarker in Head, Neck Cancer

MONDAY, June 10, 2019 (HealthDay News) — Human papillomavirus (HPV) DNA detected from a mouth rinse may be an effective marker for prognosis during treatment of HPV-positive head and neck cancer, according to a study recently published in JAMA Oncology.

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Out-of-Pocket Medical Expenditure Up for Cancer Survivors

FRIDAY, June 7, 2019 (HealthDay News) — Cancer survivors have significantly higher annual out-of-pocket medical expenditures than individuals without a cancer history, according to research published in the June 7 issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.

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Fewer Black Men Adopt Active Surveillance for Prostate Cancer

FRIDAY, June 7, 2019 (HealthDay News) — Overall rates of active surveillance are up for all men with low-risk prostate cancer, although the increase is significantly smaller for black men, according to a research letter published in the May 23 issue of the New England Journal of Medicine.

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Rapid Cycling Work Roster Improves Resident Sleep Practices

THURSDAY, June 6, 2019 (HealthDay News) — A rapidly cycling work roster (RCWR) is effective in reducing weekly work hours and the occurrence of >16 consecutive-hour shifts as well as improving sleep duration of resident physicians, according to a study published online May 20 in SLEEP.

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Survey Indicates Physician Misconduct Is Underreported

THURSDAY, June 6, 2019 (HealthDay News) — Physician misconduct is being underreported and most Americans do not know where to file a complaint, according to a report published by the Federation of State Medical Boards (FSMB).

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Gait Speed Is Prognostic in Older Patients With Blood Cancer

THURSDAY, June 6, 2019 (HealthDay News) — For older patients with blood cancers, gait speed can identify frailty and predict outcomes, according to a study published online June 5 in Blood.

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Testicular Cancer Treatment Does Not Up Risk for Offspring Birth Defects

THURSDAY, June 6, 2019 (HealthDay News) — Children of men with testicular germ-cell cancer (TGCC) have a modestly increased risk for congenital malformation (CM), which does not differ at pretreatment and posttreatment, according to a study published online June 4 in PLOS Medicine.

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Few Oncologists Refer Patients to Weight Management Programs

WEDNESDAY, June 5, 2019 (HealthDay News) — While oncology providers are aware of the link between obesity and cancer, few provide referrals to support patients’ lifestyle changes, according to a study published online May 16 in the Journal of Oncology Practice.

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Fragmentation Profiles of Cell-Free DNA Can Detect Cancer

WEDNESDAY, June 5, 2019 (HealthDay News) — Fragmentation profiles of cell-free DNA (cfDNA) can differentiate between patients with cancer and healthy controls, according to a study published online May 29 in Nature.

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Surveillance Breast MRI Ups Biopsy, Cancer Detection Rates

WEDNESDAY, June 5, 2019 (HealthDay News) — Use of surveillance breast magnetic resonance imaging (MRI) is associated with increased biopsy and subsequent cancer detection rates compared with mammography alone among women with a personal history of breast cancer, according to a study published online June 4 in Radiology.

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Young Male Adults Have Lower Cancer Burden Than Women

TUESDAY, June 4, 2019 (HealthDay News) — For young adults, there have been some notable findings for overall cancer incidence rates and death rates, according to a study published online May 30 in the Journal of the National Cancer Institute.

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Allo-HCT With Unrelated Donor Tied to Better Outcomes in AML

TUESDAY, June 4, 2019 (HealthDay News) — Allogeneic hematopoietic cell transplantation (allo-HCT) with an unrelated donor (UD) results in better transplantation outcomes than cord blood transplantation (CBT) in acute myeloid leukemia (AML) patients with active disease, according to a study recently published in the Blood Cancer Journal.

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Policy Changes Proposed to Meet Projected Need for Palliative Care

TUESDAY, June 4, 2019 (HealthDay News) — Policies to support team-based palliative care are urgently needed to meet the growing demand for specialty palliative care, according to a study published in the June issue of Health Affairs.

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ACP Issues Position on Response to Physician Impairment

MONDAY, June 3, 2019 (HealthDay News) — Providing assistance for physician impairment and rehabilitation is addressed in a position statement issued by the American College of Physicians and published online June 4 in the Annals of Internal Medicine.

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FDA Takes Hard Look at CBD

MONDAY, June 3, 2019 (HealthDay News) — The U.S. Food and Drug Administration took a good look at the safety and effectiveness of cannabidiol (CBD) products on Friday, as it weighs how to best regulate the hemp-derived compound going forward.

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Gout Linked to Increased Risk for Venous Thromboembolism

MONDAY, June 3, 2019 (HealthDay News) — Gout is associated with an increased risk for venous thromboembolism, according to a study published in the June 3 issue of CMAJ, the journal of the Canadian Medical Association.

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Higher Surgical Volume May Improve Outcomes in Cervical Cancer

MONDAY, June 3, 2019 (HealthDay News) — Surgery at high-volume centers is associated with decreased local recurrence risk and improved survival for women with early-stage cervical cancer, according to a study published in the June issue of Obstetrics & Gynecology.

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