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July 2019 Briefing – Pharmacy

Here are what the editors at HealthDay consider to be the most important developments in Pharmacy for July 2019. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Biologic Tx for Psoriasis May Reduce Coronary Inflammation

WEDNESDAY, July 31, 2019 (HealthDay News) — For patients with moderate-to-severe psoriasis, the perivascular fat attenuation index (FAI), as measured by coronary computed tomography angiography (CCTA), indicates reduced coronary inflammation in association with biologic therapy, according to a study published online July 31 in JAMA Cardiology.

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Risk for Allergy Development Increased After Gastric Acid Inhibitor Use

WEDNESDAY, July 31, 2019 (HealthDay News) — Patients receiving gastric acid inhibitors have an increase in prescriptions of anti-allergic drugs, according to a study published online July 30 in Nature Communications.

Abstract/Full Text

Oral Semaglutide Reduces HbA1c, Weight in Patients With T2DM

WEDNESDAY, July 31, 2019 (HealthDay News) — Compared with placebo, oral semaglutide monotherapy is associated with superior and clinically relevant improvements in glycated hemoglobin (HbA1c) and weight loss among patients with type 2 diabetes, according to a study published online July 18 in Diabetes Care.

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$70 Million Settlement Reached in Generic Drug Delay Case

TUESDAY, July 30, 2019 (HealthDay News) — Three drug companies will pay a total of nearly $70 million to California to settle charges of delaying the sale of generic drugs to keep brand-name drug prices high, the state’s attorney general said Monday.

AP News Article

New Opioid Rx Rules Coming for U.S. Employees’ Health Plans

TUESDAY, July 30, 2019 (HealthDay News) — Tighter rules on opioid painkiller prescriptions for U.S. government employees will be implemented in the fall, the Trump Administration says.

AP News Article

Work-Related Injuries Up Suicide and Drug-Related Death

TUESDAY, July 30, 2019 (HealthDay News) — Workplace injuries severe enough to warrant more than a week away from work may increase the risk for death among workers, according to a study published online July 12 in the American Journal of Industrial Medicine.

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SGLT-2 Inhibitor Use Not Linked to Increased Risk for UTI Events

TUESDAY, July 30, 2019 (HealthDay News) — Initiation of therapy with sodium-glucose cotransporter-2 (SGLT-2) inhibitors for type 2 diabetes mellitus is not associated with an increased risk for urinary tract infection (UTI) events compared with initiation of other second-line antidiabetic medications, according to a study published online July 30 in the Annals of Internal Medicine.

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Lifesaving Drug for Infants Costs $2.1 Million a Dose

MONDAY, July 29, 2019 (HealthDay News) — Its extremely high price tag means that a lifesaving medication to treat young children with spinal muscular atrophy is simply too expensive for most families.

NBC News Article

Serious Falls Pose Risk to People Living With HIV

MONDAY, July 29, 2019 (HealthDay News) — Benzodiazepines and muscle relaxants are associated with serious falls among people living with HIV in their 50s, according to a study recently published in the Journal of Acquired Immune Deficiency Syndrome.

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Opioid Prescribing, New Persistent Use Down After Childbirth

MONDAY, July 29, 2019 (HealthDay News) — Since 2008, there has been a decrease in opioid prescribing and new persistent use after vaginal or cesarean delivery, according to a study published online July 26 in JAMA Network Open.

Abstract/Full Text

FDA: Blood Clot, Death Risk Up With Higher Dose of Tofacitinib

FRIDAY, July 26, 2019 (HealthDay News) — New warnings about an increased risk of thrombosis and of death among ulcerative colitis patients taking the 10 mg twice daily dose of the drug tofacitinib (Xeljanz, Xeljanz XR) have been issued by the U.S. Food and Drug Administration.

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Testosterone Replacement Therapy May Increase Cardiovascular Risk

FRIDAY, July 26, 2019 (HealthDay News) — For aging men with low testosterone levels, testosterone replacement therapy (TRT) may increase the risk of cardiovascular events, especially in the first two years of use, according to a study published in the September issue of The American Journal of Medicine.

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Some Men at Risk for HIV Do Not Live Near PrEP Provider

FRIDAY, July 26, 2019 (HealthDay News) — A considerable proportion of men who have sex with men (MSM), who are eligible for HIV preexposure prophylaxis (PrEP), live in locations with no nearby PrEP provider, according to a study published online July 18 in the American Journal of Public Health.

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Review Supports Testosterone for Low Sexual Desire in Women

FRIDAY, July 26, 2019 (HealthDay News) — For postmenopausal women with low sexual desire causing distress, testosterone is an effective treatment, with a preference for nonoral administration, according to a review published online July 25 in the The Lancet Diabetes & Endocrinology.

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Vitamin D Supplementation Beneficial for Glucose Metabolism

FRIDAY, July 26, 2019 (HealthDay News) — Vitamin D3 supplementation can improve glucose metabolism in patients at high risk of diabetes or with newly-diagnosed diabetes, according to a study published online July 1 in the European Journal of Endocrinology.

Abstract/Full Text

Roxadustat Noninferior to Epoetin Alfa in Dialysis Patients

FRIDAY, July 26, 2019 (HealthDay News) — Roxadustat is noninferior to epoetin alfa for increasing hemoglobin levels among patients with anemia who are undergoing dialysis, and is superior to placebo for patients not undergoing dialysis, according to two studies published in the July 24 issue of the New England Journal of Medicine.

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Minor Changes in BMD Seen With Tenofovir PrEP in Short Term

THURSDAY, July 25, 2019 (HealthDay News) — Tenofovir preexposure prophylaxis (PrEP) therapy does not appear to be associated with clinically significant declines in bone mineral density (BMD) in the short term, according to a study published online June 19 in AIDS Research and Human Retroviruses.

Abstract/Full Text

Targeted Interventions Raise HPV Vaccine Acceptance in Women

THURSDAY, July 25, 2019 (HealthDay News) — Among young women, targeted educational interventions, particularly educational videos, increase human papillomavirus (HPV) vaccine acceptability and knowledge, according to a study published online July 9 in Obstetrics & Gynecology.

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FDA Warns CBD Product Maker About False Claims

WEDNESDAY, July 24, 2019 (HealthDay News) — A warning letter has been issued to Massachusetts-based Curaleaf Inc. for illegally selling unapproved cannabidiol (CBD) products online with unproven claims that the products treat cancer, Alzheimer disease, opioid withdrawal, pain, and other health problems, the U.S. Food and Drug Administration says.

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WHO ‘Treat All’ Recommendation for HIV Widely Implemented

WEDNESDAY, July 24, 2019 (HealthDay News) — The World Health Organization “Treat All” strategy for antiretroviral treatment (ART) initiation among patients living with HIV was the standard of care at almost all International epidemiology Databases to Evaluate AIDS (IeDEA) sites by mid-2017, according to a study published in the July issue of the Journal of the International AIDS Society.

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Periop Diabetic Ketoacidosis Seen in Patients on SGLT2 Inhibitors

WEDNESDAY, July 24, 2019 (HealthDay News) — Sodium-glucose cotransporter-2 inhibitor (SGLT2i)-associated diabetic ketoacidosis (DKA) may occur after surgery even in patients with normal or near-normal blood glucose levels, according to a review published in the July issue of the British Journal of Anaesthesia.

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Metformin May Lower Dementia Risk in Black Patients With T2DM

WEDNESDAY, July 24, 2019 (HealthDay News) — Metformin use is associated with a substantially lower risk for dementia among younger African-American patients with diabetes compared with sulfonylurea initiation, according to a study published in the July/August issue of the Annals of Family Medicine.

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Filgotinib Bests Placebo in Tx of Refractory Rheumatoid Arthritis

TUESDAY, July 23, 2019 (HealthDay News) — Among patients with moderately to severely active rheumatoid arthritis (RA) resistant to previous therapy with biologic agents, a significantly higher clinical response rate was seen at 12 weeks for those receiving filgotinib versus placebo, according to a study published in the July 23/30 issue of the Journal of the American Medical Association.

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Senate Bill Would Reduce Drug Costs for Seniors

TUESDAY, July 23, 2019 (HealthDay News) — A bill to reduce prescription drug costs for millions of Medicare recipients and lower federal and state health costs has been introduced by two U.S. senators.

AP News Article

CV Event Risk Up With Rejected, Abandoned PCSK9i Prescriptions

TUESDAY, July 23, 2019 (HealthDay News) — Patients with rejected or abandoned prescriptions for proprotein convertase subtilisin kexin type 9 inhibitors (PCSK9i) have a significantly increased risk for cardiovascular events than those with paid prescriptions, according to a study published online July 23 in Circulation: Cardiovascular Quality and Outcomes.

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Editorial

Stimulant Treatment Has Strong Protective Effect in ADHD

TUESDAY, July 23, 2019 (HealthDay News) — For youth with attention-deficit/hyperactivity disorder (ADHD), stimulants have strong protective effects on functional outcomes, according to a study published online July 23 in the Journal of Adolescent Health.

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T2DM Increases Gastric Cancer Risk After H. Pylori Eradication

TUESDAY, July 23, 2019 (HealthDay News) — Type 2 diabetes mellitus increases the risk for gastric cancer after treatment for Helicobacter pylori infection, according to a study published online July 11 in Diabetes Care.

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Nonprescription Antibiotic Use Seems Prevalent in the United States

MONDAY, July 22, 2019 (HealthDay News) — Nonprescription antibiotic use appears to be prevalent in the United States, according to a review published online July 23 in the Annals of Internal Medicine.

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Almost One in Four Adults ≥40 Takes Aspirin for CVD Prevention

MONDAY, July 22, 2019 (HealthDay News) — Nearly 30 million U.S. adults aged 40 years or older use aspirin to prevent cardiovascular disease (CVD), including 6.6 million without a physician’s recommendation, according to a research letter published online July 23 in the Annals of Internal Medicine.

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Light Therapy May Prevent Oral Mucositis for Some in Cancer Tx

MONDAY, July 22, 2019 (HealthDay News) — Photobiomodulation (PBM), such as laser and other light therapies, is recommended for prevention of oral mucositis (OM) in specific populations of cancer patients, according to a review published online July 8 in Supportive Care in Cancer.

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Opioid Rx Education Insufficient for Plastic Surgery Trainees

MONDAY, July 22, 2019 (HealthDay News) — Only one-fourth of U.S. plastic surgery residents report receiving opioid-prescriber education, according to a study published in the July issue of Plastic and Reconstructive Surgery.

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EPA Will Not Ban Pesticide Linked to Brain Harm in Children

FRIDAY, July 19, 2019 (HealthDay News) — Even though the pesticide chlorpyrifos has been linked to brain harm in children, it will not be banned in the United States, the Environmental Protection Agency announced Thursday.

The New York Times Article

Recommendations Developed for Japanese Encephalitis Vaccine

FRIDAY, July 19, 2019 (HealthDay News) — In the July 19 issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report, recommendations are presented for use of the Japanese encephalitis (JE) vaccine.

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Supply of Opioids Predicts Long-Term Use in Injured Workers

FRIDAY, July 19, 2019 (HealthDay News) — The number of days supplied of an initial opioid prescription is the strongest risk factor for developing long-term opioid use among previously opioid-free injured workers, according to a study published online July 17 in JAMA Network Open.

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Key Cystic Fibrosis Pathogens Reduced With Ivacaftor Use

FRIDAY, July 19, 2019 (HealthDay News) — For patients with cystic fibrosis (CF), ivacaftor use is associated with a reduction in pathogens, including Pseudomonas aeruginosa, according to a study published online July 19 in the Annals of the American Thoracic Society.

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Current Antibiotic Stewardship Program Practices Characterized

FRIDAY, July 19, 2019 (HealthDay News) — Current infection prevention and antibiotic stewardship program practices continue to include a main focus on surveillance for multidrug-resistant organisms, according to a report published online July 17 in Infection Control & Hospital Epidemiology.

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Music Relieves Preop Anxiety Before Peripheral Nerve Block

FRIDAY, July 19, 2019 (HealthDay News) — Patients undergoing preoperative peripheral nerve block placement have a similar change in anxiolytic scores when they receive music medicine versus midazolam, according to a study published online July 18 in Regional Anesthesia & Pain Medicine.

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Safety Practice Violations ID’d in Septic Arthritis Outbreak

THURSDAY, July 18, 2019 (HealthDay News) — Breaches of recommended infection prevention practices have been identified in an outbreak of septic arthritis cases after intra-articular injections performed in a private outpatient facility, according to a report published online July 17 in Infection Control & Hospital Epidemiology.

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Medical Marijuana Laws May Not Impact Opioid Use

THURSDAY, July 18, 2019 (HealthDay News) — Medical marijuana laws do not appear to impact nonmedical prescription opioid use or opioid use disorder, according to a study published online July 17 in JAMA Network Open.

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Pregnancies in Women Taking Isotretinoin Dropped Since 2006

THURSDAY, July 18, 2019 (HealthDay News) — Since initiation of the iPLEDGE program in 2006 to reduce fetal exposure to isotretinoin, there has been a reduction in pregnancies among women taking isotretinoin, although exposure still persists, according to a report published online July 17 in JAMA Dermatology.

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About One in 20 Patients Exposed to Preventable Harm

THURSDAY, July 18, 2019 (HealthDay News) — The pooled prevalence of preventable patient harm is 6 percent across a range of medical settings globally, according to a review published online July 17 in The BMJ.

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Editorial

U.S. Drug OD Deaths Fall for First Time in Three Decades

WEDNESDAY, July 17, 2019 (HealthDay News) — For the first time in three decades, drug overdose deaths in the United States fell last year, preliminary federal government data suggest.

AP News Article

WHO Declares Congo Ebola Outbreak Global Health Emergency

WEDNESDAY, July 17, 2019 (HealthDay News) — The World Health Organization on Wednesday called the year-old outbreak of Ebola in the Democratic Republic of Congo a global health emergency, The New York Times reported.

The New York Times Article

More Information: WHO

Recarbrio OK’d for Complicated Urinary Tract, Intra-Abdominal Infections

WEDNESDAY, July 17, 2019 (HealthDay News) — The antibacterial drug product Recarbrio (imipenem, cilastatin, and relebactam) has been approved to treat complicated urinary tract infections (cUTI) and complicated intra-abdominal infections (cIAI) in adults, the U.S. Food and Drug Administration announced today.

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Menstrual Cups Seem Safe for Menstruation Management

WEDNESDAY, July 17, 2019 (HealthDay News) — Menstrual cups appear to be safe for menstruation management, according to a review published online July 16 in The Lancet Public Health.

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Editorial

Intranasal Sufentanil Cuts Acute Trauma Pain Treated in the ED

WEDNESDAY, July 17, 2019 (HealthDay News) — Intranasal sufentanil (INS) is comparable to intravenous morphine (IVM) for acute severe trauma pain treated in the emergency department, according to a study published online July 16 in PLOS Medicine.

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Continuous Anticoagulants + Cold Snare Polypectomy Noninferior

WEDNESDAY, July 17, 2019 (HealthDay News) — For patients with subcentimeter colorectal polyps receiving oral anticoagulants, continuous administration of anticoagulants (CA) with cold snare polypectomy (CSP) is noninferior to periprocedural heparin bridging (HB) with hot snare polypectomy (HSP) for polypectomy-related major bleeding, according to a study published online July 16 in the Annals of Internal Medicine.

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Rituximab Noninferior to Cyclosporine in Membranous Nephropathy

WEDNESDAY, July 17, 2019 (HealthDay News) — In patients with membranous nephropathy at high risk for progressive disease, rituximab is noninferior to cyclosporine in inducing complete or partial remission of proteinuria at 12 months and is superior in maintaining proteinuria remission up to 24 months, according to a study published in the July 4 issue of the New England Journal of Medicine.

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Extremely Low LDL Cholesterol May Up Stroke Risk

WEDNESDAY, July 17, 2019 (HealthDay News) — Cholesterol levels that are too low may increase the risk for hemorrhagic stroke, according to a study published online July 2 in Neurology.

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Many Patients With Depression Do Not Need a Psychiatrist

WEDNESDAY, July 16, 2019 (HealthDay News) — Primary care doctors can detect and treat most cases of depression, according to a study published in the July/August issue of the Annals of Family Medicine.

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Educational Handout May Increase Receipt of Child Flu Shot

TUESDAY, July 16, 2019 (HealthDay News) — Providing an educational handout about influenza disease in the waiting room before a pediatric provider visit may increase receipt of child influenza vaccine, according to a study published online July 8 in Pediatrics.

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Alirocumab Cuts CV Absolute Risk the Most for Those With Diabetes

TUESDAY, July 16, 2019 (HealthDay News) — Among those receiving alirocumab in addition to statin therapy to reduce the risk for another cardiovascular event after a recent acute coronary syndrome, absolute risk reduction is greater for those with diabetes, according to a study published online July 1 in The Lancet Diabetes & Endocrinology.

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Editorial (subscription or payment may be required)

Non-Vitamin K Oral Anticoagulants May Be Best for Early-Stage CKD

TUESDAY, July 16, 2019 (HealthDay News) — Non-vitamin K oral anticoagulants (NOACs) have a superior benefit-risk profile to that of vitamin K antagonists (VKAs) for patients with early-stage chronic kidney disease (CKD), according to a review published online July 16 in the Annals of Internal Medicine.

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Congo Officials: First Ebola Case Confirmed in City of Goma

MONDAY, July 15, 2019 (HealthDay News) — The first case of Ebola in the city of Goma has been confirmed, Democratic Republic of Congo officials said Sunday.

CNN Article

Company Reaches $1.4 Billion Settlement in Opioid Treatment Investigation

MONDAY, July 15, 2019 (HealthDay News) — A drug company has reached a $1.4 billion settlement with the U.S. government over an investigation into the company’s marketing and sales of a prescription drug used to treat opioid addiction.

CNN Article

More Information: DOJ

Prepregnancy Surgery Linked to Risk for Neonatal Abstinence Syndrome

MONDAY, July 15, 2019 (HealthDay News) — Prepregnancy surgery is associated with elevated neonatal abstinence syndrome risk in future pregnancies, according to a study published in the July 15 issue of CMAJ, the journal of the Canadian Medical Association.

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Opioids Commonly Prescribed in Emergency Department for Gout

MONDAY, July 15, 2019 (HealthDay News) — More than one-fourth of patients with acute gout discharged from the emergency department receive an opioid prescription, according to a study published online July 2 in Arthritis Care & Research.

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Etanercept Tx for Autoimmune Disease May Up Risk for IBD

MONDAY, July 15, 2019 (HealthDay News) — Patients with autoimmune diseases have an increased risk for being diagnosed with Crohn disease (CD) or ulcerative colitis (UC) while under treatment with etanercept, according to a study published online July 2 in Alimentary Pharmacology and Therapeutics.

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Tool Uses Spine X-Rays to Assess Response to Osteoporosis Tx

MONDAY, July 15, 2019 (HealthDay News) — A new measure derived from conventional X-rays and a machine learning algorithm is effective for assessing bone-specific effects of osteoporosis treatment, according to a pilot study published in the July issue of Skeletal Radiology.

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Prenatal Opioid Exposure Harms Long-Term Child Development

FRIDAY, July 12, 2019 (HealthDay News) — Prenatal opioid exposure (POE) is negatively associated with neurocognitive and physical development in offspring from the age of 6 months into school age, according to a study published online July 12 in JAMA Network Open.

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Kratom Use Associated With Significant Toxicities

FRIDAY, July 12, 2019 (HealthDay News) — The unregulated herbal supplement known as kratom, which is mainly used for self-treating pain or mood disorders in the United States, is associated with significant toxicities, according to a report published in the July issue of Pharmacotherapy.

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U.S. Health, Economic Burden of Uncontrolled Asthma Projected

FRIDAY, July 12, 2019 (HealthDay News) — The economic burden of uncontrolled asthma is considerable and is projected to continue increasing, according to a study recently published in the American Journal of Respiratory and Critical Care Medicine.

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Serious Misdiagnosis-Related Harms Mostly Due to ‘Big Three’

FRIDAY, July 12, 2019 (HealthDay News) — Vascular events, infections, and cancers account for about three-quarters of serious misdiagnosis-related harms, according to a study published online July 11 in Diagnosis.

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CRP-Guided Testing Cuts Antibiotic Use in COPD Exacerbations

FRIDAY, July 12, 2019 (HealthDay News) — For patients with an acute exacerbation of chronic obstructive pulmonary disease (COPD), point-of-care testing of C-reactive protein (CRP) to guide antibiotic prescribing can reduce antibiotic use, according to a study published in the July 11 issue of the New England Journal of Medicine.

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Prescribing Fewer Tablets Can Cut Post-ACL Surgery Opioid Use

FRIDAY, July 12, 2019 (HealthDay News) — For patients undergoing anterior cruciate ligament reconstruction, prescribing fewer tablets is associated with lower postoperative opioid consumption, according to a research letter published in the June 25 issue of the Journal of the American Medical Association.

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Uncontrolled Diabetes, Hypertension Rates High in CKD Patients

THURSDAY, July 11, 2019 (HealthDay News) — For patients with chronic kidney disease (CKD), the prevalence of uncontrolled hypertension and diabetes is high and has not improved over time, according to a study published online July 11 in the Clinical Journal of the American Society of Nephrology.

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Awareness, Use of PrEP on Rise Among Men Who Have Sex With Men

THURSDAY, July 11, 2019 (HealthDay News) — There has been a recent increase in the awareness and use of HIV preexposure prophylaxis (PrEP) among men who have sex with men (MSM), according to research published in the July 12 issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.

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Medicare Drug Rebate Plan Withdrawn by Trump Administration

THURSDAY, July 11, 2019 (HealthDay News) — A plan to let Medicare patients receive rebates that drug companies currently pay to insurers and middlemen has been withdrawn by the Trump administration.

AP News Article

Exposure to 2009 pH1N1 Vaccine During Pregnancy Seems Safe

THURSDAY, July 11, 2019 (HealthDay News) — Exposure to the 2009 pandemic H1N1 (pH1N1) influenza vaccine in pregnancy is not associated with most negative health outcomes among offspring, according to a study published online July 10 in The BMJ.

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Rimegepant Shows Promise for Relief From Migraine Attacks

THURSDAY, July 11, 2019 (HealthDay News) — Compared with placebo, rimegepant, an orally administered, small-molecule, calcitonin gene-related peptide (CGRP) receptor antagonist, can increase the percentage of patients free of pain and free from their most bothersome symptom during a migraine attack, according to a study published in the July 11 issue of the New England Journal of Medicine.

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Hospitalized Pneumonia Patients Often Get Excess Antibiotics

THURSDAY, July 11, 2019 (HealthDay News) — Patients hospitalized with pneumonia often receive excess antibiotic therapy, according to a study published online July 9 in the Annals of Internal Medicine.

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Oliceridine Studied for IV Pain Relief After Abdominoplasty

THURSDAY, July 11, 2019 (HealthDay News) — Oliceridine is being proposed as an analgesic option for the relief of moderate-to-severe acute postoperative pain, according to a study recently published in Pain Practice.

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Health Care Professionals Exhibit Gender Bias

THURSDAY, July 11, 2019 (HealthDay News) — Survey results show that health care professionals have implicit and explicit gender bias, according to a study published online July 5 in JAMA Network Open.

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Editorial

Galcanezumab Can Cut Frequency of Cluster Headache Attacks

WEDNESDAY, July 10, 2019 (HealthDay News) — Galcanezumab can reduce the frequency of episodic cluster headache attacks, according to a study published in the July 11 issue of the New England Journal of Medicine.

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Lab Tests Show Experimental Ebola Treatments Effective

WEDNESDAY, July 10, 2019 (HealthDay News) — Two experimental Ebola treatments being used in the current outbreak in eastern Democratic Republic of the Congo have proved effective in laboratory tests with human cells, according to the U.S. Centers for Disease Control and Prevention. The study was published online July 9 in the The Lancet Infectious Diseases.

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Press Release: CDC

Guidance Updated for Managing Infants at Risk for Group B Strep

WEDNESDAY, July 10, 2019 (HealthDay News) — Guidelines for the management and treatment of group B streptococcal (GBS) disease in infants were published online July 8 in Pediatrics.

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Two Algorithms Can ID Patients at Risk for HIV, PrEP Candidates

WEDNESDAY, July 10, 2019 (HealthDay News) — Two new research papers, published online July 5 in The Lancet HIV, present algorithms that can help identify patients at risk for HIV and candidates for preexposure prophylaxis (PrEP).

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About 12 Percent With Ankle Sprain Fill Opioid Prescriptions

WEDNESDAY, July 10, 2019 (HealthDay News) — Overall, 11.9 percent of patients diagnosed with an ankle sprain fill an opioid prescription within seven days of diagnosis, according to a research letter published online July 9 in the Annals of Internal Medicine.

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Two-Dose Course of Vaccine After HSCT Cuts Incidence of Zoster

WEDNESDAY, July 10, 2019 (HealthDay News) — A two-dose course of recombinant zoster vaccine is associated with a reduction in the incidence of herpes zoster among adults who have undergone autologous hematopoietic stem cell transplantation (HSCT), according to a study published in the July 9 issue of the Journal of the American Medical Association.

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High Incarceration Rates Tied to More Drug-Related Deaths

WEDNESDAY, July 10, 2019 (HealthDay News) — Reduced household income and high incarceration rates are associated with drug-related deaths, according to a study published in the July issue of The Lancet Public Health.

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Xpovio With Dexamethasone Approved for Refractory Multiple Myeloma

TUESDAY, July 9, 2019 (HealthDay News) — Xpovio (selinexor) tablets have been approved for use in combination with dexamethasone to treat adults with relapsed refractory multiple myeloma, the U.S. Food and Drug Administration announced last week.

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Rule Requiring Drug Prices in TV Ads Blocked by Judge

TUESDAY, July 9, 2019 (HealthDay News) — A Trump administration rule to force pharmaceutical companies to disclose the list prices of their drugs in television ads was blocked Monday by a federal judge.

The New York Times Article

Androgen Deprivation Therapy May Up Risk of Alzheimer Disease

TUESDAY, July 9, 2019 (HealthDay News) — Among elderly patients with prostate cancer, androgen deprivation therapy (ADT) exposure is associated with subsequent diagnosis of Alzheimer disease or dementia, according to a study published online July 3 in JAMA Network Open.

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History of Liver Disease Does Not Impact Efficacy of Edoxaban

TUESDAY, July 9, 2019 (HealthDay News) — For patients with atrial fibrillation (AF), the efficacy and safety of edoxaban versus warfarin is not altered with a history of liver disease, according to a study published in the July 16 issue of the Journal of the American College of Cardiology.

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Most Supplements Offer Little Protection Against Heart Disease

MONDAY, July 8, 2019 (HealthDay News) — Certain nutritional supplements and dietary interventions may reduce the risk for some cardiovascular outcomes in adults; however, the overall effect of nutritional supplements on cardiovascular disease outcomes remains unclear, according to a review published online July 9 in the Annals of Internal Medicine.

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Eye Drops, Ointments Sold at Walgreens Recalled

MONDAY, July 8, 2019 (HealthDay News) — A number of over-the-counter eye products sold at Walgreens have been recalled by manufacturer Altaire Pharmaceuticals because the products may not be sterile.

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Early Warning Signs May Predate Eating Disorder Onset

MONDAY, July 8, 2019 (HealthDay News) — Early warning signs may help providers identify eating disorders earlier, according to a study published online July 1 in the British Journal of Psychiatry.

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Survey Reveals Gaps in Opioid Rx Patterns of Orthopedic Surgeons

MONDAY, July 8, 2019 (HealthDay News) — The vast majority of orthopedic surgeons recommend prescribing a nine-day supply of around-the-clock oxycodone doses following commonly performed orthopedic surgeries, according to a study published in the May/June issue of the Journal of Opioid Management.

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Treating Depression May Reduce Mortality in Diabetes Patients

MONDAY, July 8, 2019 (HealthDay News) — The use of most types of antidepressants (ATDs) is associated with significantly reduced mortality among patients with diabetes mellitus (DM) and comorbid depression, according to a study published online July 2 in the Journal of Clinical Endocrinology & Metabolism.

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45 Percent of U.S. Adults Have Some Doubts About Vaccine Safety

MONDAY, July 8, 2019 (HealthDay News) — Just under half of U.S. adults have some doubts about vaccine safety, according to a survey released by the American Osteopathic Association.

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Most Adult-Use Cannabis Customers Use for Pain, Sleep Relief

WEDNESDAY, July 3, 2019 (HealthDay News) — De facto medical use of cannabis for symptom relief is common among adult-use dispensary customers in Colorado, according to a study published online July 2 in the Journal of Psychoactive Drugs.

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DOJ Asks Congress to Permanently Classify Fentanyl-Like Drugs

WEDNESDAY, July 3, 2019 (HealthDay News) — A temporary order classifying fentanyl-like drugs as controlled substances should be enacted into law, the U.S. Department of Justice is telling Congress.

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Lack of Evidence for Treating Chronic Pain in Children

WEDNESDAY, July 3, 2019 (HealthDay News) — There is a lack of evidence on the efficacy and safety of pharmacological treatments for chronic pain in children, according to research published online June 19 in PAIN.

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Tanezumab Improves Scores for Pain, Function in Osteoarthritis

WEDNESDAY, July 3, 2019 (HealthDay News) — For patients with osteoarthritis (OA) of the knee or hip, tanezumab is associated with significant improvements in pain and physical function versus placebo, according to a study published in the July 2 issue of the Journal of the American Medical Association.

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Interventions Linked to Drop in Unvaccinated Kindergartners

WEDNESDAY, July 3, 2019 (HealthDay News) — Statewide legislative and educational interventions are associated with a reduction in the yearly rates of kindergartners without up-to-date vaccination status, according to a study published in the July 2 issue of the Journal of the American Medical Association.

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Most U.S. Adults Are Concerned About Antibiotic Resistance

WEDNESDAY, July 3, 2019 (HealthDay News) — Most U.S. adults have heard of and are concerned about antibiotic resistance, but 45 percent report having not taken antibiotics as prescribed, according to a report published online June 21 by the Kaiser Family Foundation.

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Anti-Vaccine Movement a ‘Man-Made’ Health Crisis, Scientists Warn

TUESDAY, July 2, 2019 (HealthDay News) — The anti-vaccination movement is now a global crisis, an international panel of scientists say, and everyone must do more to combat it.

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The Salzburg Statement on Vaccination Acceptance

Statin Use Associated With Higher Incidence of Diabetes

TUESDAY, July 2, 2019 (HealthDay News) — There may be a dose-dependent relationship between statin therapy and new-onset diabetes across the duration of statin use, according to a study recently published in Diabetes Metabolism Research and Reviews.

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Guidance Issued for Management of Fontan Circulation

TUESDAY, July 2, 2019 (HealthDay News) — A scientific statement with recommendations for follow-up care in patients with Fontan circulation surviving into adulthood was published online July 1 in Circulation.

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In Utero Opioid Exposure Tied to Poor Outcomes Throughout Childhood

TUESDAY, July 2, 2019 (HealthDay News) — In utero exposure to opioids is associated with higher risks for short- and long-term adverse outcomes, including preterm birth and neurodevelopmental and physical health disorders in children, according to a study published online June 28 in JAMA Network Open.

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Stewardship Intervention Can Cut Inappropriate Rx by a Third

MONDAY, July 1, 2019 (HealthDay News) — Antibiotic stewardship interventions for acute respiratory infection (ARI) can significantly reduce overuse in emergency departments and urgent care centers, according to a study published online June 19 in Academic Emergency Medicine.

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Metformin May Cut Mortality Risk in Post-Pancreatitis Diabetes

MONDAY, July 1, 2019 (HealthDay News) — Metformin use may promote a survival benefit in individuals with post-pancreatitis diabetes mellitus (PPDM), but not pancreatic cancer-related diabetes (PCRD), according to a study published online June 21 in Diabetes Care.

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Most Grandparents Store Meds in Containers That Are Easy to Open

MONDAY, July 1, 2019 (HealthDay News) — More than one in four grandparents report storing prescription medications in containers, primarily easy-to-open containers, according to a report published online July 1 by the National Poll on Healthy Aging.

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Romosozumab Increases Bone Formation, Cuts Bone Resorption

MONDAY, July 1, 2019 (HealthDay News) — For postmenopausal women with osteoporosis, romosozumab increases bone formation and decreases bone resorption, according to a study published online June 24 in the Journal of Bone and Mineral Research.

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