Home News Bones and Joints and Muscles News Asthma, COPD Linked to Higher Risk for Rheumatoid Arthritis

Asthma, COPD Linked to Higher Risk for Rheumatoid Arthritis

Risk for rheumatoid arthritis up after adjustment for covariates, including smoking pack-years/status

TUESDAY, March 10, 2020 (HealthDay News) — Asthma and chronic obstructive pulmonary disease (COPD) are associated with an increased risk for rheumatoid arthritis (RA), according to a study published online March 4 in Arthritis & Rheumatology.

Julia A. Ford, M.D., from Brigham and Women’s Hospital in Boston, and colleagues performed a prospective cohort study involving 205,153 women in the Nurses’ Health Study (NHS) and NHSII to examine whether asthma or COPD were associated with RA.

During 4,384,471 person-years of follow-up, the researchers identified 15,148 women with confirmed asthma; 3,573 with confirmed COPD; and 1,060 incident RA cases. Compared with no asthma/COPD, after adjustment for covariates, including smoking pack-years/status, asthma was associated with increased RA risk (hazard ratio, 1.53). Among never-smokers only, asthma remained associated with increased RA risk (hazard ratio, 1.53). COPD was also associated with elevated RA risk (hazard ratio, 1.89). In the subgroup of ever-smokers aged >55 years, the associations of COPD with RA were most pronounced (hazard ratio, 2.20).

“These novel findings further implicate chronic airway inflammation in the pathogenesis of RA, and they identify populations at-risk for RA for the purposes of research as well as informing clinical care,” the authors write.

Several authors disclosed financial ties to the biopharmaceutical industry.

Abstract/Full Text (subscription or payment may be required)

Copyright © 2020 HealthDay. All rights reserved.