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Hip, Nonvertebral Fracture Risk Up in Those With Diabetes

Risk for fracture at hip higher in younger population with type 1, type 2 diabetes

MONDAY, June 15, 2020 (HealthDay News) — Individuals with diabetes have an increased risk for hip and nonvertebral fractures, according to a study published in the August issue of Bone.

Tatiane Vilaca, M.D., from the Mellanby Centre for Bone Research at the University of Sheffield in the United Kingdom, and colleagues conducted an updated review to examine the risk for hip and nonvertebral fractures in diabetes. Forty-two records were included in the hip fracture analysis, with data from 17,571,738 participants with 319,652 fractures; the nonvertebral fracture review included 17 records, with data from 2,978,487 participants with 181,228 fractures.

The researchers identified an increase in fracture risk with diabetes for both hip fractures (relative risk, 4.93 [95 percent confidence interval, 3.06 to 7.95] and 1.33 [95 percent confidence interval, 1.19 to 1.49] for type 1 and type 2 diabetes, respectively) and nonvertebral fractures (relative risk, 1.92 [95 percent confidence interval, 0.92 to 3.99] and 1.19 [95 percent confidence interval, 1.11 to 1.28] for type 1 and type 2 diabetes, respectively). The risk for fracture at the hip was higher in the younger population for both type 1 and type 2 diabetes. Longer diabetes duration and insulin use were found to be associated with an increased risk in those with type 2 diabetes.

“We hope that by raising awareness about the greater risk people with diabetes face, bone density and bone strength will become something that doctors assess routinely in patients with the condition in the same way they do currently for other well-known complications,” a coauthor said in a statement.

Several authors disclosed financial ties to pharmaceutical companies, including Amgen, which funded the study.

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