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April 2019 Briefing – Pathology

Here are what the editors at HealthDay consider to be the most important developments in Pathology for April 2019. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are the most likely to affect clinical practice.

Rare Variants Identified in DENND1A Gene in PCOS

TUESDAY, April 30, 2019 (HealthDay News) — Rare variants have been identified in the DENND1A gene that are associated with hormonal traits of polycystic ovary syndrome (PCOS), according to research published online April 30 in the Journal of Clinical Endocrinology & Metabolism.

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Ambiguous Genitalia in Newborns Not Uncommon

MONDAY, April 29, 2019 (HealthDay News) — Ambiguous genitalia in newborns may be more common than previously thought, according to a study published online April 24 in the Journal of the Endocrine Society.

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EHR Decision Support Can Reduce Inappropriate GI Testing

MONDAY, April 29, 2019 (HealthDay News) — Electronic health record (EHR) decision support reduces inappropriate use of an expensive gastrointestinal test for patients hospitalized with diarrhea, according to a study published online April 23 in Infection Control & Hospital Epidemiology.

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Minor Birth Defects Up in Progeny of Female Gulf War Veterans

THURSDAY, April 25, 2019 (HealthDay News) — The odds of having a child with a minor birth defect are about five times higher for women veterans deployed during the Gulf War (DV) versus nondeployed women veterans (NDV), according to a study published in the April issue of the Journal of Occupational and Environmental Medicine.

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Machine Learning Can Speed Diagnosis of Genetic Diseases in Children

THURSDAY, April 25, 2019 (HealthDay News) — A machine learning process and clinical natural language processing (CNLP) can rapidly diagnose rare genetic diseases, according to a study published in the April 24 issue of Science Translational Medicine.

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Six Prognostic Factors ID’d for Invasive Disease After DCIS

THURSDAY, April 25, 2019 (HealthDay News) — In a review published online April 25 in Cancer Epidemiology, Biomarkers & Prevention, six prognostic factors are identified that may predict invasive disease after a diagnosis of ductal carcinoma in situ (DCIS).

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AAP Updates Guidance for Care in Neurofibromatosis Type 1

WEDNESDAY, April 24, 2019 (HealthDay News) — Guidance has been updated for the health supervision of children with neurofibromatosis type 1 (NF1), according to a clinical report from the American Academy of Pediatrics published online April 22 in Pediatrics.

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Personalizing Breast Cancer Tx Could Cut Initial Costs of Care

WEDNESDAY, April 24, 2019 (HealthDay News) — Personalizing breast cancer treatment based on Oncotype DX recurrence scores could result in small decreases in costs in the initial 12 months of care, according to a study published online April 24 in the Journal of the National Cancer Institute.

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Obesity May Impact the Form and Structure of the Brain

TUESDAY, April 23, 2019 (HealthDay News) — Obesity is associated with differences in gray matter volumes in the brain, according to a study published online April 23 in Radiology.

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Financial Incentives Do Not Boost Use of At-Home CRC Screening Tests

MONDAY, April 22, 2019 (HealthDay News) — Financial incentives do not increase response rates among patients mailed at-home colorectal cancer screening tests, according to a study published online March 22 in JAMA Network Open.

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National Hand Hygiene Initiative Successful in Australia

FRIDAY, April 19, 2019 (HealthDay News) — The National Hand Hygiene Initiative (NHHI) has successfully sustained improvement in hand hygiene compliance, according to a study recently published in The Lancet Infectious Diseases and presented at the European Congress of Clinical Microbiology & Infectious Diseases, held from April 13 to 16 in Amsterdam.

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Elevated Blood Lead Levels Prevalent Among Refugee Children

FRIDAY, April 19, 2019 (HealthDay News) — Almost 20 percent of refugee children have elevated blood lead levels (EBLLs), according to a study published online April 15 in Pediatrics.

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Conception by IVF May Increase Risk for Rare Childhood Cancer

FRIDAY, April 19, 2019 (HealthDay News) — There is a small association between conception by in vitro fertilization (IVF) and childhood cancer, particularly hepatic tumors, according to a study published online April 1 in JAMA Pediatrics.

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Loan Forgiveness, Educational Debt May Affect Practice Patterns

FRIDAY, April 19, 2019 (HealthDay News) — Increased educational debt appears to directly influence physician practice choice, according to a study published in the April issue of the Journal of the American Osteopathic Association.

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Sixty People Charged in Massive Opioid Painkiller Investigation

THURSDAY, April 18, 2019 (HealthDay News) — Fifty-three medical professionals, including 31 doctors, are among the 60 people charged by U.S. authorities for their alleged involvement in the illegal prescribing and distribution of opioid painkillers.

AP News Article

Machine Learning IDs Risk for Familial Hypercholesterolemia

THURSDAY, April 18, 2019 (HealthDay News) — A machine learning classifier can effectively identify patients at risk for familial hypercholesterolemia (FH), according to a study published online April 11 in npj Digital Medicine.

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Infections May Up Risk for Developing Sjögren Syndrome

THURSDAY, April 18, 2019 (HealthDay News) — Individuals with a history of infection have double the risk for developing Sjögren syndrome, according to a study published online March 20 in the Journal of Internal Medicine.

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Microbial Features ID’d for Pediatric Irritable Bowel Syndrome

WEDNESDAY, April 17, 2019 (HealthDay News) — Microbial and metabolic features can distinguish children with irritable bowel syndrome (IBS) from controls, according to a study published online April 17 in the Journal of Molecular Diagnostics.

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Low Scam Awareness May Indicate Alzheimer Risk in Seniors

TUESDAY, April 16, 2019 (HealthDay News) — Low scam awareness is associated with an increased risk for Alzheimer disease and mild cognitive impairment among older adults, according to a study published online April 16 in the Annals of Internal Medicine.

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Standardizing Demographics Ups Accuracy of Patient Matching

MONDAY, April 15, 2019 (HealthDay News) — Standardizing demographic data can improve the accuracy of patient matching, according to a study published in the May issue of the Journal of the American Medical Informatics Association.

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WHO: Congo Ebola Outbreak Still Not a Global Emergency

MONDAY, April 15, 2019 (HealthDay News) — The ongoing Ebola outbreak in Congo is of “deep concern” but does not yet qualify as a global emergency, the World Health Organization says.

AP News Article

Terminally Ill People in New Jersey Given Right to End Lives

MONDAY, April 15, 2019 (HealthDay News) — Terminally ill adults in New Jersey will soon be allowed to seek medical help to end their lives.

CNN Article

Prevalence of Extragenital STDs High in Men Who Have Sex With Men

FRIDAY, April 12, 2019 (HealthDay News) — Extragenital (rectal and pharyngeal) chlamydia and gonorrhea are prevalent among men who have sex with men (MSM), according to research published in the April 12 issue of the U.S. Centers for Disease Control and Prevention Morbidity and Mortality Weekly Report.

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CDC: Superbug Fungus Has Sickened 600 Americans

THURSDAY, April 11, 2019 (HealthDay News) — The United States has had more than 600 cases of infection with a type of fungus called a “serious global health threat” by the U.S. Centers for Disease Control and Prevention.

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Domestic Responsibilities Tied to Physician Mothers’ Satisfaction

THURSDAY, April 11, 2019 (HealthDay News) — For physician mothers in procedural specialties, being responsible for five or more domestic tasks is associated with an increased likelihood of career dissatisfaction, according to a study published online April 10 in JAMA Surgery.

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Very Low LDL-C, Triglycerides Tied to Hemorrhagic Stroke Risk in Women

THURSDAY, April 11, 2019 (HealthDay News) — Women with very low low-density lipoprotein cholesterol (LDL-C) or low triglycerides have an increased risk for hemorrhagic stroke, according to a study published online April 10 in Neurology.

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Same Services More Expensive in Outpatient Than Office Settings

WEDNESDAY, April 10, 2019 (HealthDay News) — The same services are more expensive when performed in outpatient versus office settings, according to a blog post from the Health Care Cost Institute.

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Recurrence Score May Cut Costs for High-Risk Breast Cancer Care

WEDNESDAY, April 10, 2019 (HealthDay News) — Genomic recurrence score (RS) testing using a 21-gene assay is associated with decreased cancer care costs in real-world practice among certain patients with breast cancer who would otherwise receive standard chemotherapy, according to a study published in the March issue of the Journal of the National Comprehensive Cancer Network.

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Haptoglobin Expression Tied to Outcomes in Preterm Newborns

WEDNESDAY, April 10, 2019 (HealthDay News) — The absence of haptoglobin (Hp) may be a marker of poor neonatal outcomes among preterm newborns exposed to in utero inflammation, according to a secondary analysis of a randomized controlled trial published online March 22 in EClinicalMedicine.

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Genetic Testing Underused in Breast, Ovarian Cancer

TUESDAY, April 9, 2019 (HealthDay News) — Only one-quarter of those with breast cancer and one-third with ovarian cancer undergo genetic testing, according to a study published online April 9 in the Journal of Clinical Oncology.

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New, Revised Topics Released in ACR Appropriateness Criteria

TUESDAY, April 9, 2019 (HealthDay News) — The latest edition of the American College of Radiology (ACR) Appropriateness Criteria has been released and includes 188 diagnostic imaging and interventional radiology topics, with 908 clinical variants covering more than 1,670 clinical scenarios.

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Proximity to Major Roadways Impacts Child Development

TUESDAY, April 9, 2019 (HealthDay News) — Proximity to major roadways and prenatal/early life exposure to particulate matter <2.5 µm (PM2.5) and ozone (O3) are associated with childhood developmental delays, according to a study published online April 9 in Environmental Research.

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Genetic Research Results May Warrant Updates to Participants

MONDAY, April 8, 2019 (HealthDay News) — In certain cases, research participants should be recontacted to be provided with updates on reinterpretation of variants, according to a position statement published in the April 4 issue of the American Journal of Human Genetics.

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Alcohol, Drug Misuse Tied to Long-Term Health Problems

MONDAY, April 8, 2019 (HealthDay News) — More than one-third of U.S. adults in recovery for alcohol and other drug (AOD) use have health problems related to previous substance use, according to a study published online March 16 in the Journal of Addiction Medicine.

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Female Infertility Specialists Make Less Than Male Specialists

FRIDAY, April 5, 2019 (HealthDay News) — Although women outnumber men as obstetrician/gynecology clinicians, they still make significantly less money even in subspecialties like reproductive endocrinology and infertility (REI), according to a study published online March 25 in Fertility and Sterility.

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Histologic Clearance of CIN2/3 Seen With HPV Therapeutic Vaccine

FRIDAY, April 5, 2019 (HealthDay News) — For women with cervical intraepithelial neoplasia (CIN) grade 2 or 3 associated with high-risk human papillomavirus (HPV), an immunotherapeutic tipapkinogen sovacivec (TS) HPV vaccine is effective for achieving histologic resolution, according to a study published online April 4 in Gynecologic Oncology.

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Adherence to Prenatal Screening Recommendations Varies by Lab

THURSDAY, April 4, 2019 (HealthDay News) — Laboratories vary in the extent to which they adhere to recommendations from the American College of Medical Genetics and Genomics (ACMG) for noninvasive prenatal screening (NIPS), according to a study published online April 3 in Genetics in Medicine.

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Americans Borrowed $88 Billion in Past Year to Pay for Health Care

TUESDAY, April 2, 2019 (HealthDay News) — About one in eight Americans borrowed a total of $88 billion in the past year to pay for health care, a new West Health-Gallup survey shows.

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Amyloid PET Linked to Changes in Management for MCI, Dementia

TUESDAY, April 2, 2019 (HealthDay News) — For Medicare beneficiaries with mild cognitive impairment (MCI) or dementia of uncertain etiology, amyloid positron emission tomography (PET) is associated with changes in clinical management, according to a study published in the April 2 issue of the Journal of the American Medical Association.

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Guidelines for Asymptomatic Bacteriuria Updated

TUESDAY, April 2, 2019 (HealthDay News) — Recommendations have been updated for the management of asymptomatic bacteriuria (ASB); the Infectious Diseases Society of America clinical practice guideline was published online March 21 in Clinical Infectious Diseases.

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Sex Hormone Levels May Impact Development of Asthma

TUESDAY, April 2, 2019 (HealthDay News) — Sex hormones may impact the risk for asthma, with elevated sex hormone-binding globulin (SHBG) demonstrating a protective effect in females, according to research recently published in Thorax.

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Over-the-Counter Meds Save Health Care System Money

TUESDAY, April 2, 2019 (HealthDay News) — On average, each dollar spent on over-the-counter (OTC) medicines saves the U.S. health care system $7.20, totaling nearly $146 billion in annual savings, according to a report released March 18 by the Consumer Healthcare Products Association (CHPA).

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Nasopharyngeal Microbiota Could Help Diagnose Pediatric LRTIs

MONDAY, April 1, 2019 (HealthDay News) — Nasopharyngeal microbiota seem to serve as a valid proxy for lower respiratory tract microbiota in lower respiratory tract infections (LRTIs) among children, according to a study published online March 15 in The Lancet Respiratory Medicine.

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