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Incidence of HTN Disorders of Pregnancy Underestimated

Women with history of HDP have increased risk for stroke, cardiac arrhythmias, chronic kidney disease

TUESDAY, May 5, 2020 (HealthDay News) — The incidence of hypertensive disorders of pregnancy (HDP) is underestimated when assessed on a per-pregnancy basis and confers a significant increase in risks for cardiovascular and kidney diseases, according to a study published in the May 12 issue of the Journal of the American College of Cardiology.

Vesna D. Garovic, M.D., Ph.D., from the Mayo Clinic College of Medicine in Rochester, Minnesota, and colleagues identified women of Olmstead County, Minnesota, who delivered between 1976 and 1982 and classified pregnancies into normotensive, gestational hypertension, preeclampsia, eclampsia, preeclampsia superimposed on chronic hypertension, and chronic hypertension. The incidence of HDP was calculated per pregnancy and per woman.

The researchers found that 7.3 and 3.3 percent of the 9,862 pregnancies involved HDP and preeclampsia, respectively. When assessed on a per-woman basis, the incidence of HDP and preeclampsia doubled: 15.3 percent (281 of 1,839) and 7.5 percent (138 of 1,839), respectively. The risks for subsequent diagnoses of stroke, coronary artery disease, cardiac arrhythmias, chronic kidney disease, and multimorbidity were elevated for women with a history of HDP (hazard ratios, 2.27, 1.89, 1.62, 2.41, and 1.25, respectively).

“Our study provides a population-based incidence of HDP and preeclampsia, both per-pregnancy and per-woman, and suggests that the former may underestimate the number of affected women with a history of these conditions who may be at risk for future cardiovascular disease and renal disease,” the authors write.

One author disclosed financial ties to Biogen.

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