Low-Cost, Fixed-Dose Polypill Reduces Risk for Major CV Events

Drop in risk for major cardiovascular events even greater for those with high adherence to polypill

Radiologists Performing More Paracenteses, Thoracenteses

2004 to 2016 saw increase in paracentesis, thoracentesis procedures performed by radiologists

Weight Loss Feasible Regardless of Psychiatric Meds Use

Weight loss amount similar for women taking and not taking psychiatric medications

Prurigo Nodularis Associated With Mental Health Disorders

Odds increased for mental health disorders, HIV infection, systemic illnesses

Prevalence of Celiac Disease High in First-Degree Relatives

FDRs with villous atrophy identified with high sensitivity and specificity by anti-TTG ≥2.75 of ULN

Most HPV-Linked Cancers Due to Types Targeted by 9vHPV Vaccine

In 2012 to 2016, 92 percent of cancers attributable to HPV due to HPV types targeted by 9vHPV vaccine

Hospitalizations With Psych Diagnosis Common in ESKD

Dialysis adults hospitalized with psychiatric diagnoses have higher risk of all-cause death

Reduction in PTSD Symptoms Linked to Decrease in T2DM

Patients with clinically meaningful reduction in PTSD Checklist score less likely to develop type 2 diabetes

Antibiotic Use Tied to Higher Risk of Rheumatoid Arthritis

Findings show a dose- or frequency-dependent association; all antibiotic classes linked to higher odds for RA

As-Needed Inhaler Use an Option for Children With Mild Asthma

Study in African-American children shows symptom-based adjustment of inhaled corticosteroids is feasible

Risk Factors ID’d for Worse QOL From Knee Osteoarthritis

Female gender, overweight, smoking, knee pain, lower income tied to rapidly worsening quality of life

Intensifying BP Meds at Hospital Discharge May Harm Elderly

Risk for readmissions and adverse effects higher, no long-term benefit for BP control or cardiac risk

Some Cities in Texas Susceptible to Measles Outbreaks

If vaccination rates continue to drop, considerable increase in potential outbreak predicted

Many Providers Fail to Discuss Sun-Safe Behaviors With Patients

Skin cancer counseling often takes backseat due to lack of time, other pressing health issues

Tuberculosis Rates for U.S. Children Are Low and Declining

Disparities persist by race, ethnicity, geography; incidence higher for those living in U.S.-affiliated islands

Rx Size Predicts Persistent Opioid Use After Cardiothoracic Surgery

Patients prescribed more than 450 oral morphine equivalents have more new persistent opioid use

More Physical Activity at Any Intensity May Reduce Mortality

Higher levels of total physical activity, less time spent sedentary linked to lower mortality risk

WHO: Microplastics in Drinking Water Not a Health Risk

Microplastics are 'ubiquitous in the environment' and have been found in both bottled and tap water

Opioid Addiction Treatment Used More in States That Expanded Medicaid

Fivefold increase seen in Medicaid-covered prescriptions for buprenorphine during 2011 to 2018

Online Information About Diabetic Retinopathy Is Poor

Analysis of 11 websites shows poor quality, varying accuracy, low readability

Multidrug-Resistant Salmonella Outbreak Characterized

255 cases of infection identified in 32 states; infections linked to consumption of soft cheese, beef

Coverage With HPV Vaccine Continuing to Increase in Boys

Teens whose parents received a provider recommendation had higher coverage with HPV vaccine

Type 2 Diabetes May Impact Sleep in Middle-Aged Women

Findings show more sleep-related symptoms of symptoms of higher severity

Type 2 Diabetes Risk Up With Inflammatory Bowel Disease

Risk significantly higher for patients receiving diagnosis of IBD from 2003 through 2014 versus earlier

Type 2 Diabetes Associated With Poorer Outcomes in Heart Failure

Findings include structural abnormalities in the heart, poorer quality of life with T2DM and HF

Quitting Smoking Linked to Lower CVD Risk Within Five Years

However, compared with never smokers, former smokers' risk remains elevated beyond five years

Exposure to Air Pollutants May Up Risk for Macular Degeneration

Risk for age-related macular degeneration greater in highest versus lowest quartiles of NO2, CO

Private Rooms Help Sustain Lower Rates of Some Nosocomial Colonization

Reduction seen in VRE infections, colonization; MRSA colonization but not infection reduced

Taking Buprenorphine for Opioid Use Disorder May Up Other Med Compliance

Findings seen among those taking buprenorphine and any of five other drug classes

Women With Diabetes More Likely Than Men to Not Take Meds as Prescribed

Younger adults more likely to not take meds as prescribed and to ask for lower-cost medication

High, Increasing BP in Midlife Tied to Brain Changes in Late Life

Higher DBP at age 43 years, greater increases from 36 to 43 linked to smaller whole-brain volume at 69 to 71

Family History of Diabetes Tied to Higher BMD in Normoglycemia

Lumbar spine, femoral neck BMD higher in postmenopausal women with first-degree family history

Depression, Substance Use Increasing in Former Smokers

2005 to 2016 saw increase in prevalence of major depression; marijuana use increased from 2002 to 2016

Short-Term Exposure to PM10 and PM2.5 Affects Mortality

Risk for daily all-cause, cardiovascular, respiratory mortality up with short-term exposure

Serelaxin Does Not Lower CV Death in Acute Heart Failure

No drop in incidence of death at 180 days or worsening of heart failure seen for hospitalized patients

Facial Involvement in Primary Headaches Occurs Infrequently

Facial pain reported as independent or additional symptom in 291 patients of 2,912 patient data sets

Oral Antibiotic Use Linked to Risk for Colorectal Cancer

Risk for colon cancer increased, risk for rectal cancer reduced in association with oral antibiotic use

Odds of Developing C. Diff Increased in Older Cancer Patients

Risk for Clostridiodes difficile infection significantly greater with diagnosis of liquid tumors

Virtual Reality Program Reduces Pain in Hospitalized Patients

Virtual reality helped reduce pain compared with control, was particularly effective for severe pain

Mobile Stroke Unit Speeds Access to Intraarterial Thrombectomy

Prehospital management on MSU speeds access versus EMS, but difference attenuated since 2014

MRI Shows Vaping Has Transient Impact on Vascular Function

In healthy nonsmokers, inhaling nicotine-free e-cigarette aerosol impacts endothelial function

Factors ID’d in Pregnancy Chances After Kidney Transplant

Likelihood of pregnancy after kidney transplant higher for Hispanic versus white women

Lipophilic Statins May Cut Liver Cancer in Chronic Viral Hepatitis

Inverse link is dose-dependent; lowest 10-year HCC risk seen with 600 or more lipophilic statin cDDDs

Certain Dietary Supplements Tied to Dysphagia, Choking in Seniors

Most reports of swallowing complications involve multivitamins or calcium supplements

Use of Opioids + Cannabis Tied to Poorer Mental Health

Co-use associated with anxiety and depression symptoms compared with opioid use alone

Childhood-Onset IBD Ups Risk for Psychiatric Morbidity

Risk significantly increased for suicide attempt and mood, anxiety, personality, eating disorders

Association for Diabetes, Stroke Risk Varies by Age, Race, Sex

For under 65s, stroke risk increased for white women and men, black women, but not black men

Minority, Low-Income Individuals Less Likely to Receive Oral Cancer Screening

Education level, insurance type also may affect likelihood of oral cancer screening at dental visit

Most U.K. Patients With UTI Receive Antibiotics on Same Day

Represcription rate at 28 days only 4.1 percent from 2011 to 2015; slight increase seen for men over time

Planned Parenthood Withdraws From Federal Family Planning Program

Centers across the U.S. will remain open and the group will attempt to replace loss of federal funding

DAAs Cut Deaths in Those Treated for HCV-Related Liver Cancer

Findings seen for patients receiving direct-acting antivirals with complete response to liver cancer treatment

Exposure to Pollution May Up Risk for Psychiatric Disorders

Higher rates of bipolar disorder, major depression linked to poor air quality in U.S., Denmark cohorts

Some Pregnant Women Exposed to Common MRI Contrast Agent

Exposure often occurs early in the pregnancy, likely before pregnancy has been recognized

USPSTF Recommends Genetic Counseling for High BRCA Risk

But counseling not recommended for women without personal, family history, ancestry associated with BRCA mutations

Patient Preferences Explored in Multiple Myeloma Treatment

All-oral regimen linked to higher satisfaction with treatment convenience in relapsed, refractory MM

Parents Divided on Primary Care Policies for Unvaccinated Patients

Many parents unaware of policies for unvaccinated children in their child's primary care office

GERD Associated With Chronic Temporomandibular Disorder

Somatization, anxiety, and undermined sleep moderately mediated correlation between GERD, TMD

BP Outside of Clinic May Better Predict Outcomes in Black Patients

Higher systolic blood pressure measured with ambulatory monitoring tied to cardiovascular events, mortality

Alcohol Consumption in Pregnancy Ups Miscarriage Risk

Findings show dose-dependent response when consumption is more than five drinks per week

Mechanical, Oral Antibiotic Bowel Prep Yields No Benefit for Colectomy

Authors urge reconsideration of recommendations for these types of bowel preps for elective colectomy

Parent-Targeted Intervention Can Up Communication With Teens

Intervention increased adolescent-reported frequency of parent-teen communication about sex, alcohol

Hypoglycemia Up With Intensive Glucose-Lowering Therapy

Intensive therapy resulted in estimated 9,578 hospitalizations, ED visits for hypoglycemia over two years

Genetic Liability to Insomnia Linked to Increased Odds of CVDs

Mendelian randomization analyses revealed greater odds of CAD, heart failure, ischemic stroke

VA Mental Health Initiative Linked to Improved Access to Care

Addition of mental health specialists at primary care clinics increased utilization but also cost

AHA: Prescription Omega-3 Fatty Acids Effectively Lower Triglycerides

4 g daily EPA+DHA or EPA only effective and safe for use as monotherapy or in combination

Extreme Risk Protection Orders May Help in Averting Shootings

Urgent individualized intervention may play role in efforts for prevention in analysis of cases in California

Maternal Exposure to Fluoride Linked to Lower Offspring IQ

Higher daily intake of fluoride among pregnant women linked to 3.66-point lower IQ score in boys, girls

Periop Covert Stroke ID’d in 7 Percent of Older Surgery Patients

Perioperative covert stroke tied to increased risk for cognitive decline one year after surgery

Cases of Severe Lung Injury After Vaping Reported in Three States

Health care providers should consider vaping as a cause for unexplained breathing problems, lung injury

Pediatric Cannabis Exposure Up After Medical Legalization

Cannabis exposure calls to poison control increased 140 percent after legalization in Massachusetts

Recommendations Developed for Management of Lyme Disease

Public comment period for these guidelines has been extended 30 days to Sept. 9, 2019

SAVED Score Can Predict Risk for VTE in Multiple Myeloma

Score outperforms current NCCN guidelines for MM patients receiving immunomodulatory therapy

Intensive BP Therapy Not Beneficial in Nursing Home Residents

Findings seen among long-term nursing home residents with, without cognitive impairment

Diabetes Education, Support Cuts Hypoglycemia Risk

Review shows positive impact on hypoglycemia events, symptoms, and knowledge

More U.K. Pharmacies Giving Patients Pill Organizers

Previous study showed sudden increased adherence with switch to an organizer may cause patient harm

AI Program May Aid in Pathologic Evaluation of Breast Biopsies

Computer-based automated approach promising for differentiating ductal carcinoma in situ from atypia

Air Pollutants Tied to Significant Worsening of Emphysema

Emphysema assessed quantitatively using CT imaging and lung function for patients in multiple U.S. cities

Up to Half of Patients Do Not Disclose Imminent Threats to Physicians

Patients withhold issues of depression, suicidality, abuse due to embarrassment, fear of being judged

Mental Health Burden Increased for Gender-Minority College Students

Odds of having at least one mental health problem greater for GM versus cisgender students

Burden of Obesity-Associated Cancers Shifted to Younger Age Groups

Large study shows particular increase in the 50- to 64-year-old age group from 2000 to 2016

One in Seven Internal Medicine Residents Report Being Bullied

International graduates, lower-performing residents, non-native English speakers most likely to report bullying

Vaping Industry Group Sues to Delay FDA Review of E-Cigarettes

Current deadline is May 2020 for all companies to submit their vaping products for federal review

FDA Proposes Graphic Warning Labels on Cigarettes

New labels would be the most significant change to cigarette labels in more than 35 years

Advertising Can Promote Interest in Health-Related Research

Short-term interest significantly increased for those viewing large TV monitors in ED waiting room

ACIP Recommends Catch-Up HPV Vaccines Through Age 26

For adults aged 27 to 45 years, vaccination may be beneficial for some who are inadequately vaccinated

Patients Recall Few Suggestions for Contact Lens Wear, Care

Most providers report sharing recommendations always or most of the time at checkups

Antipsychotic Rx Patterns in Children With ADHD Concerning

Mental health comorbidities associated with antipsychotic treatment in only half of this group

Model Predicts Hypoglycemia Risk in Adults With Diabetes

Positive associations seen for infection, non-long-acting insulin, dementia, recent hypoglycemia

Renal Anomaly on Fetal Scan May Up Risk for Admission for Child

Renal pelvis dilatation persisting in later pregnancy or after birth tied to increased risk for later admission

Half of Physician Directors of NCI Cancer Centers Receive Industry Payments

Authors question whether these payments serve the public interest

Nonpersistence, Low Adherence to BP Meds Common in Under 65s

Relative risks of nonpersistence, low adherence lower with initiation of ACEi, ARB, multiclass regimen

CDC: Over One-Third of U.S. Youth Exposed to Secondhand Smoke

SHS-exposed youth increased with decreasing family income

2005-2016 Saw No Improvement in Diabetes Care Cascade

Women and non-Hispanic blacks have lower odds of achieving composite target

Cost Burden of Disease Progression High in Multiple Myeloma

For patients receiving drug therapy, economic burden substantial across lines of therapy

CDC: Prescription Drug Use Similar in United States, Canada

Almost 70 percent of adults aged 40 to 79 years used at least one prescription drug in past 30 days

TSH Elevated in 6 Percent of Psychiatrically Hospitalized Youth

Elevated thyroid-stimulating hormone linked to recent weight gain, treatment with benzodiazepines

Gluten Intake, Celiac Disease Linked in Genetically Predisposed

Increased gluten intake may increase celiac disease autoimmunity, celiac disease in at-risk children

Internet Self-Referrals Aid in Diagnosis of Rare Inherited Kidney Disease

Twenty-four percent of direct family referrals to specialist center had positive genetic testing

Israeli Flight Attendant Dies of Measles

It is not known if she was infected with measles on a flight, in New York, or in Israel

Radial Artery Access Used for Neuroendovascular Procedures

Data examined from 233 consecutive cases performed via transradial access at a single institution

Postoperative Opioid Rx Size Down After Guideline Release

No change seen in satisfaction or pain scores despite reductions in prescription size, opioid use

Evidence Supports Meds Used for Pain Relief in Pediatric Migraine

But evidence insufficient to assess impact of many treatments to reduce headache frequency in youth

Antiarrhythmic Drugs May Up Fall Injuries in Older A-Fib Patients

Risk for fall-related injury and/or syncope higher for antiarrhythmic drug alone, with rate-lowering drug

AI Assists in Reading of Digital Breast Tomosynthesis Images

Concurrent use of AI system improves cancer detection, reduces reading time and recall rate

Low Muscle Mass in the Arms, Legs Tied to Mortality in Elderly

Muscle mass more predictive of mortality than visceral fat, total fat in older women

Traumatic Brain Injury May Up Risk for Suicide in Veterans

Degree of severity can influence link between TBI and risk for suicide, risk for suicide by firearm

Impulsivity Lower When Children Meet Sleep, Screen Time Guides

Children who meet sleep and recreational screen time recommendations have lower impulsivity

Adult Weight Gain Likely Explains Link Between Parity, T2DM Risk

Risk for diabetes among postmenopausal women can be reduced by preventing adult weight gain

Seniors With Dementia at Home Have More Medical Needs

Older adults living at home also more likely to be members of disadvantaged populations

Methylphenidate Tx Tied to Brain Changes in Boys With ADHD

White matter changes seen after four months of MPH versus placebo in boys, but not men, with ADHD

General, Abdominal Adiposity Linked to Mortality in Mexicans

Waist circumference strongly linked to mortality even after adjustment for BMI, hip circumference

Comorbid CVD May Up Mortality With ADT for Prostate Cancer

Seniors with preexisting cardiovascular diseases have higher risk for short-term mortality with AA, ENZ

Non-Hospital-Based Provider-to-Patient Telehealth Use Growing

2014 to 2018 saw increase of 1,393 percent from 0.007 to 0.104 percent of all medical claim lines

USPSTF Recommends Screening Adults for Illicit Drug Use

Evidence inadequate to weigh the balance of benefits and harms of screening for adolescents

‘Miracle Mineral Solution’ Is No Miracle Cure, FDA Warns

When mixed, the solution develops into a dangerous bleach

Doctors Say New Drugs ‘Cured’ Two Ebola Patients

The two drugs -- REGN-EB3 and mAb-114 -- are monoclonal antibodies that block Ebola

Erectile Dysfunction Tied to Lower Work Productivity Globally

Greater ED severity associated with worse outcomes for men worldwide

BP From Midlife to Late Life Tied to Risk for Subsequent Dementia

Smaller increase in cerebral white matter lesion volume seen with intensive blood pressure treatment

Type 1 Diabetes Misdiagnosed in One-Fourth of Children, Adults

Misdiagnosis of type 1 diabetes in children, but not adults, associated with diabetic ketoacidosis

Coffee May Speed Up Recovery of Function After Bowel Surgery

Time to first postoperative bowel movement and length of hospital stay shorter in coffee drinkers

CVD Mortality Declines Are Slowing in High-Income Countries

In most recent years, CVD mortality rate increased for U.S. men and women, Canadian women

Racial, Ethnic Disparities in Care for Preemies Have Narrowed

Disparities have narrowed in specific care practices for African-American, Hispanic versus white infants

Ultrasound Aids IV Line Placement in Children

Findings showed success of first attempts in children with presumed difficult peripheral access

Hearing Loss Increases Risk for Dementia in Taiwanese Individuals

Findings suggest that hearing protection, screening, treatment may help reduce risk for dementia

Aspirin May Improve Liver Function After Embolization of HCC

Study suggests aspirin is hepatoprotective, improves survival by reducing liver inflammation

Adjuvant RT May Cut Recurrence in Some With Prostate Cancer

Adjuvant radiotherapy after surgery may prolong biochemical recurrence-free survival

Psychotherapy Alone First Line of Treatment for Depressed Youth

Adding fluoxetine to cognitive behavioral therapy did not further reduce depressive symptoms

Flu Vaccine Tied to Better Long-Term Outcomes in Elderly ICU Survivors

Those who are vaccinated have lower risk for stroke, death in year following ICU discharge

Perfusion Assessment Key for Critical Limb Ischemia Diagnosis

Emerging technologies may improve diagnosis and management for critical limb ischemia

One-Third of Physicians Will Take 10+ Years to Pay Off Debt

Survey shows that taking extra shifts is one strategy to help doctors pay off medical school debt

EPA Will Not Approve Warning Labels for Glyphosate

Last year, Roundup maker Monsanto obtained court order blocking the warning labels

New Ebola Drugs Highly Effective, Might Shorten Outbreak in Africa

The treatments, REGN-EB3 and mAb-114, are both monoclonal antibodies

Use of Technology Now Included in Standards of Diabetes Care

Use of an intermittently scanned CGM can be considered as substitute to SMBG for adults

Adherence to Surgical Guidelines Low for Salpingo-Oophorectomy

Gynecologic oncologists more likely to fully adhere to surgical protocol than ob-gyns

Prescription Drug Misuse Common in High Schoolers

44 percent of high school seniors who misuse prescription drugs have multiple drug sources

Few at Risk for Diabetes Report Being Informed by Provider

Many individuals with elevated glucose levels are unaware of their heightened diabetes risk

AI Tool Discerns Lung Cancer Outcomes From Imaging Reports

Deep natural language processing used to detect presence of lung cancer and treatment response

Unused Pharmaceuticals Common After Cataract Surgery

Study shows both financial, environmental costs to unused pharmaceuticals across surgical sites

Vitamin D Tied to Falls, Nonmotor Symptoms in Parkinson Disease

No association seen between bone mineral density, vitamin D in patients with Parkinson disease

Red Meat Consumption May Up Risk of Invasive Breast Cancer

Findings from prospective cohort study of sisters or half-sisters of women diagnosed with breast cancer

Giant Cell Arteritis Occurs at Similar Rate in Blacks, Whites

Biopsy-proven GCA occurs more often in women versus men, but not in white versus black patients

No Evidence for Benefits of Opioids After Pediatric Tonsillectomy

Perioperative opioid fills linked to risk of return visit for constipation but not pain, dehydration or hemorrhage

Sleep Apnea Traits May Predict Response to Oral Appliance Tx

Response more likely with favorable nonpharyngeal traits, moderate pharyngeal collapsibility

Delayed/Foregone Care More Likely for Cancer Survivors With HDHPs

Having a health savings account can mitigate the impact of the high-deductible health plan

Guidelines Issued for Managing Hidradenitis Suppurativa

Two-part guideline addresses diagnosis, evaluation, management of the chronic inflammatory skin disease

Nurse-Led Quality Initiative Cuts Hypoglycemia in ICU Patients

Percentage of patients experiencing hypoglycemia decreased for those without, with diabetes

Worse Cancer Outcomes for Elderly HIV-Infected Patients

Significantly higher rates of relapse or death for HIV-infected men with prostate cancer, women with breast cancer

Excess Caffeine May Be a Trigger for Episodic Migraine Headaches

Three or more servings of caffeinated beverages associated with higher odds for headache that day

High Temps May Up Admissions, Deaths in End-Stage Renal Disease

Heterogeneity in risk observed according to geographic region

Endometriosis Tied to Adverse Pregnancy Outcomes

Association seen between endometriosis and pregnancy loss, hypertensive disorders, gestational diabetes

Method to Calculate Central Line Infections Flawed

Counting multiple concurrent central lines may help account for hospitals with patients with higher acuity of care

HbA1c, BMI Linked to Stillbirth Risk in Women With Diabetes

About one-third of stillbirths occur at term, with highest rates at week 38 and 39 for T1DM and T2DM

Ulcerative Colitis Outcomes Similar for Smokers, Nonsmokers

No significant difference in rates of flares, thiopurine use, hospitalization for persistent smokers, quitters

ADHD May Increase Risk of Premature Death

Psychiatric comorbidity plays key role for all-cause and cause-specific associations with death in adults

Major Surgery Linked to Lasting Change in Cognitive Trajectory

Major surgery on average tied to additional decline equivalent to less than five months of cognitive aging

Better CV Health in Midlife Tied to Reduced Dementia Risk Later

Lower risk of dementia with higher Life Simple 7 cardiovascular health score, measured at age 50 years

Fluoride Exposure Tied to Kidney, Liver Function Changes in Youth

Increase in plasma fluoride linked to lower eGFR, higher serum uric acid, lower blood urea nitrogen

Persistent Inflammation After Sepsis Linked to Higher Mortality

Persistent inflammation, immunosuppression linked to increased mortality and readmission after discharge

Younger CRC Patients More Likely to Present With Abdominal Pain

Young colorectal cancer patients more often present via emergency; have lowest percentage early-stage cancer

NSAIDs Contribute to Increased CVD Risk in Osteoarthritis

Considerable proportion of increased CHF, IHD, and stroke risk mediated by NSAID use

Hematological Malignancy Risk Up for First-Degree Relatives

Increased familial relative risks for the same tumor type for most hematological malignancies

Warnings Issued to Companies Illegally Selling E-Liquid, Hookah Products

FDA says companies are selling products without required marketing authorization

Medicare to Cover CAR-T Therapy for Leukemia, Lymphoma

Chimeric antigen receptor T-cell therapy boosts a patient's own immune cells

FDA Reports More Seizures Among Vapers

Agency encourages continued submission of reports related to seizures following e-cigarette use

Breast Cancer Surgery + Another Procedure Ups Complications

Findings for women undergoing additional plastic or gynecological procedure at time of breast cancer surgery

In 2018, 2,813 Cases of Domestic Arbovirus Reported in U.S.

94 percent of cases caused by West Nile Virus; 63 percent of these classified as neuroinvasive disease

Children With Type 1 Diabetes Have Poorer Educational Outcomes

Findings more pronounced in children with higher mean HbA1c

Rate of Dual Burden 37 Per 10,000 Births in California

Significant predictors of dual burden of preterm birth, severe maternal morbidity include smoking, HTN

At-Home Support Helps Stroke Patients Adjust After Hospitalization

Home-based support network includes social work case managers and online resources

Completion Rates of Recommended Vaccines Lower for Preemies

Rate of completion lower for seven-vaccine series by 19 months and 36 months of age

Recommendations Developed for Obesity Hypoventilation Syndrome

Interventions producing sustained weight loss of 25 to 30 percent of body weight recommended

Plant-Based Diets May Lower CV Disease, Deaths in Middle-Aged

Association also found for reduction in all-cause mortality but not incident cardiovascular disease

Common Therapy for Obstetric Cholestasis Found Ineffective

Treatment with ursodeoxycholic acid versus placebo yielded no significant difference in outcome

Addition of Sotagliflozin for T1DM Alters Renal Hemodynamics

Addition of SOTA tied to reductions in estimated glomerular filtration rate, blood pressure

Some Cancer Trends Differ for Oldest Old in the United States

Trends similar to 65- to 84-year age group, but risk elevated for some cancers, diagnosis at later stages

Recent Stressful Life Events Linked to Later Verbal Memory Decline

Link found for women, but not men, with stressful events within last year, but not more remote stresses

New Score Predicts Risk for VTE in Those With Multiple Myeloma

New IMPEDE VTE score outperforms International Myeloma Working Group/NCCN guidelines

Patient Who Caught Legionnaires’ Disease at Atlanta Hotel Dies

There are 11 other diagnosed cases of the disease and 61 probable cases

FDA: Approval of Zolgensma Was Based on Manipulated Data

Despite inaccurate data, FDA says it is 'confident that Zolgensma should remain on the market'

Phone Consults Grow Mental Health Service Access for Children

Statewide programs let primary care doctors consult with child psychiatrists about urgent patient issues

Strong SSRI May Be Tied to Small Decrease in Ischemic Stroke Risk

Rate of myocardial infarction similar with current use of strong, weak selective serotonin reuptake inhibitors

Nurse Intervention Using Tech May Improve PID Care in Youth

Young women enrolled in TECH-N more likely to have decreases in N. gonorrhoeae, C. trachomatis

Medicare Spending on Essential Medicines Up 116 Percent From 2011 to 2015

22 percent of increased total spending due to higher per-unit cost of existing drugs

Bone Health Management Key in Childhood Cancer Survivors

Working group reviewed bone complications to form recommendations for management of bone health

Children With ADHD Have Differences in Part of Brain Controlling Movement

Children with ADHD exhibit impaired stop cues and reduced engagement

Infant Suffocation Deaths in Bed Increased From 1996 to 2016

Rates higher for non-Hispanic black infants versus whites, although risk factors the same

Ranking for Abdominal Surgeries Not Linked to Patient Outcomes

Serious morbidity, in-hospital mortality similar for laparoscopic sx at top-ranked, nonranked hospitals

Low Specificity Limits Use of Focused Cardiac Ultrasonography

FoCUS may help rule out ventricular dysfunction, valvular disease in low-risk patients

Lifestyle Counseling Frequency, CV Outcomes Linked in Diabetes

More frequent counseling tied to lower incidence of death, CV events in adults with diabetes

Reporting of Results Often Biased in Psychiatry, Psychology Trials

Fifty-six percent of trials had spin in abstract; no correlation seen for industry funding with spin

Transdermal Optical Imaging Shows Promise for Measuring BP

Models could predict systolic, diastolic, pulse pressure within 5 ± 8 mm Hg of reference measurements

Vaccination Does Not Up Risk for Developing Multiple Sclerosis

Odds of MS lower in participants with vaccination, especially for influenza, tick-borne illness

DNA Methylation Classifier Predicts Progression in CIN2

For regression versus progression outcome, highest AUC was 0.735 for combination of S5, cytology

High-Intensity Lipid Lowering May Aid Very Elderly After ACS

Benefit of simvastatin-ezetimibe combo after acute coronary syndrome greatest for patients ≥75 years

Poor Pneumonia Outcomes Tied to Overuse of Broad-Spectrum Antibiotics

Poor outcomes include higher mortality, longer hospital stay, and greater risk for C. difficile infection

USPSTF Reaffirms Recs Against Screening for Pancreatic Cancer

Potential benefits of screening do not outweigh potential harms in asymptomatic adults

Exercise During Pregnancy May Boost Infant Development

Higher neuromotor scores seen in infants at 1 month of age

2012 to 2018 Saw Substantial Rise in Naloxone Dispensing

Regional variation in naloxone dispensing considerable; rates lowest in most rural counties

Guidance Issued for Research Use of Cardiac MRI After MI

Index CMR should be performed five ± two days after reperfusion

Premature Ovarian Insufficiency Tied to Poor Sleep Quality

Patients take longer to fall asleep, use more sleep aids, have more fatigue